Polytantalotungstates Stabilized Iron Catalysts for Carbonylation of Benzylic C-H Bonds.

Selective oxidation of benzylic C(sp)-H bonds to ketones is critical to the production of fine chemicals but typically requires toxic/precious metal catalysts under harsh conditions. While iron-based complexes have recently served as catalysts for photocatalytic C-H bond activation, most systems operate via homogeneous catalysis. Developing a light-driven strategy under visible light with O as an oxidant is of major importance.

Visible-Light-Responsive Polyoxometalate-Based Metal-Organic Frameworks for Photocatalytic Detoxification of Mustard Gas Simulant.

Two [Ru(bpy)] derivative-incorporated polyoxometalate-based metal-organic frameworks (POM@MOFs), {Cd(HO)Mn(HO)[Ru(dcbpy)][PMoMoO]}·6HO () and {Cd(HO)Cu(HO)[Ru(dcbpy)][PMoMoO]}·6HO (), have been prepared through a conventional hydrothermal method. The introduction of Ru metalloligands enhanced the visible light absorption of POM@MOFs, and the photocatalytic detoxification reaction of mustard gas simulant 2-chloroethyl ethyl sulfide (CEES) confirmed their fascinating photocatalytic performances. Under visible light irradiation (λ > 400 nm), both and exhibited efficient photocatalytic properties for the detoxification of CEES into nontoxic CEESO in air, with a selectivity of 97% and a TOF of 26.

Hypoxia-induced genome-wide DNA demethylation by DNMT3A and EMT of cancer cells.

Background: Despite the comprehensive advancement in the field of cancer therapeutics, there remains an urgent need to identify new pathophysiological mechanisms that can be targeted in isolation or in combination with existing therapeutic regimens. The epithelial-to-mesenchymal transitions (EMT) induced by hypoxia, cytokines, and growth factors involves acquisition of invasive and migratory properties by cancer cells. Epigenetic alterations of DNA methylations and/or histone modifications cause substantial transcriptomic reprogramming in cancer cells during EMT and metastasis, which can be therapeutically targeted by a thorough understanding of the mutual interactions among the epigenetic processes.

Assembly of a Pebble-Type Giant Polyoxometalate Cage {Mo} for Proton Conduction.

The modular assembly for high-nuclearity clusters is crucial for elucidating structure-activity relationships and broadening their functional applications. Herein, we prepared a novel pebble-type giant polyoxomolybdate cage NaH[MoMoO(OH)]·130HO {} hydrothermal methods. The {} cage features an elliptical molybdenum wheel {Mo} capped by three different small molybdenum building blocks with a flat inner cavity (6 Å).

Immunomodulatory potential of dexmedetomidine in perioperative pain management for patients with cancer.

•Dexmedetomidine (DEX) has immunomodulatory effects in perioperative pain management.•DEX can reduce pro-inflammatory cytokines.•DEX has dose-dependent effects on tumor progression.

HEs Consciousness Scale: a rapid and promising classification for early assessment of post-anesthesia consciousness recovery.

Postoperative cognitive dysfunction (POCD) is a common complication after thoracic surgery, especially after complex surgeries involving general anesthesia, such as lung transplantation. Improving anesthetic strategies may offer an effective approach to reducing the incidence of POCD. Non-intubated anesthesia has emerged as a transformative advancement in thoracic surgery and anesthesia.

Crown-type tetranuclear Ag-POM exhibits excellent proton conductivity performance.

A crown-type tetranuclear Ag-POM, Na[AgNa(AsWO)]·82HO (1), was synthesized based on the structural features of {AsW} using simple materials through the hydrothermal method. The polyanion of compound 1 consists of a tetranuclear silver cluster embedded in the cyclic ligand {AsW} and the polyanions linked by Na to form a 3D framework. Moreover, compound 1 exhibits excellent proton conductivity, with an optimal conductivity of 2.

Corrigendum to 'Tβ4-exosome-loaded hemostatic and antibacterial hydrogel to improve vascular regeneration and modulate macrophage polarization for diabetic wound treatment' [Mater. Today Bio,Volume 31, 2025, 101585].

[This corrects the article DOI: 10.1016/j.mtbio.

Hierarchically depicting vehicle trajectory with stability in complex environments.

The rapid development of autonomous robots has resulted in marked societal and economic benefits. However, enabling robots to navigate complex environments with human-like agility remains a formidable challenge. Unlike robots, humans excel at pathfinding because of their superior spatial awareness and their ability to leverage experience.

8-Co-Containing Polyoxomolybdate for CO Photoreduction Reaction.

An S-shaped 8-Co-containing polyoxomolydate (NH)CsH[Co{Co(OH)(HO)(VMoO)(VMoO)}]·60HO () was obtained by the one-pot reaction. Compound adopts a triple-sandwich configuration, comprising two equivalent asymmetric sandwich-type tri-Co-containing {Co(OH)(HO)(VMoO)(VMoO)} units and a di-Co core linker. In particular, the {VMoO} segment adopts a unique petal-like architecture and represents a previously unreported structural subunit in polyoxometalate chemistry, thereby expanding the structural diversity of the molybdovanadate family.

Facile synthesis of a Ru-based polyoxometalate for efficient reduction of nitrobenzene.

A non-classical Ru-based polyoxometalate, NaH[{Ru(bpy)Cl}O(PWO)]·10HO (1), was successfully constructed from mono-vacant heteropolytungstates [PWO] and [Ru(bpy)Cl]. Compound 1 has strong light trapping ability, and the yield of aniline reduced from nitrobenzene under visible light ( > 400 nm) can reach 99.8%.

Selective Hydrogenation of Phenols to Cyclohexanones Over Hydrotalcite-Supported Pd Single-Atom Catalyst.

Cyclohexanones are widely used chemicals and currently produced by the oxidation of the fossil feedstocks. Direct selective hydrogenation of lignin derivatives has great potential for producing these chemicals, but is challenging to obtain high yields. Here, we report that hydrotalcite-supported Pd single-atom (Pd/CHT-800) catalyst enabled the hydrogenation of the benzene ring in the aromatics without the overreaction of carbonyl group, which could afford >99.

Polyoxometalate Anion-Induced On-Off Spin-Crossover Property in Two Isomeric Cobalt(II) Complexes with Proton Conductivity.

The integration of polyoxometalate (POM) anions with functionalized cations within a single molecule remains a challenging task, even though POMs have garnered significant interest over an extended period. Here, we constructed two cobalt(II) complexes by incorporating isomeric POM anions with [Co(pyterpy)]. Intriguingly, a locked high-spin (HS) state and a spin-crossover (SCO) behavior of the 3-Co ion in the identical cation [Co(pyterpy)] were governed by α-type and β-type [MoO] anions, and the HS-Co(II) ion showed field-induced slow magnetic relaxation.

Unlocking aerobatic potential of quadcopters: Autonomous freestyle flight generation and execution.

Quadcopter drones are capable of executing complex aerobatic maneuvers when controlled manually by skilled pilots but are limited to simple aerobatic actions when flying autonomously in open spaces. As such, this study introduces a comprehensive system that enables drones to generate and execute sophisticated aerobatic maneuvers in complex environments with dense obstacle distributions. A universal representation is proposed, succinctly capturing flight as a series of discrete aerobatic intentions.

[Ru(bpy)] Derivatives-Incorporated POM@MOFs with Good Photocatalytic Activity for Visible-Light-Driven Oxidative Coupling of Amines to Imines.

Two novel POM@MOFs, {HZn(HO)[Ru(dcbpy)][PMoMoO]}·2HO () and {HNi(HO)[Ru(dcbpy)][PMoMoO]}·5HO (), have been synthesized through a traditional hydrothermal method. They are composed of [Ru(bpy)]-derived hexa-carboxylate and Keggin-type anion [PMoMoO]. In addition, their structures were well characterized by various spectroscopic methods.

Enhanced Oxidative Coupling of Thiols to Disulfides Using the Visible-Light-Responsive POM@MOF Constructed with Ru Metalloligands.

The photocatalytic oxidative coupling of thiols to disulfides by using visible light represents an economically viable and environmentally sustainable strategy. A novel POM@MOF photocatalyst (Ru-CdS-SiW) was synthesized through the encapsulation of Keggin-type [SiWO] within a MOF composed of Ru metalloligands and {CdSO} clusters. In this structure, the incorporation of POMs to the MOFs reduced the charge transport distance, facilitated the separation and transfer of photogenerated charges and holes, and prevented the recombination of electron-hole pairs.

Carbohydrate deacetylase, a key enzyme in oxidative chitin degradation, is evolutionarily linked to amino acid deacetylase.

The microbial oxidative cleavage of chitin, the second most abundant biopolymer in nature, generates a substantial amount of oxidized amino sugar, 2-(acetylamino)-2-deoxy-D-gluconic acid (GlcNAc1A). The catabolism of GlcNAc1A is key to the oxidative chitin degradation pathway. However, the molecular mechanism and evolution underlying this pathway remain elusive.

Visible-Light-Responsive Tetranuclear Ir-Based Polyoxometalates Achieve Photocatalytic Baeyer-Villiger Oxidation of Ketones.

Synthesizing efficient photocatalysts with a broad-spectrum response is crucial for improving solar energy utilization. In this work, we have constructed two examples of tetrameric Ir-based polyoxometalates by introducing an Ir ion. The introduction of Ir ions lowers the band gap energy, and the light absorption range is extended into the visible region.

Tβ4-exosome-loaded hemostatic and antibacterial hydrogel to improve vascular regeneration and modulate macrophage polarization for diabetic wound treatment.

Diabetic wounds often exhibit delayed healing due to compromised vascular function and intensified inflammation. In this study, we overexpressed Thymosin β4 (Tβ4) in Adipose-Derived Stem Cells (ADSCs) to produce Exosomes (Exos) rich in Tβ4. We then utilized a dual photopolymerizable hydrogel composed of Hyaluronic Acid Methacryloyl (HAMA) and Poly-L-lysine Methacryloyl (PLMA) for the sustained release of Tβ4-Exos on diabetic wounds.

Efficacy and safety of Shexiang Baoxin Pill in patients with angina and non-obstructive coronary arteries: A multicenter, randomized, double-blind, placebo-controlled, phase Ⅳ clinical trial.

Introduction: Solid evidence generated from large studies supporting the recommendation of Shexiang Baoxin Pill (MUSKARDIA) as a promising treatment for angina and nonobstructive coronary arteries (ANOCA) populations is lacking.

Objective: To evaluate the efficacy and safety of MUSKARDIA in patients with ANOCA.

Methods: In this randomized, double-blind, placebo-controlled, phase IV trial, we enrolled 239 patients with ANOCA at 11 centers across China between May 2021 and July 2023.

Genomic analysis of Isoptericola halotolerans SM2308 reveals its potential involved in fucoidan degradation.

Marine bacteria play important roles in the degradation and recycling of algal polysaccharides. However, the marine bacteria involved in fucoidan degradation and their degradation pathways remain poorly understood. Here, we report the complete genome sequence of Isoptericola halotolerans SM2308, isolated from a brown algal sample collected from an intertidal zone of the Yellow Sea in China.

Enhancing the psychological well-being and sleep quality of healthcare providers with a multimodal psychological support program: a randomized controlled trial.

Background: The COVID-19 pandemic significantly challenged the global healthcare system, especially frontline healthcare professionals, such as those working in intensive care units (ICUs). In late 2022, a sudden increase in COVID-19 cases in China led to a large number of ICU admissions, requiring new ICU staff (non-ICU professionals to work in ICUs), exacerbating their stress. This study aimed to develop an effective stress management strategy for new ICU professionals, focusing on reducing the detrimental effects of stress on their psychological state.

Visible-Light-Induced Oxidation of Styrene by a Polyoxovanadate-Based Carboxylate Derivative.

Revealing the design and synthesis of precisely tailored crystalline catalysts for achieving efficient photocatalytic conversion of styrene into high-value-added products remains a challenging task. In this work, a highly stable crystalline polyoxovanadate functionalized by the dl-tartaric acid ligand H[VO(HO)(tart)]·HO [, tart = CHO] was successfully synthesized by conventional aqueous solution methods. The photocatalytic performance was evaluated for the photosynthesis of styrene oxide by employing an oxygen source as the oxidant in the visible light (>420 nm) conditions at room temperature with compound as a heterogeneous catalyst.

Sleep deprivation affects pain sensitivity by increasing oxidative stress and apoptosis in the medial prefrontal cortex of rats via the HDAC2-NRF2 pathway.

Sleep is crucial for sustaining normal physiological functions, and sleep deprivation has been associated with increased pain sensitivity. The histone deacetylases (HDACs) are known to significantly regulate in regulating neuropathic pain, but their involvement in nociceptive hypersensitivity during sleep deprivation is still not fully understood. Utilizing a modified multi-platform water environment technique to establish a sleep deprivation model.

Ru Metalloligands Participate in the Construction of POM@MOF for Enhancing the Visible Photoinduced Baeyer-Villiger Oxidation Reaction.

Directed synthesis of high-efficiency visible photoinduced Baeyer-Villiger oxidation catalysts is of primary significance. Here, the isopolymolybdate anion [β-MoO] is for the first time encapsulated with the photosensitive metalloligand [Ru(bpy)(Hdcbpy)] (bpy = 2,2'-bipyridine; Hdcbpy = 2,2'-bipyridine-5,5'-dicarboxylic acid) to synthesize polyoxometalate@metal-organic frameworks, {(CdDMF)[Ru(bpy)(dcbpy)]([β-MoO])}·5DMF (Ru-Mo). The composite photocatalyst Ru-Mo not only has a light absorption of 700 nm but also shortens the photogenerated electron transfer distances and accelerates charge and proton transfer.