Fagopyrum esculentum polysaccharides mitigate obesity by reshaping gut microbiota and enhancing lipid metabolism in high-fat diet-fed mice.

Recent findings suggest that the gut microbiota plays a vital role in linking dietary habits to the development of obesity. Natural polysaccharides have drawn significant interest as potential candidates for preventing and managing obesity by regulating the gut microbiota. Common buckwheat (Fagopyrum esculentum Moench) polysaccharides (FEP) possess antioxidant, anti-inflammatory, and microbiota-regulating properties, yet their anti-obesity potential remains largely unexplored.

Association between the urine tobacco metabolite levels and physical health in Chinese primary school students with secondhand smoke exposure.

Background: There is limited epidemiological evidence on the association between secondhand smoke exposure and growth and developmental problems in children and adolescents. This study aimed to explore the relationship between urinary levels of nicotine, cotinine, and trans-3'-hydroxycotinine and physical health outcomes in Chinese children.

Methods: This cross-sectional study included 491 children aged 8 to 12 years from a primary school in 2023.

L. polysaccharides mitigate obesity modulation of lipid metabolism and gut microbiota in high-fat diet-fed mice.

L. polysaccharides (PEP) have been shown to ameliorate colitis through their antioxidant, anti-inflammatory, and gut microbiota-modulating properties. However, the potential of PEP in combating obesity remains unexplored.

6-Shogaol inhibits the cell motility of prostate cancer cells by suppressing the PI3K/AKT/mTOR and Ras/Raf/MAPK pathways with comparable effects to paclitaxel treatment.

Prostate cancer ranks among the top causes of cancer-related deaths in men, with a substantial number of fatalities occurring in metastatic cases. Although paclitaxel (PTX) is used as a first-line treatment, its effectiveness is hindered by side effects and drug resistance, which complicate the therapy and contribute to the progression of metastasis. Research has shown that phytochemicals can induce cancer cell death and inhibit metastasis without significantly harming normal cells, suggesting a potential alternative strategy for suppressing metastatic prostate cancer.