[Study on the therapeutic effect and potential mechanisms of astaxanthin electrospun patches on oral mucosal ulcers in rats].

Purpose: To investigate the effect and underlying mechanism of astaxanthin electrospun patches in treating oral ulcers in rats.

Methods: An oral ulcer model of rats was established by mechanical trauma, then the rats were randomly divided into astaxanthin electrospun patch group, chitosan patch group, metronidazole patch group and blank control group. The ulcer healing time and the area healing rate of each group were observed.

Expert consensus on the diagnosis and treatment of cemental tear.

Cemental tear is a rare and indetectable condition unless obvious clinical signs present with the involvement of surrounding periodontal and periapical tissues. Due to its clinical manifestations similar to common dental issues, such as vertical root fracture, primary endodontic diseases, and periodontal diseases, as well as the low awareness of cemental tear for clinicians, misdiagnosis often occurs. The critical principle for cemental tear treatment is to remove torn fragments, and overlooking fragments leads to futile therapy, which could deteriorate the conditions of the affected teeth.

Intervention of Astragalus Membranaceus Extract in rats of spinal cord injury: a systematic review and meta-analysis.

Objective: Spinal cord injury (SCI) causes motor, sensory and autonomic dysfunction below the level of injury and its incidence is increasing every year. Astragalus Membranaceus Extract (AME) has received attention in spinal cord injury in recent years, but its specific effects in spinal cord injury are unclear.

Methods: Databases of PubMed, Embase, WOS, Cochrane Library, FMRS, Clinical trial, CNKI, VIP, and WangFang were searched from their establishment to December 1, 2024 using the following terms: "Astragalus propinquus," "Huang qi," " Bunge," "Spinal cord injuries," "spinal cord diseases," "spinal cord trauma.

USP47 Regulates Excitatory Synaptic Plasticity and Modulates Seizures in Murine Models by Blocking Ubiquitinated AMPAR Degradation.

Epilepsy is a chronic neurological disorder affecting ~65 million individuals worldwide. Abnormal synaptic plasticity is one of the most important pathological features of this condition. We investigated how ubiquitin-specific peptidase 47 (USP47) influences synaptic plasticity and its link to epilepsy.

Application of enhanced recovery after surgery in perioperative management of patients undergoing laparoscopic surgery for benign gynecological conditions.

This study evaluates the effectiveness of enhanced recovery after surgery (ERAS) protocol in laparoscopic gynecological surgery and its impact on perioperative management. A retrospective analysis was conducted on 187 patients who underwent elective laparoscopic gynecological surgery at Guangyuan Central Hospital between November 2022 and December 2023. Of these, 92 patients were enrolled in the ERAS group, and 95 were assigned to the conventional care group.

Trade-offs in microplastic-adsorbed iopamidol degradation by UV-AOPs: Molecular-level insights into deiodination pathways versus iodinated disinfection by-products formation.

The divergent transformation pathways of iopamidol (IPM) adsorbed on polyethersulfone microplastics (PES-MPs) during UV/chlorine (UV/Cl) and UV/peracetic acid (UV/PAA) treatments were elucidated in this study. Molecular-level trade-offs between degradation efficiency and disinfection byproducts (DBPs) toxicity were unraveled through fourier-transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) analysis. Radical-mediated cleavage of aromatic C-I bonds was predominantly observed in UV/Cl process, yielding low-molecular weight chlorinated aliphatics (300-500 Da).

Global, regional and national burdens of otitis media in children and adolescents from 1990 to 2021 and its predictions to 2040.

Background: Otitis media (OM), including acute OM, chronic OM, and OM with effusion, is associated with varying degrees of hearing impairment. Children and adolescents (CAAs) are particularly vulnerable to OM. However, epidemiological data on OM in CAAs is relatively scarce.

JC124 confers multimodal neuroprotection in epilepsy by suppressing NLRP3 inflammasome activation: evidence from animal and human neuronal models.

Background: Despite continuous development of antiseizure medications (ASMs), global seizure control rates remain unsatisfactory, highlighting the urgent need for novel ASMs targeting distinct pathophysiological mechanisms. Inhibition of NLRP3 inflammasome activation represents an emerging strategy to simultaneously attenuate seizures and associated neuropsychiatric comorbidities. Therefore, this study investigates whether JC124, a novel NLRP3 inflammasome inhibitor, exerts neuroprotective effects in kainic acid (KA)-induced epileptic mice and in human induced pluripotent stem cell (hiPSC)-derived neurons stimulated by lipopolysaccharide (LPS) and adenosine triphosphate (ATP).

Evaluating placental microstructure and microcirculation in predicting the progression of gestational hypertension to preeclampsia: a systematic comparison between virtual MR elastography, IVIM, ultrasound and lab indexes.

Objective: We aimed to utilize functional magnetic resonance imaging (fMRI), including placental virtual magnetic resonance elastography (vMRE), intravoxel incoherent motion (IVIM) parameters, MRI morphological parameters, ultrasound and laboratory indexes to predict the progression of GH to PE and differentiate patients with GH and controls.

Methods: Between January 2018 and March 2023, we retrospectively collected 382 pregnant women and ultimately included 68 subjects: 24 with PE, 14 with GH, and 30 healthy controls. The stiffness value (μ) from vMRE, true diffusion coefficient, pseudo-diffusion coefficient, perfusion fraction (f) from IVIM-based analysis, and apparent diffusion coefficient were calculated.

Combining biomarkers to predict the disease activity of graves' ophthalmopathy: a combinatory model of the NLR, TRAb and FT4.

Purpose: The aim of this study was to identify potential biomarkers associated with active Graves' ophthalmopathy (GO) and develop a model for predicting the occurrence and progression of active GO.

Methods: A retrospective study was conducted on 220 GO patients (n=120 in the active phase, n=100 in the stable phase) and 70 healthy controls. Laboratory and other clinical indicators were compared in GO patients at different stages and healthy controls.

Keratin and hyaluronic acid-based microneedle patches with hop extract: An alternative strategy in oral ulcer treatment.

Oral ulcers are a prevalent manifestation of various oral diseases, often resulting in notable pain and discomfort, potentially leading to infection or even malignancy without proper intervention. However, the effectiveness of local therapeutic drugs is limited owing to their short residence time in the oral cavity, with the unique environment such as saliva flow and mechanical actions of lips and tongue, leading to difficulty in penetrating the mucosal and pseudomembrane barriers. Herein, keratin and hyaluronic acid-based microneedle patches loaded with hop extract (KMNs@HE) have been developed for the treatment of oral ulcers.

Reducible burden of laryngeal cancer in men aged 50 and older attributable to smoking and alcohol use: insights from the global burden of disease study 2021.

Background: Smoking, alcohol use, advanced age, and male gender are well-established risk factors for laryngeal cancer. As smoking and alcohol consumption are modifiable behaviors, the burden of laryngeal cancer attributable to these factors is potentially reducible. This study aims to quantify the global, regional and national burden of laryngeal cancer attributable to smoking and alcohol use in men aged 50 years and older, assess temporal trends from 1990 to 2021, and project the disease burden through 2040.

Synergistic TA/(NH)SO conditioning for sludge dewatering: Mechanisms of EPS redistribution and hydrophobic enhancement.

With the rapid development of wastewater treatment plants during China's urbanization, efficient dewatering of waste activated sludge (WAS) has become a critical challenge for sludge reduction and resource recovery. In this study, tannic acid (TA) coupled with ammonium sulfate ((NH)SO) conditioning methods were employed to improve WAS dewatering, and the intrinsic mechanism was explored. The experimental results demonstrated that the combined application of 26.

Multidisciplinary analysis of the prognosis and biological function of NUBPL in gastric cancer.

Background: Researchers are currently concentrating on molecular markers and potential therapeutic targets associated with gastric cancer in light of recent developments in precision medicine and molecular biology. Disulfidptosis was first proposed in 2023 as a novel programmed cell death mode associated with the cytoskeleton. Disulfidptosis-related proteins are essential for the preservation of protein stability and abnormal expression of disulfidptosis-related genes may be linked to cancer development and drug resistance.

Preliminary investigation of the epigenetic regulation of KMT2D via H3K4me1/H3K27ac in oral squamous cell carcinoma.

Unlabelled: Histone lysine methyltransferase 2D (KMT2D/MLL4) critically modulates gene expression by methylating and acetylating histones H3K4/H3K27, thereby regulating the expression of specific target genes. Although KMT2D is highly mutated in a variety of cancers, its role in the progression of oral squamous cell carcinoma (OSCC) remains unclear. The purpose of this study was to reveal the significance of KMT2D expression in OSCC and to preliminarily explore the regulatory effect of KMT2D on the expression of OSCC-related genes by influencing histone modifications.

First-Second-Trimester Dietary Inflammatory Index and Anemia Risk in the Third Trimester: A Prospective Cohort Study.

Dietary conditions are closely related to maternal health. This study aims to investigate the causal relationship between the first-second-trimester Dietary Inflammatory Index (DII) and developing anemia in the third trimester. This prospective cohort study comprised 545 pregnant women, with dietary data assessed via a semi-quantitative food frequency questionnaire (FFQ).

Broad host range phage LPC-1 reduce the risk of Listeria monocytogenes contamination in different food matrices.

Listeria monocytogenes forms biofilms in food and food-processing environments, entering food through cross-contamination. Phages, as antimicrobial agents, have demonstrated efficacy in addressing this issue. This study demonstrated that the LM (Listeria monocytogenes, LM) lytic phage LPC-1 isolated from livestock slaughterhouse effluent effectively lysed LM, Listeria welshimeri, Listeria innocua, and Enterococcus faecium ATCC 35667.

Structural amine-induced interfacial electrical double layers for efficient photocatalytic H evolution.

The efficiency of photocatalytic hydrogen evolution is fundamentally constrained by limited charge carrier separation. Herein, we deliberately engineered an electric double layer (EDL) surface modification with positively charged molecules, which optimizes the charge carrier dynamics. The anchoring of both diethylenetriamine (DETA) molecules and Pt species on CdS (denoted as Pt/CdS-D) achieves remarkable H evolution performance, delivering an exceptional rate of 6295 μmol g h and an apparent quantum efficiency of 14.

The role of triglycerides in predicting new-onset arthritis in the general population over 45 years old: evidence from the China health and retirement longitudinal study.

Background: Arthritis is a common degenerative joint disease with a high prevalence especially in the elderly population. Due to its strong association with chronic pain and dysfunction, arthritis has become an important challenge in public health. Recent studies have shown that triglyceride (TG) levels, as key metabolic markers, may play an important role in the pathogenesis of arthritis, and its associated inflammatory response may accelerate joint degeneration and inflammatory process.

CD2AP shapes a stromal reduced tumor microenvironment and contributes to immunotherapy in gastric cancer.

Gastric cancer (GC) ranks as the fifth most prevalent malignant tumor and stands as the fourth leading contributor to cancer-related fatalities on a global scale. The specific link between CD2 Associated Protein (CD2AP) expression and the tumor microenvironment (TME) remains unclear, and further exploration is needed to understand its potential role in immune response and as a target for immunotherapy in GC. Utilizing RNA sequencing data acquired from The Cancer Genome Atlas (TCGA) for a pan-cancer analysis, a comprehensive evaluation was carried out to determine the expression pattern and immunological involvement of CD2AP.

Association Between the Dietary Inflammatory Index and Depression in Mid-Pregnancy: Mediating Effect of Sleep Quality.

Objective: The aim of this study was to assess the association between the Dietary Inflammatory Index (DII) and depression in mid-pregnancy and the mediating effect of sleep quality according to the Edinburgh Postnatal Depression Scale (EPDS).

Methods: This was a cross-sectional study conducted in 2017-2019 at a maternal and child health centre in Hunan Province. After applying the inclusion and exclusion criteria, 749 pregnant women were finally included in this study.

The effect of social participation on depressive symptoms in older women adults in China: A tracking survey database.

Unlabelled: Background Under the context of active aging, older women face prominent mental health risks due to their dual vulnerability stemming from biological characteristics and social roles. Given the existing practical bottlenecks in current research namely, unclear mechanisms regarding how social participation alleviates geriatric depression and insufficient studies on population heterogeneity. It is important to analyze the impact of social participation on depressive symptoms of older women in China and to implement corresponding policy systems.

E2F8-induced GRPEL2 promoted colorectal cancer progression via targeting TIGAR.

Background: Colorectal cancer (CRC) is the leading cause for cancer mortality across the world. GRPEL2 is a critical regulator of mitochondria's function with an oncogenic role in different kinds of cancer. The exact function of GRPEL2 -driven mitochondrial regulation and CRC progression have not been elucidated.