Design of lightweight neural network model for provenance discrimination of Lycium barbarum based on hyperspectral imaging technology.

The study aimed to build a lightweight neural network model for Lycium barbarum provenance discrimination using hyperspectral imaging technology. Firstly, hyperspectral images (336.2-1038.

KIAA1429 Silencing ameliorates osteosarcoma progression through promoting ferroptosis via Nrf2/NQO1 axis.

Background: Osteosarcoma (OS) is the most common primary malignant bone tumor. Recent insights into ferroptosis have opened new avenues for OS therapy. However, the role of KIAA1429 in regulating ferroptosis and its underlying mechanisms in OS remain unclear.

A General Strategy to Develop Highly Sensitive FAPα Fluorescent Probes for Invasive Cancer Detection.

Fibroblast activation protein α (FAPα) has been reported to be expressed in many carcinoma cells and associated with tumor growth, invasive, and metastasis. However, due to the lack of appropriate fluorescent probes, detecting FAPα with high sensitivity in tumor and clearly delineating tumor margins remains a challenge. Herein, we developed a general design strategy-introducing a positive charge into the fluorophore skeleton-for the construction of FAPα-activated fluorescent probe with enhanced sensitivity.

Biomimetic anlotinib-loaded FePc-silicate nanoparticles for sonodynamic and immunotherapy in non-small cell lung cancer via dual PD-L1 modulation.

Non-small cell lung cancer (NSCLC) accounts for approximately 85 % of all lung cancer cases, in urgent need for multimodal therapeutic strategies. Sonodynamic therapy (SDT) has recently emerged as a promising non-invasive strategy. Programmed death-ligand 1 (PD-L1) antibody represented immunotherapy has shown limited efficacy due to inadequate tumor accumulation and persistent intracellular PD-L1 signaling.

Small-world network properties and cortical responses of Tai Chi Yunshou: Insights from fNIRS.

Objective: This study aims to characterize the time-domain features and functional network properties from Tai Chi Yunshou across four states (rest, observation, imagination, and motion) using functional near-infrared spectroscopy (fNIRS), thereby discriminating the neural mechanisms underlying the mental regulation and integrative body-mind harmony of Tai Chi Yunshou.

Methods: 100 healthy participants were included and administered with rest, observation, imagination and motion states of Tai Chi Yunshou. The forty-channel wearable fNIRS system was utilized to evaluate the real-time cortical responses during four states.

Three-Dimensional Flower Multiphase Interface CuBiS/CuS/BiS for Efficient Electromagnetic Wave Absorption.

Metal sulfide composites present an opportunity to construct efficient electromagnetic wave (EMW) absorbing materials, owing to their tunable structure and excellent dielectric properties. This research presents the successful preparation of CuBiS/CuS/BiS (CSB) composites with a three-dimensional flower-like structure using a two-step microwave method. CuS with high conductivity was added to the BiS-based composite material to optimize impedance matching and regulate conductivity.

A Novel GLP-1 and FGF21 Fusion Protein for the Treatment of Non-alcoholic Steatohepatitis (NASH).

Purpose: The objective of this study was to develop and produce a novel fusion protein that combines GLP-1 (glucagon-like peptide-1) and FGF21 (fibroblast growth factor 21), with the aim of achieving synergistic pharmacological effects through the targeting of dual pathways, followed by validation of these effects in a non-alcoholic steatohepatitis (NASH) model.

Methods: We utilized C57Bl/6J mice to establish a high-fat diet (HFD)/CCl NASH model, with the aim of assessing the drug efficacy across low, medium, and high (0.3, 1, 3 mpk) dose groups administered twice a week for 28 days.

Impact of IK Channel on CD34 Cells in Angiotensin II-Induced Arteriole Remodeling of Hypertensive Mice.

Background: Mechanisms of endothelial repair in hypertension remain unclear. CD34 cells are reported to contribute to vascular regeneration; however, their origin and regulation in hypertension are poorly understood. We investigated the role of IK channels in CD34 cell-mediated endothelial repair during Ang II (angiotensin II)-induced arteriole remodeling.

Microwave-Driven Dielectric-Magnetic Regulation of Graphite@α-MnO Toward Enhanced Electromagnetic Wave Absorption.

The advancement of wireless communication technologies necessitates materials that absorb electromagnetic waves and shield against electromagnetic interference. The research is propelled by the necessity to develop materials that possess both properties. Here, an electromagnetic wave-absorbing material that synergistically regulates dielectric and magnetic properties is developed.

Acetylcholine from tuft cells promotes M2 macrophages polarization in Hirschsprung-associated enterocolitis.

Background: Hirschsprung-associated enterocolitis (HAEC) is one of the most severe complications in patients with Hirschsprung's disease (HSCR). Previous research has indicated that acetylcholine (ACH) plays an anti-inflammatory role during inflammation by acting on the α7 nicotinic acetylcholine receptor(α7nAchR) to promote the secretion of anti-inflammatory factors. However, the specific role of ACH in HAEC remains unclear.

Prophylactic application of sodium new houttuyfonate to regulate macrophage activation and antifungal infection in intra-abdominal candidiasis model mice.

The abuse of immunosuppressants causes damage to the immune system, while the pathological proliferation and translocation of symbiotic Candida albicans can result in abdominal infection in immunocompromised people. In this study, we established a mouse peritoneal C. albicans infection model and investigated the effects of preventive application of Sodium New Houttuyfonate (SNH) by analyzing the proportion of immune cells, polarization of peritoneal macrophages, changes in fungal tissue load, and histology, and the data showed prophylactic SNH administration yields a double anti-infection effect in phagocytosis and regulation of immunity according to the immune inflammatory states of the body.

Apoprotein Intermolecular Interactions and Heme Insertion for 3D Domain Swapping in Myoglobin.

Many proteins, including heme proteins undergo three-dimensional domain swapping (3D-DS). The loop between E and F helices is converted to a helical structure in the myoglobin (Mb) 3D-DS dimer. However, the relationship between 3D-DS and heme insertion in Mb remains unclear.

Air Pollution and Childhood Asthma Hospitalizations in Chengdu, China: A Time-Series Study.

Purpose: Research on the relationship between air pollutants and hospitalization for asthma in children in developing countries remains inadequate. This study aimed to assess the short-term effects of air pollutants, including sulfur dioxide (SO), nitrogen dioxide (NO), carbon monoxide (CO), ozone (O), particulate matter ≤ 2.5 µm (PM), and particulate matter ≤ 10 µm (PM), on children hospitalized for asthma in Chengdu, China, from 2017-2022.

Benchmarking Photon-Counting Computed Tomography Angiography Against Invasive Assessment of Coronary Stenosis: Implications for Severely Calcified Coronaries.

Background: Clinical guidelines do not recommend coronary computed tomographic angiography (CTA) in elderly patients or in the presence of heavy coronary calcification. Photon-counting coronary computed tomographic angiography (PCCTA) introduces ultrahigh in-plane resolution and multienergy imaging, but the ability of this technology to overcome these limitations is unclear.

Objectives: The authors evaluate the ability of PCCTA to quantitatively assess coronary luminal stenosis in the presence and absence of calcification, comparing both the ultrahigh-resolution (UHR)-PCCTA and the multienergy standard-resolution (SR)-PCCTA with the criterion-standard 3-dimensional invasive quantitative coronary angiography (3D QCA).

TRAF3 loss protects glioblastoma cells from lipid peroxidation and immune elimination via dysregulated lipid metabolism.

Glioblastoma (GBM) is a highly aggressive form of brain tumor characterized by dysregulated metabolism. Increased fatty acid oxidation (FAO) protects tumor cells from lipid peroxidation-induced cell death, although the precise mechanisms involved remain unclear. Here, we report that loss of TNF receptor-associated factor 3 (TRAF3) in GBM critically regulated lipid peroxidation and tumorigenesis by controlling the oxidation of polyunsaturated fatty acids (PUFAs).

Comparative analysis of clinical characteristics of symptomatic pituitary adenomas in elderly patients: a consecutive series of 114 patients.

Background: Pituitary adenomas (PAs) present with clinical features such as neuroendocrine abnormalities and mass effects, common in the general morbidity population. However, in elderly patients, the disease progression renders some clinical features difficult to detect and identify in time. Consequently, elderly patients with PAs are often not identified and receive sufficient intervention on time to achieve a satisfactory outcome.

Medium- to long-term outcomes of seton placement for fistula-in-ano in children: the experience of 103 patients from a single institution.

Purpose: The aim of this study was to evaluate the efficacy of seton placement for anal fistula in children.

Methods: The clinical data of children with anal fistula treated by seton placement admitted from January 2017 to September 2022 were retrospectively analyzed. Our primary treatments for perianal abscess (PA) are conservative treatment and drainage.

Oxidation Behavior of Aluminide Coatings on Cobalt-Based Superalloys by a Vapor Phase Aluminizing Process.

In this work, the oxidation behavior of an aluminide coating at 900, 1000, and 1100 °C was investigated. The aluminide coating was prepared on a cobalt-based superalloy using a vapor phase aluminizing process, which is composed of a β-(Co,Ni)Al phase outer layer and a Cr-rich phase diffusion layer. The experimental results showed that the oxidation of the coating at 900-1100 °C all obey the parabolic law.

The characteristics of event-related potentials in generalized anxiety disorder: A systematic review and meta-analysis.

Objectives: Previous studies have reported inconsistent findings regarding event-related potentials (ERPs) abnormalities in individuals with generalized anxiety disorder (GAD). This meta-analysis aimed to systematically review and synthesize the existing evidence on ERP alterations in individuals with GAD.

Methods: A comprehensive literature search was conducted in PubMed, the Cochrane Library, Excerpta Medica Database, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Database (VIP), Wanfang database, and China Biology Medicine (CBM) databases from inception to November 11, 2024.

The role and mechanism of vascular wall cell ion channels in vascular fibrosis remodeling.

Fibrosis is usually the final pathological state of many chronic inflammatory diseases and may lead to organ malfunction. Excessive deposition of extracellular matrix (ECM) molecules is a characteristic of most fibrotic tissues. The blood vessel wall contains three layers of membrane structure, including the intima, which is composed of endothelial cells; the media, which is composed of smooth muscle cells; and the adventitia, which is formed by the interaction of connective tissue and fibroblasts.

Unraveling Chain Branching in Cool Flames.

In cool flames, autoxidation of organic compounds forms alkyl hydroperoxides and ketohydroperoxides, and this controls the critical rate of chain branching, but there have been large uncertainties in the decomposition rate constants. We synthesized a series of hydroperoxides and measured their decomposition rate constants in pyrolysis experiments by spray-vaporization jet-stirred-reactor synchrotron vacuum ultraviolet photoionization mass spectrometry. Structural variation of the hydroperoxides, including alkyl, cycloalkyl, aromatic, and heterocyclic functionalities, has only a slight effect on their decomposition rate constants.

Coronary artery calcification detected on low-dose computed tomography in high-risk participants of an Australian lung cancer screening program: A prospective observational study.

Background And Objectives: Coronary artery calcification (CAC) is a frequent additional finding on lung cancer screening (LCS) low-dose computed tomography (LDCT). Cardiovascular disease (CVD) is a major cause of death in LCS participants. We aimed to describe prevalence of incidental CAC detected on LDCT in LCS participants without prior history of coronary artery disease (CAD), evaluate their CVD risk and describe subsequent investigation and management.