Electrostatic and functional group-mediated biosorption of microalgae and lead using biosafe Aspergillus oryzae 3.042 fungal pellets.

Co-occurring algal blooms and lead (Pb) pollution pose severe threts to freshwater ecosystems. In this study, Aspergillus oryzae (A. oryzae) 3.

Neurosyphilis Presenting as Sleep Disorder and Muscle Soreness Complicated With HIV Infection: A Case Report.

Neurosyphilis is a tertiary syphilis complication or manifestation caused by which invades the central nervous system. Its clinical manifestations are often nonspecific. Neurosyphilis symptoms frequently resemble those of spinal cord diseases and mental disorders, posing significant challenges for early diagnosis.

Clinical Characteristics and Prognosis of AIDS Complicated with Talaromycosis marneffei Infection: a Single-Center Retrospective Study.

Introduction: The objective of the study was to determine the clinical features and prognostic risk factors of acquired immunodeficiency syndrome (AIDS) combined with Talaromyces marneffei (TM) infection.

Methods: We retrospectively analyzed the clinical data of 133 hospitalized patients diagnosed with AIDS and TM co-infection. Patients were divided into an improvement group and a deterioration group on the basis of their discharge outcomes.

Removal of soluble chlorides and valorization of incineration bottom ash through alkali fusion and hydrothermal techniques.

Improving the removal of chloride as well as the quality and application value of products is crucial for the practical treatment and utilization of waste incineration bottom ash. This research innovatively employed alkali fusion and hydrothermal techniques to achieve these objectives simultaneously and compared with traditional methods. Additionally, the effects of different parameters and the optimal operating conditions were identified and the characteristics of synthetic zeolite were examined.

Effect of Nucleos(t)ide Analogues Withdrawal on Survival Outcomes in Patients With Hepatitis B Virus-Related Acute-on-Chronic Liver Failure.

Background/aims: Nucleos(t)ide analogues (NA) withdrawal is an important cause of hepatitis B virus (HBV) infection relapse or flare, potentially triggering HBV-related acute-on-chronic liver failure (HBV-ACLF). Although both NA withdrawal and spontaneous severe acute exacerbation (SAE) of chronic hepatitis B are recognised HBV-ACLF triggers, comparative evidence regarding their distinct clinical trajectories remains absent. This multicenter retrospective cohort study sought to determine whether NA withdrawal independently predicts adverse outcomes in HBV-related ACLF compared to SAE-induced cases.

A 96 dB Input Dynamic Range Galvanic Skin Response Readout IC with 3.5 pArms Input-Referred Noise for Mental Stress Monitoring.

This paper presents a low-noise, low-power galvanic skin response (GSR) sensing circuit capable of simultaneously measuring skin conductance level (SCL) and skin conductance response (SCR) for psychological stress monitoring. The circuit incorporates second-order sub-ten-hertz filters that suppresses out-of-band interference and a programmable gain amplifier (PGA) to accommodate signals of varying magnitudes. Additionally, a dynamic range adjustment mechanism optimizes the primary amplifier's operating range based on real-time SCL readings.

PTPN2 modulates antiviral immunity in grouper by promoting TBK1 degradation and suppressing interferon signaling.

As a member of the class I non-receptor protein tyrosine phosphatase family, Tyrosine-protein phosphatase non-receptor type 2 (PTPN2) plays a pivotal role in the regulation of cellular signaling pathways. In this study, we successfully cloned and characterized a PTPN2 homolog from Epinephelus coioides, designated as EcPTPN2. The open reading frame (ORF) of EcPTPN2 spans 1186 nucleotides, encoding a protein of 395 amino acids (Accession number: PV289599).

A Case Report of Gilbert Syndrome Presenting With Acute Cholecystitis.

A 38-year-old male with Gilbert syndrome presented with acute cholecystitis, jaundice, and elevated liver enzymes. This case highlights the importance of genetic testing for unexplained jaundice, avoiding misdiagnosis, and guiding personalized treatment for Gilbert syndrome.

Hydroxyurea-related ileocecal region ulcers as a rare complication: A case report.

Background: Hydroxyurea, an antimetabolite, is frequently prescribed for various hematological disorders, and its common side effects include gastrointestinal problems, cutaneous or mucosal lesions and pyrexia/fever.

Case Summary: This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary thrombocythemia. Colonoscopy revealed an ileocecal ulcer.

MetaQ: fast, scalable and accurate metacell inference via single-cell quantization.

To overcome the computational barriers of analyzing large-scale single-cell sequencing data, we introduce MetaQ, a metacell algorithm that scales to arbitrarily large datasets with linear runtime and constant memory usage. Inspired by cellular development, MetaQ conceptualizes each metacell as a collective ancestor of biologically similar cells. By quantizing cells into a discrete codebook, where each entry represents a metacell capable of reconstructing the original cells it quantizes, MetaQ identifies homogeneous cell subsets for efficient and accurate metacell inference.

Integrated Transcriptomic and Targeted Metabolomic Analysis Reveals the Key Genes Involved in Triterpenoid Biosynthesis of .

is a traditional Chinese medicinal fungus, and ganoderma triterpenoids (GTs) are one of the main bioactive compounds. These compounds have various pharmacological functions, including anti-tumor, antioxidant, anti-inflammatory, liver-protective, and immune-regulating effects. However, the manner in which they accumulate, and their biosynthesis mechanisms remain unclear.

Effect of dyslipidemia on HBsAg clearance in nucleos(t)ide analogues-experienced chronic hepatitis B patients treated with peginterferon alfa.

Background: While previous reports have shown that hepatitis B virus (HBV) infection affects lipid metabolism and vice versa, the impact of dyslipidemia on the functional cure of HBV infection following peginterferon alfa (PegIFNα) therapy remains unknown. Hence, this study aimed to investigate the effect of dyslipidemia on hepatitis B surface antigen (HBsAg) clearance and develop a nomogram model for predicting patients for whom PegIFNα therapy is indicated.

Methods: A total of 160 nucleos(t)ide analogues (NAs)- experienced chronic hepatitis B (CHB) patients treated with PegIFNα (180 µg/week) were enrolled in this study.

Degradation of sulfonamide antibiotic via UV/MgO system: kinetic, application, and mechanism.

In response to antibiotic residues in the water, a novel advanced oxidation technology based on MgO was used to remediate sulfamethazine (SMTZ) pollution in aquatic environments. Upon appropriate regulation, the remarkable removal efficiency of SMTZ was observed in a UV/MgO system, and the pseudo-first-order reaction constant reached 0.4074 min.

Psychosocial stress in children with Tourette syndrome and chronic tic disorder.

Background: This study aimed to understand the longitudinal relationship between psychosocial stress with tic exacerbation in children with Tourette syndrome (TS) and chronic tic disorder.

Methods: Consecutive ratings of tic severity as well as child and parental reports of psychosocial stress were obtained for 373 children (296 males, 77 females; mean age 9y 5mo; SD 3y 3mo) with TS and chronic tic disorder between January 2018 and December 2020. The Yale Global Tic Severity Scale (YGTSS) global severity score, total tic score, and impairment rating were calculated.

Hibiscus Anthocyanins Extracts Induce Apoptosis by Activating AMP-Activated Protein Kinase in Human Colorectal Cancer Cells.

Apoptosis, a programmed cell death process preventing cancer development, can be evaded by cancer cells. AMP-activated protein kinase (AMPK) regulates energy levels and is a key research topic in cancer prevention and treatment. Some bioactive components of L.

Two-Fold Genes, Three-Fold Control Regions, lncRNA, and the "Missing" Found in the Mitogenomes of (Rhacophridae: ).

In prior research on the mitochondrial genome (mitogenome) of , the one copy of gene was translocated to the control region (CR) and the gene was not found. Gene loss is uncommon among vertebrates. However, in this study, we resequenced the mitogenomes of from different regions using a "primer bridging" approach with Sanger sequencing technologies, which revealed the "missing" gene in as well as three other previously published .

Novel gene rearrangements in mitochondrial genomes of four families of praying mantises (Insecta, Mantodea) and phylogenetic relationships of Mantodea.

The mitochondrial genome (mitogenome) plays an important role in phylogenetic studies of many species. The mitogenomes of many praying mantis groups have been well-studied, but mitogenomes of special mimic praying mantises, especially Acanthopoidea and Galinthiadoidea species, are still sorely lacking in the NCBI database. The present study analyzes five mitogenomes from four species of Acanthopoidea (Angela sp.

Detection of lactate in human sweat via surface-modified, screen-printed carbon electrodes.

Real-time and continuous monitoring of lactate levels in sweat has been used as an indicator of physiological information to evaluate exercise outcomes and sports performance. We developed an optimal enzyme-based biosensor to detect the concentrations of lactate in different fluids (i.e.

A Multimodality Electrochemical and Impedance Spectroscopy System-on-a-Chip With Temperature Sensing and Impedance-Boosting Techniques.

This article presents a multimodal electrochemical sensing system-on-chip (SoC), including the functions of cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and temperature sensing. CV readout circuitry achieves an adaptive readout current range of 145.5 dB through an automatic range adjustment and resolution scaling technique.

Single-Cell RNA-Seq Debiased Clustering via Batch Effect Disentanglement.

A variety of single-cell RNA-seq (scRNA-seq) clustering methods has achieved great success in discovering cellular phenotypes. However, it remains challenging when the data confounds with batch effects brought by different experimental conditions or technologies. Namely, the data partitions would be biased toward these nonbiological factors.

Metabolic status indicators and influencing factors in non-obese, non-centrally obese nonalcoholic fatty liver disease.

Non-obese nonalcoholic fatty liver disease (NAFLD) is characterized by metabolic disorders and related complications. This study aimed to provide an integrated description of clinical, metabolic, and influencing factors for a specific category of patients with non-obese NAFLD. A total of 36 participants with body mass index (BMI) < 28 kg/m2 and visceral adipose tissue < 100 cm2 were classified into 2 groups: the non-obese, non-centrally obese control group (n = 17) and non-obese, non-centrally obese NAFLD group (n = 19).

The Genetic Diversity and the Divergence Time in Extant Primitive Mayfly, Ulmer, 1920 Using the Mitochondrial Genome.

In this study, the mitochondrial (mt) genomes of (Ephemeroptera: Siphluriscidae) were evaluated in specimens collected from two sites in China: Niutou Mountain, Zhejiang Province ( NTS) and Leigong Mountain, Guizhou Province ( LGS) and were successfully sequenced. The lengths of the mt genomes of NTS and LGS were 15,904 bp (ON729390) and 15,212 bp (ON729391), respectively. However, an in-depth comparison of the two mt genomes showed significant differences between the specimens collected from the two sites.

Dual Contrastive Prediction for Incomplete Multi-View Representation Learning.

In this article, we propose a unified framework to solve the following two challenging problems in incomplete multi-view representation learning: i) how to learn a consistent representation unifying different views, and ii) how to recover the missing views. To address the challenges, we provide an information theoretical framework under which the consistency learning and data recovery are treated as a whole. With the theoretical framework, we propose a novel objective function which jointly solves the aforementioned two problems and achieves a provable sufficient and minimal representation.