HDAC3 represses Nrf2-GDF11 signaling to drive chondrocyte adipogenesis in temporomandibular joint osteoarthritis.

Introduction: Aberrant biomechanical force-induced chondrocyte adipogenesis is involved in the development of temporomandibular joint osteoarthritis (TMJ OA). Growth differentiation factor 11 (GDF11) has been implicated in this process. However, whether mechanosensitive histone deacetylase 3 (HDAC3) regulates GDF11 signaling in the context of TMJ OA remains to be elucidated.

Nickel exposure aggravates aortic dissection by exacerbating neutrophil recruitment and NETosis to compromise endothelial barrier.

Nickel exposure elevates aortic dissection (AD) risk, yet its pathogenic mechanisms remain unclear. Here, we demonstrate that nickel accelerates AD progression, particularly in hypertensive individuals. Bioinformatics analysis of GEO datasets identified chemokine-mediated endothelial-neutrophil crosstalk as a key pathway.

Flash and ultrasound-assisted extraction of polysaccharides from Lyophyllum decastes and evaluation of their fecal fermentation characteristics.

The extraction methods of polysaccharides significantly affect their characteristics and functional properties. However, the impact of flash extraction and ultrasound-assisted extraction on the physicochemical properties and prebiotic effect of Lyophyllum decastes polysaccharides remains poorly understood. In this study, polysaccharides from Lyophyllum decastes were extracted using ultrasound-assisted and flash extraction methods, yielding the fractions LDP-R and LDP-S after purification, respectively.

Exosomal LncRNA MALAT1 Derived from Hepatocytes in Nonalcoholic Fatty Liver Disease Regulates the miR-579-3p/Keap1/Nrf2 Pathway to Exacerbate Obstructive Sleep Apnea Syndrome.

Background And Objective: Obstructive sleep apnea syndrome (OSAS) is a common sleep breathing disorder, and nonalcoholic fatty liver disease (NAFLD) may affect OSAS. This study aimed to explore the influence of exosomes (Exos) derived from liver cells in NAFLD on the progression of OSAS and the underlying molecular mechanisms.

Methods: C57BL/6J mice were exposed to chronic intermittent hypoxia (CIH) to establish an OSAS animal model, and SH-SY5Y cells treated with CIH were used as the in vitro cellular model.

Dynamic Profiling of Lipoteichoic Acid (LTA) and/or Lipopolysaccharide (LPS) Positive Extracellular Vesicles in Plasma as Diagnostic and Prognostic Biomarkers for Bacterial Infection.

Bacterial extracellular vesicles (EVs) are emerging as promising biomarkers for diagnosing bacterial infections. This study explores the diagnostic potential of plasma EVs carrying bacterial lipopolysaccharide (LPS) or lipoteichoic acid (LTA). Using immunoelectron microscopy (IEM) and nanoflow cytometry (nano-FCM), LTA is confirmed on cytoplasmic membrane vesicles (CMVs) from Gram-positive bacteria and LPS on outer membrane vesicles (OMVs) from Gram-negative bacteria, and quantified LTA-positive or LPS-positive (LTA/LPS) EVs in plasma.

Ionic strength effects on rheology, microstructure, and properties of diacylglycerol-based high internal phase Pickering emulsion-myofibrillar protein gels.

This study examined the effects of various ionic strengths (0, 0.1, 0.3, and 0.

Bilateral breast metastases from rectal malignant melanoma: case report and literature review.

Rectal melanoma is an extremely rare and highly aggressive disease, and rectal melanoma metastasis to the breast is rare. This is a 48-year-old female who presented with rectal melanoma carcinoma Following the diagnosis of locally advanced rectal cancer (TxN3M0), she received chemotherapy, immunotherapy with radiotherapy, and metastases to the lung, bone and vulvar developed during the therapy. After one year of treatment, the patient developed bilateral breast metastases.

Unveiling the enigma of anxiety disorders and depression: from pathogenesis to treatment.

Anxiety disorders and depression are among the most prevalent and disabling mental health conditions globally, profoundly impairing both individual well-being and societal functioning. Recent research has elucidated key neurobiological underpinnings of these disorders, including neurotransmitter imbalances, dysregulation of stress response systems, and dysfunctions within neural circuits governing emotion regulation. These insights offer significant potential for refining diagnostic approaches, enhancing prevention strategies, and improving therapeutic interventions.

Turbulent Flow-Driven Synthesis of Graphene-Skinned Boron Nitride Heterostructures for Dendrite-Free Potassium Metal Batteries.

Potassium metal batteries are considered as promising candidates for next-generation energy storage systems. However, their practical development is hindered by the insufficient capacity output and persistent dendritic proliferation at the anode side. Here graphene-skinned hexagonal boron nitride powder is demonstrated synthesized via fluidized bed-chemical vapor deposition, realizing conformal growth of layer-controlled graphene (5-90 layers) over h-BN with atomically coupled heterointerfaces.

Latent profile analysis of empathy for pain and its associations with coping styles among nurses in China.

Objectives: This study sought to evaluate the prevalence of empathy for pain among nurses in Chinese hospitals through latent profile analysis, identify latent subgroups and their demographic characteristics and examine the relationship between different subgroups and coping styles.

Design: A multicentre cross-sectional study.

Setting: The study was conducted in 43 hospitals across Guangdong Province, China, comprising 36 general medical hospitals and 7 specialty hospitals.

TASK2-Inspired pH-Gating Polymeric Nanochannels with Multiple Interconvertible Permeability States by Synergistic Regulation of Conformation and Charge.

Biological ion channels can regulate finely the ion transmembrane permeation, with superhigh ion selectivity and on-off ion flux in response to external stimuli, for signal transduction and energy conversion. However, fabricating smart artificial nanochannels with analogous functions remain challenging by single design of structure or charge property. In vivo, function basis of pH-gated TWIK-related acid-sensitive K channel 2 (TASK2) channels is attributed to synergy control of geometrical conformation and surface potential for filter gates.

Zooplankton community structure and its influencing factors in the Henan section of the Yellow River.

We conducted a sampling survey of zooplankton at typical sections (mainstream, tributaries, and reservoirs) of Henan section of the Yellow River in July 2021, and analyzed the zooplankton community structure and key influencing factors. The results showed that a total of 32 genera and 47 species of zooplankton were recorded, with the density ranging from 0.4 ind·L to 612.

Assessment of surgical precision and safety in oncoplastic breast-conserving surgery for breast cancer under the guidance of imaging.

Background: Oncoplastic breast-conserving surgery (OBCS) has become an essential component of breast cancer treatment. Imaging guidance in breast surgery has the potential to enhance surgical precision. Despite increasing recognition, a comprehensive evaluation of its specific impact on OBCS for breast cancer is needed.

Shared and distinct alterations of thalamic subregional functional connectivity in early- and late-onset obsessive-compulsive disorder.

Background: Studies highlight the thalamus as a key region distinguishing early- from late-onset obsessive-compulsive disorder (OCD). While structural thalamic correlates with OCD onset age are well-studied, resting-state functional connectivity (rsFC) remains largely unexplored. This study examines thalamic subregional rsFC to elucidate pathophysiological differences in OCD based on different onset times.

A Comprehensive Review on Physical Modifications of Plant Proteins: Mechanism, Influencing Factors, Structural and Functional Properties.

Plant proteins have received increasing attention from food researchers with the growing demand for plant proteins and the emphasis on healthy food and "clean labeling". However, due to their complex and dense structure and greater susceptibility to external factors, plant proteins exhibit poor functional properties, which are not conducive to processing and application in the food industry. Currently, physical modifications of plant proteins have been increasingly reported to improve their functional properties.

A Pseudomonas aeruginosa endolytic muramidase targets cell-wall peptidoglycan in bacterial competition.

Pseudomonas aeruginosa is an opportunistic pathogen that frequently resides in multispecies communities. During chronic infections, P. aeruginosa employs a diverse arsenal of antibacterial weapons to complete with other bacteria for resources and space.

Characterization of Lactococcus lactis ZB1 from traditional fermented bacon: Genomic insights and antifungal potential for food preservation.

Lactococcus lactis strains from traditional fermented foods are important sources of both probiotic candidates and natural biopreservatives. In this study, L. lactis ZB1, isolated from Zhenba bacon (Shaanxi, China), was comprehensively characterized for its genomic features and antifungal activity.

Incidence, Risk Factors, and Prediction Model of Parastomal Hernia After Abdominoperineal Resection for Rectal Cancer.

Background: Parastomal hernia (PSH) is a frequent complication of abdominoperineal resection (APR), yet large-scale studies characterizing its long-term incidence and tools for individualized risk stratification remain lacking. To determine the long-term incidence, independent risk factors, and develop a clinical prediction model for PSH after APR in rectal cancer patients.

Methods: We conducted a retrospective cohort study of 836 patients with rectal adenocarcinoma who underwent APR and permanent end colostomy at a high-volume tertiary center (2014-2018).

Isolation, Identification, and Antitumor Activities of Glucosinolates and Isothiocyanates in Chinese Cabbage Seeds.

Isothiocyanates (ITCs), which are derivatives of glucosinolates (GSLs) from plants, have been investigated as anticancer agents. An extensively studied anticancer ITC is sulforaphane, which is found in low amounts in Chinese cabbage. We aim to investigate the types and content of GSLs (precursors of ITCs with anticancer activity) in Chinese cabbage seeds.

Excitation-inhibition imbalance in the motor control network: a key factor in post-stroke spasticity.

Spasticity is a recognized motor dysfunction that frequently arises following a stroke and significantly impacts the quality of life of affected patients. It is characterized by involuntary muscle activation resulting from overexcitation of the stretch reflex. Currently, therapeutic options for post-stroke spasticity are limited, and the underlying pathological mechanisms remain inadequately understood.

Characteristics, traditional uses, chemistry, pharmacology, and clinical trials of Olibanum (Ru Xiang): A critical review.

Ethnopharmacological Relevance: Olibanum, a precious traditional Chinese medicine, has been utilized in China for millennia. It has historically been used to treat various pain disorders caused by qi stagnation and blood stasis, such as rheumatic arthralgia, chronic abdominal pain, gastric pain, and angina pectoris, as well as intestinal abscess, deafness, and insomnia.

Aim Of The Study: Dedicated to evaluating the current research status of Olibanum, encompassing traditional medicinal uses, chemical composition, pharmacological effects, clinical trials, and safety assessments, to comprehensively understand its development progress and provide guidance for future research directions.

Microorganism-derived biogenic amine degrading enzymes: mechanisms, molecular modifications, and applications in fermented foods.

Biogenic amines (BAs) threaten food safety and quality. Microorganism-derived BA-degrading enzymes, prized for safety and efficiency, enable BA oxidative degradation in fermented foods. Despite extensive research on enzyme characterization and modification, translating these findings to real fermented food systems for BA reduction remains elusive.

Enhanced Single-Molecule Imaging via Intersystem Crossing Suppression.

The red-emitting cyanine dye Cy5 is widely used in single-molecule imaging, but its utility is limited by triplet-state accumulation. This state facilitates energy transfer to molecular oxygen, producing reactive oxygen species (ROS) that lead to photobleaching. The triplet state also causes the dye's fluorescence intermittency and introduces temporal noise.

Multiple stressors enhance Microcystis dominance and modulate phycospheric antibiotic resistome in aquatic mesocosm.

Assessing the response of phycospheric antibiotic resistance genes (ARGs) to pollutants such as antibiotics and microplastics (MPs) under the background of climate warming is crucial for understanding ARG fate in aquatic ecosystems. In this work, we conducted mesocosm experiments to evaluate how these stressors influence phytoplankton dominance, phycospheric bacteria, and ARG evolution. Results showed that in Microcystis-dominant ecosystem, a single stressor strengthened Microcystis dominance (up to 82.

mutations cause high myopia by triggering PI3K-AKT and NF-κB-mediated signaling pathway in humans and mice.

High myopia (HM) is a severe form of refractive error that results in irreversible visual impairment and even blindness. However, the genetic and pathological mechanisms underlying this condition are not yet fully understood. From a cohort of 1015 patients with HM in adolescents, likely pathogenic missense mutations were identified in the gene in four patients by whole exome sequencing.