Association of Urinary Iodine Concentration With Cognitive Function Among Older Adults: NHANES 2011-2014.

The purpose of this study is to investigate the relationship between urinary iodine concentrations (UIC) and cognitive function among elderly individuals in certain regions of the United States, addressing a significant gap in the existing literature regarding urinary iodine and cognitive decline in older populations. UIC and cognitive function assessments of participants in the National Health and Nutrition Examination Survey were selected for the 2011-2014 cycle. Cognitive function assessments included: (1) a word learning and recall module from the Coalition to Establish a Registry for Alzheimer's Disease (CERAD); (2) an animal fluency test; and (3) the Digit Symbol Substitution Test (DSST).

Development and validation of a nomogram prediction model for factors influencing I-refractory Graves' hyperthyroidism.

Objective: To examine the factors influencing I-refractory Graves' disease (GD) hyperthyroidism in patients, develop a nomogram prediction model, and conduct its validation.

Methods: A total of 272 hyperthyroidism patients who received initial I treatment at our hospital from January 2021 to January 2022 were randomly selected. Patients were divided into refractory hyperthyroidism group (92 cases) and non-refractory hyperthyroidism group (180 cases) based on whether they were cured after one course of I treatment.

Methicillin-Resistant (MRSA): Resistance, Prevalence, and Coping Strategies.

Increased antimicrobial resistance requires effective ways to overcome the global challenge of bacterial infections, including methicillin-resistant (MRSA). From the emergence of MRSA to its continued evolution, it is important to explore this pathogen from fresh perspectives and develop corresponding coping strategies to counter its growing threat. New coping strategies are continuously emerging, including but not limited to enhancing penetration capabilities or targeting their virulence.

Balancing complexity and accuracy for defect detection on filters with an improved RT-DETR.

Filters are critical components in automotive engine systems, responsible for maintaining stable operation by removing impurities from liquids and gases. Their performance is highly sensitive to surface defects, rendering high-precision automated inspection essential. However, existing defect detection algorithms often struggle to balance between detection accuracy and the computational efficiency required for industrial deployment.

[Clinical and genetic analysis of a Chinese pedigree with autosomal recessive familial intrahepatic cholestasis type I due to a novel variant of ATP8B1 gene].

Objective: To investigate the clinical and genetic features of a Chinese pedigree with Progressive familial intrahepatic cholestasis (PFIC) and explore its genotype-phenotype correlation.

Methods: A patient with PFIC diagnosed at Xinxiang Central Hospital in 2023 was selected as the study subject. The patient was subjected to abdominal magnetic resonance imaging (MRI) and painless gastroscopy.

Clinical characteristics, treatment patterns, and survival outcomes of 1031 patients with peripheral T cell lymphoma in china: a multicenter, real-world study.

Background: The data about the clinical features and outcomes of Chinese patients with peripheral T-cell lymphomas (PTCLs) are limited.

Method: This retrospective study included 1031 patients of PTCL from January 2014 to March 2022 at 21 centers in China. The clinical features, treatment patterns, and survival outcomes of the Chinese PTCL population were reported.

Protective effect of scutellarin on myocardial cells treated with high glucose.

Diabetic cardiomyopathy (DCM) is an important cause of death in patients with diabetes. DCM can be simulated by cardiomyocyte injury induced by high glucose (HG) . Scutellarin (Scu) is a flavonoid extracted from .

Dimetridazole potentiates cefotaxime against multidrug-resistant E. coli via membrane disruption and fatty acid composition.

The rising prevalence and rapid spread of multidrug-resistant bacteria have resulted in ineffective treatments, impacting millions of lives globally. In response to these challenges, drug repurposing has garnered attention as a viable alternative to traditional drug discovery and development processes. This study aimed to investigate the synergistic effects of dimetridazole and cefotaxime by evaluating their efficacy against E.

[Clinical Applications of Circulating Tumor DNA in Response Evaluation and Relapse Monitoring of Primary Mediastinal Large B-Cell Lymphoma].

Objective: To explore the clinical significance of circulating tumor DNA (ctDNA) in response evaluation and relapse monitoring for patients with primary mediastinal large B-cell lymphoma (PMBCL).

Methods: The clinical characteristics, efficacy and survival of 38 PMBCL patients in our hospital from January 2010 to April 2020 were retrospectively analyzed. The ctDNA monitoring was conducted by targeted next-generation sequencing (NGS).

Research Progress on the Antibacterial Activity of Natural Flavonoids.

The use of antibiotics has greatly improved the treatment of bacterial infections; however, its abuse and misuse has led to a rapid rise in multidrug-resistant (MDR) bacteria. Therefore, the search for new antimicrobial strategies has become critical. Natural flavonoids, a class of widely existing phytochemicals, have gained significant research interest for their diverse biological activities and antibacterial effects on various drug-resistant bacteria.

Prognostic impact of the timing of immunotherapy in first-line immunochemotherapy for patients with advanced lung adenocarcinoma: A propensity score-matched analysis.

Immunochemotherapy combinations have been the standard first-line therapy for advanced lung adenocarcinoma (LUAD) without driver mutations, wherein concurrent chemotherapy and immunotherapy are conventionally anchored in the established dosing regimen. A few studies have suggested that the timing of immunotherapy in combinations may have a significant impact on the efficacy. However, this issue has not been addressed in an advanced LUAD cohort.

Subclinical Mastitis in Small-Holder Dairy Herds of Gansu Province, Northwest China: Prevalence, Bacterial Pathogens, Antimicrobial Susceptibility, and Risk Factor Analysis.

This cross-sectional study assessed the prevalence, bacterial distribution, antimicrobial susceptibility, and potential risk factors associated with subclinical mastitis (SCM) in small-holder dairy herds in Gansu Province, Northwest China. Forty small-holder cow farms were randomly selected from eight cities/counties in six districts of Gansu Province, and a total of = 530 lactating cows were included in this study. SCM prevalence was noted at 38.

In-situ Sprayed platelet-derived small extracellular vesicles for the skin flap survival by reducing PANoptosis.

Necrosis at the distal end of random skin flaps remains a significant challenge, limiting the clinical application of these flaps in plastic and reconstructive surgery. Inhibiting ischemia/reperfusion (I/R) injury and promoting the formation of neovascular networks are critical preventive strategies. Platelet-derived small extracellular vesicles (PL-sEV) are nanocarriers of growth factors that provide an alternative to clinically used platelet-rich plasma and platelet lysates, offering higher growth factor concentrations and lower immunogenicity.

In Vitro Antimicrobial Synergistic Activity and the Mechanism of the Combination of Naringenin and Amikacin Against Antibiotic-Resistant .

Bacterial drug resistance is becoming an increasingly serious problem, and the development of antibacterial synergists is urgently needed. Combining existing antibiotics with promising nonantibiotic agents is one strategy that has been shown to be effective at overcoming the widespread emergence of antibiotic-resistant pathogens. In this study, we investigated the antibacterial activities and mechanism of naringenin (NG) combined with amikacin (AMK) against multidrug-resistant ().

Global research trends of antibiotic-loaded bone cement: A bibliometric and visualized study.

Objective: Antibiotic-loaded bone cement (ALBC) plays an indispensable role in the treatment of infectious diseases of bone and joint. Here, we intended to analyze the research status, hot spots and frontiers in the field of ALBC, and to provide reference for future research ideas.

Methods: The related English literature in the field of ALBC in the Web of Science Core Collection database was retrieved from January 1, 2009 to July 11, 2023.

Dual-tracer PET/CT in the management of hepatocellular carcinoma.

Background & Aims: Combined F-fluorodeoxyglucose (FDG) and C-acetate (dual-tracer) positron-emission tomography/computed tomography (PET/CT) is being increasingly performed for the management of hepatocellular carcinoma (HCC), although its role is not well defined. Therefore, we evaluated its effectiveness in (i) staging, (ii) characterization of indeterminate lesions on conventional imaging, and (iii) detection of HCC in patients with unexplained elevations in serum alpha-fetoprotein (AFP) levels.

Methods: We retrospectively assessed 525 consecutive patients from three tertiary centers between 2014 and 2020.

Fluffy hybrid nanoadjuvants for reversing the imbalance of osteoclastic and osteogenic niches in osteoporosis.

Osteoporosis is majorly caused by an imbalance between osteoclastic and osteogenic niches. Despite the development of nationally recognized first-line anti-osteoporosis drugs, including alendronate (AL), their low bioavailability, poor uptake rate, and dose-related side effects present significant challenges in treatment. This calls for an urgent need for more effective bone-affinity drug delivery systems.

The impact of bolus on clinical outcomes for post-mastectomy breast cancer patients treated with IMRT: data from China.

Purpose: This study aims to investigate the effects of chest wall bolus in intensity-modulated radiotherapy (IMRT) technology on clinical outcomes for post-mastectomy breast cancer patients.

Materials And Methods: This retrospective study included patients with invasive carcinoma ((y)pT0-4, (y)pN0-3) who received photon IMRT after mastectomy at the Affiliated Hospital of Qingdao University from 2014 to 2019. The patients were divided into two groups based on whether they received daily bolus application or not, and the baseline characteristics were matched using propensity score matching (PSM).

Potential diagnostic markers shared between non-alcoholic fatty liver disease and atherosclerosis determined by machine learning and bioinformatic analysis.

Background: Evidence indicates that chronic non-alcoholic fatty liver disease (NAFLD) can increase the risk of atherosclerosis (AS), but the underlying mechanism remains unclear.

Objective: This study is intended for confirming key genes shared between NAFLD and AS, and their clinical diagnostic value to establish a foundation for searching novel therapeutic targets.

Methods: We downloaded the Gene Expression Omnibus (GEO) datasets, GSE48452 and GSE89632 for NAFLD and GSE100927, GSE40231 and GSE28829 for AS.