Nano-single-crystal co-free li-rich Mn-based layered cathode for long-cycling high-energy lithium-ion batteries.

Although high energy density Li-rich layered oxide is a promising cathode due to its extremely high energy density (≥ 1000 Wh kg), the commercialization is largely hindered by lattice oxygen escape, voltage fading, and short lifetime during cycling. Single-crystalline engineering is believed to be an effective strategy to solve these problems. However, low-cost Li-rich Co-free layered cathode is mainly synthesized by molten salt-assisted method followed by additional washing and recalcination, which is not only a multi-step method but also lack economy and universality.

Are There Culture-Specific Patterns of Psychological Well-Being? The Role of Survival Versus Self-Realisation Values.

Hedonic and eudaimonic well-being were studied depending on indicators of distress in countries with cultures differing in survival/self-realisation values. A total of 2216 respondents from Chile, China, Italy, Russia and the United States participated. The Psychological Well-Being Scale, the Satisfaction With Life Scale, and the Depression, Anxiety, Stress Scale were used.

Refractory Gout and Metabolic Syndrome in a Chinese Cohort: A Propensity Score Matching and Nonlinear Relationship Analysis.

Objective: The coexistence of refractory gout and metabolic syndrome may worsen patient prognosis, but the association and the nonlinear relationships with clinical parameters have not been fully elucidated. This study aimed to explore this association and reveal its potential nonlinear patterns in a Chinese cohort.

Methods: This retrospective study included clinical data from 4111 gout patients from a single center in Tianjin, China between 2014 and 20234.

Signal pathways in the treatment of Rheumatoid Arthritis with traditional Chinese medicine.

Ethnopharmacological Relevance: Rheumatoid arthritis (RA) is a chronic autoimmune disorder of unknown etiology that severely impairs patients' quality of life and may ultimately result in functional disability and increased mortality. Traditional Chinese medicine (TCM) possesses extensive clinical experience and has demonstrated favorable outcomes in managing RA. At present, it has been found that TCM compound and effective active ingredients can effectively treat RA, and its mechanism of action needs further study.

Nonlinear association between rheumatoid factor and interstitial lung disease risk in patients with rheumatoid arthritis.

Background: Patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) face a significantly elevated mortality risk. However, the association between rheumatoid factor (RF) and RA-ILD remains unclear. This study aimed to investigate the relationship between RF and RA-ILD risk, with a focus on potential nonlinear associations and threshold effects.

Chinese expert consensus on clinical diagnosis and treatment of breast cancer targeting HER2.

Background: Human epidermal growth factor receptor 2 (HER2) is an important driver gene and prognostic indicator of breast cancer and also a key predictor of HER2-targeted therapies. Both the low expression and the positive expression of the HER2 protein are clinically significant for disease treatment and prognosis.

Methods: (I) Establishment of expert group: the expert group consists of experts from departments such as medical oncology, breast surgery, and pathology; (II) literature search: mainly conducted in English databases (such as PubMed, Embase, and Cochrane Library) with a search cutoff date of June 1, 2025; (III) assessment of evidence quality and recommendation strength: evidence quality and recommendation opinions are graded based on the evidence category and recommendation level of the Chinese Society of Clinical Oncology (CSCO) guidelines.

Real-world efficacy and safety of trastuzumab deruxtecan in heavily pre-treated HER2-low metastatic breast cancer across distinct immunohistochemistry statuses.

Background: There are limited clinical data to compare the efficacy of trastuzumab deruxtecan (T-DXd) between the immunohistochemistry (IHC) 1+ and 2+ subgroups of human epidermal growth factor receptor 2 (HER2)-low metastatic breast cancer (MBC). This study investigated the outcomes of T-DXd across distinct IHC statuses in HER2-low MBC.

Methods: Patients with HER2-low MBC treated with T-DXd from June 2022 to December 2023 at The Fifth Medical Centre of Chinese PLA General Hospital were enrolled.

Transcriptome-based analysis reveals key molecular mechanisms and functional characterization of MaCAX3 gene involved in manganese stress responses in mulberry plants.

Background: Manganese (Mn) deficiency and toxicity are major constraints on crop production in soil. Plants have evolved cascade strategies and specific mechanisms to tolerate these stresses. Understanding the molecular mechanisms of tolerance to Mn stress is crucial for improving the efficiency of conferring Mn tolerance and phytoremediation, which is intriguing for evolutionary research on plant adaptation to abiotic stresses.

Melatonin Enhances Panax vietnamensis Resistance to Leaf Blight Pathogen Neofusicoccum ribis via the PvWRKY40-PvCOMT2 Module-Driven Lignin Biosynthesis.

Panax vietnamensis, a medicinally valuable perennial herb, is highly susceptible to leaf blight under cultivation; however, the molecular mechanisms underlying this disease remain poorly understood. In this study, we identified Neofusicoccum ribis as the causal agent of P. vietnamensis leaf blight through pathogen isolation and fulfilment of Koch's postulates.

Trust and subjective well-being across the lifespan: A multilevel meta-analysis of cross-sectional and longitudinal associations.

Trust in other people and institutions is associated with people's well-being across the lifespan. Yet, the strength of these associations varies considerably across studies, and it remains unclear which factors account for this variation. Moreover, some longitudinal studies indicate that trust not only predicts well-being but that subjective well-being also predicts levels of trust.

Oxidant-free cross-dehydrogenative oxyalkylation enables late-stage functionalization of drugs.

Late-stage functionalization is an attractive strategy that allows chemists to bypass lengthy synthetic processes, facilitating the rapid generation of drug analogs with potentially enhanced pharmacokinetic and pharmacological properties. This study describes a novel approach for cross-dehydrogenative oxyalkylation, leveraging a unique γ-ray-enabled photoredox process to generate oxyalkyl radicals, followed by a Minisci-type addition in an aqueous solution. The metal- and oxidant-free aqueous conditions, coupled with excellent functional group compatibility, establish this method as a versatile protocol for the late-stage oxyalkylation of unprotected, structurally complex drug molecules.

Genetic Causal Relationship Between Systemic Lupus Erythematosus and Malignant Tumors of the Female Reproductive System: A GWAS Analysis in European Populations.

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that primarily affects women of reproductive age. Existing studies have demonstrated complex associations between SLE and various diseases, but its genetic relationship with malignant tumors of the female reproductive system has not been fully elucidated. This study is aimed at exploring the potential genetic associations and shared molecular basis between SLE and female reproductive system malignancies using genome-wide association studies (GWASs) and cross-trait analysis.

Enhanced recovery in unilateral vestibular hypofunction: The synergistic effect of medication and vestibular rehabilitation training.

Objective: This study aimed to compare the efficacy of medication combined with personalized vestibular rehabilitation training (VRT) versus medication alone in unilateral vestibular hypofunction (UVH) and identify predictors of long-term symptom progression.

Methods: Forty-eight UVH patients were randomized into a VRT group (n = 23, medication combined with personalized VRT) and a control group (n = 25, medication alone). Bithermal caloric tests, Dizziness Handicap Inventory (DHI), Vestibular Rehabilitation Benefit Questionnaire (VRBQ), Visual Analog Scale (VAS), Activities-specific Balance Confidence Scale (ABC), and Self-Rating Anxiety Scale (SAS) were assessed at baseline, 2 weeks, and 4 weeks.

Bayesian fine-mapping and Mendelian randomization leveraging expression quantitative trait loci reveal novel candidate causal genes for body conformation traits in cattle.

Cattle body size measurements constitute the conformation traits that facilitate their production, fertility, and longevity status. Prioritizing functional variants and causal genes of conformation traits is essential for understanding their genetic basis. In this study, we conducted single-trait and multitrait GWAS for 20 body conformation traits using imputed sequence data in 7,674 Chinese Holstein individuals and identified 27 QTL regions.

Development and initial validation of the health-related quality of life pictorial inventory for children (HEALTH-PIC).

Purpose: This 3-study paper aimed to develop and validate a self-reported Health-Related Quality of Life Pictorial Inventory for Early Childhood Children (HEALTH-PIC). The scale was designed to overcome existing barriers of parent-proxy response styles such as observation bias and offer an alternative to age-suited literary questionnaires to assess self-reported health-related quality of life, including physical health, emotional health, social health and school health in early childhood.

Methods: Each study targeted a specific aspect of scale development, employing distinct samples to refine and validate the inventory.

Integrated multi-omics analysis and functional validation uncovers RPL26 roles in regulating growth traits of Asian water buffaloes (Bubalus bubalis).

Background: Asian water buffaloes (Bubalus bubalis) in the Yangtze River Basin of China are the important meat provider for local residents because of its outstanding body size. Several previous studies have highlighted their genetic basis of growth characteristics, but the crucial genes regulating growth traits via multi-layer omics are still rarely investigated.

Results: We conducted a comprehensive multi-omics analysis integrating blood and muscle transcriptome, plasma metabolome, rumen fluid metagenome, and genome of Haizi water buffaloes.

Clinical-radiomics model for predicting internal mammary lymph node metastasis in operable breast cancer patients.

Objective: Although preoperative prediction of axillary lymph nodes status has been achieved using radiomics and combined models, there is a dearth of research on internal mammary lymph node (IMN) metastasis status prediction. We developed a predictive model by combining clinicopathological factors with preoperative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) radiomics to accurately predict IMN metastasis in breast cancer.

Methods: Patients who had no evidence of IMN metastasis on preoperative images but underwent internal mammary sentinel lymph node biopsy (IM-SLNB) were included in this study.

The Targeted Metabolomic Signatures of Phytohormones in Leaves of Mulberry ( L.) Are Crucial for Regrowth and Specifically Modulated by the Differential Stubble Lengths.

Vegetative propagation of mulberry ( L.) via sapling methods, due to the ability to exponentially multiply lateral buds on stem cuttings to enhance rapid shoot formation, is crucial for sericulture industries. The sprouting of mulberry using stubbles is an emerging method for rapid and mass production of mulberry leaves, but the growth mechanisms associated with its use remain obscure.

Neutrophils in Rheumatoid Arthritis Synovium: Implications on Disease Activity and Inflammation State.

Background: Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation driven by immune cell infiltration. While neutrophils have traditionally been associated with acute inflammation, emerging evidence suggests their significant role in chronic RA synovitis. Synovial pathology reports from our center reveal lymphocyte-predominant infiltration in most RA cases, with synovial neutrophils (SNs) observed in only 30% of patients.

Does grandparental care play a role in Chinese children's self-control? Evidence from meta-analyses.

Studies have found that parental care is closely associated with child self-control. In addition to parents, grandparents are also important family members and play a critical role in child development. Many studies have explored the associations between grandparental care and child self-control, especially in the Chinese context.

A multilevel latent profile analysis to job demands, job resources, and personal resources in early childhood educators: Implications for multidimensional well-being.

Early childhood educators' (ECEs) well-being is important for many outcomes. Drawing on the job demands-resources model, many variable-centered studies have found that job demands, job resources, and personal resources are linked to ECEs' well-being. Yet, little is known about the heterogeneity of these demands and resources and their implications for well-being, especially considering school-level effects and the adoption of a holistic view of well-being.

Determination of A1 and A2 β-casein in cow milk by high-performance liquid chromatography tandem mass spectrometry.

A2 β-CN milk has gained widespread acceptance due to its nutritional benefits. To verify the authenticity and detect adulteration and contamination in A2 milk, we developed an HPLC-MS/MS method for determining the characteristic peptides of A1 and A2 β-CN in cow milk. The method demonstrated good specificity, sensitivity, and linearity for both A1 and A2 characteristic peptides, with limit of detection of 0.

Analysis of risk factors affecting prognosis of fulminant myocarditis in children: a ten-year single-center study.

Objective: The present study aimed to analyze the risk factors affecting the prognosis children with fulminant myocarditis.

Methods: The medical records of all patients (n = 40) who were diagnosed with fulminant myocarditis and admitted to the Cardiac Intensive Care Unit (CICU) and Pediatric Intensive Care Unit (PICU) at the Guanzhou Women and Children's Medical Center, Guangzhou Medical University between January 2014 and December 2023 were retrospectively analyzed. Patients were divided into two groups based on their in-hospital prognosis, namely, a survival group (n = 32) and an non-survival group (n = 8).