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http://dx.doi.org/10.7554/eLife.108007 | DOI Listing |
Orthop Traumatol Surg Res
September 2025
Hôpital Joseph-Imbert, Centre Hospitalier d'Arles, Arles, France.
It is essential to master the techniques of tendon transfer and to know the indications, so as to be able to treat tendinopathy, tendon tear or static deformity in the foot and ankle. The type of transfer depends on the pathology, with the aim of reconstructing or supplementing the affected muscle. Complete clinical and paraclinical assessment is needed to determine feasibility and draw up the preoperative plan according to axial deformity and associated retraction.
View Article and Find Full Text PDFThe rising legal acceptance of cannabis and the high comorbidity between cannabis use disorder (CUD) and post-traumatic stress disorder (PTSD) highlight the importance of understanding how stress and cannabis influence the brain. We recently discovered that cannabis use promotes two PTSD-like symptoms: avoidance coping behaviors and the generalization of stress-coping responses to a neutral stimulus not previously linked to stress. To investigate the neuroadaptations behind these changes, we used in vivo zymography and confocal microscopy to examine how stress and cannabinoid use influence multipartite synaptic plasticity in the nucleus accumbens core (NAcore), including astroglial plasticity, Synapsin-I density, and matrix metalloproteinases (MMP-2,9) activity.
View Article and Find Full Text PDFWorld J Surg Oncol
August 2025
Department of Laboratory, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, 48 Huaishuxiang, Wuxi, Jiangsu Province, 214002, People's Republic of China.
Int J Mol Sci
August 2025
Division of Dermatology, Tohoku Medical and Pharmaceutical University, Sendai 981-8558, Miyagi, Japan.
Vitiligo is a chronic autoimmune dermatosis defined by selective melanocyte depletion and patchy depigmentation. IFN-γ-driven recruitment of autoreactive CD8 T cells and induction of melanocyte apoptosis are central to its pathogenesis. Current therapies-including UVB phototherapy, tacrolimus, vitamin D3 analogs, and surgical methods-show limited and inconsistent efficacy.
View Article and Find Full Text PDF