Homologous nanocellulose modification: A "like cures like" strategy against coffee-ring and infiltration effects in paper-based colorimetric detection.

Background: While paper-based colorimetric assays have seen significant progress in recent years, persistent challenges including the coffee-ring effect and infiltration effect continue to affect the color uniformity of detection results, leading to decreased sensitivity and accuracy of the detection. Recent advancements in suppressing these two effects mainly depend on chemical modification of cellulose fibers or application of specific functional coatings. However, the former's complex procedures impede large-scale implementation, while the latter's non-cellulosic additives risk unpredictable interactions with analytes or interference in colorimetric reactions.

Hollow Cu/Zn-MOF@Au/Ferrocene Nanoarchitectures: A Universal Leap from Colorimetric to Dual-Mode Colorimetric/Electrochemical Lateral Flow Assays.

Dual-mode lateral flow assays (LFAs) have gained significant attention, yet existing systems predominantly combine optical modalities, leaving hybrid colorimetric-electrochemical configurations underexplored despite their potential to achieve diagnostic synergy and minimize interference. Here, we present a universally compatible, low-cost lateral flow platform leveraging dual-signal nanohybrids for synchronized colorimetric-electrochemical detection. A hierarchically hollow Cu/Zn-metal-organic framework (MOF) bearing carboxyl functional groups was rationally designed to anchor gold nanoparticles (AuNPs) in situ for colorimetric signaling, followed by covalent immobilization of aminoferrocene to establish electrochemical signaling.

Cellulose-based molecularly imprinted core-shell microspheres with dual environment responsiveness for specific recognition and enrichment of paclitaxel.

Paclitaxel (PTX), a natural diterpene alkaloid with potent anticancer activity, has been a focus of global research due to its complex structure, significant biological effects, unique mechanism of action, and limited natural availability. In this study, cellulose was used as the raw material to synthesize functionalized pH-responsive modified cellulose porous hydrogel microspheres (MCC/SA/MA-POSS-PTX) via inverse suspension polymerization, using sodium alginate (SA) as the pH-responsive material. Based on this using PTX as the template molecule, 4-VP as the functional monomer, N-isopropylacrylamide (NIPAM) as the thermosensitive monomer, cellulose-based PTX molecularly imprinted hydrogel microspheres (CDLMIHM-PTX) with dual pH and temperature responsiveness were prepared.

Play on Electrodes.

Maximizing the efficiency of electrode usage is a crucial step in enhancing the integration of wearables. Currently, electrodes are combined in an additive manner to enable multiplexed sweat screening. The additive sensor requires significant space to accommodate single-function electrodes, which limits the integration of the wearable sensors.

Stacking paper sheets into multi-purpose quick response sensing code with built-in nitrocellulose-membrane-free lateral flow assay for detecting tetracycline in food samples.

Lateral flow assays (LFAs) have found extensive applications in food safety and quality monitoring. Now, smartphone technology is redefining how tests are conducted at the point of use. At the same time, quick response (QR) codes enhance digital connectivity for information transmission, data collection, and response linkage.

Discovery of Novel PROTAC-Based HPK1 Degraders with High Potency and Selectivity for Cancer Immunotherapy.

Hematopoietic progenitor kinase 1 (HPK1, MAP4K1), a serine/threonine (SER/THR) kinase, has been identified as a negative immune regulator of T-cell receptor signaling. Deprivation of the HPK1 function suppresses tumor growth, providing an attractive strategy for cancer immunotherapy. Herein, we present a novel PROTAC-based HPK1 degrader compound with high selectivity and potency.

Functionalized nano cellulose double-template imprinted aerogel microsphere for the targeted enrichment of taxanes.

Paclitaxel, a diterpenoid isolated from the bark of Taxus wallichiana var. chinensis (Pilger) Florin, is currently showing significant therapeutic effects against a variety of cancers. Baccatin III (Bac) and 10-Deacetylbaccatin III (10-DAB) are in great demand as important precursors for the synthesis of paclitaxel.

Making commercial bracelet smarter with a biochemical button module.

Despite the rapid development of mobile health based on wearable devices in recent years, lack of access to biochemical detection remains a vital challenge for most commercial wearable devices, which hinders the provision of effective electronic health records (EHRs) for disease control strategies, and further constraining the development of personalized precision medicine. Herein, we propose a strategy to graft biochemical detection function onto commercial bracelet. Different from the conventional development process of designing a completely new wearable biochemical device, we prefer to upgrade existing commercial wearable device to achieve simpler, faster, and more effective research and commercialization processes.

A Case of Oropharyngeal Syphilis.

We present a case of a 50-year-old male who complained of a sore throat persisting for 2 months. Upon physical examination, multiple mucous patches were observed in the oropharynx region, but no skin lesions were found. Fiberoptic laryngoscopy confirmed these findings.

Spatiotemporal variations, influence factors, and simulation of global cooling degree days.

The cooling degree days (CDDs) can indicate the hot climatic impacts on energy consumption and thermal environment comfort effectively. Nevertheless, seldom studies focused on the spatiotemporal characteristics, influence factors, and simulation of global CDDs. This study analyzed the spatial-temporal characteristics of global CDDs from 1970 to 2018 and in the future, explored five determinants, and simulated CDDs and their interannual changing rates.

Hantzsch Ester-Mediated Visible-Light-Induced Radical Ethoxycarbonyldifluoromethylation of Aryl Alkynes: Kinetic-Controlled Stereoselective Synthesis of --Difluoroallyl Esters.

A kinetic-controlled photocatalyst-free visible-light-induced stereoselective synthesis of α,α--difluoro--allyl esters was succeeded at room temperature in moderate to excellent yields with up to -isomer-only stereoselectivities through a reductive radical ethoxycarbonyldifluoromethylation of terminal aryl alkynes with blue LED (465 nm)-excited Hantzsch ester. The geometry optimizations obtained by the DFT/B3LYP calculation with a standard 6-31G(d,p) basis set were also employed for the mechanism study on the formation of a key α,α-difluoroallyl ester radical intermediate, which was generated from the addition of the ethoxycarbonyldifluoromethyl radical to aryl alkyne substrates and the stabilization effect of the neighboring group. Subsequent steric hindrance-determined hydrogen generated from the Hantzsch ester radical cation led to the formation of final aryl-substituted -difluoroallyl esters.

Crystallization and crystallographic studies of a novel chickpea 11S globulin.

Chickpea is a crop that is known as a source of high-quality proteins. CL-AI, which belongs to the 11S globulin and cupin superfamily, was initially identified in chickpea seeds. CL-AI has recently been shown to inhibit various types of α-amylases.

Spatial Characteristics Analysis for Coupling Strength among Air Pollutants during a Severe Haze Period in Zhengzhou, China.

This paper investigates the multifractal characteristics of six air pollutants using the coupling detrended fluctuation analysis method. The results show that coupling correlations exist among the air pollutants and have multifractal characteristics. The sources of multifractality are identified using the chi square test.

[Synthesis and luminescence properties of Y10W2O21:Eu nanophosphor].

In the present paper, a novel nanophosphor, Y10W2O21:Eu was synthesized through a simple and low-cost method: co-precipitation. The results of XRD show that resultant samples are Orthorhombic phase and primitive lattice. The average crystallographic sizes could be confirmed to be approximately 80 nm by means of the Scherrer formula, which are in good agreement with the particles sizes exhibited by SEM.

Study on luminescent properties of Eu3+ doped Gd2WO6, Gd2W2O9 and Gd2(WO4)3 nanophosphors prepared by co-precipitation.

Eu3+ doped Gd2WO6, Gd2W2O9 and Gd2(WO4)3 nanophosphors with different concentrations have been prepared by co-precipitation. XRD (X-ray diffraction) and SEM (scanning electron microscopy) were used to investigate the structure and morphology. The emission spectra, excitation spectra and fluorescence decay curves were measured, and partial J-O parameters and quantum efficiencies of Eu3+ 5D0 energy level were calculated.