Modulation of senescence-related genes by the transcription factor PlPLATZ5 prolongs the lifespan of Paeonia lactiflora petals.

Four PLATZ family members were identified in the petals of herbaceous peony (Paeonia lactiflora), all of which contained two typical domains, BBOX and PLATZ. Notably, PlPLATZ5 was up-regulated during the transition from flowering to senescence, exhibited high expression in floral organs, and was localized to the nucleus, as revealed by subcellular localization analysis. Transient overexpression of PlPLATZ5 in P.

OsMYB67 Knockout Promotes Rice Heading and Yield by Facilitating Copper Distribution in Panicles.

Copper (Cu) is an essential micronutrient required for rice flowering and seed setting. Here, we identified that Cu-induced R2R3-MYB transcription factor, OsMYB67, acts as a negative regulator that controls rice heading and yield production by affecting Cu distribution in panicles. OsMYB67 was constitutively expressed, with the highest expression in the roots.

Interfacial H-bond Network/Concentration Fields/Electric Fields Regulation Achieved by D-Valine Anions Realizes the Highly Efficient Aqueous Zinc Ion Batteries.

Uncontrolled mobile anions and proton transport result in many issues, including interfacial anion depletion, irregular multiphysics fields fluctuations, space charge layer-induced interfacial Zn dendrites, and hydrogen evolution reaction (HER), which seriously exacerbates the cycling stability of zinc-ion batteries. Herein, this work constructs an efficient D-valine anion interface structure to reversely regulate the Zn/H dynamic chemistry and unlocks the multiple regulation effects of this anionic interface by investigating interfacial proton transport and complex concentration/electric fields distribution of Zn anode through dynamic in-situ spectroscopy analysis, static energy calculations, and molecular dynamics simulation. We unravel core factors affecting complicated interfacial HER processes and the generation of the space charge layer.

Spin polarization regulation of Fe-N by Fe atomic clusters for highly active oxygen reduction reaction.

The Fe-N motif is regarded as a leading non-precious metal catalyst for the oxygen reduction reaction (ORR) with the potential to replace platinum (Pt), yet achieving or surpassing the performance of Pt-based catalysts remains a significant challenge. In this study, we introduce a modification strategy employing homogeneous few-atom Fe cluster to regulate the spin polarization of Fe-N. Experimental research and theoretical calculations show that the incorporation of the Fe cluster significantly enhances the adsorption of Fe-N motif toward OH ligands, leading to a structural transformation from a square-planar field (Fe-N) to a square-pyramid field structure (Fe(OH) -N).

Adsorption of methanol on cationic cobalt clusters in the gas phase.

Knowledge about the adsorption and activation of methanol on metal catalysts is essential to obtain insights into the conversion of methanol to sustainable chemicals. In this work, the adsorption of methanol on Con+ (n = 1-60) clusters is investigated using low-pressure collision cell experiments in combination with time-of-flight mass spectrometry. Experiments are conducted using both methanol and deuterated methanol in order to examine potential isotope effects and to gain insights into the reaction mechanism.

Novel anti-HER2 ADCs vs dual anti-HER2 antibody for HER2-positive metastatic breast cancer failed to tyrosine kinase inhibitor.

Background: Both novel anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugates (ADCs) and pertuzumab and trastuzumab (HP) combined with chemotherapy(C) regimens are the choice of treatment for HER2 positive metastatic breast cancer (MBC) after tyrosine kinase inhibitors (TKIs). Our team's previous research has shown significant therapeutic effects of novel anti-HER2 ADCs in patients with TKIs treatment failure. Unfortunately, there is currently no data available to compare novel anti-HER2 ADCs with HP combined with chemotherapy regimens.

Interfacial Domino Effect Triggered by β-Alanine Cations Realized Highly Reversible Zinc-Metal Anodes.

Realizing durative dense, dendrite-free, and no by-product deposition configuration on Zn anodes is crucial to solving the short circuit and premature failure of batteries, which is simultaneously determined by the Zn interface chemistry, electro-reduction kinetics, mass transfer process, and their interaction. Herein, this work unmasks a domino effect of the β-alanine cations (Ala) within the hydrogel matrix, which effectively triggers the subsequent electrostatic shielding and beneficial knock-on effects via the specifical adsorption earliest event on the Zn anode surface. The electrostatic shielding effect regulates the crystallographic energetic preference of Zn deposits and retards fast electro-reduction kinetics, thereby steering stacked stockier block morphology and realizing crystallographic optimization.

Wireless Sensor System Based on Organohydrogel Ionic Skin for Physiological Activity Monitoring.

Supermolecular hydrogel ionic skin (i-skin) linked with smartphones has attracted widespread attention in physiological activity detection due to its good stability in complex scenarios. However, the low ionic conductivity, inferior mechanical properties, poor contact adhesion, and insufficient freeze resistance of most used hydrogels limit their practical application in flexible electronics. Herein, a novel multifunctional poly(vinyl alcohol)-based conductive organohydrogel (PCEL) with a supermolecular structure was constructed by innovatively employing sodium carboxymethyl cellulose (CMC-Na) as reinforcement material, ethylene glycol as antifreeze, and lithium chloride as a water retaining agent.

Oxygen-enriched pitch-derived hierarchically porous carbon toward boosted zinc-ion storage performance.

The lack of cathode materials with satisfactory Zn storage capability substantially hinders the realization of high-performance aqueous zinc-ion hybrid capacitors (ZHCs). Herein, we propose a facile KMnO template-assisted KOH activation strategy to prepare a novel oxygen-enriched hierarchically porous carbon (HPC-1-4). This strategy efficiently converts coal tar pitch (CTP) into a well-tuned carbon material with a large specific surface area of 3019 m g and a high oxygen content of 9.

Cholesterol homeostasis confers glioma malignancy triggered by hnRNPA2B1-dependent regulation of SREBP2 and LDLR.

Background: Dysregulation of cholesterol metabolism is a significant characteristic of glioma, yet the underlying mechanisms are largely unknown. N6-methyladenosine (m6A) modification has been implicated in promoting tumor development and progression. The aim of this study was to determine the key m6A regulatory proteins involved in the progression of glioma, which is potentially associated with the reprogramming of cholesterol homeostasis.

Novel Anti-HER2 Antibody-Drug Conjugates Versus T-DM1 for HER2-Positive Metastatic Breast Cancer After Tyrosine Kinase Inhibitors Treatment.

Background: Antibody-drug conjugates (ADCs) have been the preferred regimens for human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) after trastuzumab. Unfortunately, there is little data showing which ADCs should be chosen for those patients whose treatment with tyrosine kinase inhibitors (TKIs) failed. This study aims to analyze the efficacy and safety between novel anti-HER2 ADCs and trastuzumab emtansine (T-DM1) for those with TKIs failure.

Transcription factor OsSNAC1 positively regulates nitrate transporter gene expression in rice.

Nitrogen (N) is a critical factor for crop growth and yield. Improving N use efficiency (NUE) in agricultural systems is crucial for sustainable food production. However, the underlying regulation of N uptake and utilization in crops is not well known.

Amorphous Heterostructure Derived from Divalent Manganese Borate for Ultrastable and Ultrafast Aqueous Zinc Ion Storage.

Aqueous zinc-manganese (Zn-Mn) batteries have promising potential in large-scale energy storage applications since they are highly safe, environment-friendly, and low-cost. However, the practicality of Mn-based materials is plagued by their structural collapse and uncertain energy storage mechanism upon cycling. Herein, this work designs an amorphous manganese borate (a-MnBO ) material via disordered coordination to alleviate the above issues and improve the electrochemical performance of Zn-Mn batteries.

Manipulating Deposition Behavior by Polymer Hydrogel Electrolyte Enables Dendrite-Free Zinc Anode for Zinc-Ion Hybrid Capacitors.

Rechargeable aqueous zinc-ion hybrid capacitors (ZHCs) have aroused unprecedented attention because of their high safety, cost effectiveness, and environmental compatibility. However, the intractable issues of dendrite growth and side reactions at the electrode-electrolyte interface deteriorate durability and reversibility of Zn anodes, deeply encumbering the large-scale application of ZHCs. Concerning these obstacles, a negatively charged carboxylated chitosan-intensified hydrogel electrolyte (CGPPHE) with cross-linked networks is reported to stabilize Zn anodes.

High Levels of Zinc Affect Nitrogen and Phosphorus Transformation in Rice Rhizosphere Soil by Modifying Microbial Communities.

Due to global industrialization in recent decades, large areas have been threatened by heavy metal contamination. Research about the impact of excessive Zn on N and P transformation in farmland has received little attention, and its mechanism is still not completely known. In this study, we planted rice in soils with toxic levels of Zn, and analyzed the plant growth and nutrient uptake, the N and P transformation, enzyme activities and microbial communities in rhizosphere soil to reveal the underlying mechanism.

MicroRNA-582-5p Contributes to the Maintenance of Neural Stem Cells Through Inhibiting Secretory Protein FAM19A1.

Epigenetic regulations on the maintenance of neural stem cells (NSCs) are complicated and far from been fully understood. Our previous findings have shown that after blocking Notch signaling in NSCs , the stemness of NSCs decreases, accompanied by the downregulated expression of miR-582-5p. In the current study, we further investigated the function and mechanism of miR-582-5p in the maintenance of NSCs and .

Natural Polysaccharide Strengthened Hydrogel Electrolyte and Biopolymer Derived Carbon for Durable Aqueous Zinc Ion Storage.

Aqueous zinc-ion hybrid supercapacitors (ZHSCs) represent one of the current research subjects because of their flame retardancy, ease of manufacturing, and exceptional roundtrip efficiency. With the evolution into real useful energy storage cells, the bottleneck factors of the corrosion and dendrite growth problems must be properly resolved for largely boosting their cycling life and energy efficiency. Herein, a natural polysaccharide strengthened hydrogel electrolyte (denoted as PAAm/agar/Zn(CFSO)) was engineered by designing an asymmetric dual network of covalently cross-linked polyacrylamide (denoted as PAAm) and physically cross-linked loose polysaccharide (e.