Bisphenol E Neurotoxicity in Zebrafish Larvae: Effects and Underlying Mechanisms.

As typical environmental hormones, endocrine-disrupting chemicals (EDCs) have become a global environmental health issue of high concern due to their property of interfering with the endocrine systems of organisms. As a commonly used substitute for bisphenol A (BPA), bisphenol E (BPE) has been frequently detected in environmental matrices such as soil and water in recent years. Existing research has unveiled the developmental and reproductive toxicity of BPE; however, only one in vitro cellular experiment has preliminarily indicated potential neurotoxic risks, with its underlying mechanisms remaining largely unelucidated in the current literature.

The Global, Regional, and National Burden of Three Female Pelvic Cancers Attributable to High Body Mass Index from 1990 to 2021: A Systematic Analysis for the Global Burden of Disease Study 2021 and Projection to 2050.

High body mass index (BMI) is an important risk factor for female colon and rectal, ovarian, and uterine cancers. Current comprehensive studies on its effects on these cancers are limited. This paper aims to explore regional and age differences in the impact of high BMI on these cancers and the commonalities among the three by using the Global Burden of Disease (GBD) 2021.

MPO-anchored ENO1 mediates neutrophil extracellular trap DNA for enhancing Treg differentiation via IFITM2 during sepsis.

Sepsis is a life-threatening disease caused by a dysfunctional host response to infection. During sepsis, inflammation-related immunosuppression is the critical factor causing secondary infection and multiple organ dysfunction syndrome. The regulatory mechanisms underlying regulatory T-cell (Treg) differentiation and function, which significantly contribute to septic immunosuppression, require further clarification.

Impact of stopping Tenofovir disoproxil fumarate at various times on elevated postpartum ALT levels and breastfeeding in pregnant women with chronic hepatitis B: a prospective observational cohort study.

Background: To investigate the impact of tenofovir disoproxil fumarate (TDF) withdrawal timing on elevated postpartum alanine aminotransferase (ALT) levels and breastfeeding in pregnant women who received TDF therapy to prevent mother-to-child transmission (MTCT) of hepatitis B virus (HBV) infection.

Methods: All enrolled women began treatment with TDF during weeks 24-32 of pregnancy and were divided into three groups that stopped TDF at delivery (Group A), at 4 weeks postpartum (Group B), or at 12 weeks postpartum (Group C). The biochemical and virological markers of hepatitis B were regularly measured and compared.

Associations of blood pressure fluctuation patterns with cognitive function: the mediating role of cumulative blood pressure.

Background: The impact of different fluctuation patterns of blood pressure (BP) on episodic memory remains underexplored, and the role of cumulative BP in this association remains unclear.

Methods: Using data from the China Health and Retirement Longitudinal Study, 6563 participants aged 45 years or more were analyzed. BP was measured in wave 1 (2011), wave 2 (2013), and wave 3 (2015).

Effectiveness and mechanism of using PBS-ZVI carriers to enhance granulation in UASB reactors for coking wastewater treatment.

Slow anaerobic granulation and poor shock load resistance in up-flow anaerobic sludge blanket (UASB) reactors present significant challenges in treating difficult-to-degrade coking wastewater. In this study, we developed a novel poly(butylene succinate)-zero-valent iron (PBS-ZVI) carrier (KT) and examined its effects on anaerobic granulation and shock load resistance. The addition of KT increased the quantity of anaerobic granular sludge (AGS) larger than 1 mm in the UASB by a factor of 2.

Impact of Traditional Chinese Medicine therapy focused on strengthening the body on postoperative recurrence and metastasis prevention in stage IIIA non-small cell lung cancer: a real-world retrospective cohort study.

Background: This study aimed to evaluate the impact of Traditional Chinese Medicine (TCM) therapy focused on strengthening the body on postoperative recurrence and metastasis prevention in patients with stage IIIA non-small cell lung cancer (NSCLC).

Methods: This retrospective cohort study analyzed real-world data from patients with stage IIIA NSCLC who underwent radical surgery between January 2016 and January 2022 at Longhua Hospital, Shanghai University of Traditional Chinese Medicine. Patients were classified into an exposed group, receiving adjuvant chemotherapy or radiotherapy combined with TCM therapy, and a non-exposed group, receiving only adjuvant chemotherapy or radiotherapy.

Treatment of liver abscess caused by Klebsiella pneumoniae with multi-site infection: a case report.

Background: Pyogenic liver abscesses are a fatal condition often seen in emergency departments. The major clinical presentations include weakness, anorexia, fever, chills, ventosity and abdominal pain. They occur in immunocompromised individuals who suffer from diabetes mellitus, malignant tumors, hepatocirrhosis, kidney failure, and solid organ transplantation, or those with long-term administration of glucocorticoids.

Analyses of GWAS and Sub-Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk.

Schizophrenia (SCZ) is highly polygenic, and its biological underpinnings remain unclear. In this study, a cost-effective strategy of including sub-threshold GWAS (subGWAS) loci (i.e.

Decoding ligand recognition and constitutive activation of histamine H3 and H4 receptors.

Histamine H3 receptor (H3R) and H4 receptor (H4R) are key members of the histamine receptor family, with H3R as a potential target for narcolepsy treatments and H4R as a candidate for next-generation antihistamines for inflammatory and allergic diseases. Although progress has been made in understanding the structure of histamine receptors, the detailed mechanisms of ligand recognition and receptor antagonism for H3R and H4R remain unclear. In this study, using cryo-electron microscopy, we present an inactive structure of H4R bound to a selective antagonist, adriforant, and two Gi-coupled structures of H3R and H4R in complex with histamine.

Multiple substance use and the risk of pancreatitis: a systematic review.

Background: The impact of multiple substance use on the risk of pancreatitis remains underexplored.

Objective: To systematically review peer-reviewed observational studies assessing the association of multiple substance use with the risk of acute pancreatitis (AP) or chronic pancreatitis (CP) in adults.

Design: We conducted a systematic review informed by the Preferred Reporting Items for Systematic Review and Meta-Analyses guideline.

Understanding biological motion through the lens of animate motion processing.

Biological motion (BM), the movement generated by living entities, transmits signals of life and conveys vital cues for animacy perception. In this review, we synthesize empirical findings from human and non-human animal studies to reveal how BM enjoys a unique position in visual perception as an animate motion and how it elicits animacy perception. Compared to non-biological and inanimate motions, BM engages specialized perceptual processing mechanisms and a dedicated cortical-subcortical network.

Periarticular Corticosteroid for Superior Pain Relief After Total Knee Arthroplasty: A Randomized Controlled Trial.

Background: Dexamethasone can alleviate pain and reduce inflammatory response following total knee arthroplasty (TKA). This study aimed to compare the effects of periarticular injection (PAI) and intravenous dexamethasone in patients who underwent TKA.

Methods: In this randomized controlled trial, 160 patients who underwent primary ipsilateral TKA were randomized into four groups: intravenous dexamethasone (Group I, n = 40), topical dexamethasone (Group T, n = 40), combined dexamethasone (Group IT, n = 40), and a control group without dexamethasone (Group C, n = 40).

Cannabinoid Receptors CB1 and CB2 Activation Restores Hippocampal Lipid Profiles and Alleviates Autism-Like Behaviors in Valproic Acid-Induced ASD Rats.

Objective: Emerging evidence suggests lipid metabolism dysregulation contributes to autism spectrum disorders (ASD), with the endocannabinoid system (cannabinoid receptors CB1R/CB2R) implicated in lipid homeostasis. This study investigated whether CB1R/CB2R activation improves hippocampal lipid metabolism and ASD-like behaviors in a valproic acid (VPA)-induced ASD rat model.

Methods: Male offspring from dams exposed to VPA (600 mg/kg, i.

Deinococcus lichenicola sp. nov., A Bacterium Isolated from a Lichen Sample.

A Gram-stain-positive bacterium, designated as YIM 134068, was isolated from a lichen. Strain YIM 134068 was non-motile, non-spore forming, coccus shaped, oxidase, and catalase positive. Cells could grow at 10-40 °C (optimum 28 °C) and pH 7.

Effects of vitamin supplementation on related symptoms in women with endometriosis: a systematic review and meta-analysis.

Background: Endometriosis is a gynecological disease with high occurrence, and symptoms include dysmenorrhea, infertility, and dyspareunia, which seriously affect women's quality of life. Antioxidants are beneficial in improving the symptoms of endometriosis, but there are still differences in their results. The aim of this study was to comprehensively evaluate the effects of vitamin supplementation (vitamin C, vitamin E, and vitamin D) on the related symptoms in women with endometriosis.

Perceiving facial emotions in context: The intertwined roles of emotional valence and consciousness.

Facial emotion perception in real life is inevitably influenced by the affective context, such as the expressions on nearby people's faces. However, to what extent and how the expressions of others exert a contextual influence on our interpretation of target facial emotions remains largely unclear. Using psychophysical methods, we demonstrated that the emotional facial context alone (i.

DNA methylation signature of oxidative stress and its mediating role in response to metal exposure.

Metal exposure could induce oxidative stress, yet the underlying epigenetic mechanisms remain unclear. Herein, we aimed to investigate the DNA methylation signatures associated with oxidative stress biomarkers, including 8-hydroxyguanine (8-OHdG) and 8-iso-prostaglandin-F2α (8-iso-PGF2α), and evaluate their mediating role in metal-induced oxidative stress. A genome-wide DNA methylation association study was conducted in discovery panel (Shiyan, N = 155) with validation in an independent replication panel (Wuhan-Zhuhai, N = 50).

Microbial synergistic interactions shape the heavy metal speciation preferences between paddy and upland soils.

Heavy metal contamination in agricultural soils poses escalating ecological risks, necessitating urgent remediation strategies. Through integrated approaches including soil sample collection, ecological network analysis, functional bacterial strain isolation, and validation via soil simulation experiments, this study systematically investigated the bacterial regulation of metal speciation in contrasting paddy and upland ecosystems within the middle Yangtze River Basin. Findings revealed that upland microbial communities functioned to reduce heavy metal mobility compared with paddy systems.

Structural basis of peptide recognition and modulation for neuropeptide FF receptors.

Neuropeptide FF receptors 1 and 2 (NPFFR1 and NPFFR2) are RF-amide peptide receptors that couple to G proteins and regulate pain, opioid tolerance, and metabolism. Despite their physiological significance, their ligand selectivity and activation mechanisms remain unclear. Using cryoelectron microscopy, we resolved four NPFFR1 and NPFFR2 structures bound to NPFF or NPVF, revealing conserved C-terminal RF-amide interactions within the orthosteric pocket and N-terminal variations driving subtype specificity.

Evaluating the Oxidative Balance Score for Peripheral Artery Disease Risk: Integrating Epidemiologic Modeling and SHAP-Interpretable Machine Learning in NHANES.

Oxidative stress plays a central role in the development of peripheral artery disease (PAD), yet composite indices quantifying its impact remain underutilized. The oxidative balance score (OBS), integrating dietary and lifestyle exposures, may offer a comprehensive approach to vascular risk stratification. We analyzed data from 7249 U.

The aerial part of Panax japonicus alleviates HFD-induced non-alcoholic fatty liver via activation of the AMPK/ACC pathway in rats.

This study investigated the saponin fraction (SF) from P. japonicus aerial parts against NAFL. The saponin fraction was isolated from P.

gen. nov., sp. nov., a vitamin B-producing bacterium isolated from the coral sp. in South China Sea.

A Gram-stain-negative, aerobic, non-motile and short rod-shaped bacterium, designated strain SCSIO 64248, was isolated from the stony coral sp. collected from South China Sea. Phylogenetic analysis indicated that strain SCSIO 64248 belonged to the family and showed the highest 16S rRNA gene similarities with the types of (90.

Pregnane Steroids From the Whole Herb of Pachysandra terminalis and Their Cytotoxic Activity.

Four new pregnane steroids, terminalones A-D (1-4), were obtained from the whole herb of Pachysandra terminalis Sieb. et Zucc (Buxaceae). The structures were determined by various spectral techniques.

Tapered graded-index multimode-fiber coupled sapphire Fabry-Perot cavity for high-temperature dynamic strain measurement.

Real-time dynamic strain measurements under a high temperature environment is important for many applications, e.g. component fault diagnosis of aeroengines.