Exploring Molecular Characteristics and Therapeutic Strategies for Primary Sinonasal Mucosal Melanoma with Distant Metastasis.

Sinonasal mucosal melanoma (SNMM) is a rare aggressive malignancy of the sinonasal tract. Due to its advanced clinical presentation and frequent late-stage diagnosis, the 5-year survival rate is less than 30%, with an even worse prognosis in patients with distant metastasis (SNMM-M). Therefore, characterizing the molecular landscape of SNMM may provide novel therapeutic targets for SNMM-M.

Novel Histopathologic Features of Extramammary Paget's Disease in Metastatic Primary Cutaneous Apocrine Carcinoma to the Esophagus.

Primary cutaneous apocrine carcinoma (PCAC) is an exceptionally rare cutaneous malignancy originating from apocrine glands, occurring most commonly in the axilla and anogenital regions. It typically follows a slow-growing clinical course, although aggressive behavior has been documented in select cases. While local recurrence and regional metastasis are not uncommon in PCAC, instances of distant metastases are rare, with only a handful of cases reported, including involvement of the liver, bone, and lung.

Integrative proteogenomic characterization of Wilms tumor.

Wilms tumor (WT), the most common pediatric renal malignancy, exhibits a relatively low mutational burden compared to adult cancers, which hinders the development of targeted therapies. To elucidate the molecular landscape of WT, we perform integrative proteomic, phosphoproteomic, transcriptomic, and whole-exome sequencing analyses of WT and normal kidney tissue adjacent to tumor. Our multi-omics approach uncovers prognostic genetic alterations, distinct molecular subgroups, immune microenvironment features, and potential biomarkers and therapeutic targets.

Do urinary bladder smooth muscle neoplasms show morphologic and immunophenotypic features of their uterine fumarate hydratase-deficient counterparts?

While the morphologic and immunophenotypic features of smooth muscle neoplasms of the uterus and skin have been well-described in relationship to fumarate hydratase (FH) deficiency (FHD), a potential association of urinary bladder smooth muscle tumors with FH tumor predisposition syndrome (FHTPS) has not been previously investigated. Given an index urinary bladder leiomyoma which showed some of the purported morphologic features seen in uterine FHD leiomyomas, we performed a multi-institutional search for bladder smooth muscle tumors to further evaluate a putative FHTPS association. Cases were re-reviewed for the presence of the following well-described FHD-associated cytomorphologic features: macronucleoli ("cherry red") surrounded by halo, isolated nuclear pleomorphism ("symplastic" nuclei), cytoplasmic eosinophilic globules, staghorn vasculature, alveolar-pattern edema, and chain-like distribution of smooth muscle fibers.

Esoteric Diagnostic Considerations for Small Round Cell Tumors in Biopsy Specimens With Extensive Negative Immunohistochemical Profiles: Utilizing Subtle Histopathological Features Prior to Molecular Testing.

Small round cell tumors (SRCTs) are characterized by primitive round cells and a broad differential diagnosis due to their undifferentiated nature, making their diagnosis particularly challenging. Molecular testing is often essential for definitive classification; however, subtle histomorphological features can significantly narrow the differential diagnosis. Here, we present the case of a 44-year-old male who presented with a painless mass (up to 15.

Integrating Dialectical Behaviour Therapy Into the Treatment of Adolescent Depression: A Retrospective Study.

Background: Globally, the prevalence of depression among adolescents is on the rise, posing serious societal problems. Dialectical behaviour therapy (DBT) and selective serotonin reuptake inhibitors (SSRIs), such as sertraline, are two commonly employed therapeutic approaches that have shown good clinical outcomes. This study aims to investigate the therapeutic effects of DBT with or without sertraline on adolescent depression.

New species of green lacewings indicate the diversity of Mesypochrysa (Insecta, Neuroptera, Chrysopidae) from the Middle Jurassic of China.

Three new species of Mesypochrysa Martynov, 1927: Mesypochrysa paucinervis sp. nov., Mesypochrysa angusta sp.

Effects of Long-Term Noise Exposure on Mental Health and Sleep Quality of Emergency Medical Staff and Coping Strategies.

Objective: This study aimed to explore the effects of long-term noise exposure on the mental health and sleep quality of medical staff in an emergency department and noise-coping strategies.

Methods: In this cross-sectional study, 126 emergency medical staff (49 doctors and 77 nurses) and 100 medical staff (40 doctors and 60 nurses) from the general inpatient department of two hospitals in China were selected as subjects. The research period was from January to October 2024.

Acquired aberrant partial CD3 expression in recurrent Epstein-Barr virus-negative solitary plasmacytoma of tonsil.

The aberrant expression of specific T-cell maker CD3 in B-cell neoplasms can be a potential diagnostic pitfall leading to a misclassification of cell lineage. Here, we report a case of recurrent solitary plasmacytoma with new aberrant expression of CD3. The neoplastic plasma cells of the recurrent tumor were kappa restricted, positive for CD138, MUM1, negative for CD20, cyclin D1, and Epstein-Barr virus.

STOX1 Isoform A Promotes Proliferation and Progression of Hepatocellular Carcinoma by Dual Mechanisms of Transcriptionally Upregulation of Cyclin B1 and Activation of ROS-Dependent PTEN/AKT1 Signaling.

Background: Dysregulation of transcription factors is one of the most common factors for the pathogenesis of hepatocellular carcinoma (HCC). To the best of our knowledge, no study has yet investigated the clinical significance and functional role of STOX1 in HCC.

Methods: Real-time PCR, Western blotting and immunohistochemistry were performed to examine the expression of STOX1-A in HCC specimens.

Country-level antibiotic risk assessment in the multiple environmental matrices based on decennial data.

The overuse of antibiotics has led to widespread environmental detection. However, country-level antibiotic risks from a global perspective remain unclear, highlighting a crucial need for antibiotic management worldwide. This study elucidated a global assessment of antibiotic detection frequencies and concentrations across various countries, compared detection levels of antibiotic classifications across compartments in representative countries, and conducted a risk assessment based on predicted no-effect concentrations (PNECs) for antibiotic resistance and minimum inhibitory concentrations (MICs) relevant to microbial nitrogen cycling.

Dynamic interplay between niche variation and flight adaptability drove a hundred million years' dispersion in iconic lacewings.

The form and change of animal biogeography reflects the long-term interplay between organisms and their environment, involving physiological limitation, dispersal capability, and adaptive evolution versus plate tectonics, global climatic shifts, and changing landscapes. This is especially manifest for lineages with extended geological histories, which, therefore, evokes questions as to the associated processes producing such patterns. Insects, as the earliest flying animals, have exceptional abilities for expanding their range and habitats and to avoid detrimental conditions.

POU6F2 promotes liver metastasis of gastric adenocarcinoma by dual mechanism of transcriptional upregulation of SNAI1 and IGF2/PI3K/AKT signaling-induced conversion of hepatic stellate cells into cancer-associated fibroblasts.

Background: Activation of cancer-associated fibroblasts (CAFs) plays an important role in tumor metastasis. The purpose of this study is to investigate the role of POU6F2 in conversion of hepatic stellate cells (HSCs) into CAFs in liver metastasis of gastric adenocarcinoma (GAC).

Methods: POU6F2 expression was examined by real-time PCR, Western blot and immunohistochemical staining.

Three new species from the Middle Jurassic of China provide insights on wing spots diversity of Bittacidae (Insecta: Mecoptera).

Three new species, Antiquanabittacus punctatus Yu, Ren, Lin and Yang sp. nov., Composibittacus retroflexus Yu, Ren, Lin and Yang sp.

New Wasps of Maimetshidae (Hymenoptera: Ceraphronoidea) from the Mid-Cretaceous Myanmar Amber.

One new genus and five new species of the extinct family Maimetshidae from mid-Cretaceous Kachin amber are described based on five well-preserved specimens as follows: Li, Kopylov and Rasnitsyn, sp. nov.; Li, Kopylov and Rasnitsyn, sp.

New fossil Anaxyelidae (Insecta: Hymenoptera: Siricoidea) from the Lower Cretaceous Yixian Formation of northeastern China.

One new genus and two new species, Hemisyntexis lepida gen. et sp. nov.

A cretaceous fly trap? remarkable abdominal modification in a fossil wasp.

Background: Carnivorous insects have evolved a range of prey and host capture mechanisms. However, insect predation strategies in the fossil record remain poorly understood.

Results: Here, we describe †Sirenobethylus charybdis n.

Transcriptional Analysis Reveals That the FHL1/JAK-STAT Pathway is Involved in Acute Cartilage Injury in Mice.

ObjectiveThis study aimed to identify genes and signaling pathways associated with acute cartilage injury using RNA sequencing (RNA-seq).MethodsKnee joint cartilage samples were collected from normal mice and 2 models of acute cartilage injury (non-invasive and groove models) within an 8-hour time limit. RNA-seq revealed differential gene expression between the injury models and controls, with subsequent validation using real-time quantitative polymerase chain reaction (RT-qPCR) for 9 representative genes.

A new approach to MADM problem using interval-valued hesitant Fermatean fuzzy Hamacher operators and statistical variance.

Water ecological civilization construction (WECC) is regarded as the core and cornerstone of ecological civilization construction. However, a lot of uncertainty is involved in assessing the WECC level, which presents serious and intricate difficulties for the related multiple- attribute decision-making (MADM) processes. The interval-valued hesitant Fermatean fuzzy set (IVHFFS) is a powerful tool for handling uncertainty in MADM issues.

The modern pattern of insect herbivory predates the advent of angiosperms by 60 My.

Modern ecosystems display complex associations of plants-insects that underwent a long evolutionary process since the appearance of mid-Paleozoic vascular plants. Although several major hypotheses explain the evolution of these plant-insect associations, the initial pattern of modern insect herbivory is poorly understood. To understand the antiquity of modern patterns of terrestrial arthropod herbivory, functional feeding group-damage type (FFG-DT) data were used to analyze a 305 My interval from Late Pennsylvanian to present, in which 134 plant assemblages were used to assess turnover (replacement of some species by other species between sites) and nestedness (difference in composition when no species are replaced between sites) in pairwise comparisons of DTs.

Clinicopathologic Characteristics of 40 Cases of Juvenile Conjunctival Nevus.

Aims: Limited studies have been conducted on juvenile conjunctival nevus (JCN) in Asian populations. This study aims to investigate the clinical and pathologic characteristics of JCN cases among the Han ethnicity in northwest China, providing insights for pathologists and ophthalmologists in diagnosing this condition.

Methods: A subset of conjunctival nevi in children and adolescents, characterized by a confluent growth pattern and lack of maturation, was identified and defined as JCN.