Efficient separation of impurities from pyrolusite and the enhancement of its products for improving the performance of lithium-ion batteries.

Manganese sulfate is a derivative of manganese resources with multiple applications. In addition to its traditional uses, it plays a critical role in various environmental and energy sectors. Manganese sulfate not only contributes to water treatment but also plays a significant role in the production of lithium-ion battery materials.

Transcription factor ETV1 promotes angiogenesis after myocardial infarction via activation of the VEGFA/VEGFR2/eNOS pathway.

Background: In our previous study, through integrative transcriptomic and ChIP-seq analysis, we revealed that ETV1 is a potential transcription factor involved in ventricular remodeling in the early stage of MI. This study aims to investigate the regulatory roles of ETV1 and whether ETV1 regulates angiogenesis after MI.

Methods: In this study, MI model was induced by ligating the left anterior descending coronary artery.

Visualizing and analyzing global knowledge maps and emerging research trends in tumor-derived exosomes using CiteSpace.

Objective: Tumor-derived exosomes testing can be effective in diagnosing disease and assisting in the treatment of disease. Our study utilizes bibliometric analysis to identify research hotspots related to tumor-derived exosomes, predict emerging research frontiers and development trends, and offer diverse perspectives for advancing research in this field.

Methods: Search the Web of Science Core Collection for English-language literature published on the field of tumor-derived exosomes from 2015 to 2024.

Synthesis of Upconversion Nanoparticles with Manipulable Crystal Phase, Size Specification, and Morphological Features.

Rare earth-doped upconversion nanomaterials are one of the luminescent materials that have received extensive attention in recent years and have important applications in fields such as biomedicine, optoelectronic devices, and security inspection. In this study, for NaYF:Yb,Er upconversion nanoparticles, the effects of experimental parameters such as reaction temperature, reaction time, and the content of surfactants on their crystal phase, size, and morphology were systematically investigated. By adjusting the experimental parameters, the size of the hexagonal phase upconversion nanoparticles can be effectively controlled within the range of 18-71 nm.

Interventional three-tube method for the management of duodenal perforation after endoscopic retrograde cholangiopancreatography for choledocholithiasis: a case series.

Background: Endoscopic retrograde cholangiopancreatography (ERCP) is a common procedure for biliary and pancreatic diseases. Although duodenal perforation is a rare complication of ERCP (incidence, <1%), it is associated with a significant mortality rate (4.2-37%).

Two-hit immune activation induced autism-like phenotypes in mice: The underlying mechanism may involve the lung-brain axis.

Neuroinflammation plays important roles in the pathogenesis and development of autism spectrum disorder (ASD). However, the mechanism by which peripheral organ inflammation affects neuroinflammation is still unclear. This study aimed to investigate that the interaction between the lungs and the brain as a potential mechanism underlying this effect.

Generation of personalized whole tumor cells vaccine for pyroptosis-enhanced anticancer immunity via CuSe photothermal activation under NIR irradiation.

Autologous tumor cells demonstrate considerable promise as individualized therapeutic vaccines owing to their endogenous neoantigen repertoire. Nevertheless, their suboptimal immunogenicity substantially impedes clinical translation. Herein, we engineered an innovative whole tumor cell vaccine platform utilizing photothermal CuSe nanoparticles, which encapsulate comprehensive tumor-associated antigens and intrinsic immunostimulatory molecules to elicit a polyvalent antitumor immune response.

Toll-like receptor-mediated immune imbalance in asthma: controversies, breakthroughs, and future directions.

As a chronic inflammatory illness of the respiratory system, asthma occurs due to various factors and is characterized by a T helper 2 (Th2)-skewed immune response, airway hyperresponsiveness, and reversible airflow obstruction. Toll-like receptors (TLRs) perform a "double-edged sword" function in asthma-related immunological dysregulation by recognizing damage-associated molecular patterns and pathogen-associated molecular patterns. In turn, the activation of some TLRs stimulates epithelial cells to release inflammatory cytokines, exacerbating Th2-driven inflammation and contributing to airway remodeling.

EDTA-Mg Nano-Chelators Amplify Ferroptosis by Artificially Simulating the Epithelial-Mesenchymal Transition Process and Endogenous Iron Deprivation.

Epithelial-mesenchymal transition (EMT) is a key step in initiating tumor metastasis. Commonly, researchers focus on inhibiting EMT to prevent tumor metastasis. However, they ignore that tumor cells undergoing EMT are more vulnerable to disturbance from the external environment.

Toll-like receptor-4 in the fish immune system.

Toll-like receptors (TLRs) represent a critical class of protein molecules integral to nonspecific immunity (innate immunity), and serve as key mediators bridging between nonspecific and specific immune responses. As an important member of the TLR multigene family, toll-like receptor 4 (TLR4) holds particular significance due to its broad expression across various animal tissues and its pivotal roles in pathogen recognition, signal transduction, and the modulation of inflammatory responses. In aquaculture, Tlr4 has emerged as a promising target for the development of vaccines, immune enhancers, and adjuvants aimed at bolstering the health and disease resistance of aquatic animals, thereby reducing the reliance on antibiotics.

Lanthanide nanocrystals-based direct triple-state energy converters for mitophagy and ferroptosis-induced antitumor immunoreaction.

Achieving multiple antitumor efficacy in a single nanostructure is important for the development of photo-functional nanomedicines. In this paper, we report a direct triplet state energy converter (NCPRB) based on lanthanide nanocrystals, which can reduce the loss of near-infrared (NIR) light and improve the efficiency of generating reactive oxygen species (ROS) to induce ferroptosis through the process of direct energy transfer from rare earth ions (Nd) to the triplet state of the photosensitive molecule (chlorin e6, Ce6). Experimental results showed that the generated ROS combined with loaded resveratrol (RES) inhibited oxidative phosphorylation (OXPHOS) and electron transport chain (ETC) processes in the mitochondria of tumor cells and induced the onset of mitochondrial autophagy.

Streamlining Thoracic Radiotherapy Quality assurance: One-Class Classification for Automated OAR Contour Assessment.

PurposeAutomating quality assurance (QA) for contours generated by automatic algorithms is critical in radiotherapy treatment planning. Manual QA is tedious, time-consuming, and prone to subjective experiences. Automatic segmentation reduces physician workload and improves consistency.

Progressive Evaluation of Ischemic Occlusion in a Macaque Monkey with Sudden Exacerbation of Infarction During Acute Stroke: A Case Report.

Early neurological deterioration is associated with poor functional outcomes in stroke patients, but the underlying mechanisms remain unclear. This study aims to understand the progression of stroke-related brain damage using a rhesus monkey model with ischemic occlusion. Multiparameter MRI was used to monitor the progressive evolution of the brain lesion following stroke.

Retrieving oceanic constituents and inherent optical properties in global oceans using multi-angular polarimetric measurements.

Multi-angle polarization characteristics of water-leaving radiation are crucial for the retrieval of the oceanic constituents and the inherent optical properties (IOPs). However, the feasibility of using the polarization spectrum to retrieve the oceanic constituents and IOPs in global oceans remains unclear. In this study, global radiative transfer (RT) simulations for the Stokes vectors of water-leaving radiance () were performed, and a global polarization-based algorithm using the fully connected U-Net (FCUN) for retrieving the oceanic components and IOPs was developed.

Medial prefrontal glutamate response to acute stress is associated with social subordination in female rhesus macaques.

Chronic psychosocial stress is associated with increased risk of psychiatric disorders. Magnetic resonance spectroscopy (MRS) in humans has been used to show that glutamate levels in medial prefrontal cortex (mPFC) following acute stress exposure adapt to recent chronic stress levels. Here, we sought to determine the presence of this glutamate stress response adaptation in rhesus macaques, whose societies are maintained by dominance relationships that are enforced by agonistic interactions and result in chronic stress phenotypes seen in humans.

Cardiovascular abnormalities already occurred in newly-diagnosed patients with early-onset type 2 diabetes.

Background: The prevalence of early-onset type 2 diabetes (EOD) is rapidly increasing. This study intends to screen for early cardiovascular abnormalities in patients newly diagnosed with EOD and evaluate the cardiovascular risk across cluster phenotypes.

Method: A total of 400 patients ≤ 40 years old with newly diagnosed type 2 diabetes were enrolled from the START cohort (the Study of The newly diAgnosed eaRly onset diabeTes).

Acidity-unlocked glucose oxidase as drug vector to boost intratumor copper homeostatic imbalance-enhanced cuproptosis for metastasis inhibition and anti-tumor immunity.

As one of the key tools of biocatalysis, natural enzymes have received extensive attention due to their unique activity. However, the non-selective catalysis and early leakage induced by delivery dependency of natural enzymes can cause side effects on normal tissues. Moreover, although cuproptosis is an emerging tumor-inhibiting programmed cell death, the occurrence of cuproptosis leads to high expression of Cu-dependent lysyl oxidase-like 2 (LOXL2), which promotes tumor metastasis.

Feasibility and safety of interventional radiology-guided biopsy for esophageal stenosis.

Background: Endoscopic clamp biopsy is generally performed to confirm the pathological diagnosis of esophageal stenosis. However, it might be challenging in patients with severe esophageal stenosis. Hence, we aimed to investigate the feasibility and safety of interventional radiology-guided clamp biopsy under fluoroscopy for diagnosing esophageal stenosis.

MutL Interaction with RaxM Regulates Expression in pv. .

Rice XA21 is the cognate resistance (R) protein of the avirulence protein AvrXA21 (RaxX) of pv. (). The RaxX precursor must be modified by the peptidase RaxB and the tyrosine sulfotransferase RaxST to transform into an active form that has ability to bind and activate XA21.

Clinical value of miR-216a-5p and miR-34a in early screening for cervical cancer.

Objective: To investigate the clinical value of miR-216a-5p and miR-34a in early screening for cervical cancer (CC).

Methods: 99 patients were selected and classified into a cervical cancer group, a precancerous lesion group, and a chronic cervicitis group, with 33 patients in each group. The miR-216a-5p and miR-34a levels in the morning urine samples of patients in the three groups were detected.

Polyguluronate sulfate has potential to mitigate hyperlipidemia by inhibiting the PCSK9-mediated degradation of LDLR.

Hyperlipidemia has become a major global health challenge and one of the leading causes of mortality. Proprotein convertase subtilisin/kexin type 9 (PCSK9), a circulating plasma protein, promotes the lysosomal degradation of hepatic low-density lipoprotein receptors (LDLR), thereby reducing the clearance of low-density lipoprotein (LDL) from blood plasma. PCSK9 has increasingly become a prominent therapeutic target for the development of lipid-lowering agents.