ctDNA detects residual disease after neoadjuvant chemoradiotherapy and guides adjuvant therapy in esophageal squamous cell carcinoma.

The diagnostic accuracy of circulating tumor DNA (ctDNA) for detecting molecular residual disease (MRD) after multimodal treatment remains unclear. In a prospective cohort of 132 patients with locally advanced esophageal squamous cell carcinoma (ESCC) undergoing neoadjuvant chemoradiotherapy (nCRT) followed by clinical response evaluation and surgery, tumor-informed personalized-panel and fixed-panel ctDNA assays are applied to serial blood samples. Personalized ctDNA assay demonstrates a superior baseline detection rate (99.

Comparison of oncological outcomes between wedge resection and segmentectomy for T1a/bN0M0 non-small-cell lung cancer: a population-based retrospective cohort study.

Background: Sublobar resection, including wedge resection (WR) and segmental resection (SR) has been considered for early-stage non-small-cell lung cancer (NSCLC). However, the optimal sublobar approach continues to be a subject of extensive debate within the thoracic surgical community. This study aimed to compare the oncological outcomes of WR and SR in such patients.

Graphene oxide-based dual-color thin-film fluorescent nanolabels for enhanced immunochromatographic detection of pesticides.

Background: The excessive use of pesticide pollutants in agricultural production seriously threatens food safety. Traditional detection techniques are difficult to meet the detection requirements due to the complex sample pretreatment and high detection costs. The immunochromatography method (ICA) is simple to operate and fast, and is suitable for on-site rapid detection.

Hierarchical extreme learning machine for dimensionality reduction in near-infrared spectral analysis.

Dimensionality reduction (DR) is a crucial step in the analysis of high-dimensional near-infrared (NIR) spectroscopy. However, traditional spectral DR techniques are often challenged by selection difficulties and limited effectiveness in improving model accuracy. A novel Hierarchical Extreme Learning Machine (HELM) for DR was proposed in this paper.

Circulatory extracellular vesicles transport complement C1q for promoting neuronal amyloid-β production in Alzheimer's disease.

Unlabelled: Alzheimer’s disease (AD) is the most common type of dementia. A major pathological feature of AD is the aggregation of amyloid-β (Aβ), primarily driven by β-secretase (BACE1) activity. However, the mechanisms underlying continuous Aβ accumulation remain unclear.

Thermophoresis of Janus nanoparticles in liquids.

In this work, we investigate the thermophoresis of Janus nanoparticles in liquids through molecular dynamics simulations. Thermophoretic forces acting on cylindrical Janus nanoparticles are calculated through MD simulations by varying the particle size, the heterogenous surface energies, and the mean temperature of the fluid. It is found that a transition from negative thermophoresis to positive thermophoresis occurs when these parameters are varied.

Constraint-Driven Causal Representation Learning for Vigilance Robust Estimation in Brain-Computer Interface.

Vigilance estimation is a critical task within the field of brain-computer interfaces, extensively applied in monitoring and optimizing user states during human-machine interaction using electroencephalography (EEG). However, most existing vigilance prediction frameworks are prone to spurious correlations stemming from inherent biases in collected data. These biases involve relevant but vigilance-independent information, which may lack robustness when applied to different data distributions, i.

The investigation of factors influencing the prognostic nutritional index in patients with esophageal cancer-a cross-sectional study.

Background: The prognostic nutritional index (PNI) has garnered increasing attention for its role in predicting the nutritional status and prognosis of cancer patients. However, its influencing factors are still unclear, which limits its precise clinical application. This study aims to investigate the correlation between nutrition-related indicators and PNI and their impact on PNI, with the expectation of providing a more reliable basis for clinical nutritional assessment and intervention, filling the current gap in the research of influencing factors of PNI, and promoting the implementation of individualized nutritional therapy in the comprehensive management of esophageal cancer.

Caregiver experiences after the death of a person with dementia with Lewy bodies: A mixed-methods analysis.

BackgroundDementia with Lewy bodies (DLB) is a common degenerative dementia, but no studies investigate bereaved caregiver experiences.ObjectiveTo investigate the experiences of caregivers three months after the death of persons with DLB using a mixed-methods approach.MethodsDyads of individuals with moderate-advanced DLB and their primary informal caregivers were followed prospectively every 6 months until the person with DLB died.

Dynamic progression of Wernicke encephalopathy in a gastric cancer patient: Multimodal MRI insights with arterial spin labeling perfusion imaging.

Rationale: Wernicke encephalopathy (WE), a neurological emergency caused by thiamin deficiency, is traditionally diagnosed based on the triad of ophthalmoplegia, ataxia, and confusion. However, this classic presentation occurs in fewer than 10% of cases, complicating early recognition. Untreated cases risk irreversible brain damage or progression to Korsakoff syndrome.

PPDPF promotes the progression of esophageal squamous cell carcinoma via c-Myc/CD24 axis.

Background: Despite a series of attempts during the last decades, the prognosis for esophageal squamous cell carcinoma (ESCC) remains poor. Although clinical immunotherapy trials have shown encouraging results, their benefits are limited. This study aims to identify novel targets for immunotherapy in ESCC.

Exploring the Multifactorial Regulation of PIEZO1 in Chondrocytes: Mechanisms and Implications.

The mechanosensitive PIEZO1 ion channel plays a pivotal role in the regulation of chondrocyte function and is involved in various physiological and pathological processes, including cartilage degradation and osteoarthritis (OA). This review explores the regulatory mechanisms governing PIEZO1 activation and its interactions with mechanical stress, extracellular matrix (ECM) stiffness, inflammatory factors, and other ion channels. We discuss the role of PIEZO1 in calcium signaling, its modulation by ECM stiffness, and the implications for cartilage health, particularly under high mechanical load or inflammatory conditions.

Surgical Outcomes for Cervical Esophageal Cancer: A Retrospective Cohort Study.

Background: Although definitive chemoradiotherapy (dCRT) remains the standard for cervical esophageal cancer (CEC), studies on surgical outcomes have reported conflicting results. This highlights the need for more data on surgical treatment for CEC.

Methods: This study reviewed 152 patients who underwent surgical treatment for CEC at a single center between May 2014 and May 2024.

Elucidating the Role of Graphene Oxide Surface Architecture and Properties in Loess Soil Remediation Efficacy.

Loess Plateau is the region with the most concentrated loess distribution and the deepest loess soil layer in the world, and it is facing serious problems of soil erosion and ecological degradation. The nano carbon modification of soil surface properties is a novel strategy for soil improvement and enhancing the soil's capacity to sequester carbon, which has been extensively researched. However, the mechanisms underlying the influence of carbon surface structure on the efficacy of loess soil remediation remain unclear.

[Study on mechanisms of changes of TTX-R/TTX-S sodium channels in dorsal root ganglion neurons after acupoint sensitization induced by myocardial ischemia in mice].

Objectives: To explore the relation between acupoint sensitization and alterations of electrical signals of dorsal root ganglion (DRG) neurons from the perspective of ion channel dynamics in myocardial ischemia (MI) model mice.

Methods: Sixty-four male C57BL/6J mice were randomly assigned to control and model groups (=32/group). The MI model was established by ligation of the left anterior descending (LAD) of the coronary artery.

Extract of camellia seed cake ameliorates glycolipid metabolism disorder in mice through inhibiting ACOX1 activity.

Acyl-CoA oxidase 1 (ACOX1) plays a key role in glycolipid metabolism disorders. Camellia seed cake, a byproduct of oil production, was identified as a source of ACOX1 inhibitors. Under optimized conditions (58 % ethanol, 70 °C, 62 min), the extract exhibited an 83.

Decellularized cartilage scaffolds derived from wharton's jelly facilitate cartilage regeneration and inhibit angiogenesis.

The avascular nature of articular cartilage severely limits its ability to self-repair after injury, which poses a challenge for clinical treatment, and tissue engineering aims to address this issue with scaffold-based strategies. However, the defining characteristics of an optimal scaffold remain controversial. In this study, we prepared two types of decellularized wharton's jelly (dWJ) scaffolds by trypsin combined with repeated freeze-thawing (TFT) and nuclease combined with repeated freeze-thawing (NFT), respectively.

Efficacy and safety of ruxolitinib-based regimen in the treatment of paediatric Epstein-Barr virus-associated haemophagocytic lymphohistiocytosis.

Ruxolitinib (RUX) has demonstrated efficacy in haemophagocytic lymphohistiocytosis (HLH) patients, but large cohort studies regarding its clinical application in children with Epstein-Barr virus-associated HLH (EBV-HLH) remain scarce. This retrospective study analysed the efficacy and safety of RUX-based regimen (n = 53) and compared it with adjusted HLH-94 chemotherapy (n = 42) in the treatment of paediatric EBV-HLH. The patients treated with the RUX-based regimen received RUX monotherapy as front-line therapy.

Surpassing Shockley-Queisser Efficiency Limit in Photovoltaic Cells.

The Shockley-Queisser (S-Q) model sets a theoretical limit on the power conversion efficiency (PCE) of single-junction solar cells at around 33%. Recently, a PCE of 50%-60% was achieved for the first time in n-type single-junction Si solar cells by inhibiting light conversion to heat at low temperatures. Understanding these new observations opens tremendous opportunities for designing solar cells with even higher PCE to provide efficient and powerful energy sources for cryogenic devices and outer and deep space explorations.

MRI-Driven Longitudinal Studies of Hippocampal Alterations During the Initial Cognitive Decline.

Based on available magnetic resonance imaging (MRI) studies, hippocampal alteration is one of the hallmarks during cognitive decline. However, the longitudinal hippocampal morphometric changes during the initial cognitive decline are unclear. Exploring a validated biomarker with high clinical relevance is urgent.

Continuous Wavelet Transform-Based Method for High-Sensitivity Detection of Image Signals of Fluorescence Lateral Flow Assay.

Fluorescence lateral flow assays (FLFA) based on quantum dot probes have attracted significant attention in recent years due to their high sensitivity and quantitative detection capabilities. FLFA requires the use of a straightforward fluorescence reader for quantitative detection. Most fluorescence readers employ narrowband filters for auxiliary imaging, which facilitates the acquisition of high-contrast signals.

Anastomotic leakage following robot-assisted minimally invasive esophagectomy (RAMIE): which anastomosis should be preferred?

Background: The optimal technique for intrathoracic esophagogastric anastomosis in esophagectomy remains undetermined. This study evaluates different anastomotic techniques in robot-assisted minimally invasive esophagectomy (RAMIE) and their impact on anastomotic leakage rates.

Materials And Methods: This observational, retrospective, comparative cohort study analyzed data obtained from the Upper GI International Robotic Association (UGIRA) Esophageal Registry.

Promising Applications of Chiral Nanomaterials for Plant Protection and Nutrition.

Monitoring biotic and abiotic stress in agricultural crops is important for sustainable food and agriculture. Nanotechnology provides emerging opportunities for plants to boost stress tolerance, wherein chiral nanomaterials have been developed and studied for their intrinsic chirality or spatial asymmetry at the nanoscale. Chiral nanomaterials have been proposed for a wide range of uses, including the development of biosensors, the production of targeted antiviral and antibacterial agents, and the preparation of superior fertilizers, showing the potential to achieve higher yields and improved quality of crops.

[Identification and determination of organic compounds in the gas and particulate matter released by incense burning by ultrasonic extraction-gas chromatography-mass spectrometry].

Statistical evidence indicates that individuals spend approximately 90% of their time indoors on a daily basis. A multitude of human activities， including incense burning， cooking， smoking， and the use of electrical appliances， can contribute to indoor air pollution. This phenomenon poses a significant risk of indoor exposure to human health risks.