Homologous nanocellulose modification: A "like cures like" strategy against coffee-ring and infiltration effects in paper-based colorimetric detection.

Background: While paper-based colorimetric assays have seen significant progress in recent years, persistent challenges including the coffee-ring effect and infiltration effect continue to affect the color uniformity of detection results, leading to decreased sensitivity and accuracy of the detection. Recent advancements in suppressing these two effects mainly depend on chemical modification of cellulose fibers or application of specific functional coatings. However, the former's complex procedures impede large-scale implementation, while the latter's non-cellulosic additives risk unpredictable interactions with analytes or interference in colorimetric reactions.

Virulence-mediated colonization mechanism for TEP as a promising watershed-scale recorder and source-tracking indicator of human pathogens.

Waterborne pathogens related diseases have been a global health concern. Precise source tracking of pathogens in rivers is crucial for understanding and reducing waterborne pathogens transmission risks. Current microbial source tracking techniques are still limited by identifying pathogen indicators at low concentrations, particularly in highly dynamic confluence zones of rivers where the coalescence of microbiomes exacerbates community disturbances.

Navigator motion-resolved MR fingerprinting using implicit neural representation: Feasibility for free-breathing three-dimensional whole-liver multiparametric mapping.

Purpose: To develop a multiparametric free-breathing three-dimensional, whole-liver quantitative maps of water T, water T, fat fraction (FF) and R*.

Methods: A multi-echo 3D stack-of-spiral gradient-echo sequence with inversion recovery and T-prep magnetization preparations was implemented for multiparametric MRI. Fingerprinting and a neural network based on implicit neural representation (FINR) were developed to simultaneously reconstruct the motion deformation fields, the static images, perform water-fat separation, and generate T, T, R*, and FF maps.

Ellagic acid on milk production performance, blood and milk hormones, antioxidant capacity and fecal microbial communities in lactating Yili mares.

Ellagic acid (EA), a natural polyphenol, exerts potent antioxidant and anti-inflammatory effects in humans and other animals, while contributing to intestinal microbiota homeostasis. This study investigated the impact of EA supplementation on milk production, hormone secretion, antioxidant activity, and gut microbiota in lactating Yili mares. Eighteen lactating Yili mares with an average body weight of 400.

Differential Effects of Short- and Long-Term Negative Affect on Smartphone Usage: The Moderating Role of Locus of Control.

In the digital age, smartphones are often used as tools for emotion regulation. While prior research has examined affective predictors of smartphone use, few studies have considered the combined impact of short-term and long-term affective states. This study investigates how daily negative emotional states and psychological distress relate to smartphone use and whether these associations are moderated by locus of control, a core belief about perceived control.

MoC Ceramic Electrode Embedded with PtMo Nanograins for Hydrogen Evolution Reaction at High Current Density.

The scarcity and high price seriously hinder the large-scale industrial application of Pt as the preferred catalyst for the hydrogen evolution reaction (HER). A PtMo@MoC catalytic electrode was designed based on a porous MoC ceramic membrane with finger-like holes, where PtMo nanograins were uniformly embedded in the surface of the MoC grains by electrodeposition and thermal reduction. The loading of Pt is as small as 7.

ACAA2 lactylation and expression mediate mitochondrial dysfunction in phenylephrine-induced cardiomyocyte hypertrophy.

Background: Pathological cardiac remodeling under chronic stress involves metabolic reprogramming, with lactylation emerging as a critical post-translational regulator of cardiac energetics. Emerging evidence reveals that lactate, beyond serving as an energy substrate, dynamically regulates cellular processes through lactylation-mediated epigenetic modifications. This study investigates ACAA2, a fatty acid β-oxidation enzyme, exploring its lactylation dynamics and metabolic implications in pressure overload-induced cardiomyopathy.

Development and validation of a simple risk score to predict gastroesophageal reflux disease after sleeve gastrectomy: a multicenter retrospective cohort study.

Background: Laparoscopic sleeve gastrectomy (LSG) is the most commonly performed bariatric procedure worldwide. However, the development of gastroesophageal reflux disease (GERD) following LSG remains a significant clinical concern that can compromise long-term patient outcomes and satisfaction.

Materials And Methods: In this multicenter retrospective cohort study, a total of 968 patients were screened, of whom 851 met eligibility criteria and were included in the final analysis.

Intelligent Adolescent Idiopathic Scoliosis Detection Method Based on Three-Dimensional Measurements.

Adolescent Idiopathic Scoliosis (AIS) is a prevalent latent disorder among adolescents. Early detection and screening are crucial for preventing the progression of deformities. Current assessment methods for spinal curvature rely on X-ray imaging to measure the Cobb angle and detect scoliosis.

Intervention of Astragalus Membranaceus Extract in rats of spinal cord injury: a systematic review and meta-analysis.

Objective: Spinal cord injury (SCI) causes motor, sensory and autonomic dysfunction below the level of injury and its incidence is increasing every year. Astragalus Membranaceus Extract (AME) has received attention in spinal cord injury in recent years, but its specific effects in spinal cord injury are unclear.

Methods: Databases of PubMed, Embase, WOS, Cochrane Library, FMRS, Clinical trial, CNKI, VIP, and WangFang were searched from their establishment to December 1, 2024 using the following terms: "Astragalus propinquus," "Huang qi," " Bunge," "Spinal cord injuries," "spinal cord diseases," "spinal cord trauma.

Hydrophilic Engineering of Pyrene-Based COFs for Enhanced Photocatalytic Hydrogen Evolution.

In this study, we incorporated hydroxyl (COF-JLU71) and methoxy (COF-JLU72) functional groups into the 2D framework of 4,4',4'',4'''-(1,9-dihydropyrene-1,3,6,8-tetrayl)tetrabenzaldehyde and synthesized two hydrophilic COFs by Schiff base condensation with 4,4'-(benzo[c][1,2,5]thiadiazole-4,7-diyl) aniline. Their structural features were compared, and it was found that such modifications are beneficial for the construction of hydrogen bond networks, the tuning of photostructures, the enhancement of hydrophilicity, and the improvement of photocatalytic water splitting efficiency.

ZnO@MIPs-NR ratiometric fluorescent probe for ultra-sensitive on-site tiletamine detection.

The abuse of tiletamine has emerged in many countries around the world. In this study, a ratiometric fluorescence probe was innovatively proposed for detecting of the anesthetic tiletamine by combining ZnO QDs-based molecularly imprinted polymers (ZnO@MIPs) and Nile blue oxazone (Nile Red, NR). The ZnO@MIPs constructed by sol-gel method exhibit strong green fluorescence emission at 510 nm, which can be selectively quenched in the presence of tiletamine.

Study on the Modification of Dietary Fiber and Degradation of Zearalenone in Corn Germ Meal by Solid-State Fermentation with K6.

Although corn germ meal is a rich source of dietary fiber, it contains a relatively low proportion of soluble dietary fiber (SDF) and is frequently contaminated with high levels of zearalenone (ZEN). Solid-state fermentation has the dual effects of modifying dietary fiber (DF) and degrading mycotoxins. This study optimized the solid-state fermentation process of corn germ meal using K6 through response surface methodology (RSM) to enhance SDF yield while efficiently degrading ZEN.

Doughnut-biting photon capturing scheme for drone-based orbital angular momentum quantum key distribution.

Drone-based quantum key distribution (QKD) offers a flexible, cost-effective, and reconfigurable approach to extending the reach of spatial and temporal quantum communication. The rotation-invariant properties of orbital angular momentum (OAM) effectively mitigate issues related to reference frame alignment from the drone platform. Utilizing OAM encoding to achieve high-dimensional quantum key distribution (HD-QKD) exhibits significant advantages in terms of communication capacity and robustness.

Reconfigurable metasurfaces to realize BB84 protocol for wireless quantum communication.

Metasurfaces showcase unique abilities to arbitrarily manipulate the amplitude, phase, and polarization of electromagnetic (EM) waves, facilitating their application in wireless communication. In the propagation of EM waves, traditional methods cause severe security concerns in channel/deciphering under eavesdropping. Fortunately, quantum communication, based on quantum key distribution (QKD) of the BB84 protocol, endows the transmission with high security.

Hadamard single-pixel imaging in the ultraviolet band based on a CdS/GaN heterojunction photodetector.

The demand for ultraviolet (UV) photodetectors is increasing, and the breakthrough progress of 2D materials in the optoelectronic detection field has opened new avenues for UV imaging. However, traditional UV photodetectors often have slower response speeds, and fast response is crucial for single-pixel imaging (SPI). In this work, to achieve high-quality UV-band imaging, we utilized a high-performance CdS/GaN photodetector and designed an SPI system with Hadamard modulation.

Comparative performance evaluation of FilmArray RP 2.1 and targeted next-generation sequencing in upper respiratory tract infections.

Introduction: Upper respiratory tract infections (URTIs) represent a significant global health burden, impacting patient morbidity and quality of life. The implementation of accurate pathogen detection methods is crucial for precise diagnosis and effective clinical management of URTIs. This study evaluates the clinical performance of targeted next-generation sequencing (tNGS) as a diagnostic tool for comprehensive identification of URTI-associated pathogens.

Preparation of 3D-Printed Intelligent Label Loading with Natural Pigment Nanoparticles and Its Freshness Monitoring Application.

This paper constructed a kind of MSA-BA-GE 3D-printed intelligent label loading with MSA-BA composite nanoparticles. Innovatively, MSA-BA composite nanoparticles were used as the color indicator system, viscous fluid gelatin solution was used as the matrix, and the mixture of MSA-BA composite nanoparticles and viscous fluid gelatin was put into a 3D printer to prepare a 3D-printed intelligent label. The microstructure, morphology, pH responsiveness, and food freshness monitoring performance of the MSA-BA composite nanoparticles and the MSA-BA-GE 3D-printed intelligent label were studied.

Localized surface plasmon resonance effect dominates room temperature formaldehyde gas sensor with ultra-high sensitivity and selectivity.

Universal sensitivity and high operating temperature have always been the serious problems faced by semiconductor based gas sensors in practical applications. The use of photoelectric and Localized Surface Plasmon Resonance (LSPR) effects can replace heating to provide energy to electrons. However, the differences between electrons generated by photoelectirc effect and LSPR effect, as well as the impact of these differences on gas sensing performance are still unclear.

HBV-Specific TCR-T Cell Therapy Combining mRNA Electroporation and Lentiviral Transduction: Treatment Regime for Recurrent HBV-Related HCC Post-Liver Transplantation.

Background & Aims: This study aimed to preliminarily evaluate the safety, tolerability, and antitumor efficacy of HBV-specific TCR-T cell therapy combining mRNA electroporation and lentiviral transduction in patients with recurrent HBV-HCC post-LT.

Methods: In this pilot study (NCT04677088), two types of autologous HBV-specific TCR-redirected T cells were assessed without prior lymphodepletion: (1) multiple infusions of mRNA-electroporated HBV-TCR-T cells (mRNA-HBV-TCR-T cells) and (2) one to three infusions of lentiviral-transduced HBV-TCR-T cells (lenti-HBV-TCR-T cells). Treatment-related adverse events were assessed using the Common Terminology Criteria for Adverse Events (CTCAE), and anti-tumor efficacy was evaluated using computed tomography (CT) imaging according to RECIST 1.

Photoacoustic and fluorescence hybrid microscope for cortex-wide imaging of neurovascular dynamics with subcellular resolution.

Simultaneously monitoring cortex-wide microvascular dynamics, blood oxygenation metabolism, and neuronal activities with high spatiotemporal resolution is essential for understanding neurovascular coupling (NVC). However, it remains a challenge for existing neuroimaging tools. Here, we report a linear transducer array-based hybrid microscope (LiTA-HM) that integrates photoacoustic microscopy and confocal fluorescence microscopy to achieve simultaneous neurovascular imaging with a field of view (FOV) of 6 millimeters by 5 millimeters, a spatial resolution of ~6 micrometers, and a temporal resolution of 0.

Rapid and simultaneous detection of antibodies against three feline viruses using colloidal gold immunochromatographic assay with smartphone integration.

A multiplex colloidal gold immunochromatographic assay (mCGIA) was developed for the simultaneous detection of feline calicivirus (FCV), feline panleukopenia virus (FPV), and feline herpesvirus (FHV) antibodies in feline serum. The expressed and purified recombinant FCV-VP1, FPV-VP2, and FHV-gD proteins exhibited strong antigenic reactivity. The mCGIA test strip achieved rapid (< 15 min) and specific detection, showing no cross-reactivity with other feline viral antibodies.

Melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1.

A major obstacle in type 2 diabetes mellitus (T2DM) is sleep fragmentation (SF), which negatively affects testicular function. However, the underlying mechanisms remain to be elucidated. In this study, we demonstrate that SF induces testicular damage through a mechanism involving lipid metabolism, specifically mediated by melatonin (MEL) receptor 1a (MT1).

A review of acupoint localization based on deep learning.

The development of deep learning has brought unprecedented opportunities for automatic acupoint localization, surmounting many limitations of traditional methods and machine learning, and significantly propelling the modernization of Traditional Chinese Medicine (TCM). We comprehensively review and analyze relevant research in this field in recent years, and examine the principles, classifications, commonly used datasets, evaluation metrics and application fields of acupoint localization algorithms based on deep learning. We categorize them by body part, algorithm architecture, localization strategy, and image modality, and summarize their characteristics, pros and cons, and suitable application scenarios.

The effect of different exercise modalities on older adults' quality of life: an assessor-blinded randomized controlled trial.

This assessor-blinded randomized trial was designed to evaluate the effects of aerobic exercise, resistance training, and traditional Chinese gong methods on the quality of life (QoL) of older adults aged 66-96 years living in a nursing facility. Seventy - eight participants, who were over 65 years old, free from severe heart disease, asthma, and other conditions specified in the exclusion criteria, were randomly allocated into three groups to receive 12-24 weeks of different exercise interventions. The SF - 36 Health Survey Scale was employed to assess QoL before the intervention and 12 and 24 weeks after it.