[Expert consensus on prognostic evaluation of cochlear implantation in hereditary hearing loss].

Hearing loss is the most prevalent disabling disease. Cochlear implantation（CI） serves as the primary intervention for severe to profound hearing loss. This consensus systematically explores the value of genetic diagnosis in the pre-operative assessment and efficacy prognosis for CI.

Targeting Neutrophil/Eosinophil Extracellular Traps by Aptamer-Functionalized Nanosheets to Overcome Recalcitrant Inflammatory Disorders.

Excessive generation of neutrophil extracellular traps (NETs) and eosinophil extracellular traps (EETs) can drive various inflammatory disorders by stimulating intracellular nucleic acid receptors. Although extracellular traps (ETs) are promising therapeutic targets for recalcitrant chronic inflammation, for example, otitis media with effusion (OME), practical and specific targeting of NETs/EETs in pathological tissues remains challenging. In this study, an ultrathin, 2D sheet-like nanoscavenger C-TA is developed by modifying copper indium thiophosphate (CIPS) nanosheets with tannic acid (TA) and histone aptamers.

Utilizing temporal imaging to enhance early diagnosis of eosinophilic otitis media in clinical practice.

Purpose: The diagnosis of eosinophilic otitis media (EOM) remains a major challenge. Current diagnostic methods rely primarily on accurate samples of middle ear tissue or secretions, which can be complex. In this study, we sought to explore the diagnostic value of mastoid pneumatization combined with other temporal radiological features for EOM.

ONNXPruner: ONNX-Based General Model Pruning Adapter.

Recent advancements in model pruning have focused on developing new algorithms and improving upon benchmarks. However, the practical application of these algorithms across various models and platforms remains a significant challenge. To address this challenge, we propose ONNXPruner, a versatile pruning adapter designed for the ONNX format models.

Leveraging Frequency Analysis for Image Denoising Network Pruning.

As a common model compression technique, network pruning is widely used to reduce storage and computational cost of deep models in the resource-constrained regime. However, most current pruning methods are designed for high-level vision tasks, with few developed for low-level vision tasks. We observed that the norm-based pruning criterion, originally designed for high-level vision tasks, is highly unsuitable for low-level image denoising networks.

Cochlear Organ Dissection, Immunostaining, and Confocal Imaging in Mice.

The organ of Corti, located in the inner ear, is the primary organ responsible for animal hearing. Each hair cell has a V-shaped or U-shaped hair bundle composed of actin-filled stereocilia and a kinocilium supported by true transport microtubules. Damage to these structures due to noise exposure, drug toxicity, aging, or environmental factors can lead to hearing loss and other disorders.

Ultrasound-Triggered NO Release to Promote Axonal Regeneration for Noise-Induced Hearing Loss Therapy.

Intense noise poses a threat to spiral ganglion neurons (SGNs) in the inner ear, often resulting in limited axonal regeneration during noise injury and leading to noise-induced hearing loss (NIHL). Here, we propose an ultrasound-triggered nitric oxide (NO) release to enhance the sprouting and regeneration of injured axons in SGNs. We developed hollow silicon nanoparticles to load nitrosylated N-acetylcysteine, producing HMSN-SNO, which effectively protects NO from external interferences.

18 F-FDG PET/CT Findings of Isolated Renal Metastasis From Squamous Cell Lung Cancer.

We present the 18 F-FDG PET/CT findings of a 64-year-old man with isolated renal metastasis. He had a history of radical surgery for squamous cell lung cancer 14 months ago, followed by chemotherapy and immunotherapy. The renal metastasis presented as a small focus of increased FDG uptake in the restaging 18 F-FDG PET/CT scan, which was regarded as renal cortical tracer retention.

Linking clinical manifestations and causative organisms may provide clues for the treatment of peritoneal dialysis-associated peritonitis.

Introduction: Different initial manifestations of peritoneal dialysis-associated peritonitis (PDAP) may depend on the type of pathogenic organism. We investigated the association between the clinical characteristics of PDAP and susceptibility to vancomycin and investigated the possibility of using vancomycin monotherapy alone as an initial treatment regimen for some PDAP patients to avoid unnecessary antibiotic exposure and secondary infection.

Methods: Patients with culture-positive PDAP were retrospectively analyzed and divided into two groups: peritonitis with only cloudy effluent (PDAP-cloudy) or with cloudy effluent, abdominal pain and/or fever (PDAP-multi).

Taste Disturbance After Endoscopic Tympanoplasty with Tragal Cartilage Graft and Improvement Strategies.

To explore the risk factors of early postoperative taste disturbance (EPTD) after type I endoscopic tympanoplasty and operative modification strategies to improve taste disturbance. This was a controlled study. One hundred and twenty-four patients who underwent type I endoscopic tympanoplasty with tragal cartilage graft were separated evenly into control and modified groups.

Pathologic Status of Tissue Around the Malleus Handle Tip in Endoscopic Tympanoplasty: Potential Impact on Surgical Decisions.

To avoid postoperatively acquired cholesteatoma, whether there was any squamous epithelial tissues residue around the tip of the malleus handle, and the need to remove these tissues were explored. This prospective study enrolled 197 patients who underwent endoscopic tympanoplasty. A postoperative pathological evaluation of the tissue around the tip of the malleus handle was performed to determine the presence of squamous epithelium.

A 3D and Explainable Artificial Intelligence Model for Evaluation of Chronic Otitis Media Based on Temporal Bone Computed Tomography: Model Development, Validation, and Clinical Application.

Background: Temporal bone computed tomography (CT) helps diagnose chronic otitis media (COM). However, its interpretation requires training and expertise. Artificial intelligence (AI) can help clinicians evaluate COM through CT scans, but existing models lack transparency and may not fully leverage multidimensional diagnostic information.

Planar Cell Polarity in the Multiciliated Epithelial Lining of the Mouse Eustachian Tube.

Objectives: Planar cell polarity (PCP) signaling, essential for uniform alignment and directional beating of motile cilia, has been investigated in multiciliated epithelia. As a complex structure connecting the middle ear to the nasopharynx, the eustachian tube (ET) is important in the onset of ear-nose-throat diseases. However, PCP signaling, including the orientation that is important for ciliary motility and clearance function in the ET, has not been studied.

Detection of SARS-CoV-2 virus in middle ear effusions and its association with otitis media with effusion.

A large-scale outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) occurred in Shanghai, China, in early December 2022. To study the incidence and characteristics of otitis media with effusion (OME) complicating SARS-CoV-2, we collected 267 middle ear effusion (MEE) samples and 172 nasopharyngeal (NP) swabs from patients. The SARS-CoV-2 virus was detected by RT-PCR targeting.

A novel intronic TCOF1 pathogenic variant in a Chinese family with Treacher Collins syndrome.

Background: Treacher Collins syndrome (TCS; OMIM 154500) is a craniofacial developmental disorder.

Methods: To investigate the genetic features of a four-generation Chinese family with TCS, clinical examinations, hearing tests, computed tomography, whole-exome sequencing (WES), Sanger sequencing, reverse transcription (RT)-PCR, and the Minigene assay were performed.

Results: The probands, an 11-year-old male and his cousin exhibited typical clinical manifestations of TCS including conductive hearing loss, downward slanting palpebral fissures, and mandibular hypoplasia.

Microscopic Versus Endoscopic Ear Surgery for Early-Stage Glomus Tympanicum Tumors.

Glomus tympanicum tumors are benign primary tumors of the middle ear that can be completely removed using modern surgery. We compared endoscopic ear surgery (EES) to traditional microscopic ear surgery (MES) in terms of the removal of early-stage glomus tympanicum tumors. We retrospectively reviewed 25 cases treated from 2003 to 2021 that were of Grade I or II based on the Glasscock-Jackson classification system.

Study of S poisoning mechanism on LaMnO perovskite catalyst surface based on DFT method.

The sulfur poisoning mechanism of low-temperature SCR de-NO catalyst has always been one of the hot spots in academic circles. By studying the surface sulfur poisoning mechanism, low-temperature catalysts can be developed pertinently. In this paper, the mechanism of sulfur poisoning on the surface of LaMnO catalyst was studied by DFT method, and the adsorption process of sulfur oxides on the surface and its influence on SCR reaction process, as well as the morphology and decomposition process of ammonium sulfate on the surface were calculated.

Insights into Nb doping effects on the catalytic activity and SO tolerance of Mn-Cu/BCN catalyst for low-temperature NH-SCR reaction.

Biochar-based supported denitration catalysts have shown tremendous potential in reducing NO, while improving low-temperature NH-SCR catalytic activity and SO tolerance still faces great challenges. In this work, Mn-Cu/BCN and Mn-Cu-Nb/BCN catalysts were prepared by one-step wet impregnation. The enhanced effect of Nb doping on the catalytic performance and SO tolerance over the Mn-Cu/BCN catalyst was evaluated in the temperature range of 75-275 °C.

Key Genes and Endoscopic Radical Surgery in Primary Middle Ear Oncocytic Papillomas.

Objective: Papillomas originating from the Schneiderian epithelium within the middle ear are extremely rare and may be associated with a high rate of recurrence and malignant transformation. Oncocytic papillomas represent the rarest pathological subtype of such tumors. The current investigation aimed to determine whether there exists a distinct mechanism underlying the incidence of oncocytic papillomas arising primarily within the middle ear, and to explore potential treatment strategies to ensure complete removal and prevent recurrence.

Full Endoscopic Resection of Intralabyrinthine Schwannomas: A Case Series.

To investigate the technique and efficacy of fully endoscope resection of intralabyrinthine schwannomas (ILS) by transcanal transpromontorial endoscopic approach (TTEA). Retrospective case review. Hospital.

Rab11a Is Essential for the Development and Integrity of the Stereocilia and Kinocilia in the Mammalian Organ of Corti.

The cochlea hair cells transform mechanic sounds to neural signals with a remarkable sensitivity and resolution. This is achieved via the precisely sculpted mechanotransduction apparatus of the hair cells and the supporting structure of the cochlea. The shaping of the mechanotransduction apparatus, the staircased stereocilia bundles on the apical surface of the hair cells, requires an intricate regulatory network including planar cell polarity (PCP) and primary cilia genes in orienting stereocilia bundles and building molecular machinery of the apical protrusions.

The co-pyrolysis of waste urea-formaldehyde resin with pine sawdust: co-pyrolysis behavior, pyrocarbon and its adsorption performance for Cr (VI).

Urea-formaldehyde (UF) resin is difficult to degrade and classified as hazardous organic waste. To address this concern, the co-pyrolysis behavior of UF resin with pine sawdust (PS) was studied, and the adsorption properties of pyrocarbon were evaluated with Cr (VI). Thermogravimetric analysis revealed that adding a small amount of PS can improve the pyrolysis behavior of UF resin.

Involvement of Dmp1 in the Precise Regulation of Hair Bundle Formation in the Developing Cochlea.

Dentin matrix protein 1 (Dmp1) is a highly phosphorylated, extracellular matrix protein that is extensively expressed in bone and teeth but also found in soft tissues, including brain and muscle. However, the functions of Dmp1 in the mice cochlea are unknown. Our study showed that Dmp1 was expressed in auditory hair cells (HCs), with the role of Dmp1 in those cells identified using Dmp1 cKD mice.

Density Functional Study on Adsorption of NH and NO on the γ-FeO (111) Surface.

γ-FeO is considered to be a promising catalyst for the selective catalytic reduction (SCR) of nitrogen oxide (NO). In this study, first-principle calculations based on the density function theory (DFT) were utilized to explore the adsorption mechanism of NH, NO, and other molecules on γ-FeO, which is identified as a crucial step in the SCR process to eliminate NO from coal-fired flue gas. The adsorption characteristics of reactants (NH and NO) and products (N and HO) at different active sites of the γ-FeO (111) surface were investigated.