Phase-Reconstruction of S-Doped (NiCo)WC for Efficient and Stable Oxygen Evolution Reaction Electrocatalysis.

Developing highly active and stable nonprecious electrocatalysts toward sluggish alkaline oxygen evolution reaction (OER) is essential for large-scale green hydrogen production via electrochemical water splitting. Here we report phase and surface co-reconstruction of S-doped (NiCo)WC nanoparticles into (NiCo)C with amorphous electroactive NiCoOOH layer for highly efficient alkaline OER by W dissolution and NiCo surface oxidation. The W dissolution results in the formation of Brønsted base WO ions, which electrostatically accumulate around electrode to promote water dissociation into abundant OH* intermediates, in situ constructing a locally strong alkaline microenvironment to facilitate OH* adsorption on NiCoOOH sites and trigger lattice-oxygen oxidation path.

Carboxymethyl chitosan/oxidized carboxymethyl starch Schiff base hydrogels containing fasudil for islet encapsulation and transplantation.

Islet transplantation offers a promising therapeutic strategy for type 1 diabetes patients with inadequate glycemic control or severe complications. Islet encapsulation using biocompatible materials presents a potential solution to reduce immune rejection. This study fabricated and characterized Schiff base hydrogels (CMOCs) composed of varying ratios of carboxymethyl chitosan (CMCS) and oxidized carboxymethyl starch (OCMS).

POU6F1 promote lumbar motor circuit reorganization following spinal cord injury.

Spinal cord injury (SCI) causes irreversible motor deficits due to disrupted lumbar circuitry. However, transcriptional mechanisms in distal lumbar circuits are poorly understood. We identify POU6F1 as a critical transcriptional regulator in spinal lumbar segment (SLS, L3-L5) motor circuit regeneration.

Ligand-metal charge transfer-enabled copper-gallate nanozyme rescue oxidative stressed reparative cells for inflammatory dental tissue regeneration.

Dental tissue regeneration is often challenged by the hostile inflammatory microenvironment and the dysfunction of reparative cells due to oxidative stress. This study presents a reactive oxygen species (ROS)-scavenging nanozyme induced by ligand-to-metal charge transfer, engineered as a multifunctional capping material through the in situ growth of copper-gallate (CuGA) on hydroxyapatite nanofibers (HAFs). The obtained CuGA@HAF demonstrates superior ROS-scavenging capacity through its multi-enzyme mimetic activity, effectively rescuing the function of dental pulp stem cells (DPSCs) under oxidative stress by restoring mitochondrial homeostasis.

Recaticimab in adult heterozygous familial hypercholesterolemia (REMAIN-3): A multicentre, randomised, double-blind, placebo-controlled phase 3 study.

Aims: Heterozygous familial hypercholesterolemia (HeFH) is a genetic disorder, characterised by high plasma concentrations of low-density lipoprotein cholesterol (LDL-C) from birth. This study aimed to assess the efficacy and safety of recaticimab, a new humanised anti-PCSK9 antibody capable of reducing LDL-C levels in patients with poorly controlled HeFH.

Methods And Results: REMAIN-3 was a multicentre, randomised, double-blind, placebo-controlled phase 3 study done at 25 sites in China.

Identification of a Novel Core Structure of Apo-Ido1 Inhibitors Through Virtual Screening and Preliminary Hit Optimization.

Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme considered as a potential therapeutic target for neurodegenerative diseases and cancer. However, the further development of traditional IDO1 inhibitors has been hindered by their limited clinical efficacy. Recently, type IV apo-IDO1 inhibitors offer a new strategy for developing IDO1 inhibitors due to their highly selective and durable inhibition.

Cyclic Heptapeptide FZ1 Acts as an Integrin αvβ3 Agonist to Facilitate Diabetic Skin Wound Healing by Enhancing Angiogenesis.

Diabetic wound healing remains a persistent clinical challenge, necessitating the development of effective therapeutic agents and a deeper understanding of regulatory mechanisms. The cyclic heptapeptide FZ1, characterized by favorable biocompatibility, exhibited significantly greater efficacy than rh-bFGF and Cy in promoting cell proliferation and migration. In diabetic wound models, FZ1 markedly accelerated tissue regeneration and stimulated angiogenesis, as indicated by the upregulation of CD31 and α-SMA.

Quantifying aerosol and microbial exposure of healthcare workers in endoscopy suites: a time-based study.

Objectives: This study aimed to quantify aerosol and microbial exposure levels during different working hours, analyze temporal air pollution trends in the endoscopy suite, and provide evidence to optimize infection prevention strategies.

Methods: A portable laser particle counter and an airborne bacteria sampler were used to measure aerosol particle concentrations and microbial loads at four time points: before the commencement of work (baseline), and 1, 2, and 3 h after work initiation. Continuous data collection was conducted over 10 consecutive working days.

Correction: Monocyte count combined with GTVnx is an independent prognostic factor in non-metastatic nasopharyngeal carcinoma receiving radiotherapy.

[This corrects the article DOI: 10.3389/fonc.2025.

Value of urinary lipoarabinomannan levels for tuberculosis diagnosis and monitoring of therapy.

Background: The urinary lipoarabinomannan (LAM) assay has emerged as a promising tool for tuberculosis (TB) diagnosis and treatment monitoring. This study aimed to evaluate the diagnostic and monitoring performance of LAM compared to Acid-fast bacilli (AFB), Mycobacteria Growth Indicator Tube (MGIT), and GeneXpert, and to establish its clinical utility in a stratified TB population.

Methods: A prospective cohort study included TB patients stratified by AFB/MGIT status into three groups.

Genetic and Cellular Architecture of Breast Cancer Risk in Multi-Ancestry Studies of 159,297 Cases and 212,102 Controls.

Breast cancer genome-wide association studies (GWAS) have identified over 200 independent genome-wide significant susceptibility markers. However, most studies have focused on one or two ancestral groups. We examined breast cancer genetic architecture using GWAS summary statistics from African (AFR), East Asian (EAS), European (EUR) and Hispanic/Latina (H/L) samples, totaling 159,297 cases and 212,102 controls, comprising the largest multi-ancestry study of breast cancer to date.

Discovery of novel 1,2,4-triazole schiff bases hybridized with 1,4-naphthoquinones as potent STAT3 inhibitors.

Signal transducer and activator of transcription 3 (STAT3) is closely related to a variety of cancers. The research of novel STAT3 inhibitors is an important and meaningful project for pharmaceutical chemist. In this study, 10 novel 1,4-naphthoquinones carrying 1,2,4-triazole derivatives were synthesized via a four-step synthesis starting from 2-hydroxynaphthalene-1,4-dione.

DyFiLM: A framework to handle the distribution shifts on dynamic graphs with hypernetworks.

Dynamic graph representation learning has garnered increasing attention since dynamic graphs can accurately reflect the changes and evolutionary processes in the real world. Existing approaches typically train a fixed model to capture temporal patterns and then utilize the fixed model to infer future evolution. They assume that the dynamic graph evolves with the same law over time.

Effect of Precipitation Change on Desert Steppe Aboveground Productivity.

Precipitation changes have significant impacts on biodiversity and ecosystem productivity. However, the effects of precipitation changes on species diversity have been the focus of most previous studies. Little is known about the contributions of different dimensions of biodiversity (species, functional, and phylogenetic diversity) in linking long-term precipitation changes to ecosystem functions.

The GmPRL1b-GmST2-GmAOC3/4 Module Confers Salt Tolerance and Botrytis cinerea Resistance by Inducing Jasmonic Acid Biosynthesis in Soybean.

Abiotic and biotic stress significantly limit crop yields. However, most stress-tolerance genes identified to date provide resistance to either biotic or abiotic stress and inhibit normal plant growth, limiting their application in breeding. We identified the soybean (Glycine max) NAC transcription factor gene GmST2, which is induced by salt and Botrytis cinerea stresses.

A novel personalized time-varying biomechanical model for estimating lung tumor motion and deformation.

Background: Accurate prediction of lung tumor motion and deformation (LTMD) is essential for precise radiotherapy. However, existing models often rely on static, population-based material parameters, overlooking patient-specific and time-varying lung biomechanics. Personalized dynamic models that capture temporal changes in lung elasticity are needed to improve LTMD prediction and guide treatment planning more effectively.

The Process From Turnover Intention to Turnover Decision in Chinese Nurses With Master's Degree: A Grounded Theory Study.

This study explores the stages from turnover intention to turnover decision-making among Chinese nurses with a master's degree, aiming to identify the enablers and barriers influencing turnover decisions. A constructivist grounded theory approach was adopted to develop a theoretical framework for understanding turnover decision-making among master's degree nurses. Through purposive and theoretical sampling, nurses with a master's degree who had either left their positions or expressed a high turnover intention within the past 2 years were selected.

Effect of sorafenib on prognosis in patients with low-allelic-ratio FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation.

Background: The effect of sorafenib in acute myeloid leukemia (AML) patients with low-allelic-ratio FMS-like tyrosine kinase 3 internal tandem duplication(FLT3-ITD) is still unclear.

Objective: The purpose of this study was to evaluate whether sorafenib can improve prognosis in FLT3-ITD AML patients.

Study Design: In this study, the effect of sorafenib on the prognosis of patients with FLT3-ITD AML was retrospectively explored.

Contrasting the influences of phosphate and phosphite on growth of .

Phosphite serves as an alternative phosphorus material in terrestrial ecosystems. (), a prominent phosphate-solubilizing fungus (PSF), facilitates phosphorus and leaches heavy metal ions via organic acids and enzymes. With the synergistic effect of phosphate materials, heavy metal ions can be effectively immobilized by to achieve remediation of contaminated soils.

Metabolic dysfunction-associated fatty liver in type 2 diabetes mellitus patient: can a systematic review of and meta-analysis of commonly used TCM-preparation shed light on their efficacy?

Background: Type 2 diabetes mellitus (T2DM) and Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) are mutually causal, which can jointly promote the development of the disease. As an important means to evaluate the steatosis of MAFLD, Controlled Attenuation Parameter (CAP) can also evaluate the metabolism related fat parameters. Whether Traditional Chinese Medicine preparation (TCM-preparation) can improve CAP has not been reported yet, so the purpose of this meta-analysis is to evaluate the effect of TCM-preparation on CAP in T2DM patients with MAFLD.

Population-specific genetic differences of acute coronary syndrome in Han and Uyghur Chinese.

Background: Acute coronary syndrome (ACS) is a critical cardiovascular condition with diverse clinical presentations, necessitating personalized therapeutic approaches. This study explores the genetic variation associated with ACS subtypes in the Han and Uyghur Chinese populations to support the development of precision medicine approaches tailored to ethnic-specific genetic backgrounds.

Methods: A total of 985 ACS patients (668 Han and 317 Uyghur Chinese) representing different ACS subtypes were enrolled.

Imaging biomarkers in antibody-mediated autoimmune encephalitis.

Background: Imaging, particularly multimodal magnetic resonance imaging (MRI), serves as an essential auxiliary examination for diagnosing autoimmune encephalitis (AE). The diversity of autoantibodies complicates the imaging presentation of AE, exhibiting both common and individual features across different subtypes of AE. Currently, there is a lack of comprehensive studies on the imaging features of different subtypes of AE.