Heterobilayer Ferroelectricity with Competitive Polarization.

Two-dimensional ferroelectrics with large out-of-plane polarization (OOP) are promising for the design of low-power memory and logic devices, but their experimental realization remains limited due to the scarcity of homobilayers and the complexity of heterobilayers. Here, we perform high-throughput screening of 24,960 configurations and identify 43 semiconducting heterobilayer ferroelectrics with an OOP exceeding the experimentally reported value in MoS/WS while maintaining sliding barriers below 100 meV/f.u.

Positively Charged Polyurethane Scaffolds Reshape the Microenvironment to Promote Endogenous Regeneration after Brain Injury.

Traumatic brain injury (TBI) induces a prolonged inflammatory response throughout the damaged brain, which is exacerbated by the sustained accumulation of damage-associated molecular patterns (DAMPs), and consequently impairs endogenous neural regeneration significantly. To mitigate postinjury inflammation and explore the role of positively charged scaffolds in brain repair, two distinct structures of positively charged scaffolds were developed. Both scaffold types effectively reduce inflammation and promote brain tissue repair by eliminating DAMPs, markedly reducing glial scar formation, and promoting angiogenesis in peritrauma areas within 4 weeks of implantation.

Nonlinear Associations of Depression and Stigma With Subclinical Hikikomori in Cancer Survivors.

Background: Cancer survivors often experience depression and stigma associated with chronic diseases, which may increase the risk of subclinical hikikomori.

Aims: This study examined the prevalence of subclinical hikikomori and its nonlinear associations with depression and stigma among cancer patients.

Methods: A cross-sectional survey was conducted among 1951 cancer survivors.

The impacts of polypropylene microplastics on carbon and nitrogen cycling in coastal wetlands: Field evidence.

Coastal wetlands are hotspots for carbon and nitrogen cycling and serve as sinks for microplastics (MPs). Although MP effects on these biogeochemical cycles have been investigated under laboratory experiments, field-based evidence is lacking. This study presents the first field investigation of MP impacts, specifically polypropylene (PP), on sediment carbon and nitrogen cycling in intertidal and supratidal zones of a coastal wetland, employing in-situ culture over three months.

Hybrid pneumatic-hydraulic actuation for MRI-guided robotic stereotactic neurointervention.

Stereotactic neurointervention is a common procedure for biopsy, injection, ablation, and implantation of electrodes for deep brain stimulation. Guided by preoperative imaging, conventional approaches are mostly performed manually, lacking operation stability and interactive feedback. The intraoperative magnetic resonance imaging (MRI) guidance enables both structural and functional assessment during operation, permitting interactive adaptation to tissue deformation and avoidance of critical anatomical regions.

Inter-relationships of Depressive and Insomnia Symptoms With Health Satisfaction in Heart Disease and Heart Disease-Free Older Adult Samples: Findings From a United States National Survey.

Background: Older adults with heart disease experience higher rates of depression and insomnia compared with heart disease-free peers. Aside from these psychological disturbances, overall health satisfaction, as a key indicator of subjective health status, may be affected by heart disease status. In spite of these overall associations, symptom-level relationships between depression, insomnia, and health satisfaction remain unclear.

Associations Between Sleep Duration Trajectories and Depressive Symptoms Among Middle-Aged and Older Adults: Findings From a Nationally Representative Survey.

Objectives: The relationship between sleep duration and depressive symptoms remains controversial in middle-aged and older adults. The aim of this study is to investigate the relationship of sleep duration trajectories with depressive symptoms and conduct further exploration through network analysis.

Methods: Based on the five waves of data on 8681 middle-aged and older adults from 2011 to 2020 in the China Health and Retirement Longitudinal Study database, group-based trajectory modeling was employed to depict their sleep trajectories.

Epsin1 enforces a condensation-dependent checkpoint for ubiquitylated cargo during clathrin-mediated endocytosis.

Clathrin-mediated endocytosis internalizes proteins and lipids from the cell surface. A flexible condensate of initiator proteins catalyzes assembly of clathrin-coated vesicles in diverse organisms. Here we reveal that an endocytic adaptor protein, Epsin1, conditionally stabilizes this network, creating a cargo-dependent endocytic checkpoint.

Intravenous administration of adenosine triphosphate combined with escitalopram in major depressive disorder: protocol for a randomised, double-blind, placebo-controlled trial.

Introduction: Major depressive disorder (MDD) is the most prevalent mental illness. Antidepressants with rapid efficacy and acceptable tolerance have been investigated for many years. A preclinical study performed by our group revealed that the dysregulation of extracellular ATP is related to the pathophysiology of depression and that the medial prefrontal cortex-lateral habenula pathway is a potential cellular and neural circuit target for ATP involvement in depression-like behaviour.

The association between healthy lifestyle trajectory and depressive symptoms: Findings from the Chinese Longitudinal Healthy Longevity Survey (CLHLS).

Objective: Depression places a significant burden on older people, and some studies have found that certain lifestyles are associated with depressive symptoms. This study aimed to observe the relationship between integrated lifestyles and depressive symptoms from the perspective of dynamic change.

Method: The data for this study comes from the China Health and Longevity Longitudinal Survey (CLHLS) conducted in three waves in 2011-2012, 2014, and 2017-2018.

A high lipid-soluble probe for ONOO recognition in the endoplasmic reticulum and imaging of cerebral ischemia-reperfusion injury.

Cerebral ischemia/reperfusion injury (CIRI) is a highly damaging pathological process in stroke. In CIRI, ER stress is the main source of cellular reactive oxygen species (ROS) and significantly contributes to neurological damage. Among ROS, peroxynitrite (ONOO) exhibits potent oxidative and nucleophilic properties.

Depression in older adults: longitudinal study findings from a national survey in China.

Background: Late-life depression (LLD) is a significant global public health challenge among older adults. Identifying predictive/influential symptoms based on longitudinal data can contribute to early prevention, detection, and intervention of LLD. This study examined significant influential symptoms of LLD using cross-lagged panel network (CLPN) analysis based on a longitudinal national survey.

The Efficacy of Zinc Supplementation Alone or in Combination for Improving Pregnancy and Infant Outcomes: A Systematic Review and Meta-Analysis.

Objective: To evaluate zinc supplementation's efficacy in pregnancy, addressing gaps in previous reviews regarding high-risk subgroups and combination therapies.

Methods: Systematic review of six databases through March 27, 2025 for randomized controlled trials (RCTs) on prenatal zinc supplementation. Risk of bias was assessed using the Cochrane Risk of Bias 2.

Association of CT-derived extracellular volume fraction combined with serological markers with histological grading of colorectal cancer.

This study evaluates the association between computed tomography-derived extracellular volume fraction (CT-ECV), serological markers, and histological grading in colorectal cancer, and to assess their diagnostic value in predicting poorly differentiated tumors. This retrospective study included 200 patients with pathologically confirmed primary colorectal cancer from February 2021 to May 2024. All underwent dual-phase contrast-enhanced CT and serological testing before treatment.

A Tetrazine-Based Light-Assisted Activation Probe for Time-Controllable Monitoring of O

Photoactive probes are important derivatives of small molecule fluorescent probes that provide spatiotemporally controllable imaging capabilities. However, conventional photoactive probes are limited by short auxiliary light wavelengths, prolonged irradiation times, and lack of analytes, making it difficult to achieve time-controlled imaging applications. Herein, a tetrazine-based probe (-) was synthesized for the light-assisted activation study.

Advances in the management of ovarian cancer liver metastasis.

Liver metastasis represents a critical challenge in cancer progression, with particularly complex therapeutic implications. In ovarian cancer patients, ovarian cancer liver metastasis (OCLM) marks a distinct stage of disease progression that demands specialized diagnostic and therapeutic approaches. Despite its clinical significance, guidance for OCLM management remains notably absent in current clinical practice.

Ionocyte CFTR Coordinates Chloride Absorption and Secretion to Balance Airway Fluid.

Rationale: The cystic fibrosis transmembrane conductance regulator (CFTR) channel contributes to the precise control of airway surface liquid (ASL) volume by regulating fluid absorption and secretion, both of which are disrupted in cystic fibrosis (CF). CFTR is highly expressed in pulmonary ionocytes, yet conflicting evidence has emerged regarding how pulmonary ionocytes regulate ion and fluid transport. Different groups have shown that pulmonary ionocytes mediate chloride and fluid absorption, but whether ionocytes and/or secretory cells mediate chloride secretion remains unclear.

Short-term prognosis of patients in different stages of severe tricuspid regurgitation after transcatheter tricuspid-valve replacement.

Background: The tricuspid regurgitation (TR) syndrome, based on the extent of cardiac and extracardiac involvement, is a newly proposed staging method to evaluate the progression of TR. This study aimed to explore cardiac structural characteristics and the short-term prognosis after transcatheter tricuspid valve replacement (TTVR) in patients at different stages.

Methods: A post-hoc analysis of patients enrolled in the first-in-man and confirmatory study and an investigator-initiated trial of the LuX-Valve Plus system was conducted.

Enhanced tumor retention and therapeutic potency in radionuclide therapy using GSH-induced self-assembling peptides.

Radiolabeled small-molecule drugs hold significant potential for tumor radionuclide therapy (TRT). However, the clinical application of TRT is constrained by the rapid clearance of small molecules from tumor sites and inadequate tumoral radiation sensitivity. To address these limitations, we report an in situ strategy to consume glutathione for assembly that enhances TRT by increasing reactive oxygen species and extending therapeutic time.

Profiling with senescence-associated secretory phenotype score identifies GDC-0879 as a small molecule sensitizing glioblastoma to anti-PD1.

Senescence-associated secretory phenotype (SASP) in cancer refers to the bioactive secretome produced by senescence cells in the tumor microenvironment, which could be triggered by therapeutics or local stress conditions. Here, we provided a SASP Score in glioblastoma (GBM) with generating a SASP gene panel to identify the potential small molecular candidate targeting SASP in GBM. The effectiveness of this scoring method was firstly interrogated with our in-house GBM cohort and public datasets, including transcriptomic data from bulk and single cell GBM samples.

An electrospun membrane incorporating lipocalin 2-enhanced exosomes effectively facilitated the repair of critical bone defects.

The clinical management of critical size bone defects (CSBD) remains a formidable clinical challenge, with no universally efficacious treatment currently established. The intricate interrelationship between bone formation and vascular plasticity constitutes a fundamental prerequisite for successful repair of CSBD. Lipocalin 2 (LCN2), a secretory protein identified within extracellular vesicles derived from osteoblasts, has exhibited notable bone protective properties.

Comparative efficacy of oral and intravenous cyclophosphamide in the treatment of connective tissue disease-associated interstitial lung disease and analysis of its influencing factors: a clinical trial.

Introduction: Connective tissue disease (CTD) commonly affects the lungs, with interstitial lung disease (ILD) as its main complication; although cyclophosphamide (CTX) is the standard immunosuppressant for CTD-ILD, the optimal route of administration (oral vs. intravenous) remains unclear. This research aimed to analyze the efficacy of oral and intravenous CTX in the treatment of CTD-ILD and analysis of its influencing factors.

A Network Analysis of Depressive Symptoms and Cognitive Functions Among Older Adults Distressed by Body Pain: Findings From a National China Survey.

BackgroundBody pain is common among older adults who often experience comorbid depressive symptoms and cognitive impairments. This study examined differences in depressive symptoms and cognitive functions between older adults distressed with body pain and those without pain and explored symptom interrelationships in the pain-distressed group.MethodsData from the 2020 China Health and Retirement Longitudinal Study (CHARLS) were analyzed.