MPO-anchored ENO1 mediates neutrophil extracellular trap DNA for enhancing Treg differentiation via IFITM2 during sepsis.

Sepsis is a life-threatening disease caused by a dysfunctional host response to infection. During sepsis, inflammation-related immunosuppression is the critical factor causing secondary infection and multiple organ dysfunction syndrome. The regulatory mechanisms underlying regulatory T-cell (Treg) differentiation and function, which significantly contribute to septic immunosuppression, require further clarification.

Water-Based Nanoparticulate Formulation of Lambda-Cyhalothrin and Its Enhancement of Bioavailability.

Low efficacy and frequent use of conventional pesticide formulations have led to various food safety and ecological concerns. Green and effective nanoformulation offers promising solutions to water-insoluble pesticides. Herein, we prepared a water-based nanoparticulate formulation of lambda-cyhalothrin (LC WBNF) using high-gravity rotating packed bed (RPB) combined with lyophilization.

Interfacial stability and strain-modulated electronic properties in LaAlO3/SrTiO3 (110) heterostructures: A first-principles study.

Perovskite oxide interfaces exhibit functional properties that are absent in their bulk counterparts. Compared to the well-studied LaAlO3/SrTiO3 (001) interface, the LaAlO3/SrTiO3 (110) interface remains relatively unexplored. Here, we investigate the interfacial properties of n-type LaAlO3/SrTiO3 (110) heterostructures, including cleavage energy, two-dimensional electron gas (2DEG) formation, and the effects of biaxial strain, using first-principles density functional theory calculations.

A study on ecological risk identification based on ecosystem service supply and demand in Xinjiang.

Due to the rapid urbanization and global climate change, arid and semi-arid regions are becoming more vulnerable to the growing disparity between the supply and demand of ecosystem services. Conventional ecological risk assessments have predominantly emphasized landscape pattern analysis, often overlooking considerations related to human well-being. This study focuses on the Xinjiang Uygur Autonomous Region (XUAR) and examines four key ecosystem services: water yield (WY), soil retention (SR), carbon sequestration (CS), and food production (FP).

Detection of transient tissue displacement using wavelet MR elastography: Phantom validation and in vivo human brain repeatability study.

Purpose: While standard MR elastography (MRE) uses harmonic mechanical waves, there are some applications in which imaging and analysis of transient mechanical motion are of interest. Wavelet MRE has been developed for detecting broadband motion from transient excitation. The goal of this study was to evaluate the accuracy and efficiency of wavelet MRE for transient displacement detection in brain MRE applications.

Review of black cohosh-induced toxicity and adverse clinical effects.

Black cohosh () has been utilized for centuries by Native Americans as a traditional herbal medicine. The rhizome and root extract from black cohosh (BCE) is one of the most popular herbal dietary supplements worldwide. Due to its claimed estrogen-like effects, contemporary uses of black cohosh products are primarily for alleviating menopausal and perimenopausal symptoms.

MYLIP attenuates hypoxia tolerance by inducing K27-linked polyubiquitination and subsequent proteasomal degradation of HIF-α.

Hypoxia tolerance is mainly controlled by the hypoxia signaling pathway and HIF-1α/2α serve as master regulators in this pathway. Here we identify MYLIP, an E3 ubiquitin ligase thought to specifically target lipoprotein receptors, as a downstream target of HIF-2α and a negative regulator of both HIF-1α and HIF-2α. MYLIP interacts with HIF-1α/2α and catalyzes K27-linked polyubiquitination at lysine 118/442 (HIF-1α) or lysine 117 (HIF-2α).

Zebrafish fkbp5 attenuates antiviral innate immunity by autophagic degradation of transcription factor irf7.

Activation of the type I interferon (IFN-I) signaling pathway is crucial for protecting host cells against viral infections. IFN-I production requires the transcription factors IFN regulatory factor 3 (IRF3) and IRF7, and its regulation must be finely tuned to both combat infection effectively and prevent excessive immunopathology. Here, we report that selective autophagy mediated by zebrafish FK506-binding protein 5 (Fkbp5), a PPIase (peptidyl-prolyl isomerase) promotes the degradation of Irf7 and Irf3, thereby inhibiting virus-induced type I IFN production.

[Evolution Trade-offs and Synergistic Relationships in Ecological Functional Areas Based on Ecosystem Service Bundles： A Case Study of the Turpan-Hami Region].

Clarifying the spatial distribution and compositional structure of the ecological functional zone and understanding the evolution of the trade-offs and synergies among multiple ecosystem services （ESs） are essential for scientific management and restoration of Turpan-Hami Region ecosystems. The objective of this study was to explore the driving forces of the trade-offs/synergies for each ecosystem service bundle （ESB） and to develop differentiated ecological management strategies based on the ecological characteristics. Six ecosystem services （carbon storage （CS）, water yield （WY）, soil retention （SR）, habitat quality （HQ）, food production （FP）, and aesthetic landscape provision （ALP））, were quantified in the Turpan-Hami Region.

[A study on the predictive model of porous hyperelastic properties of human alveolar bone based on computed tomography imaging].

Alveolar bone reconstruction simulation is an effective means for quantifying orthodontics, but currently, it is not possible to directly obtain human alveolar bone material models for simulation. This study introduces a prediction method for the equivalent shear modulus of three-dimensional random porous materials, integrating the first-order Ogden hyperelastic model to construct a computed tomography (CT) based porous hyperelastic Ogden model (CT-PHO) for human alveolar bone. Model parameters are derived by combining results from micro-CT, nanoindentation experiments, and uniaxial compression tests.

X-ray based radiomics machine learning models for predicting collapse of early-stage osteonecrosis of femoral head.

This study aimed to develop an X-ray radiomics model for predicting collapse of early-stage osteonecrosis of the femoral head (ONFH). A total of 87 patients (111 hips; training set: n = 67, test set: n = 44) with non-traumatic ONFH at Association Research Circulation Osseous (ARCO) stage II were retrospectively enrolled. Following data dimensionality reduction and feature selection, radiomics models were constructed based on anteroposterior (AP), frog-lateral (FL), and AP + FL combined view using random forest (RF), support vector machine (SVM), and stochastic gradient descent (SGD).

Feasibility study of the application of magnetic resonance elastography to diagnose uterine adenomyosis.

Objective: Magnetic resonance elastography (MRE), a novel imaging technique that allows in vivo measurement of tissue mechanical properties, was used to test the prediction that the stiffness of the uterus may be increased due to fibrotic changes in patients with adenomyosis.

Design: A feasibility study in which a 3-dimensional (3D) MRE imaging protocol was developed to measure the stiffness of the tissues of the uterus.

Subjects: Four patients with suspected adenomyosis and heavy menstrual bleeding diagnosed via transvaginal ultrasound and clinical history and 1 healthy control were recruited.

S100A9 as a promising therapeutic target for diabetic foot ulcers.

Background: Diabetic foot is a complex condition with high incidence, recurrence, mortality, and disability rates. Current treatments for diabetic foot ulcers are often insufficient. This study was conducted to identify potential therapeutic targets for diabetic foot.

The driving path of green entrepreneurial orientation from a configuration perspective.

Based on institutional theory and upper echelons theory, this paper explores the causal and complex driving mechanisms of green entrepreneurial orientation (GEO) from the perspective of configuration. Using 356 sample cases through fuzzy set qualitative comparative analysis (fsQCA), the results show that (1) the reasons for enterprises to choose GEO are the result of six elements, and the path leading to enterprises to choose GEO is not the only one; (2) there are three types of groups that generate high GEO: institutional pressure-driven, moral responsibility-driven and internal profit-driven. Normative pressure plays a general role in generating high GEO; and (3) there is asymmetric relationship between high GEO and non-high GEO, and incentive regulation pressure has nothing to do with non-high GEO.

Constructing a disease-specific ceRNA coregulatory network for keratoconus diagnosis and landscape of the immune environment.

Purpose: The early diagnosis of keratoconus (KC) is crucial for making treatment decisions. Therefore, the purpose of this study was to determine the potential disease-specific gene biomarker and landscape the immune environment in KC.

Methods: The transcriptome data of KC was obtained from Gene Expression Omnibus (GEO) and ArrayExpress databases for next analysis.

Zebrafish hif1β attenuates antiviral innate immunity by suppressing Irf7 transcriptional activity.

HIF1β, which serves as a common binding partner of the aryl hydrocarbon receptor and hypoxia-inducible factor (HIF)-α subunits, plays a key role in 2 cellular signaling pathways: the aryl hydrocarbon receptor and HIF pathways. Whether HIF1β is involved in antiviral innate immunity remains to be determined. In this study, we show that zebrafish hif1β is induced by viral infection.

Atomic Layer Deposition Synthesis of VO@Al-O Core-Shell Structure with Enhanced Oxidation Resistance for Adaptive Infrared Camouflage Application.

VO has attracted extensive attention as an adaptive camouflage material due to its structural change during the metal-insulator transition (MIT) at 68 °C, which can rapidly respond to ambient temperature and actively modulate the infrared emissivity. However, its thermal instability has limited its application in the optical field. In this paper, VO@AlO core-shell micronanoparticles (VO@Al-O) with controllable shell thickness were first prepared by the atomic layer deposition method, and their thermal stability and infrared modulation performance were systematically studied.

Free-breathing hepatic 2D magnetic resonance elastography.

Purpose: To evaluate the test-retest repeatability of a rapid, free-breathing two-dimensional (2D) MR elastography (MRE) technique and to assess the reliability of the liver-stiffness measurements compared with conventional breath-hold MREs.

Methods: Fifteen and 115 participants were enrolled in the technical repeatability and measurement equivalence assessment cohorts, respectively. All participants underwent rapid free-breathing and conventional breath-hold 2D MRE (twice in repeatability cohort) on 1.

Characterizing the Pulmonary Toxicity and Potential Mutagenicity of Formaldehyde Fumes in a Human Bronchial Epithelial Tissue Model.

Formaldehyde (FA) is a highly reactive aldehyde that is regarded as an inhalation hazard and human carcinogen. Herein, we report a follow-up study evaluating the effects of exposure duration on the toxicity and mutagenicity of FA using a human in vitro air-liquid-interface (ALI) airway tissue model. Previously we exposed ALI cultures to 7.

Polydopamine-Mediated Nanofillers Reinforced Zwitterion Hydrogel Electrodes for Supercapacitors in Bioelectronics.

Supercapacitors that can function when in direct contact with human tissue are of paramount importance for wearable bioelectronics but face mismatching with biological tissue and its movement. Herein, we developed a zwitterion hydrogel elastomer electrode-based all-hydrogel supercapacitor (AHSC) characterized by good energy storage properties, bioadhesion, body movement-matching mechanical properties, and biocompatibility. These functions were realized by integrating a [2-(methacryloyloxy)ethyl]dimethyl-(3-propylsulfonate)ammonium hydroxide (DMAPS) and hydroxyethyl acrylate (HEA)-copolymerized zwitterion hydrogel electrode (DMAPS-HEA) with redox-active nanofillers.

Case report: Short-course hypofractionated radiation therapy combined with immune checkpoint inhibitors for the treatment of advanced ovarian mucinous cystadenocarcinoma.

Background: Ovarian mucinous cystadenocarcinoma is a rare subtype of ovarian epithelial carcinoma that is resistant to platinum-based chemotherapy and has a poor prognosis, and there is no standard treatment plan for patients for whom multiline treatment has failed.

Case Presentation: oma with FIGO stage IVB disease who was sequentially treated with paclitaxel liposomes+carboplatin, 5-Fu+CF+oxaliplatin, capecitabine+oxaliplatin, bevacizumab+FOLFOX4, S-1, and bevacizumab+oxaliplatin+raltitrexed chemotherapy. After the progression of the disease, a combination of short-course hypofractionated radiation therapy and immune checkpoint inhibitors was used.

Disinfection efficacy of peroxyacetic acid against bacterial spores.

Peracetic acid (PAA) is an emerging disinfectant known to be highly effective against various microorganisms. However, the capability of PAA to eliminate spores under different conditions and its application in liquid and gaseous forms remain unclear. Here, we aimed to develop a stabilized single-composite PAA and evaluate its disinfection efficacy in both liquid and gaseous form against suspended or surface-coated spores under varying temperature and humidity conditions.

A hyperspectral stealth material design method based on the composition and mixing spectral feature of desert soil.

In this study, we used desert soil from Gansu, China, as a sample to propose a method for designing hyperspectral stealth coatings against desert soil backgrounds within the spectral range of 400-2500 nm, and the corresponding coating was prepared. Firstly, the correlation between the composition and typical spectral detected characteristics of the desert soil was systematically analyzed. It was found that the color and the spectrum of the desert soil in the range of 400-1000 nm were influenced by different types of iron oxides.

Gut dysbiosis-induced vitamin B6 metabolic disorder contributes to chronic stress-related abnormal behaviors in a cortisol-independent manner.

Chronic stress can result in various conditions, including psychological disorders, neurodegenerative diseases, and accelerated brain aging. Gut dysbiosis potentially contributes to stress-related brain disorders in individuals with chronic stress. However, the causal relationship and key factors between gut dysbiosis and brain disorders in chronic stress remain elusive, particularly under non-sterile conditions.

Pyridoxine Prevents Postoperative Nausea and Vomiting in Gynecologic Laparoscopic Surgery: A Double-blind Randomized Controlled Trial.

Background: Postoperative nausea and vomiting are common complications after gynecologic laparoscopic surgery. Pyridoxine has been recommended as a first-line drug to prevent and treat nausea and vomiting during pregnancy; however, its efficacy in preventing postoperative nausea and vomiting remains unclear.

Methods: Patients of 18 to 65 yr old who received elective gynecologic laparoscopic surgery under general anesthesia were randomized into either the pyridoxine group or the control group.