Bystin is a Prognosis and Immune Biomarker: From Pan-Cancer Analysis to Validation in Breast Cancer.

Introduction: The Bystin gene (BYSL) contributes to cancer development and is a probable therapeutic target in cancer therapy. However, no systematic studies have been conducted on BYSL value in pan-cancer diagnosis, prognosis, and immunology.

Methods: We performed a pan-cancer analysis of BYSL using TCGA, GEO, and other databases to assess its expression, clinical significance, genetic variants, methylation, and immune correlation.

Urinary bladder paraganglioma in pregnancy: a case report and literature review.

Urinary bladder paragangliomas (UBPs) are rare tumors of chromaffin tissue originating from the sympathetic innervation of the bladder wall. It constitutes less than 0.05% of bladder tumors and 0.

SAMHD1 deficiency disrupts macrophage autophagy-lysosomal homeostasis and promotes inflammation via the mTOR-MITF-CTSD axis in ulcerative colitis.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by dysregulated immune responses and macrophage-driven inflammation. In this study, we identify SAMHD1 (SAM domain and HD domain-containing protein 1) as a critical regulator of macrophage homeostasis in UC. Single-cell RNA sequencing (scRNA-seq) of colonic tissues revealed reduced SAMHD1 expression in UC-associated macrophages.

A protective role of SRC-1 against aging associated cognitive decline.

Introduction: Research indicates a strong correlation between obesity and the risk of dementia, both are linked to steroid receptor coactivator-1 (SRC-1), a transcriptional coactivator.

Methods: We used RNA sequencing analysis (RNA-Seq) to investigate the transcriptome of SRC-1-KO mice, and identified S100 calcium-binding protein A6 (S100A6), an AD associated gene, as one target of SRC-1. We tested cognitive behaviors in SRC-1-KO mice and mice with a humanized SRC-1 mutation (SRC-1), and performed promoter luciferase assays on S100A6.

Interfacial Engineering to Construct Two-Dimensional Boron-Doped Iron Disulfide/Metal-Organic Framework Heterostructures for Selective Anodic Reaction in Seawater.

Hydrogen production from seawater is promising; however, the complex chemistry and corrosive nature of seawater are a huge bottleneck. Therefore, it is imperative to design catalysts that provide highly active and stable catalytic sites for preferential seawater catalysis. Here, we constructed an interface by heterostructuring boron-doped iron disulfide (B-FeS) sheets with metal-organic framework (MOF) sheets to achieve higher activity and longer life, confirmed through theoretical and experimental results.

Prolonged exposure to food odors suppresses feeding via an olfactory bulb-to-hypothalamus circuit.

Olfactory perception of food odors is a key determinant of eating behavior, including triggering appetite, facilitating food seeking and influencing food choice. While transient food-related olfactory cues stimulate appetite and provoke cravings in states of hunger, emerging evidence implies that prolonged and sustained exposure to food-derived odor (FO) suppresses feeding. However, the mechanisms by which olfaction induces hypophagia remain elusive.

Precise Identification and Analysis of Maize Germplasm Resistance to Ear Rot Caused by Six Species.

Maize ( L.) is one of the most important crops worldwide, but ear rot poses a significant threat to its production. Diverse pathogens cause ear rot in China, with spp.

Bayberry tannin-functionalized melamine foam: A recyclable scaffold for nZVI-catalyzed metronidazole reductive degradation.

The presence of metronidazole (MNZ) in medical wastewater poses a potential threat to environmental safety and people's health. Herein, we report an innovative strategy to fabricate a recyclable bayberry tannin (BT)-functionalized melamine foam (MF)-supported nanoscale zero-valent iron (MFBT-Fe) catalyst for efficient MNZ degradation in medical wastewater. The through-pore structure of MF reduced mass transfer resistance in heterogeneous systems, while the amphiphilic BT stabilized nZVI via steric hindrance and chelating interactions and created a high-concentration MNZ microenvironment through hydrophobic combined with hydrogen bonding.

Effects of rumen-protected lysine on antler growth performance, fecal bacterial community, and blood gene expression in sika deer.

Introduction: Velvet antler is an important product of sika deer (), and its growth is closely related to dietary amino acid supplementation. Lysine is one of the major limiting amino acids in animals; however, the mechanism underlying its effect on velvet antler growth in sika deer remains unclear.

Methods: This study investigated the impact of rumen-protected lysine supplementation on velvet antler growth, nutrient digestibility, gut bacteria, serum biochemical parameters, and gene expression in sika deer.

regulating modulates gastric cancer growth by inhibiting ferroptosis.

Background: Gastric cancer (GC) is a digestive system tumor with the highest incidence in China. In recent years, the role of ferroptosis in tumor occurrence and development has received more and more attention. In this study, we sought to identify the genes related to ferroptosis in GC and explain the mechanism of these related genes.

IGF2BP2 alleviates ulcerative colitis by inhibiting MEK1/2 and ERK1/2 signaling pathways in intestinal epithelial cells via m6A-dependent stabilization of LGI4 mRNA.

Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by sustained epithelial damage and heightened immune activation, with intestinal epithelial cells playing a pivotal role in its pathogenesis. N6-methyladenosine (m6A) methylation, a prevalent RNA epigenetic modification, has garnered increasing attention for its potential involvement in UC progression. However, the precise role of m6A in intestinal epithelial cells during UC remains unclear.

Effects of Restricted Blood Flow Interval Training on Lower Extremity Muscles and Motor Function in Stroke Patients.

Objective: To examine how limitations in blood circulation impact the training of stroke individuals.

Methods: Between March 2022 and March 2023, a total of 34 individuals receiving treatment at the Fourth Affiliated Hospital of the School of Medicine, Zhejiang University, specifically within the Department of Rehabilitation Medicine, were chosen as participants. They were then assigned to experimental groups using a random number approach, with 17 individuals in each group, while also including a control group.

Cellular Heterogeneity and IL-17 Pathway Dynamics Reveal Insights into the Transition from Ulcerative Colitis to Colorectal Cancer Through scRNA-Seq Analysis.

Introduction: The progression of UC to CACRC involves substantial molecular and cellular alterations. A deeper understanding of these changes is essential for identifying potential therapeutic targets and improving disease outcomes.

Methods: We performed scRNA-seq on tissue samples from a patient with coexisting UC and CACRC lesions, including normal colon, UC-affected tissue, and CACRC.

The PVT1-214/miR-671-5p/SLC45A4 signaling axis regulates cell proliferation in human gastric cancer.

Background: Long non-coding RNA PVT1 (lncRNA PVT1) serves as a carcinogenic regulatory factor in several cancers; however, the expression and function of its transcriptional isomer PVT1-214 in gastric cancer (GC) are poorly understood.

Methods: PVT1-214 and miR-671-5p levels in GC cells and tissues were analyzed through quantitative real-time polymerase chain reaction (qRT-PCR). Western blotting (WB) was used to detect Homo sapiens solute carrier family 45 member 4 (SLC45A4) expression in GC cells.

Crystallization Phase Regulation of BaO-CaO-SiO Glass-Ceramics with High Thermal Expansion Coefficient.

In this work, the influence of Ba/Ca ratios on the BaO-CaO-SiO (BCS) glass network structure, crystallization phases, and coefficient of thermal expansion (CTE) was investigated. As the Ba/Ca ratio increases, the Q units in the glass network structure have undergone significant changes. The Q units in the BCS glass network transform into Q units, indicating the reduction of the glass network connectivity.

Integrated Sensors Based on Low-Temperature Co-Fired Ceramic Technology for the Inside Pressure and Temperature Monitoring of Lithium-Ion Batteries.

Monitoring internal pressure and temperature in lithium-ion batteries is essential for investigating internal chemical reactions, failure mechanisms, and providing early warnings of thermal runaway. The existing sensors face challenges in withstanding the high temperatures and corrosive electrolytes inside lithium-ion batteries. This work develops an integrated sensor with high robustness using low-temperature co-fired ceramic (LTCC) technology, which incorporates a multilayer ceramic circuit board, a digital pulse temperature sensor, a MEMS pressure sensor, and a microcontroller.

Suppression of hypothalamic oestrogenic signal sustains hyperprolactinemia and metabolic adaptation in lactating mice.

17β-oestradiol (E2) inhibits overeating and promotes brown adipose tissue (BAT) thermogenesis, whereas prolactin (PRL) does the opposite. During lactation, the simultaneous decline in E2 and surge in PRL contribute to maternal metabolic adaptations, including hyperphagia and suppressed BAT thermogenesis. However, the underlying neuroendocrine mechanisms remain unclear.

Increased keratin 80 expression predicts poor prognosis and promotes oxaliplatin resistance in gastric cancer.

Background: Keratin 80 (KRT80), a type I intermediate filament protein, is a member of the keratin family with specialized functions in epithelial tissues. While KRT80 has been implicated in both normal physiological processes and various diseases, its role in gastric cancer (GC), particularly its expression and prognostic significance, remains poorly understood. In this study, we investigated the role and underlying molecular mechanisms of KRT80 in oxaliplatin resistance in GC.

Constructing shared genetic architecture between bioavailable testosterone and luminal A breast cancer in female.

Background: Observational studies have showed a strong association between bioavailable testosterone (BT) and breast cancer. However, the role of genetic factors in their comorbidity remains unknown.

Methods: Using large genome-wide association study (GWAS) data, we employed linkage disequilibrium score regression (LDSC) to identify the breast cancer subtype most genetically correlated with BT.

Visualization analysis of breast cancer-related ubiquitination modifications over the past two decades.

Background: Ubiquitination is a type of post-translational modification, referring to the process in which the small molecular protein ubiquitin covalently binds to target proteins under the catalysis of a series of enzymes. The process of ubiquitination is vital in the onset and progression of breast cancer. The use of the ubiquitin-protease system is expected to be a new way to treat human breast cancer.

Vestibular neurons link motion sickness, behavioural thermoregulation and metabolic balance in mice.

Motion sickness is associated with thermoregulation and metabolic control, but the underlying neural circuitry remains largely unknown. Here we show that neurons in the medial vestibular nuclei parvocellular part (MVePC) mediate the hypothermic responses induced by motion. Reactivation of motion-sensitive MVePC neurons recapitulates motion sickness in mice.

Diagnostics and immunological function of CENPN in human tumors: from pan-cancer analysis to validation in breast cancer.

Background: Centromere protein N (), a member of the centromere protein family, contributes to ribonucleic assembly, mitosis progression, and chromosome separation. manifests a close link with the occurrence and progression of several malignant cancers, but there is no pan-cancer study on , and we aim to ascertain the connection between and human cancer prognosis and immunotherapy.

Methods: The function in multiple malignant tumors was comprehensively investigated with data from The Cancer Genome Atlas (TCGA) and integrated Gene Expression Omnibus (GEO) database.

A Linkage Between 25-Hydroxyvitamin D and Post-Stroke Cognitive Impairment, as Well as the Duration of Hospitalization After a Stroke.

Aims: A variety of complications can arise following a stroke, with post-stroke cognitive impairment (PSCI) being a prevalent consequence. The objective of the research was to explore the relationship between 25(OH)D levels, PSCI, and the duration of hospitalization.

Methods: Serum concentrations of 25(OH)D were measured within the first 24 h of hospital admission.