Occurrence, distribution characteristics, and potential ecological risks of perfluorinated compounds in major estuaries and adjacent offshore areas in Hainan Island.

Per- and polyfluoroalkyl substances (PFASs) have gained attention due to their chemical stability, bioaccumulation potential, and toxicity. The ocean serves as the ultimate sink for these compounds in the global environment. With the rapid development of the Hainan Free Trade Port, environmental pollution on Hainan Island has consequently become more pronounced.

A benzothiazole derivative-based turn-on fluorescent probe for specific detection of Cys.

Cysteine (Cys) is a core biological thiol that regulates cellular redox homeostasis. Abnormal concentrations of Cys are closely related to tumorigenesis, neurodegenerative diseases, and metabolic disorders, and are often used as biomarkers for cancer cells. Therefore, detecting and analyzing its levels in the microenvironment of cancer cells is important.

Significant response to toripalimab plus axitinib for metastatic chromophobe renal cell carcinoma with sarcomatoid differentiation: a case report and literature review.

Chromophobe renal cell carcinoma (chRCC) is a rare subtype of renal cell carcinoma (RCC). Sarcomatoid differentiation is considered a result of dedifferentiation of the primary tumor. The coexistence of both components (chromophobe and sarcomatoid) in a single renal tumor has been infrequently reported.

Identification and green synthesis of potato dry rot Fusarium falciforme silver nanoparticles, characterization and antibacterial activity.

Potato tubers collected from different areas showed the prevalence of dry rot with characteristic white mycelia like symptoms of Fusarium pathogen. Fusarium species from diseased tubers were isolated based on morphological features. 18 S-Internal Transcribed Spacer (ITS) and Translation Elongation factor 1-α (TEF1-α) based analysis followed by phylogenetic tree constructed using ITS, TEF1-α and RNA polymerase II subunit B (RPB2) identified Fusarium isolates as Fusarium verticilloides, Fusarium soloni, Fusarium falciforme and Fusarium oxysporum.

Mitigation of greenhouse gas emissions and nitrogen losses caused by migration and tourism in China's tropical island cities.

Islands worldwide face escalating ecological challenges from increasing migration and tourism. These pressures significantly contribute to transgression of Earth's ecosystem boundaries (ESBs). This study focuses on Hainan Island, a tropical region whose 18 cities reflect global island-ecosystem dynamics.

Multiparametric dual-energy Computed Tomography in the diagnosis of lung adenocarcinoma patients and its correlation with tissue Ki-67 expression level.

Background: The purpose of this study was to investigate the variations in quantitative analysis of lung adenocarcinoma based on gender using dual-energy Computed Tomography (DECT), as well as its correlation with Ki-67, a proliferative marker.

Methodology: A retrospective analysis was conducted on 79 patients diagnosed with lung adenocarcinoma, categorized into two groups based on gender. These patients underwent dual-energy CT scans, and the corresponding Ki-67 index was obtained.

In situ scanning testing system based on Raman spectroscopy.

Accurate characterization of localized material regions is a fundamental requirement for advancing materials science and nanotechnology. In situ observation techniques are important for gaining mechanistic insights into material behavior and optimizing structural design. However, the reliability of characterization outcomes can be substantially compromised by unstable scanning systems.

Immobilization and accelerated conversion of polysulfides using vanadium-regulated metal sulfide catalysts for Li-S batteries.

Lithium-sulfur batteries possess significant potential due to their high energy density and cost-effectiveness. However, sluggish redox kinetics, polysulfide shuttle effects, and the inadequate oxidation of LiS impede their practical application. To overcome these challenges, electrocatalysts with high intrinsic activity are essential for enhancing performance.

GAPO: A Graph Attention-Based Reinforcement Learning Algorithm for Congestion-Aware Task Offloading in Multi-Hop Vehicular Edge Computing.

Efficient task offloading for delay-sensitive applications, such as autonomous driving, presents a significant challenge in multi-hop Vehicular Edge Computing (VEC) networks, primarily due to high vehicle mobility, dynamic network topologies, and complex end-to-end congestion problems. To address these issues, this paper proposes a graph attention-based reinforcement learning algorithm, named GAPO. The algorithm models the dynamic VEC network as an attributed graph and utilizes a graph neural network (GNN) to learn a network state representation that captures the global topological structure and node contextual information.

Motion-induced phase-shifting profilometry for dynamic objects via Fourier fringe analysis and speckle correlation-assisted phase unwrapping.

Fringe projection profilometry, particularly phase-shifting profilometry, has been extensively studied and widely adopted due to its non-contact operation, high accuracy, and efficiency. However, in dynamic applications, it faces two major challenges: the increased number of encoded patterns required for absolute phase retrieval, and motion-induced phase errors. To address these limitations while preserving measurement accuracy, this study proposes a motion-induced phase-shifting method that integrates Fourier fringe analysis with speckle correlation-assisted phase matching.

Mixture Multilevel SEM vs. Multilevel SEM for comparing structural relations across groups in presence of measurement non-invariance.

Structural equation modeling (SEM) is commonly used to explore relations between latent variables, such as beliefs and attitudes. However, comparing structural relations across a large number of groups, such as countries or classrooms, can be challenging. Existing SEM approaches may fall short, especially when measurement non-invariance is present.

The Mo-14Re alloy, a promising candidate material for bioresorbable vascular scaffolds.

Zinc‑, iron‑, and magnesium‑based biodegradable metals suffer inherent limitations as bioresorbable scaffold materials, including inappropriate degradation rates and insufficient mechanical strength. Pure molybdenum (Mo) has been proposed as an alternative, but its clinical application is hampered by brittleness and potential nephrotoxicity. A Mo alloy was engineered to address these challenges.

Relationship between ankle brachial index and carotid-femoral pulse wave velocity in hypertension patients with diabetes mellitus.

Background: Ankle-brachial index (ABI) is used to diagnose peripheral artery disease. Arterial stiffness could be measured by carotid-femoral pulse wave velocity (CF-PWV). The study was to investigate relationship between ABI and CF-PWV in patients with hypertension and diabetes mellitus.

The Relationship Between Advanced Lung Cancer Inflammation Index and Adverse Clinical Outcomes in Patients with Myocardial Infarction with No-Obstructive Coronary Arteries.

Background: The advanced lung cancer inflammation index (ALI) has been suggested as a reliable prognostic indicator for cardiovascular disease. However, the association between ALI and the prognosis of patients with myocardial infarction with no-obstructive coronary arteries (MINOCA) remains undetermined.

Methods: In the present study, we consecutively included 437 MINOCA patients.

Correlation Between Hepatic Iron and Fat in Hemodialysis Patients: A Quantitative MRI Analysis.

Rationale & Objective: Hepatic iron overload and steatosis are common in hemodialysis patients with anemia who are receiving iron therapy. This study aimed to investigate the relationship between hepatic iron overload and steatosis using magnetic resonance imaging (MRI) while also measuring iron content in extrahepatic organs.

Study Design: Prospective cohort study.

Comparative Analysis of Generative Artificial Intelligence Systems in Solving Clinical Pharmacy Problems: Mixed Methods Study.

Background: Generative artificial intelligence (AI) systems are increasingly deployed in clinical pharmacy; yet, systematic evaluation of their efficacy, limitations, and risks across diverse practice scenarios remains limited.

Objective: This study aims to quantitatively evaluate and compare the performance of 8 mainstream generative AI systems across 4 core clinical pharmacy scenarios-medication consultation, medication education, prescription review, and case analysis with pharmaceutical care-using a multidimensional framework.

Methods: Forty-eight clinically validated questions were selected via stratified sampling from real-world sources (eg, hospital consultations, clinical case banks, and national pharmacist training databases).

FedSW-TSAD: SWGAN-Based Federated Time Series Anomaly Detection.

As distributed sensing technologies evolve, the collection of time series data is becoming increasingly decentralized, which introduces serious challenges for both model training and data privacy protection. In response to this trend, federated time series anomaly detection enables collaborative analysis across distributed sensing nodes without exposing raw data. However, federated anomaly detection experiences issues with unstable training and poor generalization due to client heterogeneity and the limited expressiveness of single-path detection methods.

miR-429 suppresses progression and metastasis of salivary adenoid cystic carcinoma by targeting ZEB1.

miR-429 is a tumor suppressor that has been observed in various cancers. The exact mechanism by which miR-429 affects salivary adenoid cystic carcinoma(SACC) is not fully understood. Initially, the expression of miR-429 and zinc finger E-box-binding homeobox 1 (ZEB1) in tumor tissues and matched adjacent non-tumor tissues of SACC patients were inspected by quantitative real-time polymerase chain reaction.

Exploring the rarity: insights into primary diffuse large B-cell lymphoma of the prostate from a global retrospective analysis.

Background: The purpose of this study is to comprehensively analyze cases of primary diffuse large B-cell lymphoma of the prostate (P-DLBCL-P) from a global perspective, aiming to understand the disease's characteristics, treatment responses, and outcomes. By doing so, we seek to establish a valuable reference for the clinical management of this rare malignancy.

Materials And Methods: This study conducted a retrospective review of P-DLBCL-P cases reported worldwide, using various online databases, including PubMed, Scopus, and other English databases, as well as WanFang Data and China National Knowledge Infrastructure in Chinese, collecting clinical pathology information, treatment modalities, and prognosis of patients, and conducted survival analysis using the Kaplan-Meier method.

Unclassified renal cell carcinoma with multi-organ metastasis treated with surgery and targeted therapy combination: a case report and literature review.

We present a rare case of unclassified renal cell carcinoma (RCC) in a 66-year-old woman, exhibiting multi-organ invasion. The patient was asymptomatic until a health exam revealed a left renal mass. CT scans showed an irregular, 6.

Unveiling the intermediate hydrated proton in water through vibrational analysis on the 1750 cm signature.

Hydration of proton is the key to understand the acid-base chemistry and biochemical processes, for which the Zundel and Eigen cations have been recognized as the foundation. However, their dominance remains contentious due to the challenge of attributing the infrared signature at  ~1750 cm, stemming from the theoretical dilemma of balancing structural diversity and solvent fluctuations. Herein, we circumvent this obstacle by devising an integrated approach for computing frequency-specific vibrational vectors via inverse Fourier transform of the vibrational density of states.

Genetic characteristics of human bocavirus in children with acute respiratory tract infections during 2023 in Beijing, China.

Human bocavirus (HBoV) is an emerging pathogen associated with pediatric respiratory and gastrointestinal infections, yet its genetic diversity remains understudied. The aberrant global resurgence of other respiratory viruses after the COVID-19 pandemic has raised concerns regarding significant evolutionary shifts in viral genetic profiles. Accordingly, this study characterized HBoV isolates that circulated in Beijing during 2023 by analyzing 1,442 pediatric respiratory samples associated with acute respiratory tract infections.

Effectiveness of electrical stimulation for treating male urinary incontinence after prostatectomy: a meta-analysis and systematic review.

Background: Prostatectomy frequently leads to postoperative urinary incontinence (UI), significantly impairing patients' quality of life. While pelvic floor muscle exercises (PFME) are commonly employed, the efficacy of electrical stimulation (ES) as a non-invasive adjunct remains debated. This systematic review and meta-analysis evaluated the effectiveness of ES combined with PFME versus PFME alone for post-radical prostatectomy UI.

Modeling the measurement accuracy for binocular stereo vision system.

Binocular stereo vision technology is widely used in the 3D measurements of aerospace, the automotive industry, and in other fields. However, its measurement accuracy is limited by many error factors and is difficult to improve. This paper presents a modeling method for the measurement accuracy of binocular stereo vision systems, providing a theoretical basis for system optimization design and accuracy improvement.