Enhancer Reprogramming Reveals the Tumorigenic Role of PTPRZ1 in Lung Squamous Cell Carcinoma.

Lung squamous cell carcinoma (LUSC) remains a lethal malignancy with limited therapeutic advancements, underscoring the need to identify novel oncogenic drivers. This study integrates multi-omics analyses-including ChIP-seq, bulk RNA-seq, single-cell ATAC/RNA-seq, and spatial transcriptomics-to delineate enhancer-driven transcriptional networks in 59 matched LUSC tumors and adjacent normal tissues. The analyses identify 3,447 tumor-specific oncogenic enhancers (SOEs) enriched for master transcription factors (SOX2, TP63, KLF5, GRHL2) that orchestrate malignant programs.

A Granularity-related Network Refinement Method Based on Module Division and Biological Information for Identifying Essential Proteins.

Essential proteins play a pivotal role in biological systems, and their identification is critical for elucidating complex life mechanisms and disease pathogenesis. While most existing identification methods rely on protein-protein interaction networks (PINs), the inherent noise in raw PINs frequently compromises identification efficiency. To address this limitation, researchers often employ network refinement strategies to improve PIN quality, with modularity-based approaches demonstrating particularly strong efficacy in enhancing the predictive performance of essential protein identification.

Advances in Population Pharmacokinetics of Monoclonal Antibody Drugs.

Background: Monoclonal antibody (mAb) drugs have become an important pillar of modern pharmaceutical fields. Owing to their high specificity and affinity, these drugs have shown broad application prospects in various fields, such as tumor therapy and autoimmune diseases. However, the pharmacokinetic profiles of mAbs are characterized by large individual differences that seriously affect drug efficacy and safety.

Population Pharmacokinetics of Nifedipine in High-Altitude and Plain Patients With Hypertension.

The pharmacokinetic characteristics of drugs are altered under high-altitude hypoxia. We aim to describe the population pharmacokinetics of nifedipine to investigate the effects of high-altitude hypoxia on the pharmacokinetics of nifedipine in hypertensive patients. A total of 206 plasma concentrations were collected from 50 patients with hypertension in plateau areas and 53 in plain areas.

SYHA1813, A VEGFR and CSF1R Inhibitor, in Patients With Recurrent High-Grade Gliomas: A Multicenter, Open-Label Phase I Study.

Objective: Recurrent high-grade gliomas have a poor prognosis and limited therapeutic options. This study aimed to evaluate the safety and efficacy of SYHA1813, a dual inhibitor of VEGFR and CSF1R, in patients with recurrent high-grade gliomas.

Methods: Eligible patients (aged ≥ 18) with histologically or cytologically confirmed recurrent high-grade gliomas were included.

Cluster Density-Dependent Electronic Metal-Support Interactions in Rh/CeO for Enhanced Styrene Hydroformylation.

Electronic metal-support interactions (EMSI) play a critical role in determining the performance of supported noble metal catalysts. While conventional strategies focus on modulating the size of noble metals or the properties of supports, the influence of the metal cluster density on EMSI remains unexplored. Herein, we demonstrate that precise control over Rh cluster density on CeO nanorods (NR-CeO) provides a powerful handle to systematically tune interfacial charge transfer, thereby establishing a negative correlation between Rh cluster density and its electron richness.

Identification of Malignant Progression of Gliomas through Metabolomics of Cerebrospinal Fluid and Serum.

Gliomas are the most common malignant primary intracranial tumors. The survival period of patients with recurrent gliomas is significantly shortened further. There is an urgent need for a method with higher sensitivity and specificity to distinguish between primary, recurrent, and radiation-injury gliomas.

Serum lipidomics analysis reveals yolk sac absorption differences in newly hatched chicks.

The yolk sac provides nutrients to a newly hatched chick with maternal nutrient substances including large amounts of lipids. Higher resorption of the yolk sac is generally considered positive for chick development. However, it is hard to determine yolk sac absorption differences among living chicks with similar body weight for assessing chick quality.

Edaravone plus compound cerebroside in elderly patients with carotid plaque cerebral infarction: Efficacy and prognosis.

Objective: To evaluate the clinical efficacy, long-term prognosis and recovery of cognitive function of the elderly patients with carotid plaque massive cerebral infarction (CPMCI) who did not receive reperfusion therapy.

Methods: A multi-center, retrospective, single-arm design was adopted in this study, and 184 elderly patients with CPMCI who received the combined treatment of Edaravone, dextromethorphan and compound cerebroside from January 2021 to December 2023 were included. Main outcome measures include modified Rankin scale (mRS) score and National Institutes of Health Stroke Scale (NIHSS) score.

Liposomal honokiol enhance the anti-tumor effect of bevacizumab in glioblastoma by inhibiting autophagy.

Aims: To investigate whether liposomal honokiol enhances the anti-tumor effect of bevacizumab (BEV) in glioblastoma (GBM) and explore its underlying mechanism.

Materials & Methods: A U87 cell xenograft model in nude mice was used, with groups: model (M), M + liposomal honokiol (Lip-HNK), M + BEV, and M + Lip-HNK + BEV. Tumor volume, body weight, serum levels of VEGF, VEGFR, TNF-α, and Caspase-3, and expressions of autophagy-related (Beclin-1, LC3) and UPR-related (IRE1, GRP78) molecules in tumor tissues were detected.

Impacts of changing environments on seasonal propagation from precipitation to streamflow.

Streamflow seasonality, characterized by its unequal intra-annual distribution, is predominantly shaped by precipitation dynamics in non-snowmelt-dominated regions. However, climate change and human activities can alter the hydrological cycle, weaken the consistency in precipitation-streamflow seasonality, and further modify streamflow seasonality. Despite its importance, the mechanisms modulating precipitation-streamflow seasonality consistency remain underexplored.

Research on GNNs with stable learning.

Traditional Graph Neural Network (GNN) learning patterns can only achieve optimal performance under the assumption of independent and identically distributed data. However, in real-world scenarios, numerous unpredictable factors give rise to the Out-of-Distribution (OOD) problem. Moreover, this distribution discrepancy may lead to unreliable predictions by GNNs models within unknown OOD domains.

Reaction-induced regioselective reconstruction of Ni-doped Ce(OH)/CeO enables exceptional activity and selectivity for reverse water-shift reaction.

Reconstruction of catalysts by reaction environments represents a viable approach to create highly performed active sites. Herein, we develop a reaction-induced regioselective reconstruction of Ni-doped Ce(OH)/CeO nanorods to form dual-active sites composed of carburized Ni clusters and frustrated Lewis pairs (FLPs), delivering exceptional activity, selectivity and stability for reverse water-gas shift reaction. Ni aggregation in the Ce(OH) region, coupled with in-situ carbonization by catalytically generated CO during reaction, induces the formation of the carburized Ni clusters, which effectively promoted H dissociation.

The pyroptosis-related gene signature predicts prognosis and reveals immune microenvironment infiltration in reclassified glioblastoma based on 2021 WHO classification.

Background: Glioblastoma (GBM) is a highly malignant brain tumor with a poor prognosis. The WHO Classification of Tumors of the Central Nervous System (WHO CNS5) reclassified GBM in 2021. Pyroptosis, as an inflammatory form of programmed cell death, could regulate tumor cell proliferation, invasion, and metastasis.

Ceftriaxone ameliorates tau phosphorylation and mislocalization in APP/PS1 AD mice by inhibiting endoplasmic reticulum stress.

Tau phosphorylation and mislocalization are hallmark pathological features of Alzheimer's disease (AD), with endoplasmic reticulum stress (ERS) contributing to tauopathy. We previously showed that ceftriaxone (Cef) improves cognition in APP/PS1 AD mice through regulating GLT-1-mediated glutamate homeostasis. Here, we examined Cef's neuroprotection against ERS-related tauopathy.

Engineering Optimized Defects and Abundant Closed-Pores of Hard Carbons for Enhanced Sodium Storage.

Hard carbons (HCs) are widely regarded as promising anode materials for sodium-ion batteries, but their application is confined by low initial coulombic efficiency (ICE) as well as poor specific capacity. Herein, a one-stone-for-two-birds strategy is proposed to optimize defect concentration and engineer closed pores in HCs via the introduction of Zn. The resulting HCs demonstrated a satisfactory ICE (82.

Scalable multi-stage spinning of weavable high temperature resistant SiNAFs@PSO/Aramid composite aerogel fibers.

SiO aerogel fibers are widely regarded as one of the lightest solid materials, exhibiting exceptional thermal insulation properties. However, achieving both high elasticity and spinnability remains a significant challenge in the fabrication process. A scalable and efficient vortex-assisted multi-stage spinning strategy has been employed to fabricate Silica Nanofiber Aerogel Fibers@Polysiloxane/Aramid Aerogel Fibers (SiNAFs@PSO/Aramid).

Elucidating the Mechanism of Xiaoqinglong Decoction in Chronic Urticaria Treatment: An Integrated Approach of Network Pharmacology, Bioinformatics Analysis, Molecular Docking, and Molecular Dynamics Simulations.

Introduction: Xiaoqinglong Decoction (XQLD) is a traditional Chinese medicinal formula commonly used to treat chronic urticaria (CU). However, its underlying therapeutic mechanisms remain incompletely characterized. This study employed an integrated approach combining network pharmacology, bioinformatics, molecular docking, and molecular dynamics simulations to identify the active components, potential targets, and related signaling pathways involved in XQLD's therapeutic action against CU, thereby providing a mechanistic foundation for its clinical application.

Direct Separation of -Xylene from Xylene Isomers by a Zinc Bipyrazolate Framework.

Separation of xylene isomers is an important challenge for the chemical industry. Here, we report a new zinc bipyrazolate framework MAF-70 for the separation of xylene isomers, which contains square pore channels of 8.7× 8.

Adsorption mechanism of Cu(II) and Pb(II) by starch biochar co-modified with plant extract and chitosan.

To investigate the adsorption mechanisms of heavy metal ions by starch (S)-based materials, S biochar (SB) was prepared by anaerobic calcination of S at 400 °C for 2 h. Plant extract (E) and chitosan (C) were subsequently used for single and combined modifications of SB, yielding E-modified SB (E-SB) and E/C co-modified SB (E/C-SB), respectively. The morphological features of E-SB and E/C-SB were characterized using multiple analytical techniques.

Locking-chain electrolyte additive enabling moisture-tolerant electrolytes for sodium-ion batteries.

The unstable electrolyte-electrode interface and the trace HO in commercial organic electrolytes critically limit the cycling life of batteries. Herein, a locking-chain sodium 4,4'-(1,4-phenylenebis(oxy))-bis(butane-1-sulfonate)-15-crown-5 (15PBS) is designed for phase-to-interface electrolyte optimization. In the electrolyte phase, the strong hydrophilic sulfonate groups and 15-crown-5 in 15PBS effectively transform HO from a reactive aggregated state (strong H-bond) into an inactive state (weak H-bond) through adsorption, effectively suppressing HO-induced electrolyte decomposition.

A weak acid-responsive porous polyelectrolyte membrane enables the high efficiency of a zinc anode interface.

Polymer coatings are promising candidates as artificial interfacial materials due to their significant barrier properties and zincophilicity, whereas modified zinc anodes for high depth of discharge (DOD) remain a major challenge. Herein, we present a novel approach that combines electrostatic complexation with phase separation in a weak-acid solution, which induces the formation of acid-responsive porous polyelectrolyte membranes, leading to an extended lifespan of the zinc anode of up to 900 h at a high current density of 40 mA cm. Additionally, the Zn@PEI-PSSNa anode demonstrates excellent zinc utilization, operating for up to 200 h at an ultra-high DOD of 97.

Expression of urinary exosomal miR-136-5p in diabetic kidney disease and evaluation of its clinical diagnostic value.

Diabetic kidney disease (DKD) has become a major cause of chronic kidney disease and end-stage renal disease. Numerous studies have indicated that exosomal miRNAs play a crucial role in the pathophysiological processes of DKD. We screened differentially expressed miRNAs in urinary exosomes from patients with DKD using the GEO database and performed PCR validation both in patients who were pathologically diagnosed and clinically diagnosed.

Impact of Interhospital Transfer on Mortality for Acute Aortic Dissections.

Background: There is a time-sensitive increase to mortality for acute type A dissections, yet interhospital transfer has not shown to increase operative death. Operative death does not account for all deaths attributable to transfer. We sought to determine the impact of transfer on mortality for all patients transferred with acute aortic dissections.

Amylase-producing lung adenocarcinoma with an anaplastic lymphoma kinase fusion mutation: a case report.

Introduction: Hyperamylasemia, typically a sign of digestive system disorders, especially pancreatic issues, has an unexpected link with lung cancer in some patients. This report describes such a case in which hyperamylasemia was associated with ALK fusion mutant lung adenocarcinoma.

Methods: We identified the type of tumor through histologic analysis and pulmonary biopsy of the tumor and further identified the type of genetic mutation in the tumor using genetic testing.