A smart textile fabric-based optical nano-biosensor for hydrogen peroxide and glucose monitoring.

The incorporation of nanomaterials into smart flexible interfaces is a developing requirement for real-time diagnostics applications. In this work, we report a novel optical fabric-based sensor for the analysis of glucose and hydrogen peroxide (HO), addressing critical needs of healthcare, industrial safety, and environmental analysis. In contrast to traditional rigid substrates, we utilized cotton fabric as a porous and flexible sensing platform, immobilizing cerium oxide nanoparticles (CeO₂-NPs) using hydrogel.

Secondary metabolites isolated from Fernandoa adenophylla (Wall. ex G.Don) steenis as multitarget inhibitors of cholinesterases for the treatment of Alzheimer's Disease, followed by molecular docking studies.

Alzheimer's disease (AD) is a neurodegenerative disorder categorized by the progressive loss of cognitive function, with acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) as key therapeutic targets. In this study, we report the isolation, characterization, and evaluation of the cholinesterase inhibitory potential of phytochemicals from Fernandoa adenophylla (Wall. ex G.

Change point detection to analyze air pollution and its economic effects: an exponentially weighted moving average perspective.

Air pollution has a direct impact on every society, leading to consequential effects on the economy of a nation. Poor air quality adversely affects human health, resulting in various economic outcomes such as rising healthcare costs, diminished labor productivity, negative impacts on tourism and living standards, increased regulatory expenses for businesses, and heightened economic disparities. Effective control methods are essential to monitor factors influencing the economy, including air quality.

Human plasma-derived exosomal gel: a biomimetic cargo for the transdermal delivery of methotrexate.

The aim of the study was to explore the potential of human plasma-derived exosomal gel as a carrier for transdermal drug delivery. Exosomes were isolated from human plasma through a combination of ultracentrifugation and dialysis techniques. Methotrexate (MTX), a weak acid drug with log P 1.

Green synthesis of -based silver nanoparticles: characterization and transdermal delivery for anti-inflammatory applications.

The current study aims to develop chitosan transdermal patches containing AgNPs synthesized and characterized from to reduce inflammation. Silver nanoparticles (AgNPs) were prepared utilizing the extract and characterized through Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), zeta potential measurements, and particle size analysis. The AgNPs were incorporated into chitosan-based transdermal patches, which were assessed for physicochemical properties, dermal compatibility, and anti-inflammatory effectiveness.

Charantin targets HMGCR-PCSK9 axis and activates PPAR-α signaling to ameliorate hyperlipidemia: Mechanistic insights from bioinformatics and in-vivo studies.

Plant-derived compounds have recently gained attention owing to their better safety profile and multi-targeted actions. Charantin, a plant-based natural compound known for its diverse pharmacological properties, was investigated for its anti-hyperlipdemic activity using both in-silico and in-vivo approaches. A detailed network pharmacology analysis was used to predict charantin-related targets, cross-referenced with hyperlipidemia-associated genes from GeneCards, DisGeNET, and CTD.

Assessment of DNA damage and expression variation of genes related to DNA damage in salt mine workers.

Salt mine workers are occupationally exposed to DNA damaging agents at their workplace. The present study estimates the extent of DNA damage and expression deregulation of related genes in mine workers, staff, community living nearby and unexposed controls. Blood samples were collected from all groups.

Enhanced visible light degradation of RhB in aqueous solution by using SbS modified with magnetic activated carbon.

The removal of hazardous organic dyes (e.g., Rhodamine B) from wastewater is one of the current major environmental challenge, which is related to traditional photocatalysts with low efficiencies, poor stabilities, and complex recycle process.

E2F1-autophagy-ALDH1A1 axis enhances self-renewal and drug resistance of lung cancer stem-like cells in a p53-dependent manner.

Lung adenocarcinoma (LUAD) is a predominant subtype of non-small cell lung adenocarcinoma (NSCLC). It is typically asymptomatic and associated with high mortality rates. Despite recent advancements in screening technologies and therapeutic approaches, its pathogenesis still remains elusive.

Artificial magnetic conductor backed dual-mode sectoral cylindrical DRA for off-body biomedical telemetry.

This research investigates the potential of a sectoral Cylindrical Dielectric Resonator Antenna (CDRA) for biomedical telemetry. CDRAs are known for their low-loss, ruggedness, and stability, but their limited bandwidth and size make them unsuitable for wearable devices. The research addresses these limitations by proposing a dual-mode antenna that operates in [Formula: see text] and [Formula: see text] modes.

Unlocking exceptional EMI shielding in TiCT MXenes through controlled microstructure and surface chemistry.

The rapid advancement of highly integrated electronics demands next-generation electromagnetic interference (EMI) shielding materials that combine lightweight, ultrathin, flexible, and mechanically robust properties with exceptional shielding effectiveness (SE) to mitigate signal crosstalk and ensure device reliability. In this work, we demonstrate the fabrication of high-performance EMI shields using highly conductive, additive-free aqueous TiCT (T = O, OH, Cl, F) MXene dispersions synthesized under both harsh and mild etching conditions. These dispersions were engineered into freestanding thin films and functionalized cotton fabrics vacuum-assisted filtration, enabling tunable EMI shielding properties through precise control of etchant chemistry, flake size, microstructure, thickness, and MXene loading.

Optimizing emergency response services in urban areas through the fault-tolerant metric dimension of hexagonal nanosheet.

In this work, we find the fault-tolerant metric dimension of a hexagonal nanosheet. This concept ensures robust identity of vertices inside a graph, even in situations in which a few resolving vertices fail. By extending the applicability of this parameter to city systems, we explore its practical use in optimizing emergency reaction and carrier management in cities.

Protective Effects of Luteolin on -Induced Injury: An In Vitro Study with Porcine Vascular Endothelial Cells.

(GPS) is a conditional pathogen that colonizes the upper respiratory tract in pigs and causes Glässer's disease, resulting in high morbidity and mortality in piglets. GPS infection increases the vascular endothelial permeability, but the mechanism has not been fully elucidated. Luteolin (Lut) is a naturally occurring flavonoid found in plants such as vegetables, herbs, and fruits, but its potential to treat the increased vascular endothelial permeability caused by GPS infection has not been evaluated.

Correction: Mahnashi et al. In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer's Disease. 2022, , 1055.

There was an error in the original publication [...

Assessing the effect of educational intervention on pharmaceutical promotion: a follow-up study among medical students from Pakistan.

Background: The promotional strategies implemented by pharmaceutical organizations lead to abnormal prescribing practices that both diminish physician-patient confidence and drive-up healthcare expenses. The motives of the pharmaceutical companies are to appeal students' natural preferences. So, educating them represents an essential approach to combat these effects.

Application of artificial intelligence-based stemness index in cancer.

Cancer stem cells (CSCs) exhibit self-renewal and multidirectional differentiation capacities. The stemness of CSCs is the fundamental cause of tumor progression and treatment resistance. The stemness index, evaluating the number and activity of CSCs, is a crucial indicator predicting various aspects of tumor behavior such as growth, metastasis, and prognosis.

Epidemiological Investigation on the Clinical Status of the Developmental Dyslexia and ADHD Comorbidity among School-Age Children in Pakistan.

Developmental Dyslexia (DD) and Attention-Deficit/Hyperactivity Disorder (ADHD) are neurodevelopmental disorders affecting children's learning abilities worldwide, but limited research exists in Pakistan. We tried to identify and confirm ADHD and DD in Pakistani school children and their sociodemographic associations. We conducted a case-control study, examining an extensive cohort of children (n = 1260), aged 5 - 19 years from special education program schools, rehabilitation centers, and pediatric clinics between 2022 and 2023.

Pharmacognostic Characterization of Primula denticulata by Light Microscopy, Scanning Electron Microscopy, and Analytical Techniques.

Primula denticulata (Primulaceae) has long been used in traditional medicine to treat a variety of diseases. Around the globe, it is used to cure different diseases such as bronchitis, enhanced bronchial output, making phlegm less thick, asthma, joint discomfort, fever, diarrhea, sleeplessness, urinary infections, wound healing, eye illnesses, and dysuria. The study's findings provide several pharmacognostic benchmarks that support the maintenance of P.

Precision Measurement of the Branching Fraction of D^{+}→μ^{+}ν_{μ}.

Using 20.3  fb^{-1} of e^{+}e^{-} collision data collected at a center-of-mass energy of E_{c.m.

Bielecki-Ulam stability of a hammerstein-type difference system.

In this study, we investigate the Bielecki-Ulam (B-U) stabilities of two forms of Hammerstein-type difference systems (HT-DS). Specifically, we consider the systems: and by establishing conditions under which a unique solution exists. We derive sufficient conditions for the existence and uniqueness of solutions that satisfy B-U stability criteria.

Density functional theory analysis of the structural, electronic, elastic, phonon dispersion and AIMD properties of KMgX (X = O, S, Se).

Perovskite chalcogenides have attracted significant interest due to their potential applications in optoelectronics, catalysis, and renewable energy systems. This paper examines the structural, electronic, elastic, and phononic properties of KMgX (X = O, S, Se) using density functional theory (DFT) in the context of the full-potential linearized augmented plane wave plus local orbital (FP-LAPW + lo) approach. Their stability in the cubic phase (3̄ symmetry) is confirmed by the computed lattice parameters for KMgO (4.

Computation drug design for ACE inhibitor for high blood pressure management and assessment of pharmacokinetics and toxicity of promising compounds isolated from Gymnema sylvestre.

This study employs computational drug design approaches to identify and optimize ACE inhibitors from G. sylvestre's isolated compounds, assessing their pharmacokinetic and toxicity profiles. The receptor (PDB: 1o86) was retrieved from RCSB, prepared, and analyzed for active binding sites.

Unlocking the Comparative Potential of Porous Frameworks: A Review on MOFs and COFs for Gas Sorption.

Gases are integral to Earth's climate and ecosystem balance, but human activity has significantly altered atmospheric composition by increasing greenhouse gas emissions. In 2025, carbon dioxide emissions were estimated at around 39-41 billion tons, reflecting a continued increase. Emissions of carbon monoxide, sulfur dioxide, and nitrogen dioxide were expected to remain close to 2.

Identification and green synthesis of potato dry rot Fusarium falciforme silver nanoparticles, characterization and antibacterial activity.

Potato tubers collected from different areas showed the prevalence of dry rot with characteristic white mycelia like symptoms of Fusarium pathogen. Fusarium species from diseased tubers were isolated based on morphological features. 18 S-Internal Transcribed Spacer (ITS) and Translation Elongation factor 1-α (TEF1-α) based analysis followed by phylogenetic tree constructed using ITS, TEF1-α and RNA polymerase II subunit B (RPB2) identified Fusarium isolates as Fusarium verticilloides, Fusarium soloni, Fusarium falciforme and Fusarium oxysporum.

Comparative assessment of treatment outcomes of empagliflozin add-on metformin and sitagliptin add-on metformin therapies in uncontrolled type 2 diabetes mellitus: findings from an observational study in Pakistan.

Background: Uncontrolled type 2 diabetes mellitus warrant the utilization of different combination antidiabetic therapies, however, the addition of these newer agents as add-on therapy increases the risk of side effects and needs to be further investigated in terms of their risk to benefit to the patient. Therefore, the current study aims to evaluate the clinical and safety outcomes in patients taking empagliflozin and Sitagliptin in addition to metformin.

Method: A cross-sectional study was conducted using a non-probability consecutive sampling technique to gather data at the Diabetes and Foot Care Clinic in Abbottabad from July 2023 to December 2023.