Positive relative accommodation is an independent risk factor for myopia onset: a prospective cohort study among chinese primary schoolchildren, the WEPrOM study.

Purpose: To identify independent risk factors for myopia onset in schoolchildren, with a focus on binocular visual function.

Methods: We conducted a school-based prospective cohort study in Wenzhou, China. Schoolchildren in grades 2 and 3 were recruited in 2014 and followed until graduation at grade 6.

Effects of Climate Change on the Global Distribution of (Coleoptera: Buprestidae).

(Pallas, 1773) is a significant pest that can cause serious damage to poplars and willows. To assess the impact of climate change on the suitable habitats of , this study conducted a comparative analysis of its global suitable habitats using climatic factors, global land use type, and global vegetation from different periods, in combination with the maximum entropy (MaxEnt) model. The results indicate that the annual mean temperature (Bio01), mean temperature of the coldest quarter (Bio11), precipitation of the coldest quarter (Bio19), and isothermality (Bio03) are the four most important climate variables determining the distribution of .

Gender-specific associations of blood immune markers with symptoms and cognitive function in major depressive disorder: a cross-sectional observational study.

Background: Cognitive impairments constitute a core manifestation of major depressive disorder (MDD), albeit the precise mechanisms governing these impairments remain elusive. Inflammation may contribute to cognitive impairment and clinical symptoms in MDD. We conducted an investigation into the inflammatory markers present in patients with MDD, including white blood cell (WBC) counts, monocytes, lymphocytes, neutrophils, platelets, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), and their associations with symptoms and cognitive performance.

Smart Gated Hollow Mesoporous Silica Hydrogel for Targeting Endoplasmic Reticulum Stress and Promoting Periodontal Tissue Regeneration.

Periodontitis is a multifactorial inflammatory disease involving pathogenic biofilm formation, amplified oxidative stress, and impaired tissue regeneration. In addition to its complicated pathology, effective treatment of periodontitis is challenged by a dynamic oral microenvironment that prevents drug retention. To overcome these issues, an anti-bacterial, ROS-scavenging, and tissue-regenerative hydrogel system (HQUP@TF127) is developed.

Single Mitochondrion Morphology-Function Relationship Analysis Using Fluorescent Probes and Artificial Intelligence.

The ability to decode the relationship between mitochondrial morphology and function at the level of individual organelles is central to understanding cellular responses to stress, such as hypoxia. Herein, a comprehensive strategy is presented that integrates tailored fluorescent probes with artificial intelligence (AI) for single mitochondrion analysis. Focus is on three interrelated biomarkers, reactive oxygen species (ROS), viscosity, and mitochondrial membrane potential (MMP), that together form a pathophysiological axis indicative of mitochondrial state under hypoxic stress.

In situ scanning testing system based on Raman spectroscopy.

Accurate characterization of localized material regions is a fundamental requirement for advancing materials science and nanotechnology. In situ observation techniques are important for gaining mechanistic insights into material behavior and optimizing structural design. However, the reliability of characterization outcomes can be substantially compromised by unstable scanning systems.

Impact of artificial intelligence-driven urban renewal strategies green economic efficiency and resident health in China.

Introduction: This study investigates the impact of AI-driven smart city policies on green economic efficiency and public health. It further explores how industrial structure rationalization, upgrading, and technological innovation capacity moderate these effects, aiming to provide actionable insights for sustainable urban governance.

Methods: To account for potential policy spillover effects, the study adopts a Difference-in-Differences (DID) approach integrated with a Spatial Durbin Model (SDM).

Chromosome-level genome assembly of the vegetable leafminer Liriomyza sativae (Diptera: Agromyzidae).

So far, the chromosome-level genome assembly of only one species has been known for the family Agromyzidae. The vegetable leafminer, Liriomyza sativae Blanchard, 1938, is a highly polyphagous invasive pest that poses a significant threat to a wide range of vegetable crops. However, genomic resources for this species remain unavailable, impeding our understanding of its invasive traits and extensive adaptability.

Decontamination of Cr(VI) and tetracycline hydrochloride by Bi@NH-MIL-88B-enhanced photocatalytic electron-rich microenvironment and its internal mechanism.

Non-precious metals that demonstrate surface plasmon resonance (SPR) effects have attracted considerable attention due to their ability to enhance the photocatalytic degradation of unexpected pollutants in water. Here, the interfacial charge transfer and improvement of the Bi-metal center are accomplished through in-situ synthesis, along with a comprehensive analysis of the catalytic activity and mechanism of the Bi-metal center. On this basis, the response surface method (RSM) and statistical analysis are used to evaluate the performance of Cr(VI).

Oligocopper-Loaded Lipoic Acid Nanoparticles Promote Mitochondrial Protein Lipoylation for Augmented Cuproptosis Therapy.

Cuproptosis is a modality of mitochondrial cell death driven by the binding of excess copper ions to the lipoic acid residues of dihydrolipoamide S-acetyltransferase (DLAT) protein. However, copper levels are tightly regulated within cells. Herein, an oligocopper-loaded lipoic acid nanoparticle (Cu@TcNAs) is reported that can promote mitochondrial DLAT protein lipoylation and realize augmented cuproptosis therapy.

Visible-light driven photocatalytic water body purification on 2D carbon materials.

Visible-light-driven photocatalytic water purification has garnered significant attention due to its energy saving, green process, and sustainability. Two-dimensional (2D) carbon-based materials have become strong contenders for photocatalytic water purification due to their distinctive advantages, including rapid charge transfer, low density, and plentiful reactive sites, making them ideal photocatalysts for environmental applications. In this review, the mechanisms underlying photocatalytic water purification is firstly elaborated in depth.

Cross-sectoral synergy governance programme for antimicrobial resistance control in China using a 'One Health' approach: study protocol for a mixed-methods study.

Introduction: Antimicrobial resistance (AMR) is a critical global public health concern, particularly acute in rural China. Counties, which cover extensive rural regions, face major challenges in AMR governance and thus require priority attention. Yet, AMR governance efforts across sectors are fragmented, with notable gaps in translating policy objectives into sustainable, practical governance measures.

Integrated Taxonomy Discovers Four New Species of Speiser, 1928 (Diptera: Asilidae) from China.

The genus Speiser, 1928 (Diptera: Asilidae) is a fuzzy-looking assassin fly, and adults have only been observed in autumn and winter. Currently containing four described species, this genus is readily distinguished from other Chinese asilids by the presence of two crossveins. Through integrative taxonomic analysis of over 200 specimens from multiple Chinese provinces, we combined morphological assessment with DNA barcoding and four species delimitation methods (ABGD, ASAP, mPTP, and GMYC).

Characterization of CD8 T Cells in large yellow croaker Larimichthys crocea and their dynamics in response to Cryptocaryon irritans infection.

CD8 T cells are critical cytotoxic effectors involved in pathogen clearance, including defense against parasitic infections in aquaculture species. In this study, we developed a monoclonal antibody specifically targeting the CD8α chain, enabling the identification of CD8 T cells in large yellow croaker Larimichthys crocea and providing a valuable tool for studying cytotoxic T cell responses in teleosts. Croaker CD8 T cells were more abundant in mucosal than systemic lymphoid organs, suggesting their preferential localization to sites of pathogen entry.

Association of ambient fine particulate matter (PM) and its constituents with risk of pulmonary nodules in a lung cancer screening project.

Background: Ambient fine particulate matter (PM) is a significant global public health concern. However, large-scale research has yet to explore the effects of long-term PM exposure on the pulmonary nodule characteristics.

Methods: A lung cancer screening project involving 19,414 adults who underwent chest CT scans was conducted as part of the Integrating Artificial Intelligence and Serum Protein Biomarkers cohort between 2019 and 2020.

Lenvatinib promotes hepatocellular carcinoma pyroptosis by regulating GSDME palmitoylation.

Lenvatinib, as a multi-kinase inhibitor, has been approved as a first-line drug for patients with advanced hepatocellular carcinoma (HCC). Gasdermin E (GSDME)-mediated pyroptosis, a form of programmed cell death, can be induced by chemotherapy drugs or certain kinase inhibitors. However, the role of Lenvatinib in inducing pyroptosis in HCC warrants further investigation.

Phenotypic and functional characterization of CD4-2 T cells in large yellow croaker Larimichthys crocea.

CD4 T cells, also known as helper T (Th) cells, are crucial regulators of the adaptive immune system, orchestrating and coordinating immune responses that protect the host against a broad spectrum of pathogenic threats. Two CD4 co-receptor genes, cd4-1 and cd4-2, have been identified in teleost species, including the large yellow croaker Larimichthys crocea. In this study, we developed a monoclonal antibody (mAb) that specifically recognizes croaker CD4-2, enabling the identification and characterization of CD4-2 T lymphocytes.

Harnessing the Immunomodulation of UV-Exposed Keratinocyte Extracellular Vesicles for Inflammatory Disorder Treatment.

Sunbathing excessively heightens the risk of skin carcinogenesis due to ultraviolet (UV)-mediated immunosuppression. Keratinocytes, the primary cells in epidermis, play a pivotal role in orchestrating the UV-induced immunosuppressive response by releasing platelet-activating factor (PAF) upon UV exposure. Adopting a paradigm shift that transforms a known health hazard as a potential therapeutic asset, a novel therapeutic strategy is set out to investigate for inflammatory conditions by leveraging immunosuppressive properties of UV-irradiated keratinocytes.

Extranodal extension on MRI after neoadjuvant chemoradiotherapy improves the prognostic contribution of nodal evaluation in rectal cancer.

Objectives: Evaluation of extranodal extension (ENE) after neoadjuvant chemoradiotherapy (nCRT) might improve the currently suboptimal prognostic implication of preoperative nodal evaluation in rectal cancer, but evidence is lacking. The aim of this study was to evaluate diagnostic accuracy and prognostic value of MRI-determined ENE after nCRT in rectal cancer.

Materials And Methods: This single-center study included a prospective developing dataset and a retrospective validation cohort, which enrolled patients who underwent nCRT and surgery from 2021 to 2023 and 2018 to 2019, respectively.

Air-Doctor-Blading CHNHPbI Perovskite Solar Cells via a Green Cosolvent Strategy.

Achieving high-performance perovskite solar cells (PSCs) under ambient conditions remains challenging due to uncontrolled crystallization in conventional solvents, often leading to defect-prone interfaces and morphological degradation. Here, we propose a green cosolvent strategy, combining high-polarity 2-methoxyethanol (2-Me) and low-polarity acetonitrile (ACN), to precisely regulate the crystallization kinetics and morphologies of perovskite films. This synergistic system effectively optimizes precursor coordination, balancing solubility and solvent polarity to meticulously control nucleation and growth of perovskite films.

Identification of GBP6 as a potential prognostic biomarker in esophageal carcinoma by integrated bioinformatics analysis and experiment validation.

Backgrounds: To evaluate the role of guanylate-binding protein 6 (GBP6) in esophageal cancer (ESCA).

Methods: We comprehensively evaluated the expression pattern, clinical features, prognostic role, biological functions, and immunological role of GBP6 based on the public databases. Immunohistochemistry was used to validate the results in an ESCA tissue microarray.

Distribution Pattern and Change Prediction of (Coleoptera: Tenebrionidae) Suitable Area in East Asia Under Climate Change.

(Motschulsky, 1868) is an economically important pest in traditional Chinese medicines, widely distributed in East Asia. However, the primary limiting factors affecting its distribution, potential suitable areas, as well as its response to global warming, remain largely unknown. Utilizing 295 filtered distribution points and 10 environmental variables (9 climate variables and 1 land cover type), this study uses the MaxEnt model to predict the potential distribution of under near-current and future environmental change scenarios.

Limits on Anomalous Spin-Spin Interactions Using Noble-Gas Nuclear Magnetic Resonance.

Numerous theories beyond the standard model of particle physics propose the existence of ultralight hypothetical bosons, which are prominent dark-matter candidates. One of the most promising approaches to search for these bosons is through precision measurements. The basic principle is to measure energy shifts of standard-model particles induced by hypothetical bosons with ultrahigh energy resolution.

A review of Roháček, 1983 (Diptera, Sphaeroceridae) from China with new records and three new species.

The 14 species of Roháček now known from China are reviewed and keyed, including three new species ( , , and ), three newly recorded species ( Marshall, 1987, Marshall, 1987, and Marshall, 1987), and one subspecies ( Su, 2011) is elevated to species rank. Chinese distribution records are updated, and figures and illustrations are provided for the 14 species of recorded from China.