[Expert consensus on prognostic evaluation of cochlear implantation in hereditary hearing loss].

Hearing loss is the most prevalent disabling disease. Cochlear implantation（CI） serves as the primary intervention for severe to profound hearing loss. This consensus systematically explores the value of genetic diagnosis in the pre-operative assessment and efficacy prognosis for CI.

Transcriptome and metabolome reveal the accumulation of secondary metabolites in different species of Dioscorea.

Background: The genus Dioscorea is traditional Chinese medicine producing a variety of pharmacological active substances especially saponins. In our study, the secondary metabolism of Dioscorea zingiberensis and D. opposita that have significantly different saponin contents were investigated.

Risk factors affecting drop attack in patients with Meniere's disease.

Objectives: Drop attack (DA) is a specific symptom of Meniere's diset the risk factors affecting DAs remain uncertain. This study aimed to identify clinical and imaging predictors of DAs in MD patients .

Methods: A hospital-based cross-sectional survey was conducted between October 2014 and December 2022 at a tertiary center in shanghai, China.

Smart-SNPer: Automated crRNA design for ultrasensitive RPA-Cas12a SNP detection.

Single-nucleotide polymorphism (SNP) detection is critical for precision medicine but is often hindered by complex workflows in resource-limited settings. Here, we introduce Smart-SNPer (https://smart-crisprer.com), a one-click, structure-guided crRNA design tool that automates the development of highly specific RPA (Recombinase Polymerase Amplification)-Cas12a assays (CORDSv2).

An age-related decrease in leptin contributes to CD8 T cell aging in the tumor microenvironment.

T cell dysfunction with age underlies an increased incidence of cancer in elderly individuals; however, how T cell aging is triggered in the tumor microenvironment is unclear. Here, we show that an age-associated reduction in adipocyte-derived leptin contributes to the accumulation of tumor-infiltrating senescent CD8 T cells. Single-cell profiling of human and mouse cancer tissues reveals that the frequency of intratumoral senescent CD8 T cells increases with age, leading to a weak antitumor effect.

Surface plasmonic coupling-electrochemiluminescence biosensor based on Hf-nanoMOF/square-cavity Au nanostar@CuS nanocube array for the detection of miRNA-9 in glioma diagnosis.

The integration of luminescent materials with plasmonic nanomaterials holds the potential to give rise to innovative analytical and sensing applications. In this study, novel nano-scaled luminescent Hf-MOF (Hf-nanoMOF) was prepared by the modulator-induced defect approach. Acetate was used as a modulator to preferentially coordinate with metal centers, which inhibited the formation of coordination bond between the metal clusters and 2-aminobenzene-1,4-dicarboxylic acid and limited the Ostwald ripening effect.

Pou4f3 Deficiency Obstructs the Subtype Differentiation of Vestibular Hair Cells.

Vestibular hair cells (HCs) in the inner ear, crucial for balance and spatial orientation, are classified into type I and type II subtypes, but the mechanisms regulating their differentiation remain unclear. In this study, we examined the role of Pou4f3, an important transcription factor, in vestibular HC differentiation using Pou4f3 (deficient) and Pou4f3 (knockout) mouse models. In Pou4f3-deficient mice, the HC number decreased, and immature HCs failed to develop type I characteristics, indicating a developmental arrest.

Long-term adiposity in early adulthood affects coronary artery calcification incidence in midlife: a 25-year longitudinal study.

Aims: The study aimed to evaluate longitudinal adiposity exposure, assessed by body roundness index (BRI), from young adulthood and its association with the risk of coronary artery calcification (CAC) incidence in midlife.

Methods: We included 2102 participants from the CARDIA study with available BRI measurements at eight follow-up visits over 25 years. Cardiac computed tomography at year 25 exam was used to assess the presence of CAC (CAC > 0).

Aggravation of rainbow sign on hematoma membrane by arterial spin labeling predicts chronic subdural hematoma recurrence following middle meningeal artery embolization.

Background: Recurrence remains a critical challenge in patients with chronic subdural hematoma (CSDH) treated with middle meningeal artery embolization (MMAE), yet the underlying mechanisms and reliable predictors of this phenomenon remain poorly understood. Current predictors of recurrence rely on invasive or radiation-based techniques, prompting the need for non-invasive imaging markers. This study aimed to evaluate the 'rainbow sign aggravation' by arterial spin labeling (ASL) on the hematoma membrane as a predictor of CSDH recurrence after MMAE.

Diet-derived galactose reprograms hepatocytes to prevent T cell exhaustion and elicit antitumour immunity.

Dietary nutrients are inextricably linked to antitumour immune responses. However, the effect of diet-derived galactose on antitumour immunity remains unclear. Here we show that dietary galactose augments CD8 T cell immunity to suppress tumour progression.

Structure-Inspired Lineage-Specific Matrix for Endogenous Neurogenesis in Spinal Cord Injury.

Spinal cord injury (SCI) poses substantial challenges, often leading to permanent disability and requiring adequate neuronal regeneration for functional repair. Decellularized spinal cord (DSC) matrices hold promise due to their native 3-dimensional (3D) structure and extracellular matrix (ECM)-derived biochemical components. However, their limited mechanical properties and insufficient availability of growth factors hinder their effectiveness.

Clinical characteristics and outcomes of patients with traumatic brain injury transferred from ultra-high-altitude areas: patient series.

Background: Traumatic brain injury (TBI) patients transferred from high-altitude areas present with unique challenges that complicate the treatment of these patients. This study aims to summarize the clinical characteristics and treatment experience of TBI patients transferred to the authors' center from ultra-high-altitude areas.

Observations: The authors conducted a retrospective case series analysis of 10 TBI cases admitted to their center between January 2021 and December 2023.

Regulation of emotional states by volatile herbal extracts: Multisystem physiological evidence from Rosa rugosa, Acorus tatarinowii, and Cyperus rotundus.

Background: Traditional aromatic herbs Rosa rugosa Thunb. (R. rugosa), Acrorus tatarinowii Schott (A.

Vestibular Assessment and Compensation in Unilateral Acute Vestibular Dysfunction: A Prospective Single-Armed Cohort Study of Vestibular Schwannoma After Surgery.

Background And Objectives: Acute vestibular syndrome is highly disabling in physical and psychological stress of patients. The aim of this study was to evaluate the effects of perioperative vestibular dysfunction in patients who received unilateral vestibular schwannoma (VS) surgery as unilateral acute vestibular dysfunction model cases and to study the vestibular compensation process in these patients.

Methods: The 101 participants with unilateral VS had received a series vestibular function tests including subjective visual vertical/horizontal (SVV/SVH), caloric test, cervical vestibular-evoked myogenic potentials, ocular VEMP, and video head impulse test within 3 months before surgery.

Cross-sectional and longitudinal associations of circulating bile acids and dementia: a systematic review.

Bile acids (BAs) may contribute to dementia by regulating neuroinflammation and influencing gut-brain axis signaling, especially in Alzheimer's disease (AD). However, their alterations in dementia development are rather complex and their impact on dementia risk remains inconclusive. To provide a comprehensive understanding of these associations, we systematically reviewed cross-sectional and longitudinal studies on circulating BAs and dementia.

Atomically Precise Silver Nanocluster Riveted by Uneven Charged Traps toward Enhancing Electrocatalytic Activity for the Oxygen Reduction Reaction.

Metal nanoclusters (MNCs) possessed promising potentials for catalytic applications but were hindered by the intrinsic charge-carrier mobility and the exposure of active sites. To this point, our work developed the uneven charged traps strategy to realize the homogeneous dispersion and immobilization of atomically precise silver nanoclusters (Ag) and obtained an Ag cluster-based oxygen reduction reaction (ORR) electrocatalyst with enhanced performance. As expected, the uneven charged traps derived by graphitized nitrogen-doped carbon (NDC) extended the effective catalytic active area, tuned the electrical environment, and facilitated the binding between ORR intermediates and the active sites.

Unveiling the mechanisms of CEBPD-orchestrated TAM polarization through RGS2/PAR2 pathway and its impact on ICB efficacy in clear cell renal cell carcinoma.

Background: The polarization status and function of tumor-associated macrophages (TAMs) influence tumor progression and patients' prognosis. CCAAT/enhancer-binding proteins (CEBPs) family are important transcriptional factors in macrophages differentiation physically and pathologically. This study aims to explore the mechanism of CEBPs in TAMs polarization in clear cell renal cell carcinoma (ccRCC) immune microenvironment and its impact on immune checkpoint blockers (ICBs) therapy.

The effect and mechanism of Codonopsis Radix and its active components tangshenoside I and lobetyolin on preventing gastric ulcer based on spectrum-effect relationship.

Ethnopharmacological Relevance: Gastric ulcer (GU) is a prevalent gastrointestinal disease. Codonopsis Radix (CR), including three species of Codonopsis pilosula (Franch.) Nannf.

Determination of Main Bearing Dynamic Clearance in a Shield Tunneling Machine Through a Broadband PMUT Array with a Decreased Blind Area and High Accuracy.

Traditional PMUT ultrasonic ranging systems usually possess a large measurement blind area under the integrated transmit-receive mode, dramatically limiting its distance measurement in confined spaces, such as when determining the clearance of large bearing components. Here, a broadband PMUT rangefinder was designed by integrating six types of different cells with adjacent resonant frequencies into an array. Through overlapping and coupling of the bandwidths from the different cells, the proposed PMUTs showed a wide -6 dB fractional bandwidth of 108% in silicon oil.

Association of dietary quality, biological aging, progression and mortality of cardiovascular-kidney-metabolic syndrome: insights from mediation and machine learning approaches.

Background: To investigate the association between the Dietary Inflammatory Index (DII), biological aging, and the staging and mortality of cardiovascular-kidney-metabolic (CKM) syndrome.

Methods: Data of 7,918 participants were derived from the National Health and Nutrition Examination Survey 2005-2018. Cross-sectional analyses using multivariable logistic regression were conducted to evaluate the relationship between DII and CKM staging.

Hupserrine A, a Caged Alkaloid with a 6/6/5/6/7 Pentacyclic Skeleton from .

Hupserrine A (), a alkaloid featuring a novel caged 6/6/5/6/7 pentacyclic skeleton, was isolated from . Compound possesses an unprecedented 2-azatetracyclo[6.5.

A surveillance-based epidemiological study of renal agenesis in 25 million births in china, 2007-2020.

Background: Renal agenesis (RA), a rare congenital kidney defect, varies in clinical severity. Unilateral renal agenesis (URA) is more prevalent and may cause long-term renal complications, whereas bilateral renal agenesis (BRA) is typically fatal. While epidemiological data on RA is limited in China, understanding its prevalence and associated factors is crucial for public health interventions.

Mechanism of nascent chain removal by the ribosome-associated quality control complex.

Errors during translation can cause ribosome stalling, leaving incomplete nascent chains attached to large ribosomal subunits. Cells rely on the Ribosome-associated Quality Control (RQC) complex to recognize, process, and remove these aberrant proteins to maintain proteostasis. Despite its importance, the mechanisms by which the RQC orchestrates nascent chain processing and extraction have remained unclear.

Targeting Phospholipid Metabolism as an Effective Hearing Protection Strategy.

Cochlear hair cell (HC) damage is a primary cause of sensorineural hearing loss. In this study, we performed metabolomic profiling of cochlear sensory epithelium following neomycin-induced HC injury and identified elevated arginine metabolism as a key metabolic characteristic of damaged HCs. Using a highly sensitive and specific biosensor, we confirmed that injury induced an increase in arginine levels within cochlear HCs.