[Effect and mechanism of Moringa oleifera leaves, seeds, and velamen in improving learning and memory impairments in mice based on transcriptomic and metabolomic].

Moringa oleifera, widely utilized in Ayurvedic medicine, is recognized for its leaves, seeds, and velamen possessing traditional effects such as vātahara(wind alleviation), sirovirecaka(brain clearing), and hridya(mental nourishment). This study aims to identify the medicinal part of ■ in the Sārasvata ghee formulation as described in the Bower Manuscript, while investigating the ameliorative effects of different medicinal parts of M. oleifera on learning and memory deficits in mice and elucidating the underlying molecular mechanisms.

Transcription factor ETV1 promotes angiogenesis after myocardial infarction via activation of the VEGFA/VEGFR2/eNOS pathway.

Background: In our previous study, through integrative transcriptomic and ChIP-seq analysis, we revealed that ETV1 is a potential transcription factor involved in ventricular remodeling in the early stage of MI. This study aims to investigate the regulatory roles of ETV1 and whether ETV1 regulates angiogenesis after MI.

Methods: In this study, MI model was induced by ligating the left anterior descending coronary artery.

Factors Affecting the Receptiveness of Chinese Internists and Surgeons Toward Artificial Intelligence-Driven Drug Prescription: Protocol for a Systematic Survey Study.

Background: Recently, we developed and tested an autonomous artificial intelligence (AI) agent for prescribing a drug to prevent severe acute graft-versus-host disease in patients receiving human leukocyte antigen haplotype-mismatched hematopoietic cell transplants in a prospective clinical trial. Our experience in this proof-of-concept study suggests that physicians and patients can be receptive to autonomous AI prescription. However, the generalizability of our conclusion requires testing in additional clinical settings.

Research on high-resolution reconstruction methods for microlens array snapshot hyperspectral microscopy system combining transfer learning and data decomposition-reconstruction.

The microlens array snapshot hyperspectral microscopy system has significant potential in dynamic microscopic monitoring due to its ability to rapidly acquire three-dimensional data cubes without scanning. However, its low spatial resolution and the incompatibility of existing image fusion methods limit its broader application. To address these challenges, this study proposes an image fusion method that combines transfer learning with data decomposition and reconstruction.

Deep learning-based phase retrieval with embedded data for holographic data storage.

This paper proposes a deep learning-based (DL-based) method for phase retrieval with embedded data. Utilizing known embedded data as strong constraints, in the case of multi-level phase encoding, each signal data has a unique solution for the phase difference relative to the embedded data. This innovative coding strategy reduces the arrangements of signal data and its adjacent data from 4 types to just 4, allowing a single labeled sample to contain all possible coding arrangements.

Aperiodic optical phased array with wide field of view and high sidelobe suppression ratio based on SiN-on-SOI platform.

This paper presents an aperiodic optical phased array (OPA) based on a dual-layer emission grating on a SiN-on-SOI platform. The dual-layer grating offers advantages in terms of integration process feasibility and large process tolerance. A particle swarm optimization algorithm was employed to optimize the emission array.

Comparison of Lobectomy vs Total Thyroidectomy for Medullary Thyroid Carcinoma: A SEER Analysis With Chinese Cohort Validation.

Background: This study aimed to clarify whether lobectomy provides survival benefits for patients with early-stage medullary thyroid carcinoma (MTC).

Patients And Methods: Patients with tumor size less than 4 cm, excluding those with lateral neck involvement, bilateral foci, extrathyroidal extension or distant metastases, were enrolled from the Surveillance, Epidemiology, and End Results (SEER) database and Zhejiang Cancer Hospital in China. Propensity score matching (PSM), Kaplan-Meier analysis, and Cox regression analyses were used to evaluate treatment outcomes and identify risk factors.

Heat-moisture-treated rice improves oral glucose tolerance by modulating serum and fecal metabolites in mice.

Background/objective: Heat-moisture treatment (HMT) can increase the composition of resistant starch and reduce the glycemic index in rice. However, the effect of long-term HMT-rice feeding is unknown. The objective is to investigate the effect of long-term HMT-rice feeding on alleviating hyperglycemia in mice and explore potential mechanisms.

Lobectomy vs total thyroidectomy for unilateral papillary thyroid carcinoma with ipsilateral cervical lymph node metastasis.

Objective: This study aimed to compare the prognosis of unilateral papillary thyroid carcinoma(PTC) patients with ipsilateral cervical lymph node metastasis(IC-LNM) under the treatment of unilateral lobectomy(uLT) vs total thyroidectomy(TT) in order to find out the optimal surgery for these patients without other clinical risk characteristics.

Methods: PTC patients at Zhejiang Cancer Hospital between 2012 and 2022 were retrospectively reviewed. Additionally, a propensity score matching(PSM) was performed on patients treated with uLT or TT.

Pan-cancer Analyses Refine the Single-Cell Portrait of Tumor-Infiltrating Dendritic Cells.

Dendritic cells (DCs) are pivotal orchestrators of anti-tumor immunity. DC-based anti-tumor treatments are being actively developed, but effective clinical responses have not yet been achieved. Further exploration of DC heterogeneity in the tumor microenvironment (TME) and across cancer types could provide insights for developing DC-based immunotherapies.

Anti-Thrombotic Effects of Fibrinolytic Enzyme in Zebrafish.

Objectives: This study investigated the antithrombotic properties of a fibrinolytic enzyme (CFE) purified from the culture supernatant of using a zebrafish thrombosis model.

Methods: A phenylhydrazine-induced thrombosis model was employed to evaluate the in vivo thrombolytic efficacy and mechanisms of CFE.

Results: CFE significantly attenuated thrombogenesis by inhibiting erythrocyte aggregation in the caudal vessels, reducing staining intensity (3.

Extracellular PDI in thrombosis and vascular injury.

Protein disulfide isomerase (PDI) catalyzes the reduction, oxidation, and isomerization of disulfide bonds. Although initially discovered as an endoplasmic reticulum (ER)-residing protein, PDI has been demonstrated to play critical roles on cell surfaces and in the extracellular milieu under different pathophysiological settings. During thrombosis extracellular PDI regulates both platelet activation and coagulation, while during vascular injury PDI modulates proinflammatory neutrophil recruitment and the homeostasis of vascular cells.

[Sleep quality and mental health after bloodborne occupational exposure among medical staff in a new crown square cabin: chain mediation of social support and psychological resilience].

Objective: To investigate the relationship between sleep quality, social support, psychological resilience and mental health status of medical staff following bloodborne occupational exposure in a square pod hospital, and the mediating role of social support and psychological resilience.

Methods: A whole group sample of medical staff who had blood-borne occupational exposure in Lanzhou City Square Cabin Hospital from November to December 2022 were surveyed using self-administered general information questionnaire, Pittsburgh Sleep Quality Index(PSQI), self-reporting inventory(SCL-90) scale, social support rating scale(SSRS) and psychological resilience scale(CD-RISC), and SPSS 27.0 software and Process V 4.

[Optimization of extraction process for Shenxiong Huanglian Jiedu Granules based on AHP-CRITIC hybrid weighting method, grey correlation analysis, and BP-ANN].

By employing the analytic hierarchy process(AHP), the CRITIC method(a weight determination method based on indicator correlations), and the AHP-CRITIC hybrid weighting method, the weight coefficients of evaluation indicators were determined, followed by a comprehensive score comparison. The grey correlation analysis was then performed to analyze the results calculated using the hybrid weighting method. Subsequently, a backpropagation-artificial neural network(BP-ANN) model was constructed to predict the extraction process parameters and optimize the extraction process for Shenxiong Huanglian Jiedu Granules(SHJG).

Rabies virus utilizes neuropilin 2 as an endocytic receptor to trigger TGFBR1-mediated actin polymerization.

Rabies virus (RABV), belonging to the rhabdovirus, is a typical large virus that enters cells via clathrin-mediated endocytosis (CME). RABV-containing pits are only partially clathrin-coated and require local actin polymerization for efficient internalization. This unconventional entry process suggests that a specific receptor may be required to initiate actin polymerization during RABV entry.

Porous Microspheres Loading Small Molecule Targeting REV-ERBs Modulate Inflammatory Cytokines Fluctuations to Promote Periodontal Bone Regeneration.

Alveolar bone loss, mainly due to periodontitis and local inflammation, poses a great challenge for current bone graft materials. To address this issue, we introduce PLGA-S@Gel-SeHA, a microsphere composed of Poly(lactic-co-glycolic acid) (PLGA), gelatin mineralized selenium-doped hydroxyapatite (Gel-SeHA) and STL1267 (S), which target circadian rhythm gene REV-ERBs (nuclear recerptor subfamily 1, group D, NR1D), to maintain inflammatory cytokine homeostasis for alveolar bone repair. Synthesized via iso-density emulsion and microfluidics, the PLGA-S@Gel-SeHA microspheres are of uniform size and porosity, greatly enhancing the cell adhesion and ingrowth.

Unveiling the clinical spectrum of Porto-Sinusoidal Vascular Disorder (PSVD) with chronic HBV infection: insights from a retrospective Chinese cohort.

Background: Porto-Sinusoidal Vascular Disorder (PSVD) is a non-cirrhotic vascular liver disease associated with or without signs of portal hypertension (PH). Chronic hepatitis B virus (HBV) infection frequently coexists with PSVD, but its clinical impact remains unclear. This study investigates the clinical and histopathological features of PSVD with and without chronic HBV infection.

Identification of allelochemicals from three submerged plants and the inhibitory effects of organic acids on cyanobacteria (Cylindrospermopsis raciborskii).

Cyanobacteria (C. raciborskii), as a type of harmful algal bloom cyanobacteria, has strong invasiveness and has received widespread attention in eutrophic waters. Using allelopathic organic acids from submerged plants offers a promising strategy for controlling its blooms.

Image segmentation of phase-modulated holographic data storage based on deep learning.

Phase retrieval based on data-driven deep learning (DL) is a suitable decoding method for phase-modulated holographic data storage (HDS). Once the DL network is trained, the phase can be directly retrieved from the corresponding diffraction intensity image with high data transfer rate and low bit error rate. Traditional data-driven DL-based phase retrieval requires a large number of known samples for training, which is usually laborious for practical applications such as HDS.

A semi-supervised method using cycle consistency and multi-perspective dilated for SAR-to-optical translation.

Synthetic aperture radar (SAR) is a powerful imaging sensor capable of operating in any weather and at any time, despite its image interpretation poses challenges. Translating SAR images to optical (S2O) can serve as a beneficial supplement for target detection, image alignment, and image fusion. The existing S2O translation employs solely unsupervised or supervised techniques.

Association Analysis of Polymorphisms with Somatic Cell Score in Chinese Holstein Cows.

Mastitis is an important disease limiting milk production in dairy cows. Somatic cell score is commonly used as one of the main ways to gauge the level of mastitis in dairy cows, with higher somatic cell scores usually indicating possible mastitis. However, the main molecular markers affecting somatic cell scores remain unknown.

Transcription Factor-Based Gene Therapy Enables Functional Repair of Rat Following Chronic Ischemic Stroke.

Objective: In vivo transcription factor (TF) -mediated gene therapy through astrocyte-to-neuron (AtN) conversion has shown therapeutic effects on rodent and non-human primate cortical ischemic injury in the subacute phase. However, in the clinic, subcortical regions including striatum as well as white matter are vulnerable regions of stroke, with millions of patients beyond subacute phase. In this study, we investigate whether TF-mediated AtN conversion therapy can be extended to treat chronic-phase ischemic stroke involving subcortical regions (e.

Neural correlates of insomnia with depression and anxiety from a neuroimaging perspective: A systematic review.

Insomnia affects a substantial proportion of the population and frequently co-occurs with mental illnesses including depression and anxiety. However, the neurobiological correlates of these disorders remain unclear. Here we review magnetic resonance imaging (MRI) studies assessing structural and functional brain associations with depressive and anxiety symptoms in insomnia disorder (ID; n = 38), insomnia symptoms in depressive and anxiety disorders (n = 14), and these symptoms in the general populations (n = 3).

Association between stock market volatility and severe mental disorders: a multi-city time-series study.

Background: Stock market volatility was commonly considered as a psychological stressor. However, the association between stock market volatility and severe mental disorders (SMD) has not been investigated.

Methods: Daily numbers of SMD hospital admissions and Shanghai Stock Exchange Composite (SSEC) Index in 7 cities in southwestern China from 2020 to 2023 were collected.