Intracerebral Hemorrhage: An Acute Manifestation of Small Vessel Disease?

Although intracerebral hemorrhage (ICH) and cerebral small vessel disease (cSVD) have long been considered distinct clinical entities, emerging evidence reveals significant overlap in their etiologies and imaging markers. This review aims to explore the relationship between ICH and cSVD, suggesting that ICH may represent an acute manifestation of small vessel disease. ICH is primarily caused by cerebral amyloid angiopathy and hypertension, while cSVD is mainly attributed to cerebral amyloid angiopathy and arteriolosclerosis.

Assessment of synergy-assisted EMG-driven NMSK model for upper limb muscle activation prediction in cross-country sit-skiing double poling.

Introduction: Cross-country sit-skiers are often individuals with spinal cord injuries, cerebral palsy, or lower limb disabilities, relying heavily on upper limb strength to generate propulsion during skiing. However, frequent shoulder joint movements significantly increase the incidence of shoulder joint disorders. Therefore, quantifying muscle forces during movement is crucial for understanding upper limb force generation patterns.

Tailoring the nanoscale morphology of calcium silicate hydrate for low-cost direct air carbon capture and storage.

The greenhouse effect, which affects ecosystems, weather patterns, and global temperatures, has been exacerbated by the increase in air concentrations resulting from the expansion. Direct air capture is a critical component of the strategy to combat climate change and is also essential for carbon capture, utilization, and storage, however, they are currently prohibitively expensive for practical applications, which underscores the necessity of selecting a low-cost material that has exceptional carbon capture efficacy. Considering their straightforward and economical production processes, cementitious materials are recognized as potential candidates.

MYH2-associated myopathy caused by novel compound heterozygous mutations: a case report and literature review.

MYH2-associated myopathy is a group of congenital heterogeneous diseases. Case reports with MYH2-associated myopathy due to compound heterozygous mutations are rare. We report a 63-year-old Asian female who presented with bilateral ptosis and limb weakness for over 10 years.

Unveiling exosomes in combating skin aging: insights into resources, mechanisms and challenges.

Skin ageing is a multifactorial process influenced by both intrinsic (genetic and metabolic) and extrinsic (environmental) factors, leading to noticeable changes such as wrinkles, loss of elasticity, and pigmentation disorders. Recent advancements in regenerative medicine have highlighted the potential of exosomes, small extracellular vesicles, in mediating cellular communication and promoting rejuvenation processes in skin tissues. Exosomes are secreted by various cell types and are rich in bioactive molecules such as proteins, lipids, and nucleic acids, which are crucial for modulating physiological responses.

Efficacy and Safety of Sarecycline in Chinese Patients with Moderate-to-Severe Acne Vulgaris: Randomized Phase 3 Clinical Trial with Open-Label Follow-Up.

Introduction: This study aimed to evaluate the efficacy and safety of sarecycline in Chinese patients with moderate-to-severe acne vulgaris (AV).

Methods: The 12-week (W) randomized, multicenter, double-blind (DB), placebo-controlled phase 3 trial was conducted from 29 October 2021 to 14 October 2022 at 34 centers in China, with a 36W open-label follow-up (OLFU) until 23 June 2023 for patients who responded to treatment during the DB period. Patients aged 9-45 years with AV were randomized (2:1) to sarecycline (approximately 1.

Characteristics, traditional uses, chemistry, pharmacology, and clinical trials of Olibanum (Ru Xiang): A critical review.

Ethnopharmacological Relevance: Olibanum, a precious traditional Chinese medicine, has been utilized in China for millennia. It has historically been used to treat various pain disorders caused by qi stagnation and blood stasis, such as rheumatic arthralgia, chronic abdominal pain, gastric pain, and angina pectoris, as well as intestinal abscess, deafness, and insomnia.

Aim Of The Study: Dedicated to evaluating the current research status of Olibanum, encompassing traditional medicinal uses, chemical composition, pharmacological effects, clinical trials, and safety assessments, to comprehensively understand its development progress and provide guidance for future research directions.

Intracranial Artery Calcification Relates to Brain Damage and Clinical Outcomes in Patients Receiving Intravenous Thrombolysis.

Aim: Intracranial artery calcification (IAC) in patients with acute ischemic stroke may cause cerebral hemodynamic injury and aggravate ischemia-reperfusion injury. However, its relationship with brain damage and clinical outcomes has not yet been fully explored.

Methods: Patients with acute anterior circulation ischemic stroke who underwent intravenous thrombolysis (IVT) were enrolled.

An emerging PB2-627 polymorphism increases the zoonotic risk of avian influenza virus by overcoming ANP32 host restriction in mammalian and avian hosts.

Alterations in the PB2-627 domain of avian influenza virus (AIV) can potentially increase the risk of cross-host species infections in humans and mammals. Recently, there has been a rise in human cases of AIV infections without the presence of the known mammalian determinant PB2-E627K. Here, we identified a variant, PB2-627V, which has evolved in poultry and has contributed to the increase in human AIV infections.

Engineered bilayer interfacial protection for stable aluminum metal anodes in aqueous batteries.

Aqueous aluminum-ion batteries (AAIBs) have emerged as a promising energy storage technology due to their high energy density and the natural abundance of Al resources. However, the practical application of Al metal anodes is hindered by persistent challenges, including hydrogen evolution, corrosion, and passivation. To address these issues, we developed a bilayer artificial protective interface on the Al metal surface by combining a physically blade-coated activated carbon (AC) layer with an electrochemically deposited indium (In) particle layer.

Fluorescent Tetraphenylethylene-Based Europium Metal-Organic Framework for White-Light-Emitting Diodes.

A luminescent europium-based metal-organic framework (Eu-MOF), designated as , has been synthesized. This MOF employs a tetraphenylethylene derivative ligand that exhibits aggregation-induced emission (AIE) characteristics. Comprehensive structural analyses reveal that crystallizes in the orthorhombic system and boasts remarkable thermal stability.

Interpersonal brain synchronization during sensorimotor synchronization in people with different aerobic fitness levels: A fNIRS-based hyperscanning study.

Sensorimotor synchronization (SMS) refers to the temporal coordination of individual actions with perceptible external events and rhythms. Previous research has revealed a potential relationship between SMS abilities and physical activity, with proposed links to underlying inner-brain cognitive processes. However, it needs to be explored that whether good aerobic fitness will have a strong SMS ability, its internal mechanism, and the inter-brain mechanism.

3'-C-Extended TNA: De Novo Synthesis, Enhanced Exonuclease Resistance, and Functional siRNA 3'-Overhang Modifications Without Compromising Gene Silencing.

The 3'-overhang of siRNAs is crucial for RISC assembly and stability, yet it is susceptible to nuclease degradation, significantly limiting its therapeutic applications. To address this challenge, we developed 3'-C-extended threose nucleic acid (TNA) analogs (ApioNA and BpioNA) using an asymmetric aldol synthesis strategy. Our results demonstrate that the BpioNA modification provides exceptional nuclease resistance, exhibiting a 60-fold increase in half-life compared to dT, while maintaining full gene silencing activity.

Epidemiology, Clinical Features, and Molecular Basis of TTMV::RARA-driven Acute Promyelocytic Leukemia.

Integration of torque teno mini virus (TTMV) generating the TTMV::RARA fusion represents a newly recognized subtype of acute promyelocytic leukemia (APL) that merits detailed investigation. We present the first comprehensive characterization of its epidemiologic profile, clinical presentation, virologic characteristics, and underlying molecular mechanisms. Our findings indicate that TTMV::RARA is more prevalent in pediatric patients and represents the second most common retinoic acid receptor fusion after PML::RARA.

Cadmium Inhibits Proliferation of Human Bronchial Epithelial BEAS-2B Cells Through Inducing Ferroptosis via Targeted Regulation of the Nrf2/SLC7A11/GPX4 Pathway.

Cadmium (Cd)-induced pulmonary toxicity is closely associated with ferroptosis, a regulated form of cell death characterized by iron-dependent lipid peroxidation (LPO). Luteolin (Lut) is a natural flavonoid compound that exists in many plants. In this study, we used human bronchial epithelial BEAS-2B cells to explore the impact of ferroptosis in the inhibition of Cd-induced BEAS-2B cells proliferation.

Tunable photonic spin Hall effect in the Weyl semimetals.

Time-reversal symmetry-breaking Weyl semimetals (WSMs) exhibit an interesting optical response in the mid-infrared band, offering what we believe to be a novel approach to study the manipulation of the photonic spin Hall effect (PSHE). This article theoretically investigates the PSHE phenomenon in a prism-coupled structure composed of the WSMs. It is found that the excitation of surface plasmon polaritons (SPPs) and the nonreciprocity inherent in WSMs have a positive effect on enhancing the PSHE phenomenon of the reflected light.

1.5 GHz non-invasive directional deep brain stimulation with improved focus size and minimized input power.

Temporal interference stimulation (TIS) has recently been introduced for non-invasive deep brain stimulation (NDBS). While numerous studies have highlighted its advantages over conventional technologies, TIS still encounters challenges such as limited resolution and a lack of validation using human-like models. This article introduces an innovative method for NDBS which alleviates the resolution limit.

Infrared stray radiation analysis for antireflective film coated on an optical window.

Antireflective films are extensively employed in optical detection systems to provide protection, increase signal transmittance, and suppress infrared (IR) stray radiation on optical windows. Drawing on thin film optical theory, several types of antireflective films are presented, and their optical properties are modeled. Additionally, directional spectral reflectivity at the interface between the film and the optical window is determined.

Morphological, Molecular and Phylogenetic Characterization of Auerbachia megacapsula n. sp. (Myxozoa: Coccomyxidae) from Larimichthys crocea Richardson, 1846.

Purpose: This study describes a novel myxosporean species, Auerbachia megacapsula n. sp., isolated from the gallbladders of Larimichthys crocea Richardson, 1846 from the South China Sea.

COFs, MOFs, HOFs, SOFs and XOFs: commonalities and differences.

Organic framework materials have gained attention for their intriguing structures, diverse applications, and porous materials with open frameworks. Over the past two decades, significant advancements have been made in the development and utilization of these materials across various fields, including adsorption, separation, sensing, energy storage, drug delivery, photovoltaics, and catalysis. This review focuses on covalent organic frameworks (COFs), metal-organic frameworks (MOFs), hydrogen-bonded organic frameworks (HOFs), supramolecular organic frameworks (SOFs), and halogen-bonded organic frameworks (XOFs) and underscoring the advancements in their respective fields of research.

Investigating the prevalence of medication near-misses and reporting intention among nurses in tertiary hospitals from China.

Background: Globally, medication near-misses are a public health issue as they often have serious consequences for patients and healthcare systems. Currently, few studies have investigated nurses' intention to report medication near-misses. Therefore, this study aims to examine the incidence of medication near-misses and factors influencing reporting intention among nurses in tertiary hospitals in Shandong Province, to fill the research gap in this area.

Small-world network properties and cortical responses of Tai Chi Yunshou: Insights from fNIRS.

Objective: This study aims to characterize the time-domain features and functional network properties from Tai Chi Yunshou across four states (rest, observation, imagination, and motion) using functional near-infrared spectroscopy (fNIRS), thereby discriminating the neural mechanisms underlying the mental regulation and integrative body-mind harmony of Tai Chi Yunshou.

Methods: 100 healthy participants were included and administered with rest, observation, imagination and motion states of Tai Chi Yunshou. The forty-channel wearable fNIRS system was utilized to evaluate the real-time cortical responses during four states.

Phytol enhances catalase-dependent ethanol metabolism in liver independent of PPARα.

There is an interaction between peroxisomal fatty acid β-oxidation and catalase-dependent ethanol metabolism. HO is essential for catalase to metabolize ethanol. Peroxisomal fatty acid β-oxidation rate limiting enzyme is acyl-CoA oxidase (ACOX), which generates HO for catalase to metabolize ethanol.

Araloside A Induces Raf/MEK/ERK-Dependent Autophagy to Mitigate Alzheimer's and Parkinson's Pathology in Cellular and C. elegans Models.

Alzheimer's disease (AD) and Parkinson's disease (PD) are characterized by pathological protein aggregation and oxidative stress, leading to progressive neurodegeneration. Enhancing autophagy, the primary intracellular pathway for clearing misfolded proteins, represents a promising therapeutic strategy. In this study, we identify Araloside A (ARA), a triterpenoid saponin derived from Aralia elata, as a potent autophagy inducer that alleviates AD- and PD-related pathology.