["Kidney deficiency-vessel impairment" as core pathogenesis of panvascular diseases: theoretical and clinical perspectives].

Panvascular disease is a complex systemic disorder. Research by our team has established "kidney deficiency-vascular impairment" as its core pathogenesis. Consequently, we developed a three-tiered progressive prevention and treatment strategy: early prevention phase: focuses on tonifying the kidney and reducing turbidity; mid-term control phase: focuses on tonifying the kidney and stabilizing plaque; late recovery phase: focuses on tonifying the kidney and unblocking collaterals.

Electrostatic and functional group-mediated biosorption of microalgae and lead using biosafe Aspergillus oryzae 3.042 fungal pellets.

Co-occurring algal blooms and lead (Pb) pollution pose severe threts to freshwater ecosystems. In this study, Aspergillus oryzae (A. oryzae) 3.

Research progress of animal models of antigen-induced autoimmune diseases.

Autoimmune diseases (AID) are chronic debilitating diseases characterized by excessive or prolonged autoimmune responses, which lead to the destruction of normal tissue structures and consequent clinical symptoms. AID poses a significant threat to human health, and its pathogenic mechanism remains poorly understood. Etiological studies suggest that the onset of AID primarily caused by the combined influence of environmental and genetic factors.

The hypoperfusion intensity ratio associates with APOE gene polymorphism in acute ischemic stroke patients with large vessel occlusion.

Determine whether APOE gene polymorphism is associated with hypoperfusion intensity ratio (HIR) in acute ischemic stroke (AIS) patients with large vessel occlusion (LVO). Continuously reviewed hospitalized LVO-AIS patients. According to whether the patients carried APOE allele ε 4, they were divided into 2 groups: ε4 carriers and non-ε4 carriers.

Properties of CO Micro-Nanobubbles and Their Significant Applications in Sustainable Development.

As an important part of global carbon neutrality strategies, carbon dioxide (CO) capture, utilization, and storage technologies have emerged as critical solutions for reducing carbon emissions. However, conventional CO applications, including food preservation, industrial synthesis, and enhanced oil recovery, face inherent limitations such as suboptimal gas-liquid mass transfer efficiency and inadequate long-term stability. Recent advancements in CO micro-nanobubbles (CO MNBs) have demonstrated remarkable potential across multidisciplinary domains, owing to their distinctive physicochemical characteristics encompassing elevated internal pressure, augmented specific surface area, exceptional stability, etc.

Rapid MS-Based Single-Cell Analysis Assisted by Photochemical Derivatization in Living Cell Membranes Reveals Lipidomic Patterns with Located C═C Bonds.

Traditional lipidomics methods are not well-suited for studying unsaturated lipids containing located C═C bonds in single cells. Here, we proposed a single-cell mass spectrometry (MS) platform assisted by a photochemical derivatization (PCD) method termed isible-light-activated u(bpy)-catalyzed inglet xygen-mediated ydroperoxidation (VRSOH), for the rapid and simultaneous detection of multiple lipid C═C location isomers in living cell membranes at the single-cell level. First, the VRSOH method combined with MS analysis achieved the localization of C═C bonds in mono- and polyunsaturated lipids and cellular lipid extracts.

Manipulated photocatalytic air-concentration CO into CHOH by dual hetero-metal atom pair sites.

Carbon dioxide (CO) reduction encompasses intricate protonation steps, frequently leading to unpredictable products. To achieve target product selectivity, it is essential to strategically manipulate the reaction pathway. Herein, we build Cu-Ag dual hetero-metal atom pair sites for photoreduction of 0.

MiR-183-5p inhibitor promotes mitoxantrone-induced immunogenic death of hepatoma cells by targeting STC1.

This study aimed to unravel the regulatory mechanism of the microRNA (miR)-183-5p/STC1 axis in regulating mitoxantrone (MIT)-induced immunogenic cell death (ICD) within hepatocellular carcinoma (HCC) cells and assess its therapeutic potential. Dual-luciferase reporter assays were employed to validate that miR-183-5p directly interacts with the 3'-untranslated region (3'-UTR) of STC1 mRNA. HepG2 cells were subjected to treatment with MIT, either in the presence of miR-183-5p inhibitors or STC1 knockout.

Intraoperative low-dose esketamine on postoperative quality of recovery in patients undergoing open gynecologic surgery: a double-blinded, parallel-group, placebo- controlled trial.

Background: Gynecologic laparotomy surgery often leads to moderate to severe pain. Effective analgesia is essential for patient postoperative recovery. We aimed to evaluate the effect of low-dose esketamine on quality of recovery when used as part of multimodal analgesia in patients undergoing open gynecologic surgery.

Teniposide Triggers DNA Repair Inhibition by Binding and Ubiquitination of Apurinic/Apyrimidinic Endonuclease 1 to Boost Oxidative DNA Damage for Lung Cancer Destruction.

Teniposide (Ten/VM-26) is low in toxicity and has proven to be effective in destroying malignant cells at low doses. However, the target and molecular mechanism of Ten/VM-26 are poorly understood, which limits its clinical application against solid malignant cancers. Apurinic/apyrimidinic endonuclease 1 (APEX1) expression is upregulated in lung cancer, which could effectively suppress DNA damage.

The Influence of Dimensional Parameters on the Characteristics of Magnetic Flux Concentrators Used in Tunneling Magnetoresistance Devices.

Measuring weak magnetic fields proposes significant challenges to the sensing capabilities of magnetic field sensors. The magnetic field detection capacity of tunnel magnetoresistance (TMR) sensors is often insufficient for such applications, necessitating targeted optimization strategies to improve their performance in weak-field measurements. Utilizing magnetic flux concentrators (MFCs) offers an effective approach to enhance TMR sensitivity.

Recent advances in silk fibroin-based biomaterials for tissue engineering applications.

Tissue engineering (TE) is a multidisciplinary area that offers innovative solutions to the challenges of organ repair and regeneration, with promising application potential. The core objective of TE is to construct a 3D spatial architecture made up of cells and biological scaffold materials, and the selection of suitable materials as scaffolds for cell growth is crucial. Silk fibroin (SF) is a macromolecular fibrous protein.

Self-suppression of leading-fiber-induced noise for remote fiber-optic interferometric sensor using a dual-wavelength optical signal.

Environmental disturbances in the leading fiber are a significant source of noise in remote fiber optic interferometric sensors (FOIS). As the two interrogation lightwaves propagate through the leading fiber, environmental disturbances can induce undesired demodulated phase noises, collectively referred to as leading-fiber-induced noise. This study proposes what we believe to be a novel method for leading-fiber-induced noises self-suppression, utilizing dual-wavelength optical signals as mutual reference signals, thereby eliminating the need for a reference interferometer.

Denoising of ICESat-2 photon-counting data based on the improved DENCLUE algorithm.

The Ice, Cloud, and Land Elevation Satellite-2 (ICESat-2) light detection and ranging data prove significant potential for oceanographic applications including shallow water bathymetry and coral reef monitoring. However, their utilization in precise oceanographic investigations is constrained by substantial noise contamination. Traditional spatial clustering denoising algorithms exhibit high parameter sensitivity, where a suboptimal parameter selection frequently leads to inadequate noise suppression.

Mineralized double-network hydrogels for the controlled release and improved stability of antimicrobial peptides.

Antimicrobial peptides (AMPs) have attracted considerable attention in chronic wound management and the prevention of implant-associated infections due to their excellent bactericidal activity, low toxicity, and great biocompatibility. However, their poor stability and uncontrolled release often result in transient efficacy, necessitating frequent administration. Developing a delivery system that ensures both sustained release and mechanical stability is crucial for the clinical translation of AMPs.

Mechanically robust eutectogels enabled by precisely engineered crystalline domains.

Eutectogels have emerged as promising candidates for technological applications due to their environmental stability, repeatable deformability, and high ionic conductivity. Nevertheless, the existing eutectogels often show fragile network structures, in which the simultaneous achievement of high modulus, strength, and toughness remains a real challenge. Herein, a variable-temperature solvent exchange (VTSE) strategy is proposed to fabricate mechanically robust eutectogels.

Linkage unit modulation of the polymers induces type-I to S-scheme transition in polymer/g-CN heterojunctions for enhanced hydrogen evolution and chromium (VI) reduction.

Building polymer heterojunctions (PHJs) is a promising way to enhance the performance of single-polymer photocatalysts, but it's still challenging to design the ideal structure with well-matched energy levels and strong interface synergy by precisely tuning the molecular structure of polymer. Herein, two triazine-based conjugated porous polymers (CPPs) were synthesized in advance including TB and TR via linkage unit modulation at the molecular level, and then their PHJs with carbon nitride (g-CN) nanosheet including TB/CN and TR/CN were successfully constructed by the convenient physical ball milling method. Theoretical calculations, electron paramagnetic resonance (EPR), and in situ X-ray absorption near-edge structure (XANES) spectra show that replacing thiophene rings in TR with phenyl rings in TB changes the PHJ structure from type-I (TR/CN) to an S-scheme (TB/CN) heterojunction.

Analysis of temperature field evolution in ground freezing construction of twin tunnels in a coastal urban area.

In the field of underground engineering, the artificial ground freezing method has emerged as a highly effective technique due to its excellent impermeability, controllability, and minimal environmental impact. This method is particularly advantageous in complex geological and urban settings, making it widely used in tunnel construction under challenging conditions. However, in the case of twin-tunnel (or two-lane tunnel) projects, accurately predicting the temperature field during the freezing process remains a critical challenge.

Experimental and numerical simulation studies on the mechanical properties and failure characteristics of rock masses with weak interlayers.

To elucidate the mechanical properties and failure behaviors of rock-like materials with weak interlayers of varying inclinations and thicknesses, uniaxial compression tests were conducted on such rock-like materials. The effects of interlayer inclination and thickness on the acoustic emission ringing counts and macroscopic fracture of the rock-like materials were investigated. From a mesoscopic perspective, the crack initiation and propagation processes, stress field distribution characteristics, and energy evolution laws of the rock-like materials with weak interlayers were analyzed.

Two Subunits of the Rpd3 Histone Deacetylase Complex of Cochliobolus heterostrophus Are Essential for Nitrosative Stress Response and Virulence, and Interact With Stress-Response Regulators ChHog1 and ChCrz1.

Southern corn leaf blight (SCLB), caused by Cochliobolus heterostrophus, is a destructive disease in maize-growing areas worldwide. Reactive nitrogen species derived from nitric oxide exhibit antimicrobial activities by interacting with microbial cellular components, leading to nitrosative stress in pathogens. However, the regulatory mechanisms underlying adaptation to nitrosative stress remain largely unexplored in C.

Catalyst-Free Cleavage of C─O/C─C Bonds in Lignin Linkages by Water Microdroplets.

Bulk water serves as an inert environment for lignin linkages, resulting in their natural half-lives that extend over centuries. In this study, we present the striking results of the spontaneous and ultrafast C─O/C─C bond cleavage of various lignin models in water microdroplets, yielding value-added aromatic chemicals. The β-O-4 linkages, the most abundant interunit linkages in natural lignin, were selectively cleaved at C─O bonds, producing phenols in yields exceeding 70%.

Emodin-Enhanced hUC-MSC extracellular vesicles alleviate acute pancreatitis by targeting inflammation and pyroptosis.

Background: Acute pancreatitis (AP) is a complex condition requiring immediate treatment. Both extracellular vesicles derived from human umbilical cord mesenchymal stem cells (hUC-MSC-EVs) and emodin, a naturally occurring anthraquinone used in traditional Chinese medicine, have shown therapeutic potential in treating AP. However, the mechanisms by which hUC-MSC-EVs and emodin alleviate AP, and whether they exert a synergistic effect on inflamed pancreatic tissues, remain unclear.

Comparative effect of dietary patterns on selected cardiovascular risk factors: A network study.

Cardiovascular disease (CVD) is a major global health concern associated with modifiable risk factors including obesity, hypertension, dyslipidemia, and hyperglycemia. While various dietary patterns have demonstrated cardiovascular benefits, their comparative effectiveness remains unclear. This network meta-analysis (NMA) systematically evaluates the impact of eight dietary patterns on cardiovascular risk markers.

Metal-driven anaerobic oxidation of methane and the Sturtian deglaciation.

The Sturtian and Marinoan glaciations shaped Neoproterozoic palaeoenvironmental evolution. While methane emission likely intensified the Marinoan greenhouse effect, its role during the Sturtian glaciation-coinciding with widespread iron formations (IFs)-remains poorly understood. Here, we analysed bio-essential metals (Ni, Co, Zn), rare earth elements and yttrium (REY), Fe (δFe) and Ni (δNi) isotopes in hematite and magnetite, alongside bulk-rock and in-situ C isotopes of Mn-rich carbonates from five well-preserved Sturtian-aged IFs in South China.