Machine Learning Guided Assembly of a Nested Gd@Gd @Ni Cluster via Urea Controlled Carbonate Release.

Lanthanide-based polyhedral clusters are of great interest due to their unique geometries and functional properties, but their controlled synthesis remains a major challenge. Here, we report a nested three-shell cluster, [GdNi(MeIDA)(OH)(CO) (HO)]·(ClO)·(HO) (GdNi, HMeIDA = N-Methyliminodiacetic acid), achieved by using urea as a slow-release carbonate source to direct the formation of a dodecahedral inner shell. Single-crystal X-ray diffraction reveals a unique Gd@Gd@Ni arrangement, with the innermost Gd forming a Platonic dodecahedron templated by carbonate.

Early application of nanocarbon suspension in gastric cancer patients enhances postoperative lymph node detection.

Background: This retrospective cohort study explores the association between the interval of nanocarbon application before surgery and the detection of postoperative lymph nodes in patients undergoing gastric cancer surgery.

Methods: This retrospective study included eligible patients diagnosed with T1-3NanyM0 gastric cancer at Fuzhou Traditional Chinese Medicine Hospital between March 1, 2020, and March 31, 2023, based on predefined inclusion criteria. Participants were grouped according to the timing of nanocarbon suspension application: either on the same day as surgery or at least 3 days prior.

Proton-activated chloride channel governs phagosome-mediated antibacterial immunity in peritoneal macrophages.

The success of phagosome degradation relies on the ability of phagocytes to regulate the maturation of phagosomes. However, its underlying molecular mechanisms remain poorly understood. Here, we identify the proton-activated chloride (PAC) channel as a key negative regulator of phagosome maturation.

Diagnostic Value of the Maximal Expiratory Flow-Volume Curve for Central Airway Obstruction.

Objective: To investigate the factors associated with plateau-like changes during the expiratory phase of maximal expiratory flow-volume (MEFV) curves and their diagnostic value in identifying central airway obstruction (CAO).

Methods: Totally 59 patients with expiratory phase plateau-like changes in the MEFV curves who were treated in Henan Provincial People's Hospital from January 2019 to November 2020 were included in this retrospective analysis. Patients with CAO were recruited into the experimental group, and those without CAO were recruited into the control group.

Causal Relationship Between Components of Metabolic Syndrome and Ventral Hernia: a Mendelian Randomization Study.

Background: Ventral hernia (VH) includes subtypes like incisional and umbilical hernias, which are more complex than groin hernias due to wider defects, higher recurrence rates, and more demanding surgical techniques. The purpose of the present research is to explore the causal relationship among metabolic syndrome-related components and abdominal wall hernia, and to provide genetic evidence to support the risk of metabolic syndrome-related components and abdominal wall hernia.

Methods: Data from genome-wide association studies (GWAS) were analyzed.

Single-cell analysis reveals CD34CD90 endothelial cells promote tumor metastasis in gallbladder cancer.

Gallbladder cancer (GBC) is the most common malignancy of the biliary tract, with high metastasis incidence and extremely low survival rate. The tumor endothelial cells (TECs) are fundamental components in the tumor microenvironment and significantly contribute to various tumor progression; however, the roles of TECs in GBC are poorly understood. Here, using single-cell RNA sequencing, we identify a GBC-enriched endothelial population-CD34CD90 ECs (SAEndo2).

Preliminary synthetic MRI study on Achilles tendon dynamics in amateur marathoners.

Objective: To observe alterations in the microstructure and chemical composition of the Achilles tendon (AT) in amateur marathon runners before and after a race using synthetic magnetic resonance imaging (SyMRI).

Methods: SyMRI examinations were performed on marathoners at three-time points: pre-race, 48 h post-race, and 2 months post-race. A control group also underwent SyMRI examinations.

Origin of the Optimization of Photocatalytic Activities for Titanium Oxide Film Modified by an Oxidized Copper Layer.

In this study, the surface photocatalytic activity of an anatase-titanium oxide (TiO) film was modified by a thin copper (Cu) layer with the subsequential oxidation annealing process. Through this simple annealing process, the photocatalytic activity of the TiO/Cu structure to decompose the methylene blue solution and inhibit the growth of . could be optimized.

The reprogramming impact of SMAC-mimetic on glioblastoma stem cells and the immune tumor microenvironment evolution.

Background: Intrinsically resistant glioma stem cells (GSCs) in the setting of a highly immunosuppressive tumor microenvironment (TME) remain the most predominant phenomenon leading to unfavorable therapeutic outcomes in glioblastoma (GBM). Hence there is an unmet need for novel anti-GBM therapeutic paradigms that can effectively target GSCs while simultaneously reprogramming the TME.

Methods: In this study, we leverage evidence from SMAC mimetic screening to evaluate and characterize the anti-tumor and immune TME modulating impacts of the lead SMAC mimetic Xevinapant at the single cell level in GBM.

Deciphering cholangiocarcinoma heterogeneity and specific progenitor cell niche of extrahepatic cholangiocarcinoma at single-cell resolution.

Background: Cholangiocarcinoma (CCA) is a highly heterogeneous malignancy, primarily comprising intrahepatic (iCCA) and extrahepatic (eCCA) subtypes. Reconciling the variability between iCCAs and eCCAs in clinical trials remains a challenge, largely due to the inadequate understanding of their shared and subtype-specific cellular heterogeneity. We aim to address this issue using single-cell and spatially resolved transcriptomic approaches.

Prognostic impact of somatic mutations and additional chromosomal abnormalities in patients with myelodysplastic syndromes and chromosome 20q deletion.

The 20q deletion (del(20q)) is a recurrent chromosomal abnormality in individuals with myelodysplastic syndrome (MDS) and is associated with favourable outcomes when isolated. This study aims to analyse the clinical features and prognostic impact of del(20q) based on cytogenetic and molecular alterations. Among 1,527 patients with MDS, 101 (6.

Identification of an Immune-Related Gene Signature for Prognostic Prediction in Glioblastoma: Insights from Integrated Bulk and Single-Cell RNA Sequencing.

Glioblastoma is a highly malignant brain tumor with limited treatment options and a poor prognosis, largely driven by its complex immune microenvironment. This study aimed to identify and characterize an immune-related gene signature associated with prognosis and immune regulation in glioblastoma. We performed integrative analyses using bulk and single-cell RNA sequencing data to identify prognostically significant immune-related genes.

Strong and Switchable Magneto-Optical Effect in Air-Stable Chiral Dy Complexes with Magnetic Anisotropy.

Assembling chiral and magnetic units at a molecular level is a key to achieving a strong magneto-optical (MO) effect, especially for lanthanide complexes with a specific 4 electronic configuration. However, the - transitions are generally restricted by selection rules, making the observation of the MO response extremely challenging. Herein, we reported the synthesis of two highly air-stable chiral Dy complexes and , with a pair of tailored chelating chiral ligands.

Suppressing chondrocyte cuproptosis by syringaresinol-4---d-glucoside alleviates gouty arthritis.

Background: Gouty arthritis is a rheumatic disease characterized by synovial inflammation and cartilage damage. Current therapeutic options for gouty arthritis, such as colchicine, primarily relieve the symptoms, which makes treatment challenging.

Methods: We employed an in vitro co-culture system of chondrocytes and macrophages to simulate gouty arthritis and screen compounds that can inhibit monosodium urate (MSU) associated macrophage inflammation and chondrocytes degeneration.

Identifying Disinformation on the Extended Impacts of COVID-19: Methodological Investigation Using a Fuzzy Ranking Ensemble of Natural Language Processing Models.

Background: During the COVID-19 pandemic, the continuous spread of misinformation on the internet posed an ongoing threat to public trust and understanding of epidemic prevention policies. Although the pandemic is now under control, information regarding the risks of long-term COVID-19 effects and reinfection still needs to be integrated into COVID-19 policies.

Objective: This study aims to develop a robust and generalizable deep learning framework for detecting misinformation related to the prolonged impacts of COVID-19 by integrating pretrained language models (PLMs) with an innovative fuzzy rank-based ensemble approach.

Effectiveness of antibiotic-impregnated bone cement in treating postoperative infections after femoral shaft fracture treatment with intramedullary nailing.

Postoperative infections are a significant challenge in orthopedic surgeries, particularly after procedures involving femoral shaft fractures treated with intramedullary nailing. Antibiotic-impregnated bone cement (AIBC) offers a promising solution by providing targeted antimicrobial delivery to the surgical site, potentially enhancing infection control and bone healing. A retrospective analysis was conducted from January 2020 to January 2023, involving 40 patients who developed postoperative infections after femoral shaft fracture treatment with intramedullary nailing.

Estimation of Ammonia Emissions over China Using IASI Satellite-Derived Surface Observations.

An accurate ammonia (NH) emission inventory is crucial for policymakers developing air pollution mitigation strategies. Both satellite observations and bottom-up estimates identify significant NH emission hotspots in China. However, bottom-up NH emission inventories are highly uncertain due to the lack of localized emission factors, while large and uncertain errors in IASI satellite NH columns have hindered their direct application in top-down emission inversion methods.

Landscapes of gut microbiome and metabolic signatures in vitiligo patients with co-morbid emotional distress.

Background: Vitiligo is a depigmentation disorder frequently associated with emotional distress; however, the precise mechanisms underlying this co-morbidity remain unclear.

Objective: This study aims to investigate whether gut dysbiosis and gut metabolites contributes to emotional distress in patients with vitiligo.

Methods: Depression and anxiety were assessed using the Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7, respectively.

Significance of Mutation Spots and Concurrent Gene Mutations on Prognosis and Clinical Outcomes in Myelodysplastic Syndromes With SF3B1 Mutation.

Purpose: To investigate the clinical characteristics and prognosis of mutation spots and concomitant gene mutations in myelodysplastic syndromes (MDS) with SF3B1 mutation (SF3B1).

Patients And Methods: Patients diagnosed with MDS at Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital from October 2008 to November 2023 were enrolled in this study. SF3B1 was identified by next-generation sequencing (NGS).

Understanding the role of NOTCH2 mutation in centronuclear myopathy.

NOTCH2 is a widely expressed protein that plays a crucial role in the normal development and function of various tissues, including skeletal muscle. This study focused on a pedigree with centronuclear myopathy, primarily characterized by muscle weakness and centralized nuclei, and identified the autosomal recessive NOTCH2 p.I1689F mutation through whole-exome sequencing.

AI-Enabled Piezoelectric Wearable for Joint Torque Monitoring.

Joint health is critical for musculoskeletal (MSK) conditions that are affecting approximately one-third of the global population. Monitoring of joint torque can offer an important pathway for the evaluation of joint health and guided intervention. However, there is no technology that can provide the precision, effectiveness, low-resource setting, and long-term wearability to simultaneously achieve both rapid and accurate joint torque measurement to enable risk assessment of joint injury and long-term monitoring of joint rehabilitation in wider environments.

The Role of Gut Microbiome on Glioblastoma Oncogenesis and Malignant Evolution.

Glioblastoma (GBM) remains the most aggressive primary brain tumor, with poor survival outcomes and treatment limited to maximal safe surgical resection, chemotherapy with temozolomide, and radiotherapy. While immunotherapy and targeted treatments show promise, therapeutic resistance and disease progression remain major challenges. This is partly due to GBM's classification as a "cold tumor" with low mutational burden and a lack of distinct molecular targets for drug delivery that selectively spare healthy tissue.

In situ n-doped nanocrystalline electron-injection-layer for general-lighting quantum-dot LEDs.

Quantum-dot optoelectronics, pivotal for lighting, lasing and photovoltaics, rely on nanocrystalline oxide electron-injection layer. Here, we discover that the prevalent surface magnesium-modified zinc oxide electron-injection layer possesses poor n-type attributes, leading to the suboptimal and encapsulation-resin-sensitive performance of quantum-dot light-emitting diodes. A heavily n-doped nanocrystalline electron-injection layer-exhibiting ohmic transport with 1000 times higher electron conductivity and improved hole blockage-is developed via a simple reductive treatment.

Successful Treatment of a 42-Year-Old Man with Concurrent Anti-Glomerular Basement Membrane Disease and Anti-Phospholipase A2 Receptor Antibody-Positive Membranous Nephropathy: A Case Report.

BACKGROUND Anti-glomerular basement membrane (anti-GBM) disease is an autoimmune disease mediated by deposit of antibodies to collagen type IV in glomerular and alveolar basement membranes. Membranous nephropathy (MN) is characterized by thickening of the glomerular capillary walls due to immune complex deposition. Anti-GBM disease can occur in conjunction with a second disease.