Publications by authors named "Michael Axenhus"

Hand and wrist fractures are among the most common orthopaedic injuries, with a growing trend toward surgical treatment. However, large-scale data on regional variations and treatment trends remain limited. This population-based study analyses the incidence, trends, and regional variations in hand and wrist fracture fixation with plates and screws in Sweden from 2008 to 2023, with predictive modelling for future trends.

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Purpose: Tibial osteotomy (TO) is a surgical procedure used to treat unicompartmental gonarthrosis and correct lower extremity deformities. While historically effective, TO utilization has declined, possibly due to advances in alternative procedures such as unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA). The aim of this study is to describe and highlight demographic characteristics, trends in utilization and regional variance of TO in Sweden during 2008 to 2023 as well as estimate the usage by 2030.

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Radiocarpal and intercarpal arthrodesis are common procedures for managing advanced arthritis, post-traumatic conditions, and failed interventions. This observational study analysed 5,189 cases of arthrodesis registered in the Swedish National Patient Register between 2008 and 2023 to identify surgical trends and future projections. Of these, 2,434 were radiocarpal and 2,755 intercarpal arthrodesis.

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Introduction: Hand and wrist fractures are common orthopaedic injuries, with varied postoperative management strategies. Cast immobilization, traditionally used to ensure fracture stability, is increasingly debated in favour of early mobilization. However, significant regional differences persist.

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Purpose: In older patients requiring a hip arthroplasty, the cemented straight collarless polished tapered stems (PTSs) have been linked to an increased risk of periprosthetic femur fractures (PFFs) when compared to anatomically shaped stems (ASs). This study aims to perform a 6-year follow-up of PFF rates and other adverse events of an orthopaedic department's full transition from a cemented PTS to a cemented AS.

Methods: A prospective single-centre cohort study included 1077 patients operated with a cemented hip replacement at Danderyd Hospital, Stockholm, Sweden, between 2012 and 2015.

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Over a 16-year period (2008-2023), data from the Swedish National Patient Register reveal shifting trends in operation for hand joint replacements linked to demographic, healthcare and surgical advances. Among 5382 identified cases, 63% were women, with the incidence peaking in the 65-74 age bracket, highlighting a marked gender gap in middle and older age groups. Regional analyses indicate significant disparities, as Örebro and Halland had rates exceeding 10 per 100,000, while Stockholm and Blekinge fell below 5 per 100,000.

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Objective: Wear-induced osteolysis is a leading cause of late failure in total hip arthroplasty (THA). Denosumab, a RANKL inhibitor, suppresses osteoclast activity and may slow osteolytic progression. This feasibility study aimed to assess the practicality of conducting a randomized, double-blind, placebo-controlled trial evaluating Denosumab's effect on periprosthetic osteolysis in asymptomatic THA patients.

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Purpose: Hip fractures in older adults are a significant risk factor for morbidity and mortality, with the presence of dementia further complicating outcomes. The purpose of this study was to investigate the association between hip fractures and mortality of patients with dementia and dementia types in comparison to those without dementia following hip fracture surgery.

Methods: Utilizing data from the Swedish Hip Fracture Register (SHR), Swedish Registry for Cognitive/Dementia Disorders (SveDem), National Patient Register (NPR), and National Prescribed Drug Register (PDR), we conducted a retrospective analysis of 111,353 patients aged 65 and older who underwent hip fracture surgery between 2010 and 2018.

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Background: Total hip replacement (THR) is commonly used for active and lucid elderly patients with displaced femoral neck fractures (FNF). Historically, cemented stems have been favoured, demonstrating superior early outcomes. Controversy still exists regarding the use of cemented or uncemented stems in the most active group of patients with FNF and there is a need for extended follow-up studies to assess long-term outcome of cemented and uncemented stem results.

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Background: Ankle fractures are the third most common fractures, often requiring surgical intervention to restore function and mobility. Understanding trends in ankle fracture surgeries is essential for optimizing treatment strategies and improving patient outcomes. The aim of this study is to provide a comprehensive analysis of ankle fracture surgeries in Sweden in order to highlight changes in demography and trends in surgical procedures.

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Purpose: Periprosthetic femoral fractures (PFFs) after total hip arthroplasty (THA) are increasing, particularly Vancouver B2 fractures around cemented polished tapered femoral stems. Open reduction and internal fixation (ORIF) are more frequently used in comparison to the traditional stem revision to deal with these complex fractures. This observational study aims to compare the outcomes of ORIF versus stem revision in the treatment of Vancouver B2.

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Background: Spinal fractures are a group of complex injuries whose management varies according to a number of factors. The aim of this study was to analyze trends in the management of spinal fracture surgery in Sweden from 2008 to 2023 with a focus on disparities based on gender, surgery method, age and geographical location. A secondary aim was to predict future incidence of spinal fracture surgeries.

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Background: The humeral head resurfacing arthroplasty (HHR) is normally used as a hemi shoulder arthroplasty and has been in use for the treatment of Gleno-Humeral osteoarthritis (OA) of the shoulder for more than 30 years. Some studies, however, shows that anatomical total shoulder arthroplasty provides better improvement in function than a HHR for patients with OA. Reasons for this may be a progressive glenoid wear (GW) or loosening of the HHR.

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Background And Purpose: Hand fractures are commonly presented in emergency departments, yet diagnostic errors persist, leading to potential complications. The use of artificial intelligence (AI) in fracture detection has shown promise, but research focusing on hand metacarpal and phalangeal fractures remains limited. We aimed to train and evaluate a convolutional neural network (CNN) model to diagnose metacarpal and phalangeal fractures using plain radiographs according to the AO/OTA classification system and custom classifiers.

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Introduction: Immunocompromised individuals, such as those undergoing Rituximab therapy, are susceptible to severe infections by these organisms. We present a rare case of polyarticular septic arthritis caused by disseminated Ureaplasma urealyticum in a Rituximab-treated patient.

Presentation Of Case: A 38-year-old male with a history of schizophrenia and multiple sclerosis presented with intense pain, swelling, and fever, along with limited joint mobility.

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Early detection of Alzheimer's disease is vital for timely treatment. Existing biomarkers for Alzheimer's disease reflect amyloid- and tau-related pathology, but it is unknown whether the disease can be detected before cerebral amyloidosis is observed. N-glycosylation has been suggested as an upstream regulator of both amyloid and tau pathology, and levels of the N-glycan structure bisecting N-acetylglucosamine (GlcNAc) correlate with tau in blood and CSF already at pre-clinical stages of the disease.

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Background: We aimed to use open source data to understand the incidence, trends, and regional differences of finger and partial hand amputations on a national level in individuals aged 15 or older in Sweden.

Methods: We analyzed 6,918 patients aged 15 and older who had experienced finger and partial hand amputations. Incidence rates, trends, and regional disparities were assessed using negative binomial regression models and Student's t-tests.

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Purpose: Periprosthetic (PPFF) and peri-implant femoral fractures (PIFFs) are troublesome complications of prosthetic and implant surgery, the prior being described to have a greater delay to surgery when compared with standard hip fractures. The implications of PPFF delay being disputed in the current literature and those of PIFF have not been investigated. The aim of this study was to determine whether the time from radiological examination to surgery differs between hip fractures and PPFF/PIFF, and the possible consequences of delay and group affiliation on morbidity, mortality, and readmissions.

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Introduction: Traumatic peripheral nerve injuries pose significant challenges to healthcare systems and individuals, affecting sensory function, causing neuropathic pain, and impairing quality of life. Despite their impact, comprehensive studies on the epidemiology and regional variance of these injuries are scarce. Understanding the incidence, trends, and anatomical distribution of such injuries is essential for targeted interventions and resource allocation.

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Purpose: Changes in knee surgery incidence are important factors for stakeholders and healthcare providers. The aim of this study was to examine trends and patterns in knee surgeries in Sweden from 2010 to 2022. The study focuses on gender-specific and overall rates of knee surgeries.

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Purpose: We aimed to identify temporal trends, seasonal changes and regional differences in shoulder fractures in Sweden during 2008-2022.

Methods: Data from the Swedish National Board of Health and Welfare were used to assess incidence rates per 100,000 people, categorized by sex, age, and month.

Results: Results showed an average of 17,496 fractures annually, with a decline in 2020 followed by a resurgence in 2021-2022.

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Purpose: Periacetabular bone loss poses a considerable challenge in the longevity and stability of acetabular implants used in total hip arthroplasty (THA). Innovations in implant design, specifically the introduction of three-dimensional (3D) porous titanium constructs, might reduce bone resorption. The purpose of this study was to build upon our previous randomized controlled trial, which found no change in periacetabular bone loss between a 3D porous none-hydroxyapatite coated titanium cup and a standard porous hydroxyapatite coated cup over a two year follow-up period by extending the follow-up duration to ten years post-surgery.

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Introduction: Orthopedic injuries to the foot constitute a significant portion of lower extremity injuries, necessitating an understanding of trends for effective preventive strategies and resource allocation. Demographic shifts, improved traffic safety, and lifelong physical activity may alter incidence rates, trauma mechanisms, and fracture distribution. This study explores the prevalence of foot fractures in Sweden using publicly available data.

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Introduction: Periprosthetic femoral fractures (PFFs) following hip arthroplasty, especially Vancouver B2 and B3 fractures, present a challenge due to the association with a loose femoral stem, necessitating either open reduction and internal fixation or stem revision. This study aims to compare outcomes between uncemented and cemented stem revisions in managing Vancouver B2 and B3 fractures, considering factors such as hip-related complications, reoperations, and clinical outcome.

Methods: A retrospective cohort study was conducted at Danderyd Hospital, Sweden, from 2008 to 2022, encompassing operatively treated Vancouver B2 and B3 fractures.

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Background And Purpose: Knowledge concerning the use AI models for the classification of glenohumeral osteoarthritis (GHOA) and avascular necrosis (AVN) of the humeral head is lacking. We aimed to analyze how a deep learning (DL) model trained to identify and grade GHOA on plain radiographs performs. Our secondary aim was to train a DL model to identify and grade AVN on plain radiographs.

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