Excellent high-temperature breakdown and energy storage performances of polyetherimide dielectric film with silver/alumina nanosheets derived from sequential bimetallic ion exchange.

Polymer dielectrics have attracted substantial attention for their extensive applications in advanced electronic power systems. However, their practical implementation is substantially hindered by the drastic deterioration in breakdown strength and energy storage capabilities at elevated temperatures. Herein, corrugated alumina (AlO) nanosheets anchored with uniformly dispersed silver nanoparticles (AgNPs) are fabricated via a sequential bimetallic ion exchange method using polyimide (PI) film as the sacrificing template.

Directional Navigation of Low-Temperature Leidenfrost Droplets on Femtosecond Laser-Textured Superwettable Pattern Surfaces.

The Leidenfrost effect enables near-frictionless droplet transport by suspending droplets on vapor layers, making it pivotal for contact-free manipulation in microscale chemical reactions and material transport applications. Traditional ratchet structures that drive Leidenfrost droplet motion require the substrate material to be heated above the higher Leidenfrost point (LFP) critical temperature, which imposes significant demands on energy consumption and material heat resistance. Herein, we proposed a method that integrates femtosecond laser-induced deposition with femtosecond direct writing to fabricate a textured superwettable patterned surface, achieving directional droplet navigation at a notably low temperature of just 155 °C.

A Longitudinal Case Study of Recurrent Pyostomatitis-Pyodermatitis Vegetans Followed by the Subsequent Development of Bullous Pemphigoid With the Presence of Anti-BP230 Autoantibodies Six Years Later.

Pyostomatitis vegetans (PSV) is a rare inflammatory condition that has been strongly associated with inflammatory bowel disease (IBD). Additionally, certain cases of PSV have been reported to co-occur with pyodermatitis vegetans (PDV), resulting in a distinct mucocutaneous manifestation. Herein, we present a clinical case of PSV in a 64-year-old male patient diagnosed with ulcerative colitis (UC).

Improved prebiotic-based "shield" equipped probiotics for enhanced colon cancer therapy by polarizing M1 macrophages and regulating intestinal microbiota.

Probiotics play a crucial role in colon cancer treatment by metabolizing prebiotics to generate short-chain fatty acids (SCFAs). Colon cancer patients are frequently propositioned to supplement with probiotics to enhance the conversion and utilization of prebiotics. Nevertheless, the delivery and colonization of probiotics is hindered by the harsh conditions of gastrointestinal tract (GIT).

Recent Progress on CoP as Anodes for Metal-Ion Batteries.

With the rapid development of portable electronic devices and electric vehicles, metal-ion batteries, especially lithium/sodium/potassium-ion batteries (LIBs/SIBs/PIBs), have become a research hotspot because of their high energy density and cycle stability. The battery system primarily comprises three key components: negative electrode material, positive electrode material, electrolyte, and diaphragm. The selection of the negative electrode material will directly impact the battery's energy density.

Constructing Double Heterojunctions on 1T/2H-MoS@CoS Electrocatalysts for Regulating LiO Formation in Lithium-Oxygen Batteries.

CoS electrocatalysts with mixed valences of Co ions and excellent structural stability possess favorable oxygen evolution reaction (OER) activity, yet challenges remain in fabricating rechargeable lithium-oxygen batteries (LOBs) due to their poor OER performance, resulting from poor electrical conductivity and overly strong intermediate adsorption. In this work, fancy double heterojunctions on 1T/2H-MoS@CoS (1T/2H-MCS) were constructed derived from the charge donation from Co to Mo ions, thus inducing the phase transformation of MoS from 2H to 1T. The unique features of these double heterojunctions endow the 1T/2H-MCS with complementary catalysis during charging and discharging processes.

Shared and distinct alterations of thalamic subregional functional connectivity in early- and late-onset obsessive-compulsive disorder.

Background: Studies highlight the thalamus as a key region distinguishing early- from late-onset obsessive-compulsive disorder (OCD). While structural thalamic correlates with OCD onset age are well-studied, resting-state functional connectivity (rsFC) remains largely unexplored. This study examines thalamic subregional rsFC to elucidate pathophysiological differences in OCD based on different onset times.

Gold nanoparticle-decorated hydrogen-bonded organic frameworks (HOFs@Au) as efficient SERS substrates and photocatalytic tools for ultrasensitive detection and degradation of bisphenol contaminants.

With the increasing concern for ecological environmental and food safety, the development of synergistic systems integrating efficient bisphenol trace sensing and green photocatalytic degradation has emerged as a current research focus. In this study, a novel surface-enhanced Raman scattering (SERS) sensing-degradation integrated platform was successfully developed for the detection and degradation of bisphenol through the uniform modification of hydrogen-bonded organic framework nanorods loaded with gold nanoparticles (HOFs@Au). Based on the remarkable molecular enrichment effect of the porous structure of HOFs and the strong localized surface plasmon resonance (LSPR) effect from the AuNPs, the composite system exhibited excellent trace detection performance.

A Review of Avian Influenza Virus Exposure Patterns and Risks Among Occupational Populations.

Avian influenza viruses (AIVs) pose significant risks to occupational populations engaged in poultry farming, livestock handling, and live poultry market operations due to frequent exposure to infected animals and contaminated environments. This review synthesizes evidence on AIV exposure patterns and risk factors through a comprehensive analysis of viral characteristics, host dynamics, environmental influences, and human behaviors. The main routes of transmission include direct animal contact, respiratory contact during slaughter/milking, and environmental contamination (aerosols, raw milk, shared equipment).

Design of Prefabricated Concrete-Filled Steel Pipe Columns for Pile Beam Arch Subway Stations Based on Carbon Emission Optimization.

With the rapid expansion of underground rail transit construction in China, the high carbon emissions associated with subway tunnels and stations have become an increasing concern. This study systematically examines the carbon emissions of prefabricated concrete-filled steel pipe columns (PCSPCs) during the construction phase of a Beijing subway station built via the pile beam arch (PBA) method, applying the life cycle assessment (LCA) methodology as a case study. An analytical framework for the synergistic optimization of carbon emissions and costs was developed.

Discovery of Tricyclic Aromatic Polyketides Reveals Hidden Chain-Length Flexibility in Type II Polyketide Synthases.

Type II polyketide synthases (PKSs) collectively generate polyketide intermediates of varying chain lengths, which undergo cyclization and further tailoring to produce structurally diverse aromatic polyketides. The length of the polyketide chain is a critical factor shaping the core scaffold of the final product. However, individual type II PKSs typically produce intermediates with a fixed chain length, thereby limiting the structural diversity accessible from a single biosynthetic system.

Neuroprotective effects of Yangming-Kaixin-Yizhi formula in Alzheimer's disease: dual regulation of PI3K/Akt and p38 MAPK signaling via network pharmacology and experimental approaches.

As a neurodegenerative disease characterized by progressive cognitive decline, the pathogenesis of Alzheimer's disease (AD) is still poorly understood, and there is no effective cure currently available. Traditional Chinese medicine (TCM) prescription Yangming-Kaixin-Yizhi formula (YKY) has been clinically applied for the treatment of memory loss related disorders for more than 300 years with remarkable efficacy, but its pharmacological mechanism remains unclear. This study aimed to investigate the therapeutic effects of YKY on AD and its molecular mechanisms.

Development and validation of a machine learning-based early warning system for predicting venous thromboembolism risk in hospitalized lymphoma patients undergoing chemotherapy: a multicenter and retrospective cohort study.

Background: Lymphoma patients hospitalized for chemotherapy are at increased risk of venous thromboembolism (VTE) due to prolonged treatment and bed rest. Early prediction of VTE in this group remains challenging. This study aimed to develop a machine learning-based early warning system (VTE-EWS) tailored to these patients.

Investigating the impact of an efficacy-based nursing program integrated with nutritional intervention strategies on the outcomes of multiple myeloma patients with renal failure.

Objective: To explore the effect of nursing scheme based on efficacy theory combined with nutritional intervention on patients with multiple myeloma (MM) complicated with renal failure.

Methods: Ninety-two patients with MM complicated with renal failure in our hospital from April 2022 to April 2024 were randomly divided into control group (46 cases, using conventional nursing) and observation group (46 cases, using nursing scheme based on efficacy theory combined with nutritional intervention). The CDSES score of self-efficacy, CD-RISC score of resilience, CFS score of cancer-related fatigue, nutrition related indicators (ALB, Hb, PA) and FLIC score of quality of life were compared between the two groups.

Comparative Investigation of Single-Crystalline and Polycrystalline NaNiFeMnO Positive Materials for Sodium-Ion Batteries.

Layered oxide positive materials (NaTMO) for sodium-ion batteries have received widespread attention due to their advantages of high tap density, high theoretical specific capacity, and easy scale-up preparation. However, the current research about single-crystalline and polycrystalline materials is very limited, and the effect of the single-crystalline and polycrystalline structures on the electrochemical performance is still unclear. Based on this, NaNiFeMnO (NFM111) is used as the basic system to systematically investigate in depth the single-crystalline and polycrystalline positive materials.

Enhanced Electrochromic Properties of NiO Films Through Magnesium Doping Strategy.

In order to improve the electrochromic properties of NiO films, Mg ions were introduced into NiO films using the sol-gel method and the spin-coating method. The introduction of Mg ions leads to the loose structure of the compact NiO film, which can provide more channels for the transport of OH. In addition, the introduction of Mg ions increases the oxygen vacancies and oxygen interstitial defects in the NiO film, which effectively increases the reactive sites and improves the charge transfer efficiency at the interface between the NiO film and the electrolyte.

Next generation sequencing misguided the clinical interpretation of the PRSS1 variant in pediatric pancreatitis: a case report.

Next-generation sequencing (NGS), known as massively parallel sequencing, is transitioning from research tools to a clinical diagnostic methods. Whole-exome sequencing (WES), a specific applications of NGS, has emerged as a valuablefirst-line diagnostic tool for patients with rare diseases and shows promise as aas a comprehensive approach for assessing the prevalence of hereditary pancreatitis. Herein, we present a pediatric case that highlights the pitfalls of false-positive missense variants calls in the PRSS1 gene when using NGS.

Prolonged exposure to food odors suppresses feeding via an olfactory bulb-to-hypothalamus circuit.

Olfactory perception of food odors is a key determinant of eating behavior, including triggering appetite, facilitating food seeking and influencing food choice. While transient food-related olfactory cues stimulate appetite and provoke cravings in states of hunger, emerging evidence implies that prolonged and sustained exposure to food-derived odor (FO) suppresses feeding. However, the mechanisms by which olfaction induces hypophagia remain elusive.

Bicontinuous Bilayer Metacomposites Containing Corncob-Derived Carbon and Polyaniline for Tunable Epsilon-Near-Zero and Epsilon-Negative Responses.

Metacomposites can achieve epsilon-negative (ɛ' <0, EN) and epsilon-near-zero (ɛ' ≈ 0, ENZ) responses below the GHz band, thus providing a brand-new design principle for developing meta-structure electronic components. However, its negative response presently cannot fully cover the kHz-MHz band and is thus constrained by an unclear regulation mechanism. This study offers a corncob-derived carbon/polyaniline (CC/PANI) metacomposite featuring a bicontinuous bilayer architecture to match the electromagnetic response in the frequency band of 10 kHz-45 MHz.

c-MET Inhibition Reverses the Osimertinib Resistance in Lung Circulating Tumor Cell Clusters and Suppresses Metastasis.

Background: Circulating tumor cells (CTCs) serve as the “seeds” of tumor metastasis, and the clustering of CTCs is critically associated with tumor metastasis and the mortality of lung cancer patients. Inhibiting the survival of CTC clusters represents a pivotal strategy for anti-lung cancer metastasis therapy. This study is designed to explore the impact and underlying mechanism of lung cancer CTC clusters in mediating resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), thereby offering novel insights into anti-lung cancer metastasis treatment.

[Interferon-λ1 improves glucocorticoid resistance caused by respiratory syncytial virus by regulating the p38 mitogen-activated protein kinase signaling pathway].

Objectives: To investigate the effect of interferon-λ1 (IFN-λ1) on glucocorticoid (GC) resistance in human bronchial epithelial cells (HBECs) stimulated by respiratory syncytial virus (RSV).

Methods: HBECs were divided into five groups: control, dexamethasone, IFN-λ1, RSV, and RSV+IFN-λ1. CCK-8 assay was used to measure the effect of different concentrations of IFN-λ1 on the viability of HBECs, and the sensitivity of HBECs to dexamethasone was measured in each group.

Temporal Trends and Regional Disparities in Rotavirus Vaccine Coverage for Children Under 1-Year-old in Shandong Province, China.

Background: Rotavirus vaccine is the most effective measure for preventing rotavirus-related diarrhea. The study aims to identify the coverage and trend of the rotavirus vaccine, providing insights for improving vaccination programs.

Methods: Rotavirus vaccination data from 2005 to 2024 were collected and analyzed using Joinpoint regression to identify trends and significant changes over time.