Omics Integration Reveals Hormonal Adjustments in Irrigated and Nonirrigated Rice Varieties Upon Mythimna separata Feeding.

Freshwater consumption is the biggest challenge in irrigated rice cultivation (Oryza sativa L.). Nonirrigated farmland rice cultivation is a strategy to mitigate the water resource shortage associated with traditional irrigated rice farming.

Triple-Shell Hollow FeS/MoS Heterostructure Anodes: Synergistic Effects of Built-In Electric Field on Ultra-Stable Sodium Storage.

Metal sulfides are intensively pursed as promising anode materials for sodium-ion batteries (SIBs) owing to their high theoretical capacities, abundant and inexpensive raw materials, however, challenges remain in designing their structures, particularly due to the slow Na⁺ storage kinetics in individual sulfide, and unshaped and inefficient heterostructure persists the issue of low intrinsic ion conductivity. Herein, hollow triple-shell FeS/MoS@NC structure by integrating molecular and microstructural engineering is constructed. The intimate connection between FeS and MoS in FeS/MoS@NC arises from the simultaneous sulfidation of Fe(MoO).

A label-free ratiometric fluorescent aptasensor for highly sensitive detection of metronidazole.

Antibiotic contamination in the environment poses significant threats to ecosystems and public health. However, conventional methods for detecting metronidazole (MNZ) are often unsuitable for field-deployable or real-time applications due to high equipment costs, labor-intensive sample preparation, and the need for specialized expertise. To address these limitations, we developed a novel label-free ratiometric fluorescent aptasensor for the sensitive and accurate detection of MNZ in complex samples.

Integrating Dialectical Behaviour Therapy Into the Treatment of Adolescent Depression: A Retrospective Study.

Background: Globally, the prevalence of depression among adolescents is on the rise, posing serious societal problems. Dialectical behaviour therapy (DBT) and selective serotonin reuptake inhibitors (SSRIs), such as sertraline, are two commonly employed therapeutic approaches that have shown good clinical outcomes. This study aims to investigate the therapeutic effects of DBT with or without sertraline on adolescent depression.

Effectiveness and Safety of Acupuncture as an Adjunctive Therapy for Post-Stroke Depression: An Overview of Systematic Reviews.

Background: Post-stroke depression (PSD) is a common and serious neuropsychiatric complication that requires effective treatment options. Acupuncture as an adjuvant therapy shows promise, though current systematic reviews exhibit significant discrepancies in effectiveness/safety evidence with insufficient methodological rigor.

Purpose: To evaluate systematic reviews assessing acupuncture as an adjuvant therapy for PSD.

Robust multi-task feature selection with counterfactual explanation for schizophrenia identification using functional brain networks.

Introduction: Functional brain networks measured by resting-state functional magnetic resonance imaging (rs-fMRI) have become a promising tool for understanding the neural mechanisms underlying schizophrenia (SZ). However, the high dimensionality of these networks and small sample sizes pose significant challenges for effective classification and model generalization.

Methods: We propose a robust multi-task feature selection method combined with counterfactual explanations to improve the accuracy and interpretability of SZ identification.

Progress of Biologics and Small Molecule Drugs in the Treatment of Hidradenitis Suppurativa.

Hidradenitis suppurativa (HS) is a chronic, debilitating, inflammatory skin disease that is challenging to treat. In recent years, biologic therapies and small-molecule drugs have been used to improve the treatment landscape of moderate-to-severe HS. Biologics, including anti-tumor necrosis factor-α agents and interleukin inhibitors, target specific cytokines or cell-surface receptors involved in the immunopathogenesis of HS.

A Prospective Evaluation of the Diagnostic Utility for Low-Coverage Genome Sequencing in Prenatal Samples: A Comparison With Chromosomal Microarray Analysis.

Objective: The present study aimed to evaluate the efficacy of LC-GS in detecting clinically relevant chromosomal abnormalities in comparison with conventional CMA within a prenatal context.

Methods: We conducted a prospective study involving 200 amniotic fluid samples. All specimens were analyzed via LC-GS and traditional tests, including CMA and karyotyping.

Memristors Based on Ferroelectric Cu-Deficient Copper Indium Thiophosphate for Multilevel Storage and Neuromorphic Computing.

It is essential to explore the interactions between intrinsic ferroelectricity and ionic activities in 2D ferroelectrics for theoretically understanding and experimentally modulating device performance. Due to the tendency of Cu migration in ferroelectric copper indium thiophosphate (CIPS) and formation of Cu conductive filaments, herein, Cu-deficient CIPS (CIPS) is employed to investigate resistive switching (RS). Different from CIPS with controllable threshold switching and write-once read-many-times (WORM) behaviors, CIPS shows stable non-volatile digital and analog RS behaviors by controlling the operation voltage.

Calyx and Corolla as Heliocaminiform Structures Enhance the Reproductive Adaptation of (Orobanchaceae) to Low Winter Temperatures.

The thermoregulation of plants through the heliocaminiform effect of hollow structures is widespread but overlooked. Winter-flowering plants in subtropical regions often suffer from low temperatures; however, the reproductive adaptations of these plants are not well understood. The functional advantages of persistent calyx and labiate corolla in were studied to clarify the mechanism of flower thermoregulation via heliocaminiform structures, and to understand the reproductive adaptation of floral temperature increases in winter.

Progress in single-cell sequencing of retinal vein occlusion or ischemic hypoxic retinopathy.

Retinal vein occlusion (RVO) and ischemic hypoxic retinopathy (IHR) are leading cause of irreversible vision loss worldwide, compelled by complex microvascular dysfunction, neuroinflammation, and tissue hypoxia. Despite advances in imaging and treatment, a comprehensive understanding of cellular and molecular heterogeneity underlying these pathologies remains limited. Recently, single-cell RNA sequencing (scRNA-seq) has emerged as a transformative technology, enabling unprecedented resolution of cellular dynamics, transcriptomic landscapes, and intracellular communication within the retina.

Immunosuppressive role of benzo[a]pyrene exposure in prostate cancer progression.

Epidemiological studies indicate that prostate cancer (PCa) is the second prevalent malignant tumor affecting men globally. Environmental pollution such as cigarette smoke is one of the important risk factors for the development of prostate cancer. However, as one of the main carcinogens in cigarette smoke, the role of benzo[a]pyrene (BaP) in prostate cancer is still unclear.

Weakly Dispersive Band in Synthetic Moiré Superlattice Inducing Optimal Compact Comb Generation.

The moiré superlattices attract growing interest for holding exotic physics due to their fascinating properties from electronics to photonics. Much attention has been focused on the localization effect for waves in the flat band regime or the delocalization effect from the strongly dispersive band feature. Here, we study the weakly dispersive band in between the two above scenarios in a one-dimensional synthetic frequency moiré superlattice and observe the wave packet distributions therein toward novel frequency comb generation.

Circular RNA NXN (circNXN) promotes diabetic retinopathy by regulating the miR-338-3p/FGFR1 axis.

Diabetic retinopathy (DR) is the leading manifestation of diabetic microangiopathy. However, effective biomarkers and therapies are lacking. Circular RNAs (circRNAs) have been implicated in various diseases including DR.

Autophagy is involved in the toxicity of the biocontrol agent GC16 against Tetranychus pueraricola (Acari: Tetranychidae) based on transcriptomic and proteomic analyses.

Background: GC16 is a novel pesticide with acaricidal properties against the spider mite Tetranychus pueraricola (Ehara & Gotoh). Its physiological mechanisms have been described previously, but its molecular mechanisms of action remain unclear. Thus, we aimed to explore the acaricidal mechanisms of GC16 through transcriptomic and proteomic analyses.

The important role of cuproptosis and cuproptosis-related genes in the development of thyroid carcinoma revealed by transcriptomic analysis and experiments.

Objective: Programmed Cell Death (PCD) processes have been suggested to play a role in the development of cancers. The study aimed to investigate the enrichment of different types of PCD and identify important PCD-related genes in Thyroid Carcinoma (THCA).

Methods: The whole study is based on transcriptomic analysis and Immunohistochemistry (IHC) experiments.

Impact of drug-coated balloon for vascular luminal dilatational remodeling after balloon angioplasty in intracranial atherosclerotic stenosis - a retrospective cohort study.

Objective: This study aimed to examine the effect of drug-coated balloons (DCBs) on vascular luminal dilatational remodeling (VLDR) following simple balloon angioplasty.

Methods: A retrospective cohort study was conducted using data from patients diagnosed with intracranial atherosclerotic stenosis (ICAS), who were treated exclusively with balloon angioplasty at Henan Provincial People's Hospital between June 2019 and April 2023. Inverse probability weighting (IPW) was used to create balanced cohorts of patients who underwent drug-coated balloon angioplasty (DCBA) and plain old balloon angioplasty (POBA).

Observing non-Hermiticity induced chirality breaking in a synthetic Hall ladder.

Non-Hermitian topological photonics plays a key role in bridging topological matter with gain and loss engineering in optics. Here we report the experimental observation of the break of chiral currents in a Hall ladder from the non-Hermiticity by constructing synthetic frequency dimension in two rings, where currents on both legs of the ladder co-propagate in the same direction. The origin of such phenomena is resulted from the interplay between the effective magnetic flux and the on-site gain and loss.

Evaluation of safety and efficacy of intracranial self-expanding drug-eluting stents for symptomatic intracranial atherosclerotic stenosis: a prospective, multicentre, randomised controlled, superiority clinical trial protocol.

Background: In-stent restenosis (ISR) is a crucial factor that affects the long-term efficacy of intracranial bare metal stent (BMS) implantation for intracranial atherosclerotic stenosis (ICAS). Patients with intracranial ISR are at a high risk of recurrent ischaemic events. The NOVA intracranial drug-eluting stent (DES) trial demonstrates that a DES can reduce ISR and stroke recurrence after intracranial bare stent implantation.

Microenvironment-responsive nanosystems for ischemic stroke therapy.

Ischemic stroke, a common neurological disorder caused by impaired blood supply to the brain, presents a therapeutic challenge. Conventional treatments like thrombolysis and neuroprotection drugs lack ideal drug delivery systems, limiting their effectiveness. Selectively delivering therapies to the ischemic cerebral tissue holds great potential for preventing and/or treating ischemia-related pathological symptoms.

Examining High-Risk Factors for Sleep Disorders in Depressed Patients: Evaluating the Impact of Psychological Interventions on Sleep Quality and Mental Well-Being.

Objective: This study aims to analyze the risk factors associated with sleep disorders in patients suffering from depression and investigate the efficacy of psychological interventions in improving these conditions.

Methods: A comparative observational study was conducted and a cohort of 162 patients aged 18 to 68, admitted to outpatient or inpatient departments between October 2022 and August 2023, were included in the study. All patients were diagnosed with depression according to the ICD-10 criteria.

DLK1 regulates periodontal inflammation by inhibiting NF-κB p65 and JNK signaling pathways.

The roles and molecular mechanisms of Delta-like 1 (DLK1) in periodontitis remain largely unknown. Here, we investigated the expression of DLK1 and NF-κB p65 in Porphyromonas gingivalis (Pg.)-induced periodontitis in vivo.

Infliximab inhibits TNF-α-dependent activation of the NLRP3/IL-1β pathway in acne inversa.

Background: Acne inversa (AI) is a refractory inflammatory skin disease, and TNF-α plays an important role in the pathogenesis of AI. By blocking TNF-α, infliximab (IFX) has been proven to be a promising method.

Objectives: To explore the underlying mechanisms of IFX treatment in AI patients.

Mixed uncertainty analysis on pumping by peristaltic hearts using Dempster-Shafer theory.

In this paper, we introduce the numerical strategy for mixed uncertainty propagation based on probability and Dempster-Shafer theories, and apply it to the computational model of peristalsis in a heart-pumping system. Specifically, the stochastic uncertainty in the system is represented with random variables while epistemic uncertainty is represented using non-probabilistic uncertain variables with belief functions. The mixed uncertainty is propagated through the system, resulting in the uncertainty in the chosen quantities of interest (QoI, such as flow volume, cost of transport and work).