Risk factors affecting drop attack in patients with Meniere's disease.

Objectives: Drop attack (DA) is a specific symptom of Meniere's diset the risk factors affecting DAs remain uncertain. This study aimed to identify clinical and imaging predictors of DAs in MD patients .

Methods: A hospital-based cross-sectional survey was conducted between October 2014 and December 2022 at a tertiary center in shanghai, China.

Dural arteriovenous fistula presenting as paradoxical contralateral pulsatile tinnitus due to contralateral otosclerosis-induced mixed hearing loss.

Objectives: This study aims to present a rare case of unilateral pulsatile tinnitus (PT) induced by a contralateral dural arteriovenous fistula (DAVF) in a patient with ipsilateral otosclerosis-induced mixed hearing loss, highlighting the diagnostic challenges and management implications.

Methods: A 71-year-old female presented with persistent right-sided PT and hearing loss. Clinical examination, audiological assessments, contrast-enhanced computed tomography, magnetic resonance (MR) angiography, hearing tests, and transcanal recording were performed.

Gene Therapy vs Cochlear Implantation in Restoring Hearing Function and Speech Perception for Individuals With Congenital Deafness.

Importance: OTOF gene therapy (GT) has been shown to improve hearing and speech. The efficacy of GT remains to be compared against cochlear implantation (CI), the current gold standard for congenital deafness.

Objective: To evaluate treatment outcomes in auditory and speech perception between patients with congenital deafness treated with GT, CI, or both.

Shen-Ying-Yang-Zhen formula promotes angiogenesis around hair follicles, alleviates oxidative stress, and inhibits hair follicle apoptosis through the VEGF/Akt/Caspase-9 signaling axis.

Background: Androgenic alopecia (AGA) represents the most predominant form of hair loss in clinical practice, yet currently approved pharmacological options (e.g., finasteride and minoxidil) face limitations in safety and long-term efficacy.

PIEZO1 promotes psoriasis-like skin inflammation in mice via NF-κB/IL-17 signaling pathway activation.

Background: Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferative keratinocytes and an altered immune response. , a mechanically activated ion channel, has been implicated in various cellular processes, but its role in psoriasis pathogenesis remains unclear.

Methods: We examined expression in skin samples from psoriatic patients and healthy individuals using western blot, immunohistochemistry, and mRNA expression analyses.

The role of ChatGPT-4o in differential diagnosis and management of vertigo-related disorders.

To compare the diagnostic accuracy of an artificial intelligence chatbot and clinical experts in vertigo-related diseases and evaluate the ability of the AI chatbot to address vertigo-related issues. 20 clinical questions about vertigo were input to ChatGPT-4o, and three otologists evaluated the responses using a 5-point Likert scale for accuracy, comprehensiveness, clarity, practicality, and credibility. Readability was assessed using Flesch Reading Ease and Flesch-Kincaid Grade Level formulas.

Audiological characteristics following gene therapy in patients with autosomal recessive deafness 9.

Background: Gene therapy shows promising potential for patients with autosomal recessive deafness 9 (DFNB9), with ongoing clinical trials (ChiCTR2200063181). A deeper understanding of changes in audiological characteristics is crucial for optimizing the monitoring and evaluation of patients' recovery post-treatment.

Methods: Audiological data were collected from 10 DFNB9 patients who underwent gene therapy, including auditory brain stem response (ABR), auditory steady-state response (ASSR), distortion product otoacoustic emission (DPOAE), and pure-tone audiometry (PTA) tests.

Intracranial Dural Arteriovenous Fistula Can Mimic Sigmoid Sinus Wall Anomalies Induced Pulsatile Tinnitus: Caution Before Considering It's Venous.

Objective: To highlight that dural arteriovenous fistula (DAVF) can exist in subjects with unilateral vascular pulsatile tinnitus (PT), positive internal jugular vein (IJV) compression tests, and radiologic evidence of sigmoid sinus wall anomalies (SSWA).

Methods: A retrospective analysis was conducted on 80 subjects with PT as the primary symptom and intracranial DAVF detected based on magnetic resonance angiography results. Among them, IJV and retroauricular compression tests and temporal bone computed tomography (CT) were performed.

IL-17C-Mediated Upregulation of SMURF2 Induces Psoriatic Changes in Keratinocytes by Facilitating PPP6C Ubiquitination.

Psoriasis, a persistent inflammatory skin condition, affects approximately 2%-3% of the world's population. Increased IL-17C levels are noted in psoriatic lesions, alongside IL-17's ability to diminish protein phosphatase 6 catalytic subunit (PPP6C) expression in keratinocytes. Additionally, SMAD-specific E3 ubiquitin protein ligase 2 (SMURF2) facilitates the degradation of specific substrates through ubiquitination.

Association between sun-protective behaviours and psoriasis in US adults in the National Health and Nutrition Examination Survey, 2009-2014: a cross-sectional study.

Objective: To evaluate the association between sun-protective behaviours and psoriasis in a nationally representative sample of US adults.

Design: Analysis of cross-sectional data.

Setting: National Health and Nutrition Examination Survey (NHANES), 2009-2014.

Spontaneous otoacoustic emission as a novel method to screen pulsatile tinnitus caused by sigmoid sinus wall abnormalities: a prospective study.

Objective: To evaluate the diagnostic potential of spontaneous otoacoustic emissions (SOAE), distortion product otoacoustic emissions (DPOAE), and pure-tone audiometry (PTA) in patients with pulsatile tinnitus (PT) caused by sigmoid sinus wall anomalies (SSWA).

Methods: This study included 20 PT patients and 20 matched healthy controls. SOAE, DPOAE, and PTA were assessed before and after compression of the internal jugular vein.

Programmable NIR Responsive Nanocomposite Enables Noninvasive Intratympanic Delivery of Dexamethasone to Reverse Cisplatin Induced Hearing Loss.

Local intratympanic drug delivery to the inner ear possesses significant otological clinical promise as cisplatin-induced hearing loss (CIHL) therapy, inducing significantly less side effects than systemic drug delivery. However, the multiple detoured barriers, round window membrane (RWM) and poorly controlled drug release hinder successful non-invasive drug delivery through intratympanic administration (IT). Here, a novel near-infrared (NIR) responsive nanocomposite functionalized with saponin, denoted gold nanorod@dexamethasone-mesoporous silica-saponin (AuNR@DEX-MS-saponin, NPs/DEX), is developed to enhance RWM permeation and to control the drug release spatiotemporally.

The characteristics of three-dimensional real inversion recovery MRI sequence in delayed Meniere's disease.

Background: Delayed Meniere's disease (DMD) is characterized by episodic vertigo occurring after a significant delay following longstanding sensorineural hearing loss. However, its pathogenesis and characteristics remain unclear.

Objectives: To explore the characteristics of endolymphatic hydrops (EH) in DMD and investigate its pathology using MRI.

The relationship between endolymphatic hydrops features and hearing loss in Bilateral Meniere's disease.

Background: This study aimed to investigate the relationship between the features of endolymphatic hydrops and hearing loss in patients with Bilateral Meniere's Disease.

Methods: A retrospective analysis was conducted on 77 patients diagnosed with Bilateral Meniere's Disease. The features of endolymphatic hydrops in the affected ear were evaluated through gadolinium-enhanced inner ear Magnetic resonance imaging.

Applications of Machine Learning in Meniere's Disease Assessment Based on Pure-Tone Audiometry.

Objective: To apply machine learning models based on air conduction thresholds of pure-tone audiometry for automatic diagnosis of Meniere's disease (MD) and prediction of endolymphatic hydrops (EH).

Study Design: Retrospective study.

Setting: Tertiary medical center.

Bilateral gene therapy in children with autosomal recessive deafness 9: single-arm trial results.

Gene therapy is a promising approach for hereditary deafness. We recently showed that unilateral AAV1-hOTOF gene therapy with dual adeno-associated virus (AAV) serotype 1 carrying human OTOF transgene is safe and associated with functional improvements in patients with autosomal recessive deafness 9 (DFNB9). The protocol was subsequently amended and approved to allow bilateral gene therapy administration.

Sigmoid Sinus Wall Anomalies Can Progress and May Not Be Congenital.

Objective: Sigmoid sinus wall anomalies (SSWA) are closely linked to venous pulsatile tinnitus (PT). This study aims to demonstrate that SSWA develops progressively rather than being congenital.

Methods: We retrospectively analyzed 42 PT patients with SSWA who had at least two non-operative CT scans at our clinic.

Engineering of the AAV-Compatible Hair Cell-Specific Small-Size Myo15 Promoter for Gene Therapy in the Inner Ear.

Adeno-associated virus (AAV)-mediated gene therapy is widely applied to treat numerous hereditary diseases in animal models and humans. The specific expression of AAV-delivered transgenes driven by cell type-specific promoters should further increase the safety of gene therapy. However, current methods for screening cell type-specific promoters are labor-intensive and time-consuming.

Microdrill Versus Diode Laser in Endoscopic Stapedotomy: A Comparative Study.

Background: Microdrill and diode laser are two different methods used in endoscopic stapedotomy for otosclerosis. These two methods have not been compared in endoscopic stapedotomy.

Aims/objectives: To analyze the differences between microdrill and diode laser in endoscopic stapedotomy for otosclerosis.

Traditional Chinese medicine Qingre Huoxue decoction enhances wound healing in through modulation of angiogenic and inflammatory pathways.

This study investigates the therapeutic potential of Qingre Huoxue Decoction (QHD), a traditional Chinese herbal formulation, in promoting wound healing in an imiquimod-induced murine model of psoriasis. The research was driven by the need for effective wound healing strategies in psoriatic conditions, where conventional treatments often fall short. Employing a combination of in vivo and in vitro methodologies, we assessed the effects of QHD on key factors associated with wound healing.

Hair cell-specific Myo15 promoter-mediated gene therapy rescues hearing in DFNB9 mouse model.

Adeno-associated viral (AAV) vectors are increasingly used as vehicles for gene delivery to treat hearing loss. However, lack of specificity of the transgene expression may lead to overexpression of the transgene in nontarget tissues. In this study, we evaluated the expression efficiency and specificity of transgene delivered by AAV-PHP.