Polarity-Switching Photoelectrochemical Biosensor Enabled by Metal/Semiconductor Nanostructures for Ultrasensitive MicroRNA Detection.

Developing efficient and accurate photoelectrochemical (PEC) sensing strategies to eliminate potential false positive or negative signals is crucial for practical applications. In this work, we report a PEC sensing strategy based on CuO nanoparticle-induced photocurrent polarity switching in a heterostructure of InP/ZnS quantum dots (QDs) combined with PdPt nanospheres (InP/ZnS@PdPt). The PdPt nanospheres not only provide versatile support for loading InP/ZnS QDs but also enable a 10-fold enhancement in the PEC activity of the InP/ZnS@PdPt compared to InP/ZnS QDs, attributed to the combined influence of localized surface plasmon resonance and the Schottky junction.

Study on constitutive model of marine soft soil based on disturbed state concept.

Marine soft soils are widely distributed in near-coastal areas and pose significant risks to the stability of structures due to their unique mechanical properties. While researchers worldwide have used various theoretical constitutive models and scientific methods to investigate the mechanical properties of marine soft soils, no attempts have been made to establish a mechanical model based on the concept of disturbed state for marine soft soils. In this paper, based on the concept of disturbed state, we utilize triaxial and creep test methods, apply the Duncan tensor modulus to describe the relatively complete state of marine soft soil, and modify the Cambridge model to characterize the fully adjusted state.

Review of the genus Thomson, 1864 (Coleoptera, Cerambycidae, Lamiinae, Agapanthiini).

A taxonomic review and redescription of the genus Thomson, 1864 are presented. Breuning, 1947 is proposed as a junior synonym of Thomson, 1864, and Breuning, 1959 as a junior synonym of Thomson, 1864. (Breuning, 1947), is proposed as a new combination.

Efficacy analysis of endostar combined with chemoradiotherapy and immune checkpoint inhibitors in locally advanced non-small cell lung cancer.

Objective: Lung cancer, particularly non-small cell lung cancer (NSCLC), remains a leading cause of cancer-related death globally, with treatment challenges persisting in locally advanced or inoperable cases. To evaluate the efficacy and adverse reactions of recombinant human endostatin (Endostar) combined with chemoradiotherapy and immune drugs in patients with locally advanced non-small cell lung cancer (NSCLC) who could not undergo surgery.

Methods: A retrospective analysis was conducted on 190 patients with locally advanced NSCLC who could not undergo surgery.

RPMB predicts the disease-free survival of head-and-neck squamous carcinoma after adjuvant concurrent radio-chemotherapy.

Purpose: Currently, adjuvant concurrent radio-chemotherapy (ACRT) is the standard of care for head-and-neck squamous cell carcinoma (HNSC) with microscopically involved surgical margins (MISM) and/or extra-nodal extension (ENE), whereas the toxicity of cisplatin-based chemotherapy is non-negligible.

Methods: In the current study, we identified a novel biomarker, referred to as RPMB (Repair Gene Promoter Methylation Burden), with the aim of identifying the subset of HNSC patients who are likely to respond favorably to ACRT. RPMB is defined as the proportion of methylated DNA repair genes (DRGs) relative to the total number of DRGs.

Preliminary investigation of the epigenetic regulation of KMT2D via H3K4me1/H3K27ac in oral squamous cell carcinoma.

Unlabelled: Histone lysine methyltransferase 2D (KMT2D/MLL4) critically modulates gene expression by methylating and acetylating histones H3K4/H3K27, thereby regulating the expression of specific target genes. Although KMT2D is highly mutated in a variety of cancers, its role in the progression of oral squamous cell carcinoma (OSCC) remains unclear. The purpose of this study was to reveal the significance of KMT2D expression in OSCC and to preliminarily explore the regulatory effect of KMT2D on the expression of OSCC-related genes by influencing histone modifications.

Prognostic analysis of inconsistent combinations of HPV and p16 in a Chinese/Asian oropharyngeal squamous cell carcinoma population.

Background: The aim of this study was to investigate the effect of inconsistent expression of p16 and HPV on the prognosis of patients with Oropharyngeal squamous cell carcinoma (OPSCC) in Chinese/Asian populations.

Methods: The study included 130 patients. Inclusion criteria were primary OPSCC.

Mitochondrial function changes in T cell subsets during radiotherapy for patients with nasopharyngeal carcinoma.

Mitochondrial dysfunction-mediated T cell exhaustion is associated with the efficacy of tumor therapy; however, the effect of radiotherapy (RT) on the mitochondrial function of peripheral blood immune cells remains still unclear. Therefore, the current study aimed to determine mitochondrial function indicators in immune cells, in particular mitochondrial mass (MM) and mitochondrial membrane potential (MMP), to assess the dynamic changes of immune status in patients with nasopharyngeal carcinoma (NPC) during RT. Peripheral venous blood was collected from patients with locally advanced NPC at day 1 pre-RT, at the 10th fraction of RT and within 2 days after RT.

Thrombocytopenia in an EGFR 19 Exon-Deficient Bilateral Diffuse LUAD with ARDS Treated with ECMO and Osimertinib: A Case Report.

Introduction: EGFR-sensitive mutations bilateral diffuse lung adenocarcinoma (LUAD) complicated with acute respiratory distress syndrome (ARDS) is relatively rare. It is important to consider whether EGFR-TKI can be simultaneously received when treating with extracorporeal membrane oxygenation (ECMO) and anti-infective therapy in these patients, and what adverse events should be noted?

Case Presentation: We report a case of EGFR 19 exon-deficient bilateral diffuse LUAD complicated with ARDS. When treated with ECMO and anti-infective therapy, the patient received oral osimertinib anti-tumor therapy simultaneously.

Solidified lake sediment with industrial waste and construction waste used as barrier cover material: mechanical strength, water resistance performance, and microscopic analysis.

This study introduces a novel landfill cover material, employing lake sediment as a substrate, stabilised with fly ash, slag, desulfurisation gypsum and construction waste. The mechanical properties, including shear strength parameters, unconfined compressive strength, hydraulic conductivity, volumetric shrinkage, and water content, of the solidified sludge were evaluated. The microscopic mechanism of the solidified sludge were investigated through XRD, FTIR, and SEM-EDS techniques.

Impact of mitochondrial dysfunction on the antitumor effects of immune cells.

Mitochondrial dysfunction, a hallmark of immune cell failure, affects the antitumor effects of immune cells through metabolic reprogramming, fission, fusion, biogenesis, and immune checkpoint signal transduction of mitochondria. According to researchers, restoring damaged mitochondrial function can enhance the efficacy of immune cells. Nevertheless, the mechanism of mitochondrial dysfunction in immune cells in patients with cancer is unclear.

Inflammatory markers as prognostic markers in patients with head and neck squamous cell carcinoma treated with immune checkpoint inhibitors: a systematic review and meta-analysis.

Background: Various inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and C-reactive protein-to-albumin ratio (CAR), have been linked to the effectiveness of immunotherapy in multiple types of malignancies. We investigated how these inflammatory markers affect the prognosis of patients with head and neck squamous cell carcinoma (HNSCC) receiving immunotherapy.

Methods: The databases PubMed, Embase, and Cochrane were systematically searched up until March 26, 2024, to identify relevant literature.

The impact of bolus on clinical outcomes for post-mastectomy breast cancer patients treated with IMRT: data from China.

Purpose: This study aims to investigate the effects of chest wall bolus in intensity-modulated radiotherapy (IMRT) technology on clinical outcomes for post-mastectomy breast cancer patients.

Materials And Methods: This retrospective study included patients with invasive carcinoma ((y)pT0-4, (y)pN0-3) who received photon IMRT after mastectomy at the Affiliated Hospital of Qingdao University from 2014 to 2019. The patients were divided into two groups based on whether they received daily bolus application or not, and the baseline characteristics were matched using propensity score matching (PSM).

PiR-hsa-23533 promotes malignancy in head and neck squamous cell carcinoma via USP7.

Background: With regard to head and neck squamous cell carcinoma (HNSCC), its occurrence and advancement are controlled by genetic and epigenetic anomalies. PIWI-interacting RNAs (piRNAs) are recognized with significance in tumor, but the precise molecular mechanisms of piRNAs in HNSCC largely remain undisclosed.

Methods: Differentially expressed piRNAs were identified by RNA sequencing.

The Preparation and Performance of Epoxy/Acetylene Carbon Black Wave-Absorbing Foam.

The epoxy foam material filled with an absorbing agent effectively absorbs electromagnetic waves. In this study, epoxy resin was used as the matrix, and acetylene carbon black was used as the magnetic absorbing agent to prepare an absorbing foam material (epoxy/CB). The microstructure of acetylene carbon black (CB) and its distribution in epoxy resin, as well as the effects of pre-polymerization time and CB content on the foam structure, were systematically characterized.

Clinical application of high-LET radiotherapy combined with immunotherapy in malignant tumors.

The superior physical and biological properties of high linear energy transfer (LET), as opposed to traditional low-LET rays, underscore the advantage of proton therapy (PRT) and carbon ion radiotherapy (CIRT) are better than traditional photon radiotherapy (XRT). With the advancements in science, an increasing number of hospitals have introduced new technologies. However, radiotherapy is primarily used for local treatment, which means that if the tumor has metastasized to distant sites, it is often necessary to combine it with systemic therapies such as immunotherapy.

Preparation, Structure and Properties of Epoxy/Carbonyl Iron Powder Wave-Absorbing Foam for Electromagnetic Shielding.

The application of absorbing materials for electromagnetic shielding is becoming extensive, and the use of absorbents is one of the most important points of preparing absorbing foam materials. In this work, epoxy resin was used as the matrix and carbonyl iron powder (CIP) was used as the absorbent, and the structural absorbing foam materials were prepared by the ball mill dispersion method. Scanning electron microscopy showed that the CIP was evenly dispersed in the resin matrix.

Polyene phosphatidylcholine enhances the therapeutic response of oxaliplatin in gastric cancer through Nrf2/HMOX1 mediated ferroptosis.

Oxaliplatin (OXA)-based chemotherapy is one of the first-line treatments for advanced gastric cancer. However, the potential risk for chemotherapy-induced hepatic injury can hinder its effectiveness. Polyene phosphatidylcholine (PPC) is often used as a hepatoprotective agent to counter OXA-induced hepatic injury; however, its impact on the antitumour effectiveness of OXA remains uncertain.

High-fidelity intracellular imaging of multiple miRNAs stimulus-responsive nanocarriers and catalytic hairpin assembly.

An advanced nanoplatform was developed by integrating catalytic hairpin assembly (CHA) with glutathione-responsive nanocarriers, enabling superior imaging of dual cancer-related miRNAs. Two distinct CHA circuits for the sensing of miRNA-21 and miRNA-155 were functionalized on biodegraded MnO. In the presence of GSH and the corresponding miRNAs, the degraded MnO released the DNA cargos, activating the CHA circuits and recovering the fluorescence.

Development and validation of a nomogram to predict cervical lymph node metastasis in head and neck squamous cell carcinoma.

Background: Head and neck cancers are a heterogeneous, aggressive, and genetically complex collection of malignancies of the oral cavity, nasopharynx, oropharynx, hypopharynx, larynx, paranasal sinuses and salivary glands, which are difficult to treat. Regional lymph nodes metastasis is a significant poor prognosis factor for head and neck squamous cell carcinoma. Metastasis to the regional lymph nodes reduces the 5-year survival rate by 50% compared with that of patients with early-stage disease.

Immunotherapy in SMARCB1 (INI-1)-deficient sinonasal carcinoma: Two case reports.

Background: SMARCB1/INI-1 deficient sinonasal carcinoma (SDSC) is a rare subset of sinonasal undifferentiated carcinoma with a poor prognosis. Here, we present two case reports of SDSC patients. We also review the literature on this tumor.

Identification of a six-gene signature to predict survival and immunotherapy effectiveness of gastric cancer.

Background: Gastric cancer (GC) ranks as the fifth most prevalent malignancy and the second leading cause of oncologic mortality globally. Despite staging guidelines and standard treatment protocols, significant heterogeneity exists in patient survival and response to therapy for GC. Thus, an increasing number of research have examined prognostic models recently for screening high-risk GC patients.

ER predicts poor prognosis in male lung squamous cell cancer of stage IIIA-N2 disease after sequential adjuvant chemoradiotherapy.

Introduction: The efficacy of postoperative radiotherapy (PORT) is still unclear in non-small cell lung cancer (NSCLC) patients with pIIIA-N2 disease. Estrogen receptor (ER) was proven significantly associated with poor clinical outcome of male lung squamous cell cancer (LUSC) after R0 resection in our previous study.

Methods: A total of 124 male pIIIA-N2 LUSC patients who completed four cycles of adjuvant chemotherapy and PORT after complete resection were eligible for enrollment in this study from October 2016 to December 2021.