[1 case of recurrent nasal vestibular aggressive angiomyxoma].

Invasive angiomyxoma（AAM） is characterized by unclear boundaries, non enveloped glial growth, high recurrence rate, and belongs to a benign tumor, but it is invasive and grows slowly. A patient with recurrent left vestibular invasive angiomyxoma was admitted to the Otorhinolaryngology ward of Beijing Traditional Chinese Medicine Hospital Affiliated with Capital Medical University. The patient underwent two repeated surgeries and underwent a combined internal and external nasal approach for the removal of the nasal vestibular angiomyxoma.

Interfacial stability and strain-modulated electronic properties in LaAlO3/SrTiO3 (110) heterostructures: A first-principles study.

Perovskite oxide interfaces exhibit functional properties that are absent in their bulk counterparts. Compared to the well-studied LaAlO3/SrTiO3 (001) interface, the LaAlO3/SrTiO3 (110) interface remains relatively unexplored. Here, we investigate the interfacial properties of n-type LaAlO3/SrTiO3 (110) heterostructures, including cleavage energy, two-dimensional electron gas (2DEG) formation, and the effects of biaxial strain, using first-principles density functional theory calculations.

Green emitting nitrogen-doped carbon dots as a dual recognition platform for sensitive and selective detection of 2,4,6-trinitrotoluene and glucose in wastewater.

Carbon dots (CDs) have been widely employed to fabricate various fluorescent chemosensors owing to their favorable photo-physicochemical properties and versatile surface modification feasibility. However, reports on CDs as a dual recognition platform for sensitive and selective detection of different analytes are very limited. In this study, highly negatively charged green emitting nitrogen-doped CDs were synthesized by a hydrothermal approach using 1,3,6-trinitropyrene and ascorbic acid as precursors, which subsequently self-assembled with positively charged methylviologen (MV) and polyethyleneimine (PEI) to form CDs-MV and CDs-PEI nanocomposites, respectively, by electrostatic interaction and hydrogen bond.

Rice ragged stunt virus Pns10 induces mitochondrial-mediated apoptosis to promote viral infection in Nilaparvata lugens through disrupting the NlNDUFS1-NlPHB2 interaction.

Apoptosis, a programmed cell death process, plays crucial roles in host antiviral response. Although there are many reports on the relationship between cell apoptosis and viral infection, the mechanisms underlying plant arbovirus-induced apoptosis in insect vectors remain largely unclear. Here, we reported that apoptosis promotes rice ragged stunt virus (RRSV) infection in Nilaparvata lugens (brown planthopper), and RRSV-encoded Pns10 protein can induce apoptosis in N.

Viral proteins suppress rice defenses by boosting OsTSN1 RNA decay via phase separation and multimerization.

Liquid-liquid phase separation (LLPS) forms membraneless condensates crucial for plant stress responses. However, how plant viruses utilize LLPS to escape host immunity remains largely unexplored. Here, we show that P6 protein encoded by southern rice black-streaked dwarf virus (SRBSDV) undergoes LLPS.

Programming Ion Gating and Dynamic Response of Nanopores with Responsive Tetrahedral DNA Nanostructures.

Mimicking ion-gating function with artificial nanopores empowered by well-designed responsive DNA architectures represents one of the leading maneuvers in the nanopore sensing field. However, due to the rarely preponderant orientation and uncontrollable assembly of conventional DNA constructs at heterogeneous interfaces, the recognition ability and gating efficiency remain a considerable challenge. Here, we show that manipulating the ion-gating efficiency can be readily achieved by the assembly of responsive tetrahedral DNA nanostructures in glass nanopipettes.

Effect of nonsurgical periodontal therapy on coronary artery disease or metabolic syndrome: a systematic review and meta-analysis.

Background: Periodontitis is closely related to the occurrence and development of coronary artery disease (CAD) and metabolic syndrome (MetS). However, the role of nonsurgical periodontal therapy (NSPT) in these 2 diseases is still controversial. To investigate the efficacy of NSPT in managing individuals with CAD or MetS and the differences in effects and benefits of NSPT between the 2 patient populations.

Rice black-streaked dwarf virus-encoded P6 protein impairs OsPelota-mediated antiviral RNA decay defense via promoting OsSCE1b ubiquitination and degradation in rice.

Rice black-streaked dwarf virus (RBSDV) is a major viral pathogen threatening rice production worldwide. However, the molecular mechanisms underlying the arms race between RBSDV and its host remain largely elusive. Here, we demonstrate that RBSDV infection, or the expression of viral RNA-silencing suppressor protein P6, promotes the ubiquitination and degradation of rice small ubiquitin-like modifiers (SUMO) conjugating enzyme 1b (OsSCE1b).

The safety and effectiveness of sintilimab versus camrelizumab, both plus targeted drugs, in advanced hepatocellular carcinoma.

Objectives: We aimed to evaluate the effectiveness and safety of sintilimab versus camrelizumab, both plus targeted drugs, for advanced hepatocellular carcinoma (HCC) in the real world. Then the effectiveness was compared between sintilimab-lenvatinib and camrelizumab-apatinib.

Methods: Patients diagnosed as advanced HCC were included from January 2017 to December 2023.

A plant viral effector disrupts ALD1-OSB1 immunity module to suppress chloroplast defenses.

Chloroplasts are central to plant immunity, with the chloroplast-localized protein AGD2-LIKE DEFENSE RESPONSE PROTEIN 1 (ALD1) playing a critical role in producing pipecolic acid (Pip), a key immune signal. However, the regulation of ALD1 and how pathogens evade ALD1-mediated defenses remain poorly understood. Using the geminivirus tomato yellow leaf curl China virus and its associated betasatellite (TYLCCNV/TYLCCNB) as a model, we uncovered a defense mechanism involving organellar single-stranded DNA-binding protein 1 (OSB1), which stabilizes ALD1 and promotes Pip biosynthesis to strengthen immunity.

Identification of Crucial Genes Associated With MYCN-Driven Neuroblastoma Based on Single-Cell Analysis and Machine Learning.

Background: Neuroblastoma (NB) with MYCN amplification is strongly correlated with high-risk stratification and poor prognosis. However, the underlying mechanisms remain incompletely understood. Elucidating these pathways is critical for advancing personalized treatments for MYCN-driven NB.

Meta-analysis on the efficacy and safety of Guanxin Shutong capsule in the treatment of angina pectoris of coronary heart disease.

Objective: This study aims to summarize all single clinical studies of Guanxin Shutong (GXST) capsule combined with Western medicine in the treatment of coronary heart disease angina pectoris and to systematically evaluate its efficacy and safety.

Methods: This study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Chinese and English databases were searched to collect the randomized controlled trials (RCTs) of GXST capsule combined with conventional Western medicine in the treatment of patients with angina pectoris of coronary heart disease and to extract the data.

Sublobar resection is non-inferior to lobectomy in octogenarians and older with stage Ia non‑small cell lung cancer.

Background: For individuals aged 80 years and older with early-stage non-small cell lung cancer (NSCLC), prior research has indicated that surgical intervention accompanied by lymphadenectomy may offer superior long-term survival outcomes compared to radiotherapy; however, the selection of the appropriate surgical approach continues to be a subject of debate. So, our aim is to compare overall survival (OS) differences between two surgical modalities (lobectomy and sublobar resection) in patients aged 80 years and older with pathological stage Ia NSCLC according to the 8th edition of the tumor-node-metastasis (TNM) staging system.

Methods: Patients aged ≥80 years with pathological stage Ia (T1N0M0) NSCLC from 2004 to 2021 were identified using the Surveillance, Epidemiology, and End Results (SEER) database.

Efficacy and Safety of Letermovir for Cytomegalovirus Prophylaxis Following Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Patients.

Purpose: Cytomegalovirus (CMV) infection represents a severe complication following hematopoietic cell transplantation (HCT), resulting in high mortality. The prevention of CMV reactivation is crucial for enhancing patient prognosis post-HCT. Letermovir prophylaxis has effectively reduced the incidence of clinically significant CMV infection (csCMVi) in adult HCT recipients.

Disulfidptosis in pediatric AML: a multi-omics approach to risk stratification and potential therapeutic strategy.

Background: The evolving molecular portrait of acute myeloid leukemia (AML) has exposed previously unrecognized cell death programs that fuel disease progression and treatment resistance-uncovering untapped therapeutic potential. Recent work has uncovered disulfidptosis-a novel form of programmed cell death (PDC) triggered by glucose deprivation in SLC7A11-high AML cells-as a potential therapeutic vulnerability. However, disulfidptosis in pediatric AML (pAML) remains largely unexplored, with no comprehensive studies assessing its biological significance or clinical prognostic value.

DiffBTS: A Lightweight Diffusion Model for 3D Multimodal Brain Tumor Segmentation.

Denoising diffusion probabilistic models (DDPMs) have achieved remarkable success across various research domains. However, their high complexity when processing 3D images remains a limitation. To mitigate this, researchers typically preprocess data into 2D slices, enabling the model to perform segmentation in a reduced 2D space.

[Study on the gene expression and regulation mechanisms of fibroblasts in acute inflammatory response].

Objective To investigate the gene expression and regulatory mechanisms of mouse embryonic fibroblasts (MEFs) under inflammatory conditions, aiming to elucidate the role of MEFs in inflammatory responses and provide a foundation for discovering anti-inflammatory drugs that act by modulating MEF function. Methods MEFs cultured in vitro were divided into the following groups: lipopolysaccharides (LPS)-treated group, inflammatory conditioned medium (CM)-treated group, and control group, which were treated with LPS, CM, and equal volume solvent, respectively. Transcriptome sequencing was used to analyze the effects of two stimuli on gene expression profile of MEFs.

A Novel Liquid Chromatography-Tandem Mass Spectrometry Method for Monitoring Plasma l-Asparaginase Activity in Pediatric Patients With Acute Lymphoblastic Leukemia Receiving Pegaspargase Treatment.

Background: Acute lymphoblastic leukemia (ALL) is the predominant malignancy in pediatric patients. As a crucial constituent of ALL chemotherapy, l-asparaginase is recognized as an integral element of treatment with a threshold concentration of 0.1 IU/mL used in treatment protocols.

Construction of watermelon mosaic virus-Beijing isolate infectious clone and study of the dynamic localization and accumulation of virus-encoded proteins.

Potyvirus is the largest genus of plant RNA viruses, and the members in the genus are known to cause significant damage to a wide variety of crops. In this study, we performed small RNA (sRNA) deep sequencing for identification of potential virus (es) in collected cucumber leaves with mosaic symptoms from fields in Beijing. Through this high-throughput sequencing and subsequent PCR amplification, we obtained a complete viral genome sequence of 10,044 bp, which showed the highest similarity to the watermelon mosaic virus (WMV) isolate FBR04-37 and exhibited the typical characteristics of potyviruses in its genome organization.

The AP2/ERF transcription factor GmTINY mediates ethylene regulation of Rhg1-conferred resistance against soybean cyst nematode.

The soybean complex resistance locus Rhg1 is a primary contributor to the control of soybean cyst nematode (Heterodera glycines; SCN), a major threat to soybean production worldwide. Two genes within this locus, GmAAT and GmSNAP18, are upregulated during SCN infection. In this study, we found that SCN-resistant soybean varieties exhibit elevated ethylene (ETH) production upon infection.

Selective Hydrogenation of Phenols to Cyclohexanones Over Hydrotalcite-Supported Pd Single-Atom Catalyst.

Cyclohexanones are widely used chemicals and currently produced by the oxidation of the fossil feedstocks. Direct selective hydrogenation of lignin derivatives has great potential for producing these chemicals, but is challenging to obtain high yields. Here, we report that hydrotalcite-supported Pd single-atom (Pd/CHT-800) catalyst enabled the hydrogenation of the benzene ring in the aromatics without the overreaction of carbonyl group, which could afford >99.

A CYP80B enzyme from Stephania tetrandra enables the 3'-hydroxylation of N-methylcoclaurine and coclaurine in the biosynthesis of benzylisoquinoline alkaloids.

Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant metabolites renowned for their pharmacological properties. However, sustainable sources for these compounds remain limited. Consequently, researchers are focusing on elucidating BIA biosynthetic pathways and genes to explore alternative sources using synthetic biology approaches.

Three-stage phosphorus release model during macrophyte decomposition in macrophyte-dominated eutrophic lake.

Phosphorus (P) release during macrophyte decomposition plays a pivotal role in the lake phosphorus cycle, particularly in macrophyte-dominated eutrophic (MDE) lakes. Developing a phosphorus release dynamics model is the key to establishing the complex nutrient cycling model. This study challenges the conventional one-stage phosphorus release model by proposing a three-stage framework, validated through comprehensive in-situ experiments using fresh senescent macrophyte detritus in two hydrologically distinct sub-lakes of a typical MDE lake (Wuliangsu Lake, China).

Sex-related differences in postoperative patient-reported outcomes among lung cancer patients: a multicenter cohort study.

Background: Studies on sex-related differences in post-lung cancer surgery symptoms are limited. Understanding these differences may provide insights into patient recovery. Therefore, we investigated sex-related differences in these symptoms and their underlying associated factors.

Venetoclax plus Modified-Intensity Idarubicin and Cytarabine Treatment as First-Line Treatment for Newly Diagnosed Pediatric Acute Myeloid Leukemia.

Purpose: Venetoclax (VEN) has shown excellent activity in eliminating acute myeloid leukemia (AML) blasts in preclinical and clinical trials, but clinical data in pediatric newly diagnosed AML (ND-AML) remain limited. We evaluated VEN plus modified-intensity idarubicin and cytarabine chemotherapy (VIA) in childhood ND-AML.

Patients And Methods: In an open-label, single-arm, multicenter prospective clinical trial, 65 pediatric patients with ND-AML received VIA induction.