Study on the trajectory and influencing factors of post-stroke cognitive development: based on a group-based trajectory model.

Background: Post-stroke cognitive impairment (PSCI) is one of the major complications of stroke and exhibits a dynamic progression. This study uses the Group-Based Trajectory Model (GBTM) to fit cognitive development trajectories in stroke patients and analyze the influencing factors and trends of PSCI across trajectory groups. It aims to facilitate early identification and intervention for high-risk PSCI patients, providing a theoretical basis for optimizing intervention strategies.

Multiphase MRI-Derived Delta radiomics integrated with clinical features for survival prediction in hepatocellular carcinoma after thermal ablation.

Rationale And Objectives: To evaluate the predictive value of a delta radiomic score (DRS)derived from multiphase contrast-enhanced Magnetic Resonance Imaging (MRI), in combination with clinical characteristics, forecasting overall survival (OS) and recurrence-free survival (RFS) in patients with hepatocellular carcinoma (HCC) after thermal ablation.

Materials And Methods: This retrospective study enrolled 415 patients with HCC from two centers who underwent multiphase contrast-enhanced magnetic resonance imaging and percutaneous thermal ablation. Patients in Institution 1 (n = 315) were randomly assigned to the training cohorts (n = 220) and internal tests (n = 95), while 100 patients in Institution 2 formed the external validation cohort.

Superficial spreading squamous cell carcinoma of the cervix involving the endometrium: A case report and literature review.

Superficial spreading cervical squamous cell carcinoma (SCC) constitutes a relatively uncommon subtype of cervical cancer, distinguished by the replacement of the endometrium and, in some instances, the epithelial lining of the fallopian tubes with cervical SCC cells that are contiguous with the primary cervical lesion. The present study describes a case involving a 76-year-old patient who primarily exhibited symptoms of abdominal pain and pyometra. During a routine cervical ThinPrep cytologic test, which was conducted while the patient was undergoing anti-infective treatment, high-grade squamous intraepithelial lesion of the cervix was detected.

SUMOylation-related genes define prognostic subtypes in stomach adenocarcinoma: integrating single-cell analysis and machine learning analyses.

Background: Stomach adenocarcinoma (STAD) exhibits high molecular heterogeneity and poor prognosis, necessitating robust biomarkers for risk stratification. While SUMOylation, a post-translational modification, regulates tumor progression, its prognostic and immunological roles in STAD remain underexplored.

Methods: Prognostic SUMOylation-related genes (SRGs) were screened via univariate Cox regression, and patients were stratified into molecular subtypes using unsupervised consensus clustering.

Comparison of the efficacy and safety of pulsed dye laser, narrow-band intense pulsed light, and broad-band intense pulsed light in the treatment of erythematotelangiectatic rosacea.

Background: Erythematotelangiectatic rosacea (ETR) is a chronic dermatological condition characterized by persistent facial erythema and visible telangiectasia. This study aims to compare the efficacy, safety, and patient satisfaction associated with pulsed dye laser (PDL), narrow-band intense pulsed light (NB-IPL), and broad-band IPL (BB-IPL) in the treatment of ETR.

Methods: A total of 112 patients diagnosed with ETR between May 2021 and April 2024 were retrospectively analyzed.

The inhibitory effect of extracellular vesicles derived from S. epidermidis on MRSA biofilms.

The biofilm formed by methicillin-resistant Staphylococcus aureus (MRSA) on orthopedic implants substantially impedes the penetration of antimicrobial agents, leading to recurrent bone infections and imposing a significant financial burden on patients. Prior research has demonstrated that Staphylococcus epidermidis, a conditional pathogen, exhibits low toxicity in deep tissues and effectively suppresses MRSA growth in superficial tissues. However, the mechanism by which S.

Digital adaptive intervention in the medical field: a bibliometric analysis.

Background: In recent years, the concept of adaptive interventions (AIs) has attracted the attention of researchers in the medical field. Our study aimed to visualize the publications to determine the hotspots and frontiers in research on AIs and provide guidance and reference for further study.

Methods: We searched the Web of Science Core Collection up to December 2024, and only articles and review articles about AIs were included.

Oncogenic CMTM6 drives M2a macrophages formation and fuels cervical cancer progression.

Introduction: CMTM6, a member of the CKLF like MARVEL transmembrane (CMTM) gene family, has emerged as a critical orchestrator of oncogenic processes, yet its specific role in cervical cancer (CC) remains insufficiently characterized. Mounting evidence implicates that CMTM6 in sculpting an immunosuppressive tumor microenvironment (TME).

Methods: We investigated the expression and functional role of CMTM6 in CC cells using in vitro biological assays and a mouse xenograft model.

-Difluoroalkenes as C1 Building Blocks: Iron-Catalyzed Synthesis of Trisubstituted 2-Aroyl-1,3,5-Triazines.

Herein, a cost-effective iron-catalyzed cascade annulation strategy of amidines that leverages readily available -difluoroalkenes as versatile C1 synthons is described. This innovative protocol enables the simultaneous formation of three C-N bonds and one C-O bond in a single catalytic system, delivering structurally diverse 2-aroyl-1,3,5-triazines with isolated yields up to 85%. The system exhibits broad functional group compatibility and efficient construction of triazine derivatives.

Abnormal Cerebral Perfusion and Functional Connectivity in Women with Overactive Bladder.

Overactive bladder (OAB) has been linked to abnormal cerebral blood flow (CBF) and functional connectivity (FC). However, findings related to CBF and FC changes in OAB remain inconsistent across the literature. This feasibility study employed arterial spin labeling (ASL) to investigate abnormal CBF and posterior cingulate cortex (PCC) FC in individuals with OAB, both at rest and during bladder filling.

Dual-catalytic hairpin amplification strategy as a highly efficient signal amplifier cooperative with COF@Au for ultrasensitive SERS detection of miRNA-21.

Background: MicroRNAs (miRNAs) are crucial biomarkers for early disease diagnosis, but their low abundance in biological samples poses a significant challenge for detection. Surface-enhanced Raman scattering (SERS) biosensors have emerged as a powerful tool for ultrasensitive miRNA detection due to their high sensitivity. However, achieving rapid and efficient signal amplification remains a critical hurdle.

A Parametric Study of Epoxy-Bonded CF/QF-BMI Composite Joints Using a Method Combining RBF Neural Networks and NSGA-II Algorithm.

The epoxy-bonded joint between carbon-fiber-reinforced bismaleimide (CF-BMI) and quartz-fiber-reinforced bismaleimide (QF-BMI) composites can meet the structure-function integration requirements of next-generation aviation equipment, and the structural design of their bonding zones directly affects their service performance. Hence, in this study, the carbon-fiber-reinforced bismaleimide composite ZT7H/5429, the woven quartz-fiber-reinforced bismaleimide composite QW280/5429, and epoxy adhesive film J-116 were used as research materials to investigate the influence of the bonding area size on the mechanical properties, and this study proposes a novel design methodology combining radial basis function (RBF) neuron machine learning with the NSGA-II algorithm to enhance the mechanical properties of the bonded components. First, a finite element simulation model considering 3D hashin criteria and cohesion was established, and its accuracy was verified with experiments.

Discovery of novel flavonoid derivatives targeting VEGFR2 and tubulin with potent anticancer efficacy.

The clinical efficacy of VEGFR inhibitors and tubulin inhibitors as monotherapies is restricted by adverse reactions and resistance. We reported a classic pharmacophore hybridization strategy to develop dual VEGFR2/tubulin inhibitors that simultaneously inhibited tumor angiogenesis and tubulin assembly. A series of novel flavonoid derivatives containing N, N'-diethylurea group and trimethoxyphenyl were designed and synthesized.

Optical coherence tomography angiography integrating differential phase and intensity images for imaging of a mouse retina.

Optical coherence tomography angiography (OCTA) suffers from more motion artifacts compared to optical coherence tomography, which are the primary source of image quality degradation in imaging. We propose an OCTA algorithm in this Letter that differs from motion compensation methods widely employed to reduce motion artifacts and effectively mitigates these artifacts. The algorithm integrates differential phase and intensity images based on the standard deviation of the flow signals.

Predicting enamel depth distribution of maxillary teeth based on intraoral scanning: A machine learning study.

Purpose: Measuring enamel depth distribution (EDD) is of great importance for preoperative design of tooth preparations, restorative aesthetic preview and monitoring enamel wear. But, currently there are no non-invasive methods available to efficiently obtain EDD. This study aimed to develop a machine learning (ML) framework to achieve noninvasive and radiation-free EDD predictions with intraoral scanning (IOS) images.

Preferred Parallel Alignment of Sulfonamide Enables High-performance Inverted Perovskite Solar Cells.

Molecule additives emerge as a highly effective strategy for enhancing the performance and stability of perovskite solar cells (PSCs), owing to their potential in suppressing intrinsic defects in perovskite. However, the influence of atomic configuration and electronic properties of additives on their passivation performance receives little attention. Here, two benzenesulfonamide derivatives, 4-carboxybenzenesulfonamide (CO-BSA) and 4-cyanobenzenesulfonamide (CN-BSA) are investigated, examining the effects of molecules with different electron‑acceptor functional groups on the defect passivation of perovskite layer and the photovoltaic properties of perovskite solar cells (PSCs.

Cu-Catalyzed Acylation of Quinoline--oxides with -Difluorostyrenes via the Tandem Cycloaddition/Elimination/Oxidation Process.

The copper-catalyzed defluorination and decarbonization cross-coupling reaction between quinoline--oxides and -difluorostyrenes via key 2-arylmethylquinoline intermediates to access 2-aroylquinolines is described. Versatile 2-aroylquinolines were obtained in up to 83% yield with exclusive regioselectivity. The detailed reaction mechanism investigation shows that it undergoes a tandem [3 + 2] cycloaddition/elimination of formyl difluoride/oxidation of 2-arylmethylquinolines.

Epithelial Deficiency Intensifies Caspase-11 Activation, Fueling Extracellular mtDNA Release to Activate cGAS-STING-NLRP3 Axis in Macrophages During Infection.

() infections pose a significant threat to public health, underscoring the need for deeper insights into host cellular defenses. This study explores the critical role of autophagy-related protein 5 (ATG5) in lung epithelial cells during infection. Single-cell RNA transcriptomics revealed a pronounced enrichment of autophagy pathways in type II alveolar epithelial cells (AEC2).

Anoikis classification of lung squamous cell carcinoma reveals correlation with clinical prognosis and immune characteristics.

Background: Anoikis is a new mode of cell death that has been shown to correlate significantly with tumors. However, the clinical prognostic significance of anoikis in lung squamous cell carcinoma (LUSC) remains poorly studied.

Methods: The differentially expressed ARGs and candidate genes were selected by the differential analysis to construct a predictive model.

Random heterogeneous spiking neural network for adversarial defense.

Spiking neural networks (SNNs) offer a biologically inspired alternative to artificial neural networks (ANNs) by mimicking neuronal information transmission mechanisms. However, similar to ANNs, SNNs remain susceptible to adversarial examples, raising concerns about their robustness in practical applications. To address this vulnerability, we propose the Random Heterogeneous Spiking Neural Network (RandHet-SNN), inspired by the heterogeneity and stochasticity observed in biological neural systems.

Fine particulate matter exacerbates asthma by activating STC2-mediated mitophagy through METTL3/YTHDF2-dependent m6A methylation.

The impact of fine particulate matter (PM) on respiratory health, especially in the context of asthma exacerbation, is a critical environmental concern. Our study delved into the molecular mechanisms by which PM intensified asthma in mice, with a particular focus on N6-methyladenosine (m6A) methylation, mitophagy, and the regulatory roles of STC2 and SQSTM1. Utilizing single-cell RNA sequencing (scRNA-seq), we identified significant changes in immune cell distribution and a notable decrease in epithelial cell numbers in asthmatic mice exposed to PM.

High-dose vitamin C potently induces apoptosis in acute lymphoblastic leukemia by activating ER stress response.

IntroductionHigh-dose Vitamin C has shown significant anti-tumor effects in various cancers, including hematological malignancies. However, its therapeutic efficacy against acute lymphoblastic leukemia (ALL) remains underexplored.MethodsALL cell lines and normal bone marrow mononuclear cells were treated with Vitamin C to assess cell viability, apoptosis, proliferation, and cell cycle progression.

Targeting EP300 in diffuse large b-cell lymphoma: efficacy of A485 and synergistic effects with XPO1 inhibition.

Background: Diffuse large B-cell lymphoma (DLBCL) is an aggressive hematopoietic malignancy, necessitating the exploration of innovative therapeutic approaches. Targeting epigenetic mechanisms has emerged as a promising avenue for cancer treatment. EP300 belongs to the KAT3 family of histone/non-histone lysine acetyltransferases, regulating gene expression by acetylating H3K27.

[3D visualization-based classification of left intrahepatic vessels and its application in precision hepatectomy].

Objectives: To establish a three-dimensional (3D) visualization-based classification of the left hepatic portal vein (LHPV) and left hepatic vein (LHV) systems using 3D reconstruction technology to facilitate precise segmental/subsegmental resection of left liver lesions.

Methods: Thin-slice contrast-enhanced CT datasets from 244 patients were reconstructed using MI-3DV Works software. The spatial anatomy (origins, branching patterns, and spatial relationships) of the LHPV and LHV branches was analyzed to determine their 3D classifications and segmental liver divisions for guiding surgical planning for anatomical left liver resections.