Small Ruptured Anterior Communicating Artery Aneurysms in the Endovascular Right-of-First-Refusal Era: Intraprocedural Rupture Risk and Retreatment at Follow-up.

Background: Ruptured small anterior communicating artery (ACoA) aneurysms can pose a technical challenge for endovascular therapy. We sought to explore treatment and follow-up results in the modern endovascular right of first refusal era.

Methods: Smaller (≤ 7mm) ruptured aneurysms of the ACoA undergoing treatment were compared with non-ACoA counterparts, and further dichotomized by size (≤3mm and 3-7mm).

Genome-wide association study and fine-mapping using imputed sequences to prioritize candidate genes for 30 complex traits in 50,309 Holstein bulls.

Identifying causal genetic variants underlying economically important traits in dairy cattle is essential for understanding their genetic basis and optimizing breeding programs. The growing availability of sequenced reference genomes and individuals with both phenotypic and genotypic data notably enhances our ability to detect genetic associations and further pinpoint causal effects. This comprehensive GWAS of dairy cattle used deregressed breeding values as phenotypes and analyzed 11,292,243 quality-controlled, imputed sequence variants from 50,309 Holstein bulls.

A zwitterionic dual-network hydrogel patch with anti-inflammatory properties for efficient peritoneal adhesion prevention.

Postoperative peritoneal adhesion, driven by inflammatory response and fibrotic deposition, remains the most common complication following abdominal surgeries, with limited effective solutions. Herein, a dual-network hydrogel patch (GPSB) is developed for effective peritoneal adhesion prevention through interpenetrating a gelatin network with a zwitterionic polysulfobetaine (PSB) network. The biodegradable gelatin network is dynamically crosslinked zinc ion (Zn)-polyphenol coordination, endowing the patch with inherent antibacterial and pro-healing activities.

Structural Modulation of Cu(II)-Based Coordination Polymers by Schiff Base Ligands and Electrochemical Sensing for Heavy-Metal Ions.

Retaining the topology of the framework and the metal nodes while judiciously modifying the organic linker constituents presents an opportune avenue to systematically investigate the structure-activity relationship of coordination polymers (CPs). Herein, two functionalized Schiff base ligands, HL1a (1,2-cyclohexanediamine-,-bis(3--butyl-5--dicarboxybenzo--hydroxybenzyl)) and HL2a (1,2-diphenylethylenediamine-,-bis(3--butyl-5--diacarboxybenzo--hydroxybenzyl)), were designed and prepared. In the two ligands, the amine moiety connecting the Schiff base is either 1,2-diaminocyclohexane or the more sterically hindered diphenylethylenediamine, which directly influences the pore distribution in the subsequently synthesized crystalline materials.

Lithocholic acid ameliorates ulcerative colitis via the PXR/TLR4/NF-κB/NLRP3 signaling pathway and gut microbiota modulation.

Ulcerative colitis (UC) is a chronic inflammatory condition of the colon, closely linked to dysbiosis of gut microbiota and imbalances in bile acids. Lithocholic acid (LCA), a secondary bile acid, plays a crucial role in maintaining gut health; however, its specific therapeutic potential in UC remains to be fully elucidated. This study investigates the efficacy of LCA in alleviating UC and explores the underlying mechanisms, particularly focusing on the PXR/TLR4/NF-κB/NLRP3 signaling pathway and gut microbiota modulation.

Delayed Cerebral Ischemia and Vasospasm After Aneurysmal Subarachnoid Hemorrhage: Impact of Stents and Dual Antiplatelet Therapy.

Background And Objectives: As stent-assisted coiling and flow diversion permeate the treatment armamentarium for appropriately selected ruptured aneurysms, the effect of dual antiplatelet therapy (DAPT) on hemorrhagic complications is primarily scrutinized. However, the effect of DAPT and the presence of a stent on vasospasm and delayed cerebral ischemia (DCI) is less well studied.

Methods: Our prospectively maintained institutional database of intracranial aneurysms was queried for DCI and postaneurysmal subarachnoid hemorrhage (aSAH) vasospasm among patients undergoing stent coiling/flow diversion with subsequent usage of DAPT (S-DAPT).

Nationwide data-driven quality improvement in ultrasound medicine: insights from an indicator-based initiative in China.

Background: There are only a limited number of countries systematically tracking the quality of ultrasound at the national and institutional levels. Our study presents an example of a national, data-driven approach to ultrasound medicine quality measurement and improvement through indicators.

Aim: This study aims to establish a nationwide, indicator-based framework for measuring and improving the quality of ultrasound medicine in China.

Venous Architecture Predicts Hemorrhage Risk in Sporadic CCM With DVA.

Background: To prospectively validate an imaging-based classification system for cerebral cavernous malformation (CCM) associated with developmental venous anomaly (DVA) in a multicenter cohort, and to evaluate the association between DVA subtypes and hemorrhage risk.

Methods: This prospective multicenter cohort study was conducted as part of the Quantitative Susceptibility Biomarker and Brain Structural Property for Cerebral Cavernous Malformation Related Epilepsy (CRESS) study at 2 tertiary neurosurgical centers in China. Patients with sporadic CCM and coexisting DVA were consecutively enrolled and prospectively followed for data collection between September 2019 and March 2024.

Triple signal biosensing platform for ultrasensitive and wide-range detection of HLA gene targets.

Hyperthyroidism, a multifaceted endocrine disorder, is strongly associated with specific human leukocyte antigen (HLA) alleles, which also play a critical role in drug-induced complications such as agranulocytosis. Conventional HLA genotyping methods often face limitations in simultaneously achieving high accuracy, rapidity, and operational simplicity. To address these challenges, we developed a multimodal biosensing platform for the highly sensitive detection of alleles.

Grassland ecological compensation accounting based on the flow of emergy ecological products: a case from the Qinghai Tibet region, China.

The relationship between the value of grassland ecological products and the distribution of regional benefits is key to realizing the value of ecological compensation. This study is based on an improved emergy ecological surplus model to identify the supply and demand regions for grassland ecological products, and constructs an emergy ecological product flow model to determine the flow volume and range of ecological products. Combining the regional economic level, an ecological compensation model is established to calculate the ecological compensation amount and compensation paths for the Qinghai-Tibet region.

3D-Printed Fe-Ni Porous Framework Structures for Efficient and Recyclable Degradation of Azo Dyes in Wastewater.

Advanced oxidation processes offer a potent, eco-friendly solution for degrading organic wastewater. Creating high-activity and stability catalysts is crucial to addressing water pollution concerns. Nevertheless, due to constraints in their preparation, prevalent catalysts often lack satisfactory cyclic stability and pose challenges in recovery.

Key Factors for Neuronavigation Use in Skull Lesion Surgery.

Purpose: To identify the determining factors for the use of neuro-navigation in the surgical treatment of skull lesions, with the goal of establishing a standardized framework for its application in clinical practice.

Methods: A retrospective analysis was conducted on 238 consecutive cases of skull lesions treated at Sir Run Run Shaw Hospital, affiliated with Zhejiang University School of Medicine, from 2017 to 2023. Clinical data, including patient demographics, comorbidities, lesion characteristics (such as size, location, proximity to major vessels, palpable status, and skull layer involvement), and surgical parameters, were collected.

Factors Influencing Hormone Remission in Growth Hormone-Secreting Pituitary Neuroendocrine Tumors With Residual Tumor: A Retrospective Cohort Study.

Background: Growth hormone-secreting pituitary neuroendocrine tumors (GH-secreting PitNETs) pose significant health risks due to hormone-related complications. Despite transsphenoidal surgical resection being the primary treatment, complete removal is often infeasible due to invasive growth patterns, leading to postoperative tumor residuals and uncertain hormone remission outcomes.

Methods: This retrospective study included 458 patients with GH-secreting PitNETs who underwent surgery at Beijing Tiantan Hospital.

The global incidence rate of type 2 diabetes related chronic kidney disease and predictions by Bayesian age-period-cohort analysis: findings from the Global Burden of Disease Study 2019.

Aims: To evaluate the spatial-temporal changes in the incidence of type 2 diabetes related chronic kidney disease (CKD-T2DM) from 1990 to 2019, categorized by age and sex in 21 regions with different socio-demographic indexes (SDI), and to predict the incidence rate between 2020 and 2030.

Methods: Data on the burden of CKD-T2DM were obtained from the Global Burden of Disease Study 2019. Age-standardized incidence rates (ASIR) were estimated by sex, age, region, SDI, and specifically in China.

Estimator-Based Second-Order Sliding Mode Control Design for Nonlinear Systems With Unknown Input Delay.

In this article, we propose an estimator-based second-order sliding mode (SOSM) controller tailored for uncertain nonlinear systems with unknown input delay. Distinct from existing SOSM control methods, this work tackles two principal challenges: 1) the difficulty of dealing with unknown input delay, especially given the discontinuity of sliding mode controllers; and 2) the uncertainties in the nonlinear systems bounded by functions rather than widely-used constants. We begin by establishing the SOSM dynamics with input delay and uncertainties, followed by the introduction of an auxiliary compensation system.

Natural History and Outcomes of Deep-seated Brain Arteriovenous Malformations: a Propensity Score Matched Analysis Using Nationwide Multicenter Prospective Registry Data.

Objectives: This study aims to evaluate the natural history of deep-seated brain arteriovenous malformation (AVMs), as well as the risk-benefit outcomes of interventional treatment versus conservative management.

Materials & Methods: Patients with deep-seated AVMs were selected from a nationwide prospective multicenter registry study in China (the MATCH study), and univariate and multivariate analyses were conducted to identify factors associated with AVM rupture. In the analysis of outcomes, propensity score matching (PSM) was performed between the interventional and conservative treatment groups, adjusting for baseline differences.

Wernicke's encephalopathy due to total parenteral nutrition after jejunotomy: a case report.

Introduction And Importance: Wernicke's encephalopathy (WE) is an acute central nervous system disorder resulting from thiamine deficiency. It manifests with symptoms such as ophthalmoplegia, mental confusion, and ataxia. WE is frequently linked with alcoholism but can also arise from nonalcoholic factors like gastrointestinal surgery.

Ketogenic diet ameliorates MASLD via balancing mitochondrial dynamics and improving mitochondrial dysfunction.

Background & Aims: Ketogenic diet (KD) is recognized as an effective lifestyle intervention for managing metabolic dysfunction-associated steatotic liver disease (MASLD). This research aimed to assess the impact of KD on metabolic parameters in MASLD mice and elucidate the underlying mechanism.

Methods: High-fat diet (HFD)-induced MASLD mice were subjected to KD for 2 weeks.

Expanding the Genetic and Clinical Spectrum of Hereditary Angioedema with Normal C1 Inhibitor: Novel Variants and Treatment Insights.

Hereditary angioedema with normal C1 inhibitor (HAE-nC1-INH) is a rare and genetically heterogeneous disorder with an incomplete molecular understanding. This study aimed to identify novel genetic variants associated with HAE-nC1-INH, characterize their clinical manifestations, and evaluate real-world treatment responses. Whole-exome sequencing of 27 HAE patients, including eight with HAE-nC1-INH, identified four previously unreported MYOF variants and additional pathogenic variants in KNG1 and HS3ST6, expanding the genetic spectrum of the disease.

High order Interaction and Wavelet Convolution Network for visible infrared person reidentification.

Visible-infrared person re-identification (VI-ReID) remains a challenging task due to significant cross-modal discrepancies and poor image quality. While existing methods predominantly employ deep and complex neural networks to extract shared cross-modal features, these approaches inevitably discard critical primitive features during high-level feature abstraction. To address this limitation, we propose the High-order Interaction and Wavelet Convolution Network (HIW-Net) that systematically integrates primitive features at multiple feature interaction stages, thereby compensating for information loss in High-order representations.

Acupuncture as an adjunct therapy for enhancing endometrial receptivity in female infertility: a literature review.

Infertility remains a global challenge, with female factors accounting for the majority of cases. Endometrial receptivity (ER), the ability of the endometrium to accept and support embryo implantation, is a critical determinant of successful conception. Traditional Chinese medicine, specifically acupuncture, has been widely adopted as an adjunct therapy for enhancing ER and improving reproductive outcomes in infertile women.

Synergistic Regulation Mechanism of Noodle Quality by Multi-Stage Resting: Coupled Effects of Moisture Distribution, Stress Relaxation, Gas Elimination, and Enzymatic Activity Modulation.

Noodle quality is intricately regulated through mechanisms during multi-stage resting. Insufficient mechanistic understanding often leads to simplified resting stages in industrial production, resulting in elevated cooking loss and deteriorated textural properties. Consequently, a systematic elucidation of multi-stage resting mechanisms and strategically optimizing resting stages are imperative for quality enhancement and industrial advancement.

The Bed Nucleus of the Stria Terminalis-Paraventricular Nucleus of the Hypothalamus Neural Circuit Regulates Neuropathic Pain Through the Brain-Spleen Axis.

Neuropathic pain is a chronic condition caused by damage or dysfunction in the nervous system. While the spleen may influence neuropathic pain, its role has been poorly understood. This study demonstrates that the spleen plays a crucial role in regulating neuropathic pain through the bed nucleus of the stria terminalis (BNST) - paraventricular nucleus of the hypothalamus (PVN) neural circuit in a chronic constriction injury (CCI) mouse model.

The association between sugar-sweetened beverage consumption, muscle strength, and psychological symptoms among Chinese adolescents: a multicenter cross-sectional survey.

Background: The prevalence of psychological symptoms in adolescents has been increasing and has become an important public health issue of concern to countries around the world. However, no studies have been conducted on the association between sugar-sweetened beverage (SSB) consumption, muscle strength, and psychological symptoms in Chinese adolescents. The present study may provide theoretical support and assistance for the prevention and intervention of psychological symptoms in Chinese adolescents.