Connexin43 and Its Regulation of Astrocyte Gap Junction Function: Influencing Depression Progression by Mediating Electrical and Chemical Signals.

Background: Depression is a common mental illness with a high relapse rate, which has a serious negative impact on national economic development and happiness. At present, the pathogenesis of depression is still unclear, and there are inevitable limitations in first-line clinical treatment. Therefore, it is very important to clarify the pathological mechanism of depression for the development of safe and effective antidepressants.

Comparison of the arthroscopic and open surgery for the treatment of acute high-grade acromioclavicular joint dislocation using suture button: a systematic review and meta-analysis.

Purpose: To conduct a meta-analysis of clinical studies evaluating the efficacy and safety of arthroscopic and open surgery for the treatment of acute high-grade acromioclavicular joint (ACJ) dislocation using a suture button.

Methods: The review process was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Two independent reviewers conducted the literature searches based on preferred reporting items from systematic reviews and meta-analyses.

["Kidney deficiency-vessel impairment" as core pathogenesis of panvascular diseases: theoretical and clinical perspectives].

Panvascular disease is a complex systemic disorder. Research by our team has established "kidney deficiency-vascular impairment" as its core pathogenesis. Consequently, we developed a three-tiered progressive prevention and treatment strategy: early prevention phase: focuses on tonifying the kidney and reducing turbidity; mid-term control phase: focuses on tonifying the kidney and stabilizing plaque; late recovery phase: focuses on tonifying the kidney and unblocking collaterals.

MRI-based radiomics predicts complete responses to initial transcatheter arterial chemoembolization in virus-associated early and intermediate stage HCC.

To evaluate the value of a multiparametric MRI-based nomogram on predicting response to transcatheter arterial chemoembolization (TACE) in virus-associated hepatocellular carcinoma (HCC) patients; METHODS: This study enrolled 235 and 51 patients from Center 1 and 2, respectively. All patients underwent baseline MRI scans before treatment. The least absolute shrinkage and selection operator (LASSO) regression method was used to screen radiomics features from intra- and peri-tumor areas to establish the radiomics signatures (RS).

Equivalence of oral and intravenous tranexamic acid in knee arthroplasty: a systematic review and meta-analysis of randomized clinical trials.

Background: Tranexamic acid (TXA) is widely used to manage blood loss in joint arthroplasty. This study aims to compare the efficacy and safety of oral versus intravenous TXA in knee arthroplasty, focusing on blood loss and related outcomes.

Methods: A systematic review and meta-analysis were conducted according to the PRISMA guidelines.

Deciphering diabetic neuropathy: immune cell causality revealed.

Objective: This study assessed the causal effects of immune cell phenotypes on diabetic neuropathy (DN) using Mendelian randomization (MR) analysis.

Methods: Datasets of immune cell phenotypes and DN were collected from the European Bioinformatics Institute and FinnGen. Single nucleotide polymorphisms that met the specified criteria were subjected to a stepwise selection based on the hypotheses of association, independence, and exclusivity.

Photo-homogenization assisted segregation easing technique (PHASET) for highly efficient and stable wide-bandgap perovskite solar cells.

Wide-bandgap (WBG) perovskite solar cells (PSCs) can exceed the Shockley-Queisser limit in tandem solar cells (TSCs), but phase segregation under continuous illumination limits their stability. Using in-situ microscopic characterizations, we investigate the dynamics of photon-induced phase segregation. Initial light soaking drives iodide diffusion into a metastable state, but continued redistribution increases the phase separation energy barrier, resulting in a more stable, segregation-resistant state.

The levels of miR-155 in epilepsy patients: a meta-analysis.

Background: Neuroinflammation plays an important role in the development and progression of epilepsy. It can be both a result and a potential cause of those seizures. MiR-155 plays a crucial role in inflammatory responses, and its expression is upregulated under various neuroinflammatory conditions.

Repopulation of microglia and its implications for CNS disorders: Insights from the single-cell era.

Microglia, as resident macrophages in the central nervous system (CNS), have been the focus of the scientific community. The pace of exploration in the origin and development of microglia, though tortuous, never stops. Since colony-stimulating factor receptor 1 (CSF1R) inhibitors can achieve effective depletion of microglia and the repopulated microglia can be comparable to the controls, the therapeutic potential of this repopulation has prompted increasing attention and investigation.

Development prospects of "Internet + medical and health services" in Shandong: application status and public acceptance.

Background: The integration of Internet technology into healthcare has led to the birth of the "Internet + medical and health services" model-a transformative approach to improving accessibility and efficiency in healthcare delivery.

Objective: This study aims to assess the current status, challenges, and user perceptions of the "Internet + medical and health" services platform among individuals in Shandong, China.

Methods: The cross-sectional survey was conducted between September 2023 and October 2023 on patients from public medical institutions in Shandong Province.

Gas Dynamically Confined Synthesis of Platinum-Based Intermetallic Nanowires for Active and Ultrastable Oxygen Reduction Catalysis.

Precisely controlling the surface and internal atomic structures of platinum (Pt)-based nanocrystals remains a critical challenge for developing high-performance oxygen reduction reaction (ORR) catalysts. Here, we report a gas dynamically confined strategy leveraging hydrogen adsorption to synthesize Pt-based intermetallic nanowires (NWs) with ordered bulk atomic lattices (PtFe L1, PtCo L1, PtNi L1) and abundant high-index {311}, {211}, and {221} facets. Dynamic hydrogen adsorption reduces surface energy and suppresses atomic migration during high-temperature annealing, preserving the one-dimensional morphology and enabling structural ordering, as confirmed by in situ transmission electron microscopy and density functional theory calculations.

Adaptive phase 2/3 design with dose optimization.

FDA's Project Optimus initiative for oncology drug development emphasizes selecting a dose that optimizes both efficacy and safety. When an inferentially adaptive Phase 2/3 design with dose selection is implemented to comply with the initiative, the conventional inverse normal combination test is commonly used for Type I error control. However, indiscriminate application of this overly conservative test can lead to substantial increase in sample size and timeline delays, which undermines the appeal of the adaptive approach.

Long-range cholinergic input promotes glioblastoma progression.

Glioblastoma (GBM), the most aggressive primary brain tumor, is shaped by its integration into neural networks. While glutamatergic input is linked to tumor progression, the broader architecture and function of neuron-glioma connectomes remain unclear. Using monosynaptic rabies tracing, we map brain-wide neural input to patient-derived xenografts and reveal a consistent organizational logic: local inputs are primarily glutamatergic, while long-range connections exhibit diverse neurotransmitter profiles, with basal forebrain cholinergic projections emerging as a conserved input across sites.

Feasibility and accuracy of targeted axillary dissection by carbon tattooing in biopsy-proven node-positive breast cancer: A prospective study.

Introduction: Targeted axillary dissection (TAD) is used for less-invasive axillary staging in patients with initially node-positive breast cancer undergoing neoadjuvant chemotherapy (NACT). However, the efficacy of TAD using carbon suspension remains unclear. Here, the aim was to evaluate the feasibility and accuracy of TAD, combining sentinel lymph node biopsy (SLNB) using a single blue dye tracer with target lymph node biopsy (TLNB) using carbon suspension.

Effects of Tai Chi Chuan on balance function in adults 60 years or older with type 2 diabetes and mild cognitive impairment in China: A secondary analysis of a multi-center randomized clinical trial.

Aims: To investigate the effect of Tai Chi Chuan on balance function in adults 60 years or older with type 2 diabetes and mild cognitive impairment (MCI) in China.

Materials And Methods: This was a three-arm, parallel-group, randomized controlled trial with concealed allocation, assessor blinding, intention-to-treat (ITT), and per-protocol (PP) analysis. 328 adults 60 years or older, with a diagnosis of both type 2 diabetes and MCI, were randomly allocated into Tai Chi Chuan group, fitness walking group, and control group.

Correction: Ashby et al. Femoral Structure and Biomechanical Characteristics in Sanfilippo Syndrome Type-B Mice. 2023, , 13988.

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Direct welding of diamond and glass using burst mode femtosecond pulses.

In current research, achieving a strong connection of dissimilar materials with significantly different thermophysical properties remains a formidable challenge. This paper presents for what we believe to be the first time the strong bonding of single-crystalline diamond and fused silica glass by femtosecond laser direct writing, which was achieved under the condition of non-optical contact. The micromorphology and elemental distribution of the welding region were characterized.

Development of a flexible and low-cost digital pulse processing module with α/β discrimination for portable TDCR counters.

This study developed a flexible and low-cost digital pulse processing (DPP) module with α/β discrimination for portable triple to double coincidence ratio (TDCR) counters, meeting the increasing demand for on-site activity measurement and standardization of radionuclide in nuclear power plants and medical radionuclide applications. The newly developed DPP module integrates a coincidence algorithm within the Field Programmable Gate Array (FPGA), enabling real-time extraction of pulse characteristics based on coincidence event triggers. The features extracted from each pulse are transmitted to the Personal Computer (PC) in the form of an event list, allowing flexible selection of regions of interest (ROIs) in the pulse shape discrimination (PSD)-Energy spectrum for independent spectral display via dedicated software.

METTL1 promotes cadmium-induced stress granules formation via enhancing translation of G3BP1 and expression of mG- 3' tiRNA Met.

Methyltransferase 1 (METTL1) is currently regarded as a key tRNA mG writer. Recent studies indicate its potential role in carcinogenesis via increased mG modification to stabilize tRNA and upregulate tRNA expression. Cadmium-induced stress triggers the assembly of stress granules (SGs) and production of tRNA-derived stress-induced RNAs (tiRNAs).

Interaction between the non-alcoholic fatty liver disease fibrosis score and vitamin D deficiency on left ventricular hypertrophy and impaired diastolic function in patients with type 2 diabetes mellitus.

Aims: The present study aimed to evaluate the effect of Non-Alcoholic Fatty Liver Disease Fibrosis Score (NFS), vitamin D deficiency, and their interaction on the Left Ventricle (LV) structure and diastolic function in type 2 diabetes mellitus (T2DM) patients.

Methods: A total of 595 T2DM patients were recruited and stratified according to NFS grades (low, intermediate, and high) and the level of serum 25(OH)D (with and without vitamin D deficiency). Parameters of LV structure and diastolic dysfunction were measured by echocardiography.

Elevated ubiquitin phosphorylation by PINK1 contributes to proteasomal impairment and promotes neurodegeneration.

Ubiquitin (Ub), a central regulator of protein turnover, can be phosphorylated by PINK1 (PTEN-induced putative kinase 1) to generate S65-phosphorylated ubiquitin (pUb). Elevated pUb levels have been observed in aged human brains and in Parkinson's disease, but the mechanistic link between pUb elevation and neurodegeneration remains unclear. Here, we demonstrate that pUb elevation is a common feature under neurodegenerative conditions, including Alzheimer's disease, aging, and ischemic injury.

Effect of a machine learning prediction model on the false-negative rate of sentinel lymph node biopsy for clinically node-positive breast cancer after neoadjuvant chemotherapy.

Background: Machine learning (ML) models can be used to predict axillary pathological complete responses (pCRs) in clinically node-positive (cN+) breast cancer after neoadjuvant chemotherapy (NAC). We developed an ML model combining clinicopathological characteristics and axillary ultrasound features before and after NAC to predict the possibility of axillary pCR in NAC-treated cN + breast cancer.

Methods: Patients with cN + breast cancer who received NAC were categorized into training and verification cohorts (7:3 ratio).

Design, Optimization, and Biological Evaluation of a Novel Quinoline-Based POLRMT Inhibitor for Prostate Cancer Therapy.

Mitochondrial RNA polymerase (POLRMT) plays a pivotal role in various mitochondrial functions. The upregulation of POLRMT in prostate cancer (PCa) has been well-documented, underscoring its potential as a therapeutic target. In this study, we described the rational design, optimization, and comprehensive biological evaluation of a novel series of POLRMT inhibitors.

The Prognostic Value of Nutritional and Immune Indices for Stage IB Non-Small Cell Lung Cancer Patients: Insights From a Retrospective Cohort Study.

Background: Postoperative recurrence is a critical factor affecting the prognosis of stage IB non-small cell lung cancer (NSCLC). We aimed to evaluate the prognostic value of Nutritional and Immune Indices (NII) for postoperative recurrence among IB NSCLC patients.

Methods: Clinical data of patients with pathological stage IB NSCLC who underwent surgical resection were collected.

Resection of the temporal piriform cortex in mesial temporal lobe epilepsy: Association with seizure freedom in a retrospective cohort study.

Objective: This study evaluated the association between temporal piriform cortex (tPC) resection and long-term postoperative outcomes in temporal lobe epilepsy (TLE).

Methods: We conducted a retrospective analysis of patients with TLE undergoing surgery between 2012 and 2022, with a minimum follow-up of 2 years. The extent of resection, including the tPC, hippocampal head/body, and amygdala, was assessed using magnetic resonance imaging scans.