Epidemiologic characteristics of immunoglobulin M antibodies in lower respiratory tract infection pathogens of children: association with severe pneumonia in Chengdu city from 2019 to 2023.

Objective: To analyze the epidemiologic characteristics of serum immunoglobulin M (IgM) antibody aming six pathogens in children with acute lower respiratory tract infections (LRTI) and its association with severe pneumonia, thereby providing a basis for clinical diagnosis and treatment.

Methods: A total of 25,693 children with lower respiratory tract infections who were hospitalized in the Department of Respiratory Medicine at Chengdu Women's and Children's Central Hospital from 2019 to 2023 were included and retrospectively analyzed in the study. The epidemiologic characteristics of serum IgM antibodies for six LRTI pathogens in the enrolled children were analyzed.

Related Risk Factors That Predict Moderate to Severe Asthma Attack in Children: Analysis Based on Logistic Regression and Decision Tree.

Purpose: To analyse the related risk factors of moderate to severe asthma attack in children by logistic regression and decision tree.

Patients And Methods: A retrospective analysis of clinical data of children diagnosed with asthma attacks in our hospital from January 2020 to August 2023 was conducted. The patients were divided into mild group (n=459, 57.

Epidemiological characteristics of Mycoplasma pneumoniae and viral infections in hospitalized children with recurrent lower respiratory tract infections.

Objective: To investigate the epidemiological characteristics of Mycoplasma pneumoniae and common viral infections in hospitalized children with recurrent lower respiratory tract infections in Chengdu from 2019 to 2023, and to provide scientific evidence to support clinical diagnosis, treatment, and public health prevention.

Methods: A retrospective analysis was conducted on pathogen detection results from 10,580 children hospitalized with recurrent lower respiratory tract infections at a hospital in Chengdu between January 2019 and December 2023.

Results: Among the 10,580 hospitalized children, the pathogen detection rate was 28.

Changes in airway resistance and its correlation with disease severity in children with pneumonia.

Background: pneumonia (MPP) can cause lung function damage; however, few studies have examined the correlation between airway resistance and MPP severity. This study aimed to investigate changes in airway resistance related to severe MPP (SMPP) in children and evaluate its role in assessing disease severity.

Methods: A total of 96 children with MPP, admitted to Chengdu Women's and Children's Center Hospital from December 2022 to December 2023, were recruited for the study.

IL-37 Protects Against Ventilator-Induced Lung Injury by Inhibiting NLRP3 Activation.

Mechanical ventilation is an effective strategy for managing acute respiratory distress syndrome (ARDS), but it can also exacerbate lung injury, leading to ventilator-induced lung injury (VILI). To investigate the protective role of interleukin-37 (IL-37) in the pathogenesis of VILI, we used two approaches, human IL-37 transgenic (IL37tg) mice and administration of recombinant human IL-37 (rIL37) in wild-type (WT) mice subjected to mechanical ventilation. Lung histopathology was evaluated, inflammatory cytokine levels (IL-1β, IL-6, TNF-α) were measured, and inflammasome activation was assessed by analyzing NLRP3 and Caspase-1 expression.

Assessment of the placental microbiota of preterm infants with pneumonia: a case control study.

Objective: To investigate the specific characteristics and differences in the placental microbiome of preterm infants with and without pneumonia.

Methods: Fifty-nine infants born at 32-36 weeks' gestation were enrolled in this study. Among them, 33 developed pneumonia within 48 hours of birth, while the remaining 26 did not.

Application of Impulse Oscillometry Combined with Fractional Exhaled Nitric Oxide in Monitoring Asthma Control Levels in Children.

Purpose: To investigate whether Impulse Oscillometry (IOS) could more effectively monitor children with uncontrolled asthma and evaluate small airway function changes, while establishing a prediction model in combination with fractional exhaled nitric oxide (FeNO) to assist in clinical management and treatment of asthmatic children.

Patients And Methods: A retrospective study was conducted on 203 asthmatic children who were followed up in our hospital from August 2023 to August 2024. Patients were divided into controlled asthma group (n=80) and uncontrolled asthma group (n=123).

Air Pollution and Childhood Asthma Hospitalizations in Chengdu, China: A Time-Series Study.

Purpose: Research on the relationship between air pollutants and hospitalization for asthma in children in developing countries remains inadequate. This study aimed to assess the short-term effects of air pollutants, including sulfur dioxide (SO), nitrogen dioxide (NO), carbon monoxide (CO), ozone (O), particulate matter ≤ 2.5 µm (PM), and particulate matter ≤ 10 µm (PM), on children hospitalized for asthma in Chengdu, China, from 2017-2022.

Bacterial Colonization in the Airways and Intestines of Twin and Singleton Preterm Neonates: A Single-Center Study.

Limited studies have investigated the microbial colonization of the airways and intestines in preterm neonates. We studied the composition of intestinal and airway bacterial colonies in several preterm twin pairs and singletons to explore the dominant bacteria, assess their variability, and predict their phenotypic and metabolic functions. In this descriptive study, we collected sputum and fetal stool specimens from 10 twin pairs (20 cases) and 20 singleton preterm neonates.

Chaiqin chengqi decoction alleviates acute pancreatitis by targeting gasdermin D-mediated pyroptosis.

Ethnopharmacological Relevance: Acute pancreatitis (AP) is an acute inflammatory condition of pancreas with high morbidity and mortality, which has no effective medical treatment. Chaiqin chengqi decoction (CQCQD) has been clinically used for AP for many years in China. However, the underlying mechanisms are still unknown.

Effectiveness of sublingual immunotherapy with house dust mite drops in asthmatic children at different ages.

Background: Respiratory allergies in children, such as asthma and rhinitis, are becoming progressively common every year. Recent studies found that pediatric patients with asthma receiving regular medication and specific immunotherapy (SIT) had improved therapeutic outcomes in a wide age range. However, there are few studies that have examined the effectiveness of SIT treatment in children with allergic asthma at different ages in terms of the degree of asthma control, improvements in lung function, and changes in exhaled nitric oxide (FeNO).

Long-term outcomes and predictors of patients with ST elevated versus non-ST elevated myocardial infarctions in non-obstructive coronary arteries: a retrospective study in Northern China.

Background: Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a heterogeneous disease entity with diverse etiologies and no uniform treatment protocols. Patients with MINOCA can be clinically classified into two groups based on whether they have an ST-segment elevation (STE) or non-ST segment elevation (NSTE), based on electrocardiogram (ECG) results, whose clinical prognosis is unclear. This study aimed to compare the outcomes and predictors of patients with STE and NSTE in the MINOCA population.

A pilot study exploring the association of bronchial bacterial microbiota and recurrent wheezing in infants with atopy.

Background: Differences in bronchial microbiota composition have been found to be associated with asthma; however, it is still unclear whether these findings can be applied to recurrent wheezing in infants especially with aeroallergen sensitization.

Objectives: To determine the pathogenesis of atopic wheezing in infants and to identify diagnostic biomarkers, we analyzed the bronchial bacterial microbiota of infants with recurrent wheezing and with or without atopic diseases using a systems biology approach.

Methods: Bacterial communities in bronchoalveolar lavage samples from 15 atopic wheezing infants, 15 non-atopic wheezing infants, and 18 foreign body aspiration control infants were characterized using 16S rRNA gene sequencing.

Bacterial composition and colony structure of the lower respiratory tract in infants and children with recurrent wheezing: a case-control study.

Background: The bacterial load of the human lower respiratory tract is at least several times lower than that of the other parts of the body. This study aimed to identify the bacterial composition and colony structure of the lower respiratory tract in infants and children with recurrent wheezing compared with those of children with a bronchial foreign body and clarify whether the length of wheezing in infants can contribute to differences in the lower respiratory tract's bacterial colony structure.

Methods: We collected specimens of alveolar lavage fluid from 48 infants and children who underwent fiberoptic bronchoscopy and were divided into groups: A1 (multiple wheezing: wheezing more than three times in < 1 month), A2 (persistent wheezing: > 1 month), and B (bronchial foreign body; control group).

Lower airway microbiome of children with recurrent wheezing: a clinical cohort study.

Background: Wheezing is one of the most common respiratory symptoms in childhood especially in infants. In recent years, the incidence of recurrent wheezing is on the rise worldwide To investigate the lower airway microbiota in patients with recurrent wheezing and provide insights into clinical diagnosis and treatment.

Methods: This study initially enrolled 45 hospitalised children with recurrent wheezing symptoms awaiting complete fiberoptic bronchoscopy.

Evaluation of the factors affecting lung function in pediatric patients with asthma.

Purpose: This study aimed to analyze the risk factors affecting lung function in children with asthma based on clinical data to advice on clinical treatment and prognosis.

Methods: This study included newly diagnosed patients with asthma admitted to the Respiratory Department of Chengdu Women's and Children's Central Hospital in Sichuan from July 2020 to June 2021. The factors associated with lung function were analyzed using univariate and multivariate linear regression with the forward method, while factors affecting lung ventilation function were analyzed using multivariate logistic regression.

Investigating the Intercellular Communication Network of Immune Cell in Acute Respiratory Distress Syndrome with Sepsis.

Acute respiratory distress syndrome (ARDS) is recognized as a serious public health issue that results in respiratory failure and high mortality rates. The syndrome is characterized by immune cell aggregation, communication, activation, and alveolar epithelial damage. To elucidate the complex dynamic process of the immune system's response in ARDS, we construct the intercellular communication network of immune cells in ARDS based on a single-cell RNA sequencing dataset (including three sepsis-induced ARDS patients and four sepsis-only patients).

Effectiveness and safety of early combined utilization of budesonide and surfactant by airway for bronchopulmonary dysplasia prevention in premature infants with RDS: A meta-analysis.

Objective: To address the effectiveness and safety of early airway combined utilization of budesonide and surfactant for bronchopulmonary dysplasia (BPD) prevention in premature infants with respiratory distress syndrome (RDS).

Methods: Literature retrieval was carried out in the PubMed, Web of Science, EMBASE, Cochrane Library, Wanfang, CQ VIP, and China National Knowledge Infrastructure databases, searching from the inception to September 2021. Stata 16.

Benefit Effect of Sublingual Dust Mite Drops on the Control of Asthma in Children.

Aim: To evaluate the effect of sublingual dust mite drops on inhaled corticosteroid replacement and its effect on asthma control level.

Methods: Two hundred children with asthma who had received regular treatment for one year or more were divided into the observation group (71 cases) and control group (89 cases) according to whether sublingual dust mite drops were added on the basis of conventional treatment drugs. After treatment, C-ACT score, VAS score, drug score, lung function, exhaled nitric oxide level, and "ICS avoidance" were compared between the two groups.

Etiological distribution of pertussis-like syndrome in 756 children in Chengdu.

Background: To analyze and summarize the etiological distribution of pertussis-like syndrome in children and to provide a basis for clinical treatment.

Methods: A retrospective analysis was conducted of 756 children with pertussis-like syndrome hospitalized at the Department of Pediatric Respiratory Medicine of Chengdu Women's and Children's Central Hospital, 2015 to 2019. The etiological features were classified and reviewed.

Sigh syndrome during the COVID-19 pandemic: Is it a signal of the mental health status of Chinese children and adolescents?

Background: Since the outbreak of the COVID-19 pandemic, Chinese children and adolescents have been greatly affected by the strict social isolation policies, which will undoubtedly cause psychological problems. We aimed to investigate the mental health status of Chinese children and adolescents, and provided some considerations of the contributing factors and the coping strategy.

Method: We investigated the disease composition ratio of sigh syndrome in the pediatric outpatient clinic in Chengdu after the outbreak of the COVID-19 pandemic and outbreak mitigation.

The FeNO Normal Value Analysis of Healthy Children Aged 6-15 Years Old in Chengdu.

Objective: To investigate the fractional exhaled nitric oxide (FeNO) normal value of healthy children, and provide a reliable theoretical basis for clinical diagnosis.

Methods: 481 healthy children aged 6-15-y-old in three primary schools in Chengdu were subjected for FeNO detection. Through the statistical analysis, the upper limit normal value of FeNO among the healthy children was obtained, and the related influencing factors of FeNO value were analyzed.

Effects of sublingual-specific immunotherapy on pulmonary function and exhaled nitric oxide levels in asthmatic children with and without allergic rhinitis.

Background: Allergic asthma and allergic rhinitis are common chronic respiratory diseases in children. The prevalence rate of disease is increasing year by year. And avoid allergens, drug treatments and special immunotherapy (SIT) is the fundamental treatment for respiratory allergies diseases.

Effects of Sublingual Duster Mite Drops on Lung Function and Exhaled Nitric Oxide in Children with Multiple and Single Allergic Respiratory Diseases.

Objective: To evaluate the efficiency of sublingual immunotherapy with Dermatophagoides Farinae Drops in children with single and multiple respiratory allergic diseases.

Methods: Seventy-one children with allergic respiratory diseases who had been treated with Dermatophagoides Farinae Drops for one year or more were divided into a single allergic group (12 cases) and multiple allergic group (59 cases). The rhinitis score, daytime and night symptom score of asthma, VAS score, drug score, pulmonary function, and FeNO level before and after treatment were evaluated and compared between the two groups.

[Findings of electric bronchoscopy in 67 children with recurrent wheezing].

Objective: To investigate the common causes of recurrent wheezing in young children.

Methods: Electronic bronchoscopy was performed on 67 children with recurrent wheezing or who did not respond to the conventional treatment.

Results: The electronic bronchoscopy showed intimitis in trachea and bronchi in 19 cases, intimitis and inflammatory stricture in 11 cases, foreign bodies in the bronchi in 11 cases, trachea and bronchus softening in 19 cases, and bronchopulmonary dysplasia in 3 cases.