Fluorescent Tetraphenylethylene-Based Europium Metal-Organic Framework for White-Light-Emitting Diodes.

A luminescent europium-based metal-organic framework (Eu-MOF), designated as , has been synthesized. This MOF employs a tetraphenylethylene derivative ligand that exhibits aggregation-induced emission (AIE) characteristics. Comprehensive structural analyses reveal that crystallizes in the orthorhombic system and boasts remarkable thermal stability.

Interface-Targeting Integrated Sandwich-Structured NaZrSiPO Composite Electrolyte for Ultra-Long Cycle Life Sodium Metal Batteries.

NaZrSiPO (NZSP) has stimulated considerable attention due to its remarkable ionic conductivity and exceptional chemical/electrochemical stability. However, an unstable electrolyte/electrode interface and large interface resistance severely restricted its practical application. To settle this issue, an interface-targeting integrated sandwich-like NZSP composite electrolyte was constructed by designing an artificial interface layer on both the anode and cathode sides.

Comparative outcomes of polymyxins in neurocritical care patients with carbapenem-resistant Gram-negative bacterial pneumonia: a retrospective cohort study.

Objectives: The spread of carbapenem-resistant Gram-negative bacteria (CR-GNB) related to nosocomial infections is an important public health challenge, and polymyxins have become the last line of defence against CR-GNB. In this study, we aimed to compare the efficacy and safety of different polymyxins.

Methods: This retrospective cohort study included neurocritical care patients with CR-GNB pneumonia.

Hypomyelination in autism-associated neuroligin-3 mutant mice impairs parvalbumin interneuron excitability, gamma oscillations, and sensory discrimination.

Whether and how myelin plasticity, an emerging new form of brain plasticity, is involved in autism spectrum disorder (ASD) remains unknown. Here, we identify deficits in oligodendrocyte (OL) generation and myelination in the barrel cortex (BC) of the male NL3-R451C-KI mouse model of ASD. These mice also show impaired texture recognition, disrupted gamma neuronal oscillations, and reduced excitability and myelination level in the BC-PV interneuron.

Use of GLP-1 receptor agonist and risk of osteoporosis among patients with type 2 diabetes: a real-world study.

Background: Type 2 diabetes mellitus (T2DM) is an independent risk factor for osteoporosis, increasing the risk of fractures and poor prognosis. Recent studies suggest that glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may play a protective role in bone metabolism. However, limited evidence exists on their effect on osteoporosis incidence in T2DM patients.

Oligodendrogenesis in Evolution, Development and Adulthood.

Oligodendrogenesis and myelin formation are important processes in the central nervous system (CNS) of jawed vertebrates, underpinning the highly efficient neural computation within the compact CNS architecture. Myelin, the dense lipid sheath wrapped around axons, enables rapid signal transmission and modulation of neural circuits. Oligodendrocytes are generated from oligodendrocyte precursor cells (OPCs), which are widely distributed in the adult CNS and continue to produce new oligodendrocytes throughout life.

Biochemical characterization and mucosal immune function of IgT in grass carp (Ctenopharyngodon idella).

Immunoglobulin T (IgT) is a teleost-specific immunoglobulin discovered to be specialized in mucosal immunity. For fish that live in water throughout their lives, eliciting a local mucosal immune response through immersion immunization is an important and highly suitable way for preventing fish diseases. However, due to the lack of corresponding antibodies against IgT, studies on its immune responses to pathogens and vaccines in commercial fish have largely been limited to rainbow trout.

Covalently reactive microparticles imbibe blood to form fortified clots for rapid hemostasis and prevention of rebleeding.

Owing to the inherently gradual nature of coagulation, the body fails in covalently crosslinking to stabilize clots rapidly, even with the aid of topical hemostats, thus inducing hemostatic failure and potential rebleeding. Although recently developed adhesives confer sealing bleeding sites independently of coagulation, interfacial blood hampers their adhesion and practical applications. Here, we report a covalently reactive hemostat based on blood-imbibing and -crosslinking microparticles.

Elucidating molecular lipid perturbations in trigeminal neuralgia using cerebrospinal fluid lipidomics.

Trigeminal neuralgia (TN) is a neuropathic facial pain disorder characterized by severe stabbing pain along the trigeminal nerve. While its pathogenesis remains unclear, nerve demyelination and inflammation are likely involved. Current research has primarily focused on various blood-based omics approaches, which do not fully capture the lipid alterations occurring during TN progression in brain.

Wu-Mei-Wan promotes ferroptosis in gallbladder cancer through STAT3 negative regulation: An integrated HPLC, proteomics, network pharmacology, and experimental validation study.

Ethnopharmacological Relevance: As a traditional Chinese medicine, Wu-Mei-Wan (WMW) has shown promise as a second-line treatment for gallbladder cancer, but its mechanism remains to be explored.

Aim Of The Study: To determine the specific mechanism of WMW active ingredients (Palmatine et al.) inducing ferroptosis in gallbladder cancer (GBC) and its synergistic potential with gemcitabine.

Rpl12 is a conserved ribophagy receptor.

Ribophagy is a selective autophagic process that regulates ribosome turnover. Although NUFIP1 has been identified as a mammalian receptor for ribophagy, its homologues do not exist in yeast and nematodes. Here we demonstrate that Rpl12, a ribosomal large subunit protein, functions as a conserved ribophagy receptor in multiple organisms.

Difluorocarbene-Mediated Trimethylsilylation of Nucleophiles with HCFN(TMS) as a Silylation Reagent.

Described herein is the trimethylsilylation of various nucleophiles using a combination of HCF and NaHMDS. This facile protocol enables the rapid construction of alkynylsilanes, silyl enol ethers, etc., under mild conditions.

Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson's disease via the prosaposin-GPR37-IL-6 axis.

Parkinson's disease (PD) is a common neurodegenerative disease and is difficult to treat due to its elusive mechanisms. Recent studies have identified a striking association between oligodendrocytes and PD progression, yet how oligodendrocytes regulate the pathogenesis of PD is still unknown. Here, we show that G-protein-coupled receptor 37 (GPR37) is upregulated in oligodendrocytes of the substantia nigra and that prosaposin (PSAP) secretion is increased in parkinsonian mice.

[Legacy Effects of Long-term Straw Returning on Straw Degradation and Microbial Communities of the Aftercrop].

Straw incorporation can improve soil fertility and soil structure. While numerous studies have explored the immediate impacts of straw return on soil properties and crop production, the legacy effects of long-term straw return remain less understood. In this study, the straw returning soil of a continuous 15 years （SS） and non-straw returning soil （NS） were collected from Dahe Experimental Station of Hebei Academy of Agriculture and Forestry Sciences in China.

A Lithiophilic Donor-Acceptor Polymer Modified Separator for High-Performance Lithium Metal Batteries.

As traditional lithium-ion batteries near their theoretical limits, the advancement of lithium-metal batteries (LMBs) becomes crucial for achieving higher energy densities. However, uncontrolled ion transport and unstable solid electrolyte interface (SEI) layer are key factors inducing lithium dendrite growth, hindering the development of LMBs. Separator modification is an effective strategy to address the challenges of LMBs.

Self-Template Construction of Hierarchical Bi@C Microspheres as Competitive Wide Temperature-Operating Anodes for Superior Sodium-Ion Batteries.

Huge volume changes of bismuth (Bi) anode leading to rapid capacity hindered its practical application in sodium-ion batteries (SIBs). Herein, porous Bi@C (P-Bi@C) microspheres consisting of self-assembled Bi nanosheets and carbon shells were constructed via a hydrothermal method combined with a carbothermic reduction. The optimized P-Bi@C-700 (annealed at 700 °C) demonstrates 359.

Visualizing ER-phagy and ER architecture in vivo.

ER-phagy is an evolutionarily conserved mechanism crucial for maintaining cellular homeostasis. However, significant gaps persist in our understanding of how ER-phagy and the ER network vary across cell subtypes, tissues, and organs. Furthermore, the pathophysiological relevance of ER-phagy remains poorly elucidated.

Targeting resident astrocytes attenuates neuropathic pain after spinal cord injury.

Astrocytes derive from different lineages and play a critical role in neuropathic pain after spinal cord injury (SCI). Whether selectively eliminating these main origins of astrocytes in lumbar enlargement could attenuate SCI-induced neuropathic pain remains unclear. Through transgenic mice injected with an adeno-associated virus vector and diphtheria toxin, astrocytes in lumbar enlargement were lineage traced, targeted, and selectively eliminated.

Fluorescent Tetraphenylethylene-Based Cerium Metal-Organic Frameworks for White-Light-Emitting Diodes.

Discovery of highly efficient and thermal stable phosphors is the focus of the studies in phosphor-converted white light-emitting diodes (LEDs). Herein, a tetraphenylethylene-based cerium metal-organic framework () was synthesized and characterized. The intricate architecture of shows an overall 3D → 3D 2-fold interpenetration framework.

A Novel Mitochondrial-Related Gene Signature for the Prediction of Prognosis and Therapeutic Efficacy in Lower-Grade Glioma.

Lower-grade glioma (LGG) is a common primary brain tumor with a highly heterogeneous clinical presentation, and its prognosis cannot be accurately predicted by current histopathology. It has been found that mitochondria play an important role in hypoxia, angiogenesis, and energy metabolism in glioma, and mitochondrial function may have an important impact on LGG prognosis. The goal of this study was to develop a novel prognostic model based on Mitochondrial-related genes (MRGs).

High-speed reflectance confocal microscopy using speckle modulation.

We developed a spectrally-encoded, line reflectance confocal microscope (RCM) that uses a rotating diffuser to rapidly modulate the illumination speckle pattern. The speckle modulation approach reduced speckle noise while imaging with a spatially coherent light source needed for high imaging speed and cellular resolution. The speckle-modulation RCM device achieved lateral and axial resolutions of 1.