Efficient separation of impurities from pyrolusite and the enhancement of its products for improving the performance of lithium-ion batteries.

Manganese sulfate is a derivative of manganese resources with multiple applications. In addition to its traditional uses, it plays a critical role in various environmental and energy sectors. Manganese sulfate not only contributes to water treatment but also plays a significant role in the production of lithium-ion battery materials.

eQTL and multi-omics integration reveal PPIH as a prognostic and immunotherapeutic biomarker.

Background: Malignant tumors remain a major threat to global human health. This study aimed to systematically integrate multi-omics data to identify a candidate gene with biomarker potential across diverse cancer types and to evaluate its possible clinical applications in oncology.

Methods: We first performed Mendelian randomization based on summary statistics to integrate blood expression quantitative trait loci data with genome-wide association study results from esophageal adenocarcinoma, stomach cancer, and clear cell renal cell carcinoma.

Interplay and integrated regulation of astaxanthin-lipid biosynthesis in microbial systems: A review from metabolic pathway cross-talk to biotechnological optimization.

Astaxanthin, a lipid-soluble carotenoid with antioxidant and anti-inflammatory properties, is mainly found in microorganisms. Its production is limited by lipid availability. Microbial lipids, like PUFAs, are also new food resources with health benefits.

Development of Fault Similar Material for Model Test of Fault Water Inrush Disaster.

The applicability of similar materials is a key factor affecting the results of geomechanical model tests. In order to investigate the multi-physical field evolution mechanism of surrounding rocks during water inrush disasters in tunnels crossing fault zones, based on the similarity theory of geomechanical model tests, the physical-mechanical parameters of a prototype rock's mass were first analyzed for similarity, and the target values of similar materials were determined. Secondly, using sand as coarse aggregate, talcum powder as fine aggregate, gypsum and clay as binders, and Vaseline as a regulator, a fault-simulating material suitable for model tests was developed through extensive laboratory experiments.

Transcriptomic and Proteomic Insights Into Buffalo Milk Fat Synthesis and the Role of IGFBP4 in BMECs.

The content and composition of milk fat are critical determinants influencing milk flavor, nutritional value, and economic significance. Buffalo milk is characterized by its high-fat content and complex lipid profile, characterized by elevated levels of health-beneficial fatty acids such as linoleic acid, α-linolenic acid, and arachidonic acid. However, the molecular regulatory mechanisms governing milk fat synthesis in buffaloes remain incompletely elucidated.

A Review of Maricultural Wastewater Treatment Using an MBR: Insights into the Mechanism of Membrane Fouling Mitigation Through a Microalgal-Bacterial Symbiotic and Microbial Ecological Network.

Membrane bioreactors (MBRs) have been utilized for maricultural wastewater treatment, where high-salinity stress results in dramatic membrane fouling in the actual process. A microalgal-bacterial symbiotic system (MBSS) offers advantages for photosynthetic oxygen production, dynamically regulating the structure of extracellular polymeric substances (EPSs) and improving the salinity tolerance of bacteria and algae. This study centered on the mechanisms of membrane fouling mitigation via the microalgal-bacterial interactions in the MBSS, including improving the pollutant removal, optimizing the system parameters, and controlling the gel layer formation.

Zoonotic pathogen-driven antibiotic resistance emerges in urban soils: A large-scale study in 13 cities across China.

Land-use changes drive the microbial community and associated soil resistome. Enrichment of risk antibiotic resistance genes (risk ARGs) is related to 4.95 million deaths across the globe each year, rendering them an urgent threat to human health.

Natural History and Outcomes of Deep-seated Brain Arteriovenous Malformations: a Propensity Score Matched Analysis Using Nationwide Multicenter Prospective Registry Data.

Objectives: This study aims to evaluate the natural history of deep-seated brain arteriovenous malformation (AVMs), as well as the risk-benefit outcomes of interventional treatment versus conservative management.

Materials & Methods: Patients with deep-seated AVMs were selected from a nationwide prospective multicenter registry study in China (the MATCH study), and univariate and multivariate analyses were conducted to identify factors associated with AVM rupture. In the analysis of outcomes, propensity score matching (PSM) was performed between the interventional and conservative treatment groups, adjusting for baseline differences.

Versatile photonic frequency synthetic dimensions using a single programmable on-chip device.

Investigating physical models with photonic synthetic dimensions has been generating great interest in vast fields of science. The rapidly developing thin-film lithium niobate (TFLN) platform, for its numerous advantages including high electro-optic coefficient and scalability, is well compatible with the realization of synthetic dimensions in the frequency together with spatial domain. While coupling resonators with fixed beam splitters is a common experimental approach, it often lacks tunability and limits coupling between adjacent lattices to sites occupying the same frequency domain positions.

Correction: Enhanced photothermal-ferroptosis effects based on RBCm-coated PDA nanoparticles for effective cancer therapy.

Correction for 'Enhanced photothermal-ferroptosis effects based on RBCm-coated PDA nanoparticles for effective cancer therapy' by Hongli Yu , , 2023, , 415-429, https://doi.org/10.1039/D2TB02329F.

Laparoscopic resection combined with ablation for multiple colorectal liver metastases: a multicentre propensity-matched analysis.

Background: Laparoscopic resection is the standard treatment for resectable colorectal liver metastases (CRLM). While the safety profile using combined ablation and resection (CARe) to treat CRLM has been documented, its efficacy has not been compared with that of resection alone in the laparoscopic setting. The aim of this study was to compare the short- and long-term outcomes of laparoscopic CARe with those of laparoscopic resection alone for multiple CRLM.

Impact of detection rate and preventive treatment of latent tuberculosis infection on the future burden of tuberculosis among students in shanghai: a predictive study using Markov modeling.

Background: Students represent a key demographic for tuberculosis (TB) control in China. This study utilizes a dynamic Markov model to forecast the epidemiological trends of active tuberculosis (ATB) among students in Shanghai through 2035 and evaluate the effectiveness of different control strategies.

Methods: A Markov model incorporating six distinct states of TB transmission was utilized to simulate disease dynamics within a hypothetical cohort of 100,000 individuals.

DGAT1-mediated lipid metabolism is essential for female reproduction in the silkworm, Bombyx mori.

Background: Lipid metabolism plays a critical role in maintaining energy homeostasis during various physiological processes in insects. Diacylglycerol O-acyltransferase-1 (DGAT1) is associated with the synthesis of triacylglycerol (TAG), a process that is necessary for the absorption of dietary fats and the storage of fat in mammals. However, the biological roles of DGAT1 in insects remain largely unknown.

Elevated Risk of Cerebral Arteriovenous Malformation Rupture during Pregnancy and Puerperium.

Objective: Cerebral arteriovenous malformations (AVM) pose a significant risk during pregnancy because of hormonal changes and increased hemodynamic stress. This study aims to assess the risk of AVM rupture during pregnancy and puerperium and to identify risk factors associated with rupture.

Methods: This prospective cohort study included 588 women with AVMs and a history of pregnancy, enrolled from a nationwide registry in China between August 2011 and August 2021.

Unveiling new horizons in severe aplastic anemia management: a two-decade study on intensive immunosuppressive therapy combined with unrelated cord blood efficacy.

Background: In the absence of a human leukocyte antigen (HLA)-matched donor, intensive immunosuppressive therapy (IST) combined with unrelated cord blood (IIST-UCB) a salvage treatment option for patients with severe aplastic anemia (SAA) who had failed IST. With advancements in transplantation technology, outcomes of IIST-UCB have improved considerably in recent years. Here, we will focus on the differential effects of IIST-UCB on patient survival and GVHD risk and evaluate its therapeutic efficacy between SAA and VSAA patients.

Experimental Study and Application of TPO Waterproofing Membrane Lapping Process Parameters.

Taking the TPO waterproofing membrane as an example, this paper studies the influence of temperature, speed and welding pressure on the welding quality of a TPO waterproofing membrane lap area through a peel test and a water impermeability test, determines the optimal construction process, and observes and compares the permeable path through laser confocal microscope. Finally, it is applied to the actual effect test in the project. The results show that the welding pressure test tool for the lap area of the waterproofing membrane is designed to meet the welding work test requirements of various lap areas of the waterproofing membrane.

Single-cell RNA sequencing reveals altered immune and stromal landscape in primary and liver metastasis of gastric cancer.

Background: We aimed to identify stromal cells associated with liver metastasis of gastric cancer (GC).

Methods: We downloaded single-cell RNA sequencing (scRNA-seq) datasets for GC tissues and adjacent normal tissues (NT), as well as liver metastases (LM) and healthy liver tissues (HL) from GEO. Additionally, we obtained RNA-Seq and clinical data from TCGA for the TCGA-STAD project.

polysaccharides mitigate high-fat high-cholesterol diet-induced atherosclerosis in ApoE mice regulation of lipid metabolism and gut microbiota.

Cardiovascular diseases are leading causes of death globally, often manifesting after years of atherosclerosis (AS) progression. In this study, we investigated the atheroprotective effects of three different sources of glucomannan, polysaccharide, glucomannan, and polysaccharide (AVP), using an ox-LDL-induced foam cell model and an high-fat high-cholesterol diet-fed ApoE mouse model. Both settings indicate that AVP exerts the most significant atheroprotective effects.

Effects of rumen-protected lysine on antler growth performance, fecal bacterial community, and blood gene expression in sika deer.

Introduction: Velvet antler is an important product of sika deer (), and its growth is closely related to dietary amino acid supplementation. Lysine is one of the major limiting amino acids in animals; however, the mechanism underlying its effect on velvet antler growth in sika deer remains unclear.

Methods: This study investigated the impact of rumen-protected lysine supplementation on velvet antler growth, nutrient digestibility, gut bacteria, serum biochemical parameters, and gene expression in sika deer.

Nomilin Alleviates Neuroinflammation and Depressive-like Behaviors in Mice through the Upregulation of TAX1BP1-Mediated Modulation of Microglia Polarization.

Nomilin is a limonoid compound that is found in citrus fruits. However, their functions remain to be further studied. The present study mainly analyzed the antineuroinflammation and antidepressive function of nomilin.

Human land use promotes range expansion of soil protists from temperate to subtropical regions in China.

Land-use changes are reshaping the distribution of aboveground species worldwide. However, the impact of land-use changes on the distribution of soil organisms remains poorly understood. In particular, we lack a mechanistic understanding of the environmental factors reshaping the distribution of soil microbiota in response to global biological homogenization.

M2 macrophage-derived Apolipoprotein E promotes fibroblast MMPs expression via LRP1-ERK signaling in chronic rhinosinusitis with nasal polyps.

Apolipoprotein E (APOE) expressed by macrophages modulates allergic inflammation and remodeling of the lower airway. However, its expression and functions in chronic rhinosinusitis with nasal polyps (CRSwNP) remain unclear. We sought to investigate the involvement of macrophage derived APOE in the pathogenesis of CRSwNP.

Exposure to Dioxin-like polychlorinated biphenyls during Pregnancy and fetal thyroid function; A mixture analysis.

Despite growing evidence of the endocrine-disrupting effects of dioxin-like polychlorinated biphenyls (DL-PCBs), the specific impact of maternal exposure to these pollutants on fetal thyroid hormone levels remains largely unexplored. This study uniquely investigates the association between prenatal DL-PCB exposure and thyroid hormone levels in umbilical cord blood within a cohort of pregnant women in Shenyang, China, during 2022-2023. A total of 2240 pregnant women were enrolled in the study.

Neuroimmunology-driven CAR T-cell therapeutics for gliomas: translational challenges and clinical trial paradigm innovation.

Glioma, a category of the most lethal primary brain tumors, remains incurable despite multimodal therapy combining maximal resection, radiation, and temozolomide. These interventions invariably fail due to residual invasive cells, molecular heterogeneity, and an immunosuppressive tumor microenvironment (TME) reinforced by myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs). The blood-brain barrier (BBB) further limits therapeutic access, while antigen escape and T-cell exclusion mechanisms drive relapse.

Extracellular vesicles from antler blastema progenitor cells reverse bone loss and mitigate aging-related phenotypes in mice and macaques.

Antler blastema progenitor cells (ABPCs) are a distinct population of skeletal mesenchymal stem cells found in regenerating deer antlers, with strong stemness and renewal capacity in vitro. Stem cell-derived extracellular vesicles (EVs) are emerging as potential therapeutic candidates that can mediate donor cells' beneficial effects. Here, we tested the effects of ABPC-derived EVs (EVs) on aging in mice and rhesus macaques (Macaca mulatta).