The professional experience of rural midwifery in China during the transition from traditional to modern birth practices (1950s-1970s): A qualitative study.

Background: Although home births have been largely discontinued in contemporary China, traditional birth attendants (TBAs) historically played a pivotal role in enhancing maternal and child health, particularly in rural areas.

Aim: This study explored the transformation of TBAs in China from the 1950s to the 1970s, focusing on their gradual shift from traditional to modern midwifery practices. By drawing on oral histories from TBAs, the research seeks to enrich the historical understanding of midwifery development in China.

SARS-CoV-2 nucleocapsid protein delays cell cycle in S-phase.

The emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) as the causative agent of COVID-19 precipitated a global health crisis of unprecedented scale. SARS-CoV-2 has been shown to interfere specifically with S phase progression during early stages of infection. Nucleocapsid (N) is an important structural protein.

Identification of the malonylation modification in and insight into the regulators in biofilm formation.

Background: Post-translational modifications (PTMs) are critical regulators of bacterial biofilm formation, but the role of lysine malonylation (Kmal) in biofilm formation is still poorly understood.

Methods: In this study, we analyzed the dynamic changes of protein malonylation of () DC15 during biofilm formation based on antibody affinity enrichment combined with quantitative proteomics.

Results: Quantitative profiling identified 2,833 malonylated sites across 788 proteins, with significant enrichment in biofilm-associated proteins.

IGFBP6 orchestrates anti-infective immune collapse in murine sepsis via prohibitin-2-mediated immunosuppression.

The persistent challenge of sepsis-related mortality underscores the necessity for deeper insights, with our multi-center cross-age cohort study identifying insulin-like growth factor binding protein 6 (IGFBP6) as a critical regulator in sepsis diagnosis, prognosis, and mortality risk evaluation. Mechanistically, IGFBP6 engages in IGF-independent binding to prohibitin2 (PHB2) on epithelial cells, driving PHB2 tyrosine phosphorylation during sepsis. This process disrupts STAT1 phosphorylation, nuclear translocation, and its recruitment to the CCL2 promoter, ultimately impairing CCL2 transcription and macrophage chemotaxis.

An age-related decrease in leptin contributes to CD8 T cell aging in the tumor microenvironment.

T cell dysfunction with age underlies an increased incidence of cancer in elderly individuals; however, how T cell aging is triggered in the tumor microenvironment is unclear. Here, we show that an age-associated reduction in adipocyte-derived leptin contributes to the accumulation of tumor-infiltrating senescent CD8 T cells. Single-cell profiling of human and mouse cancer tissues reveals that the frequency of intratumoral senescent CD8 T cells increases with age, leading to a weak antitumor effect.

Regulation of cisplatin resistance in lung cancer by epigenetic mechanisms.

Lung cancer remains one of the most prevalent and lethal malignancies worldwide, responsible for nearly 1.8 million deaths annually, which accounts for approximately 18.7% of global cancer-related mortality.

The investigation of factors influencing the prognostic nutritional index in patients with esophageal cancer-a cross-sectional study.

Background: The prognostic nutritional index (PNI) has garnered increasing attention for its role in predicting the nutritional status and prognosis of cancer patients. However, its influencing factors are still unclear, which limits its precise clinical application. This study aims to investigate the correlation between nutrition-related indicators and PNI and their impact on PNI, with the expectation of providing a more reliable basis for clinical nutritional assessment and intervention, filling the current gap in the research of influencing factors of PNI, and promoting the implementation of individualized nutritional therapy in the comprehensive management of esophageal cancer.

Luminescence characterization and performance modulation of CaScBO: Eu near-infrared phosphors for night vision lighting applications.

To facilitate the development of near-infrared light sources for photovoltaic and night-vision lighting applications, it is crucial to obtain novel near-infrared emitting phosphors. Herein, a novel Eu-activated broadband near-infrared emitting phosphor CaScBO: Eu is reported. Under 558 nm light excitation, CaScBO: Eu exhibits broadband near-infrared emission centered at 780 nm with a full width at half maxima of 147 nm.

Diet-derived galactose reprograms hepatocytes to prevent T cell exhaustion and elicit antitumour immunity.

Dietary nutrients are inextricably linked to antitumour immune responses. However, the effect of diet-derived galactose on antitumour immunity remains unclear. Here we show that dietary galactose augments CD8 T cell immunity to suppress tumour progression.

Comprehensive analysis of pyroptosis-related genes in psoriasis and targeted gene editing of CASP1 and CASP5 using lipid nanoparticles to alleviate skin inflammation.

Psoriasis is a chronic inflammatory skin disorder driven by immune dysregulation and excessive cell death. Pyroptosis, a form of inflammatory programmed cell death, has not been extensively studied in the context of psoriasis despite its importance in inflammation. In this study, we systematically analyzed the expression of pyroptosis-related genes (PRGs) in psoriasis to identify critical players involved in disease progression.

Impact of social support on cognitive function in patients with breast cancer undergoing chemotherapy: The chain-mediating role of fatigue and depression.

Objective: This study aims to examine the chain-mediating roles of fatigue and depression in the association between social support and cognitive function among patients with breast cancer undergoing chemotherapy.

Methods: This study involved a secondary analysis of cross-sectional data from 647 patients recruited from four provinces in China. Patient-reported outcomes were measured using the Chinese version of the Patient-Reported Outcomes Measurement Information System (PROMIS) Cancer Function Brief Scales, assessing cognitive function, social support, fatigue, and depression.

Diagnostic value of low-dose CT pulmonary angiography combined with iterative reconstruction in suspected pulmonary embolism.

Objective: Assessing the utility of low-dose computed tomographic pulmonary angiography (CTPA) employing iterative reconstruction (IR) for the detection of pulmonary embolism (PE), we compared its image quality, and radiation exposure with standard-dose CTPA protocols.

Methods: Patients with suspected PE were prospectively and randomly allocated to either a low-dose CTPA with IR arm (study group, n = 80) or a standard-dose CTPA plus IR arm (control group, n = 80). The low-dose group used 70 kVp and automatic tube current modulation, while the standard-dose group used 120 kVp with conventional parameters.

Knowledge, Attitudes and Practices of Critical Care Nurses Regarding Eye Care Across 17 Hospitals: A Multicentre Cross-Sectional Survey.

Background: While international guidelines emphasise the importance of eye care for critically ill patients' eye complication prevention, the current study reveals significant gaps in clinical implementation, demonstrating that up to 89.3% of intensive care unit (ICU) patients develop eye disorders despite established protocols.

Aim: To investigate the eye care competency of ICU nurses in China and identify key determinants influencing clinical implementation.

Targeting Frequent Efferocytosis in Tumor Microenvironment is a New Direction for Cancer Treatment.

A variety of factors, such as dietary habits, the external environment, and individual genetic differences, can lead to the development of cancer. While chemotherapy and radiotherapy are commonly used for cancer treatment, drug resistance and side effects are prevalent issues. Therefore, there is an urgent need to find new treatment modalities.

PromptSED: An evolving topic-enhanced prompting framework for incremental social event detection.

The recent success of Transformer-based pre-trained language models (PLMs) offers a novel perspective on social event detection (SED), which seeks to identify clusters of social messages corresponding to real-world events. However, employing PLMs for SED tasks necessitates careful consideration of the inherent characteristics of social data, including the short text format with limited information, as well as the continuous updates as new events emerge over time. To address these challenges, this work introduces PromptSED, an evolving topic-enhanced prompt learning framework for SED.

Design and implementation of mHealth applications for older people with cancer: A scoping review.

Objective: This scoping review aimed to systematically synthesize the evidence on the functions, design, implementation strategies, and evaluation approaches of mobile health (mHealth) applications (apps) developed for older adults with cancer, to inform future research and practice.

Methods: A scoping review was conducted using Arksey and O'Malley's methodological framework, with an updated systematic search of five databases (Medline, Web of Science, CINAHL, Embase, and the Cochrane Library) from January 1, 2008, to February 28, 2025. The review adhered to the PRISMA-ScR guidelines for scoping reviews.

Exploring factors affecting the implementation of prehabilitation: a descriptive qualitative study from nurses' perspective.

Background: Prehabilitation aims to optimize preoperative risk factors to better prepare the patient for the upcoming surgery. Nurses are an integral part of the multidisciplinary teams and are essential in promoting the effective implementation of prehabilitation. The aim of study was to explore factors affecting the implementation of prehabilitation from nurses' perspective.

Genetic structure analysis and core germplasm construction of Robinia pseudoacacia and its closely related species based on SNP.

Robinia pseudoacacia is a forest biomass energy tree species with substantial potential for development and utilization. However, the lack of research on its genetic structure and the unclear genetic background of its germplasm resources impede the conservation and improvement of R. pseudoacacia.

Research on the combined impact of high-flux dialysis and levocarnitine on the functionality of arteriovenous fistulas in patients undergoing maintenance hemodialysis.

To explore the influence of levocarnitine on arteriovenous fistula (AVF) function in patients undergoing high-flux dialysis and delve into its potential mechanisms. Complication Reduction: The treatment group had markedly lower incidences of vascular stenosis (4.69% vs.

Evaluation of C07 Isolated from Fermented Whey: Insights into Antimicrobial Properties and Its In Situ Biopreservative Application in Chinese Rubing Cheese.

A strain of () C07 was isolated from the fermented whey of Chinese Rubing Cheese (CRC). This strain demonstrated significant antibacterial activity against multidrug-resistant DC.RB-015, with an inhibition zone measuring 19.

Activin A exacerbates neonatal necrotizing enterocolitis via ALK4-mediated apoptosis and barrier disruption.

Background: Necrotizing enterocolitis (NEC) is a life-threatening gastrointestinal disorder in neonates, yet the role of Activin A (ACV A) in NEC pathogenesis remains unclear.

Methods: NEC was induced in neonatal mice through hypoxia, hypothermia, LPS, and formula feeding. An in vitro intestinal epithelial injury model was established using LPS-stimulated IEC-6 cells.

Perioperative Pain Threshold Trajectories and Influencing Factors Among Lung Cancer Patients.

Purpose: Managing postoperative pain in lung cancer patients remains challenging. Pain threshold (PT), an objective indicator reflecting the body's sensitivity to pain, can be used to predict postoperative pain. This study aims to investigate the dynamic trajectory of perioperative pain threshold in lung cancer patients, hypothesizing that heterogeneity exists in the pain threshold trajectories.

Lactate dehydrogenase B facilitates disulfidptosis and exhaustion of tumour-infiltrating CD8 T cells.

The aberrant accumulation of intracellular disulfides promotes cancer cell disulfidptosis; however, how disulfide stress influences tumour-infiltrating CD8 T cell function remains unknown. Here we demonstrate that lactate dehydrogenase B (LDHB) facilitates intratumoural CD8 T cell disulfidptosis and exhaustion, leading to impaired antitumour immunity. SLC7A11-mediated cystine uptake by CD8 T cells induces disulfidptosis, which plays critical roles in the development of exhausted CD8 T cells.

Engineering cellulosic paper into a bending strain sensor using chemical additives: Metal salt-based treatment and ethanol-assisted processing.

The pulp and paper industry, traditionally focused on basic material production, is now expanding into innovative areas, such as advanced functional materials. Papermaking wet-end chemistry & chemical additives is a specialized field that integrates process control in wet-end paper production with the versatile use of chemical additives, which can be tailored for both wet-end and non-wet-end applications. By combining the optimization of wet-end processes with the adaptability of chemical additives-designed specifically for papermaking or adapted from other industries-this field offers immense potential for bridging traditional papermaking with emerging technologies.