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Dynamic graph representation learning has garnered increasing attention since dynamic graphs can accurately reflect the changes and evolutionary processes in the real world. Existing approaches typically train a fixed model to capture temporal patterns and then utilize the fixed model to infer future evolution. They assume that the dynamic graph evolves with the same law over time. While the underlying data generation distribution of graphs may shift over time and introduce new evolution patterns. To resolve this challenge, we propose a learning-to-learn framework entitled Dynamic Feature-wise Linear Modulation (DyFiLM), which employs a hypermodel to adjust the representation learning model to change with the distribution shifts. By employing a hypermodel to directly modulate the representation learning model based on time-varying input data, our framework captures evolutionary patterns from diverse time and expresses them through the modulation. Training both hypermodel and representation learning model in a distribution-shifting environment endows the framework with the capability for cross-distribution generalization. We apply our proposed framework to three different models and conduct extensive experiments on four datasets to verify the effectiveness of DyFiLM. The experimental results demonstrate that the DyFiLM achieves significant improvements compared with related approaches.
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http://dx.doi.org/10.1016/j.neunet.2025.108006 | DOI Listing |
BMC Musculoskelet Disord
September 2025
Department of Clinical Sciences at Danderyds Hospital, Department of Orthopedic Surgery, Karolinska Institutet, Stockholm, 182 88, Sweden.
Background: This study evaluates the accuracy of an Artificial Intelligence (AI) system, specifically a convolutional neural network (CNN), in classifying elbow fractures using the detailed 2018 AO/OTA fracture classification system.
Methods: A retrospective analysis of 5,367 radiograph exams visualizing the elbow from adult patients (2002-2016) was conducted using a deep neural network. Radiographs were manually categorized according to the 2018 AO/OTA system by orthopedic surgeons.
Nat Biomed Eng
September 2025
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Phenotype-driven approaches identify disease-counteracting compounds by analysing the phenotypic signatures that distinguish diseased from healthy states. Here we introduce PDGrapher, a causally inspired graph neural network model that predicts combinatorial perturbagens (sets of therapeutic targets) capable of reversing disease phenotypes. Unlike methods that learn how perturbations alter phenotypes, PDGrapher solves the inverse problem and predicts the perturbagens needed to achieve a desired response by embedding disease cell states into networks, learning a latent representation of these states, and identifying optimal combinatorial perturbations.
View Article and Find Full Text PDFCell Syst
September 2025
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:
Spatial transcriptomics allows for the measurement of gene expression within the native tissue context. However, despite technological advancements, computational methods to link cell states with their microenvironment and compare these relationships across samples and conditions remain limited. To address this, we introduce Tissue Motif-Based Spatial Inference across Conditions (TissueMosaic), a self-supervised convolutional neural network designed to discover and represent tissue architectural motifs from multi-sample spatial transcriptomic datasets.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Computer Science, COMSATS University Islamabad, Sahiwal, Pakistan.
The widespread dissemination of fake news presents a critical challenge to the integrity of digital information and erodes public trust. This urgent problem necessitates the development of sophisticated and reliable automated detection mechanisms. This study addresses this gap by proposing a robust fake news detection framework centred on a transformer-based architecture.
View Article and Find Full Text PDFBioinformatics
September 2025
Novo Nordisk Foundation Center for Protein Research, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Motivation: Representation learning has revolutionized sequence-based prediction of protein function and subcellular localization. Protein networks are an important source of information complementary to sequences, but the use of protein networks has proven to be challenging in the context of machine learning, especially in a cross-species setting.
Results: We leveraged the STRING database of protein networks and orthology relations for 1,322 eukaryotes to generate network-based cross-species protein embeddings.