Ten-Day Versus 14-Day Vonoprazan and Amoxicillin Dual Therapy for the Firstline Eradication of Helicobacter pylori Infection: A Multicenter, Randomized Controlled Trial.

Background: The optimal duration for vonoprazan and amoxicillin dual therapy (VA-DT) remains unclear, and studies on gastric acid suppression of vonoprazan during eradication are still lacking.

Objective: This study conducted a multicenter, randomized controlled trial to compare the eradication efficacy between 10 and 14-day VA-DT, and to identify the dynamic changes of gastric pH during treatment.

Methods: This study included 418 naïve adult patients with Helicobacter pylori infection, who were randomly divided into 10 or 14-day VA-DT groups (vonoprazan 20 mg twice daily and amoxicillin 1000 mg thrice daily).

Boxing Punch Detection and Classification Using Motion Tape and Machine Learning.

The objective of this study is to classify the types of boxing punches using machine learning algorithms that processed skin-strain time history measurements from a self-adhesive, elastic fabric, wearable sensor called Motion Tape. A human participant study was designed to capture movements during boxing training. Subjects were asked to perform multiple sets of punches during the entire test, which consisted of jabs and hooks with and without striking a heavy bag.

Near-Infrared Optoelectronic Memristor with All-Optical Modulation for Microscopic Biological Motion Recognition.

Near-infrared (NIR) synaptic devices are characterized by unique optical sensitivity and synaptic plasticity, possessing high potential to significantly broaden the visual spectrum accessible to humans. Moreover, these devices seamlessly integrate neuro-morphological computing with infrared optical communication, attracting significant attention for future low-power, high-efficiency neuromorphic visual systems. However, the irreversible optical response of most optical synapses under short-wavelength infrared light severely restricts the practical application of these devices.

Dissecting the role of gut microbiota heterogeneity in the onset of chronic lung diseases.

Evidence from observational studies and clinical trials has reported that gut microbiota (GM) was associated with chronic lung diseases (CLDs). However, the causal relationships between GM and CLDs have yet to be fully ascertained. The Mendelian randomization (MR) based causal analysis was performed using the genome-wide association study (GWAS) summary statistics from the MiBioGen and FinnGen consortium.

Ultrasound Phase Aberrated Point Spread Function Estimation with Convolutional Neural Network: Simulation Study.

Ultrasound imaging systems rely on accurate point spread function (PSF) estimation to support advanced image quality enhancement techniques such as deconvolution and speckle reduction. Phase aberration, caused by sound speed inhomogeneity within biological tissue, is inevitable in ultrasound imaging. It distorts the PSF by increasing sidelobe level and introducing asymmetric amplitude, making PSF estimation under phase aberration highly challenging.

How Humor Use by Nurse Supervisors, Reduced Time Pressure, and Years in the Profession Jointly Reduce Nurse Turnover Intention.

Aim: To investigate how humor use by nurse supervisors, reduced time pressure, and years in the profession jointly reduce nurse turnover intention.

Background: Nurses encounter various workplace stressors that cause negative outcomes. Humor use among nurse supervisors is known to help form cohesive relationships and reduce job burnout.

Inverse association between dietary oxidative balance score and myocardial infarction in hypertensive patients: A cross-sectional study based on NHANES 1999-2018.

ObjectiveHypertension is a major risk factor for myocardial infarction. However, the association between the dietary oxidative balance score and myocardial infarction risk among individuals with hypertension remains unclear. This study aimed to investigate the relationship between dietary oxidative balance score and the risk of myocardial infarction in hypertensive adults.

Kirenol relieves rheumatoid arthritis by targeting the TWEAK/Fn14 pathway.

Fibroblast‑like synoviocytes (FLSs) are the primary drivers of synovial tissue hyperplasia in rheumatoid arthritis (RA). Activation of the tumor necrosis factor‑like weak inducer of apoptosis (TWEAK)/fibroblast growth factor‑inducible immediate‑early response protein 14 (Fn14) pathway significantly contributes to the pathogenesis of RA. Kirenol (Kir), a compound with anti‑inflammatory and antirheumatic properties, has an unclear mechanism of action.

Lenvatinib promotes hepatocellular carcinoma pyroptosis by regulating GSDME palmitoylation.

Lenvatinib, as a multi-kinase inhibitor, has been approved as a first-line drug for patients with advanced hepatocellular carcinoma (HCC). Gasdermin E (GSDME)-mediated pyroptosis, a form of programmed cell death, can be induced by chemotherapy drugs or certain kinase inhibitors. However, the role of Lenvatinib in inducing pyroptosis in HCC warrants further investigation.

In-Plane Anisotropic Two-Dimensional ReSe Optoelectronic Memristor for a Polarization-Sensitive Neuromorphic Vision System.

A polarization-sensitive neuromorphic vision system (PNVS) that synchronously possesses the capacities of polarized light perception and neuromorphic computing enables the detection of potential information or hidden features. While developing a polarization-sensitive optoelectronic memristor presents an intriguing avenue for building the foundational hardware of PNVS, it has proven challenging. In this work, a polarization-sensitive optoelectronic memristor based on the in-plane anisotropic two-dimensional ReSe is proposed.

Optogenetics-Inspired Nanofluidic Artificial Dendrite with Spatiotemporal Integration Functions.

Dendrites play an essential role in processing functions by facilitating the integration of spatial and temporal information in biological system. Nanofluidic memristors, which harness ions for signal transmission within electrolyte solutions, closely resemble biological neuronal ion channels and hold the potential for the development of biorealistic neuromorphic devices. Herein, inspired by the optogenetic technique that utilized light to tune the ions dynamic, an optical-controlled nanofluidic artificial dendrite by embedding layered graphene oxide (GO) within a polydimethylsiloxane (PDMS) elastomer is developed.

Photopic Adaptation Mimicked by YO-Based Optoelectronic Memristor for Neuromorphic Visual System.

Visual adaptation is one of the most significant features that helps organisms process complicated image information in time-varying environments. Emulating this function is highly desirable for energy-efficient image perception. In this work, we demonstrate an yttrium oxide (YO)-based optoelectronic memristor and emulate photopic adaptation behavior in a single device.

Comparison of Cefuroxime-Based Dual Therapy With Quadruple Therapy in Helicobacter pylori-Infected Treatment-Naive Patients: A Prospective, Multicenter, Randomized Controlled Trial.

Background: High-Dose Dual Therapy With Amoxicillin Has Shown Advantages to Eradicate Helicobacter pylori (H. pylori), but Not for Penicillin-Allergic Patients. It Is Recommended That Cefuroxime Could Be an Alternative, but Whether Cefuroxime Could Be Used in Dual Therapy Has Not Been Reported.

Immunomodulating platelet-mimicking nanoparticles for AIE-based enhanced photodynamic immunotherapy against lung cancer.

Lung cancer has become the leading cause of cancer related death worldwidely. Nowadays, immune checkpoint inhibitor (ICI) plays an important part in the treatment of lung cancer. However, immunologically cold tumor microenvironment (TME) hinders the therapeutic effect of ICIs.

Bioinspired Adaptive Neuron Enabled by Self-powered Optoelectronic Memristor and Threshold Switching Memory for Neuromorphic Visual System.

Visual adaptation allows organisms to effectively analyze visual information in varying light conditions by autonomously adjusting photosensitivity, which is essential for the visual system to perform accurate perception in complex environments. In order to realistically implement the functionality of the visual system, the exploration of bioinspired electronics with adaptive capability is highly desired. Herein, a self-powered optoelectronic memristor based on ZnO/WO heterojunction is developed, which can exhibit the visual adaptation functions of desensitization and Weber's law.

Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription.

Hypoxia-induced metabolic reprogramming is closely linked to breast cancer progression. Through transcriptomic analysis, we identified PRMT1 as a direct target of hypoxia-inducible factor 1α (HIF1α) under hypoxic conditions in breast cancer cells. In turn, PRMT1 enhances the expression of HIF1α-driven glycolytic genes.

Association between atherogenic index of plasma and future cardiovascular disease risk in middle-aged and elderly individuals with cardiovascular-kidney-metabolic syndrome stage 0-3.

Background: Cardiovascular disease (CVD) is strongly correlated with plasma atherogenic index (AIP); however, there is limited literature exploring the association between trajectories of change in AIP and the risk of CVD. This study aimed to investigate whether changes in AIP are associated with CVD in individuals with cardiovascular-kidney-metabolic (CKM) syndrome stage 0-3.

Methods: Data were sourced from the China Health and Retirement Longitudinal Study (CHARLS), aimed to compile high-quality microdata on individuals and households aged 45 and older in China.

ZC3H13 Regulates Ferroptosis to Enhance Osteogenic Differentiation in Osteoporotic BMSCs.

N6-methyladenosine (mA) modification is critical in the regulation of osteoporosis (OP). Although ZC3H13 is an important mA methyltransferase, its specific regulatory effects and mechanisms in osteoporosis are not yet fully understood. Therefore, we investigated the impact of ZC3H13 on the osteogenic potential of bone marrow-derived mesenchymal stem cells (BMSCs) in osteoporosis and attempted to elucidate its underlying mechanism.

Exploring the Causal Relationship Between Gut Microbiota and Pulmonary Artery Hypertension: Insights From Mendelian Randomization.

Background: Research into the "gut-lung" axis links gut microbiota to pulmonary artery hypertension (PAH). However, the mechanisms by which gut microbiota influence PAH remain unclear. We aimed to investigate the causal relationship between the gut microbiota and PAH using Mendelian randomization analysis, identify key microbiota and metabolites, and explore the regulatory role of associated genes in PAH pathogenesis.

A Semi-Supervised Retinal Vessel Segmentation Method via Adaptive Uncertainty Estimation.

We introduce a semi-supervised vessel segmentation technique that leverages a minimal amount of labeled data alongside substantial unlabeled data. This method addresses the limitations of supervised learning in medical image segmentation, which typically requires labor-intensive pixel-level labeling by experts. Using semi-supervised learning, our proposed adaptive uncertainty estimation (AUE) method enhances model performance through pixel-level uncertainty estimation and adaptive thresholding.

High-dose dual therapy for Helicobacter pylori eradication inducing less impact on the gut microbiota.

Background: Helicobacter pylori (H. pylori) eradication regimens may have different effects on the gut microbiota. Few studies have analyzed the safety of high-dose dual therapy (HDDT) from a micro-ecological perspective.

Progress in the genetics and epigenetics of pelvic floor disorder.

Pelvic floor disorder (PFD) is a common gynecological disorder, and with the ageing of the population, PFD has a serious impact on the physical and mental health of patients and their quality of life. The most prominent of these are pelvic organ prolapse (POP) and urinary incontinence (UI), about which the etiology is still unclear, and it is urgent to explore their pathogenesis. Advances in genetics and epigenetics have provided new insights into the pathophysiology of PFD.

Association of pan-immune inflammation value and lung health in adults.

Background: Lung health is intricately linked with inflammation. The pan-immune-inflammation value (PIV) emerges as a promising biomarker, offering reflection into systemic inflammatory states and assisting in the prognosis of diverse diseases. This research aims to explore the associations between PIV and respiratory symptoms, respiratory diseases and lung function.

All-Optically Controlled Memristive Device Based on CuO/TiO Heterostructure Toward Neuromorphic Visual System.

The optoelectronic memristor integrates the multifunctionalities of image sensing, storage, and processing, which has been considered as the leading candidate to construct novel neuromorphic visual system. In particular, memristive materials with all-optical modulation and complementary metal oxide semiconductor (CMOS) compatibility are highly desired for energy-efficient image perception. As a p-type oxide material, CuO exhibits outstanding theoretical photoelectric conversion efficiency and broadband photoresponse.

Pyruvate Kinase M2-Responsive Release of Paclitaxel and Indoleamine 2,3-Dioxygenase Inhibitor for Immuno-Chemotherapy of Nonsmall Cell Lung Cancer.

Paclitaxel (PTX) is a first-line chemotherapeutic drug for non-small cell lung cancer (NSCLC) but it can induce indoleamine 2,3-dioxygenase (IDO) activation, which severely lowers down its immuno-chemotherapeutic effect. To address this issue, a smart peptide hydrogelator Nap-Phe-Phe-Phe-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-OH (Nap-T), which co-assembles with PTX and an IDO inhibitor GDC0919 to form a hydrogel GP@Gel Nap-T, is rationally designed. Upon specific phosphorylation by pyruvate kinase M2 (PKM2), an overexpressed biomarker of NSCLC, Nap-T is gradually converted to Nap-Phe-Phe-Phe-Lys-Ser-Thr(HPO)-Gly-Gly-Lys-Ala-Pro-Arg-OH (Nap-Tp), leading to dehydrogelation and sustained release of PTX and GDC0919 within NSCLC tissues.