Synergistically Enhanced NiCo(OH)@NiS Heterojunction Catalyst for High-Performance Ethanol Electrooxidation.

Coupling the ethanol electrooxidation reaction (EOR) with the hydrogen evolution reaction is an effective way to obtain green energy. Although Ni-based catalysts have the characteristics of low cost and good stability, meanwhile, the activity needs to be further improved. Here, we report a Ni-based heterojunction EOR catalyst, NiCo(OH)@NiS, composed by two phases of NiS and NiCo(OH).

Effects of a 6-week semi-supervised exercise training program on physical fitness and mental health in post-COVID-19 healthcare workers: a randomized clinical trial.

Background: Healthcare workers rank among the groups that are most vulnerable to the SARS-CoV-2 infection. Deterioration in physical fitness and mental health is a common manifestation in the post-COVID-19 person, which require specific and effective treatment. This study aimed to evaluate the effects of a 6-week, semi-supervised exercise intervention on physical fitness and mental health in post-COVID-19 healthcare workers (HCWs).

Characterization of Muscle Tissue Cell Diversity and Clinical Implications in Idiopathic Inflammatory Myopathy.

Background: Idiopathic inflammatory myopathies (IIMs) exhibit diverse cellular microenvironments in muscle tissues, yet the full spectrum of cell populations and changes remains unclear. This study aimed to characterize cellular heterogeneity, explore cell-cell interactions and assess the prognostic value of cell subtype abundances across IIM subtypes in Han Chinese.

Methods: Muscle samples from six IIMs and three normal controls (NC) underwent single-cell RNA sequencing (scRNA-seq), whereas bulk RNA sequencing was performed on 203 IIMs and 19 NC.

Using Restricted Mean Time Lost to Evaluate the Prognostic Effects on Locally Advanced Breast Cancer Considering Competing Risks.

Background: In the presence of competing risks, when the baseline risk is unclear, if only the sub-distribution hazard ratio (SHR) is reported in the results, which is related to the cumulative incidence function, the survival disparity of events of interest between groups cannot be clarified. In contrast, the difference in restricted mean time lost (RMTLd), which is the difference in the areas under the cumulative incidence between two groups, can well compensate for the deficiencies of SHR and explain the effects on a time scale, facilitating clinical interpretation and communication.

Methods: The Surveillance, Epidemiology, and End Results (SEER) database was used to collect information on female patients with locally advanced breast cancer diagnosed between 2010 and 2015.

Running exercise reverses depression-induced bone marrow myeloid skewing and neuroinflammation via the lactate-GPR81 axis.

Exercise has emerged as a powerful non-pharmacological intervention for mental health, yet its precise mechanisms in alleviating depression remain incompletely understood. Here, using a chronic unpredictable stress (CUS) mouse model, we demonstrate that prolonged stress induces hematopoietic stem cell (HSC) activation, leading to myeloid-biased hematopoiesis and an overproduction of Ly6C monocytes, which contribute to systemic and hippocampal inflammation. Notably, treadmill running exercise effectively mitigated depressive and anxiety-like behaviors in CUS mice by suppressing stress-induced HSC activation, restoring hematopoietic balance, and reducing peripheral Ly6C monocyte infiltration into the brain.

Conductive Microneedles Loaded With Polyphenol-Engineered Exosomes Reshape Diabetic Neurovascular Niches for Chronic Wound Healing.

Diabetic wound healing remains a major clinical challenge due to the accumulation of advanced glycation end products (AGEs), reactive oxygen species (ROS), and proinflammatory cytokines under hyperglycemic conditions, which collectively impair neurovascular regeneration. Here, a biological-electrical therapeutic platform is reported by synergizing polyphenol-engineered Saccharina japonica exosomes (CA@Exos)-derived biological signals with electroconductive microneedles (pCNTs-ASA MNs)-delivered electrical cues, achieving a dual-pathway to reshape neurovascular niches during the diabetic wound healing process. CA@Exos serve as bioactive cargo to suppress AGE formation, scavenge ROS, and reverse the inflammatory microenvironment, while their intrinsic bioactivities in modulating angiogenesis and neurotrophic signaling enhanced Schwann cell-vascular endothelial cell crosstalk.

RingMo-Aerial: An Aerial Remote Sensing Foundation Model With Affine Transformation Contrastive Learning.

Aerial Remote Sensing (ARS) vision tasks present significant challenges due to the unique viewing angle characteristics. Existing research has primarily focused on algorithms for specific tasks, which have limited applicability in a broad range of ARS vision applications. This paper proposes RingMo-Aerial, aiming to fill the gap in foundation model research in the field of ARS vision.

Plasticity of physiological, anatomical, and structural traits defines seedling growth during sustained drought.

Understanding how trees acclimate to sustained drought by altering physiological, anatomical and structural traits is crucial for elucidating their acclimation to water scarcity. This study investigated the plasticity of Tilia amurensis seedlings under moderate (50% of field moisture capacity) and severe drought (30%) over two years by assessing a range of anatomical, structural and physiological traits. Our results showed that drought reduced photosynthesis by 29.

Current status and challenges of CGA in EDs: A comparative study between community and general hospitals.

Background: As China faces a rapidly aging population, older adults now account for nearly 40 % of emergency department (ED) visits, creating urgent demand for age-appropriate care models. Comprehensive Geriatric Assessment (CGA) has been internationally recommended to improve outcomes for older patients, yet its application in China's emergency settings remains limited. Within the country's tiered healthcare system, Community Health Service Centers (CHSCs) and General Hospitals (GHs) differ in resources and functions, affecting CGA feasibility.

Ultrasound-guided selective supraclavicular nerve block combined with modified clavipectoral fascial plane block for midshaft clavicule fracture surgery: a case report.

Background: Conventional anesthesia for clavicular fracture surgery poses significant challenges. General anesthesia risks pulmonary complications, while traditional nerve blocks may cause diaphragmatic paralysis or motor impairment. Ultrasound-guided techniques improve precision, but standalone superficial cervical plexus or interscalene brachial plexus blocks often fail to fully anesthetize the deep clavicular region, especially in polytrauma patients.

Podocyte Proteomics Revealed hUCMSC-Exosomes Ameliorate Diabetic Kidney Disease through Inhibiting Talin-1 Mediated EMT.

Background: Podocytes injury drives proteinuria in diabetic kidney disease (DKD). Exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSCs) have demonstrated therapeutic potential in kidney diseases. However, the effects of hUCMSCs on podocyte injury and the underlying mechanisms in DKD remain unexplored.

Is Bone Mineral Density at the Tendon-Bone Interface After ACL Reconstruction Associated With Graft Maturation? A Quantitative Computed Tomography Analysis.

Background: The revision rate due to postoperative instability after anterior cruciate ligament reconstruction (ACLR) remains at 4% to 25%. The physiological mechanisms of tendon-bone healing involve intricate processes, particularly neovascularization and osseointegration at the bone tunnel interface. Currently, no standardized noninvasive method exists to comprehensively evaluate tendon-bone healing progression.

Modulation of Memristive Characteristics by Dynamic Nanoprecipitation Inside Conical Nanopores.

Nanofluidic memristors have demonstrated great potential for neuromorphic system applications with the advantages of low energy consumption and excellent biocompatibility. Here, an effective way is developed to regulate the memristive behavior of conical nanopores by leveraging the reversible formation and dissolution of nanoprecipitates induced by ion enrichment and depletion in nanopores under opposite voltages. Through the interplay between precipitation dynamics at the pore tip and the ion enrichment/depletion inside the nanopore, conical nanopores exhibit pronounced current hysteresis loops in the presence of CaHPO, a slightly soluble inorganic salt.

A synaptic mechanism for encoding the learned value of action-derived safety.

Motivated behavior is often framed in terms of biologically grounded outcomes, such as food or threat. Yet many motivated actions, like the pursuit of safety or agency, depend on outcomes that lack explicit sensory value and must instead be inferred from experience. Here, we identify a thalamostriatal circuit mechanism by which such internally constructed outcomes acquire motivational value.

Global association between air pollution and risk of influenza-related outcomes: a systematic review and meta-analysis.

Despite extensive research, air pollution-influenza associations remain inconsistent. This evidence synthesis aggregated evidence from 28 studies to quantify air pollution-influenza associations, employing the Office of Health Assessment and Translation (OHAT) and Navigation Guide tools for quality assessment. We derived combined relative risk () per 10 µg/m increase in air pollution, 95% confidence intervals (s) and 95% prediction intervals (s) to quantify the link.

Spatiotemporal Dynamics of Language Information Representation within the Left Inferior Parietal Lobule Network: An Intracranial SEEG Study.

The left inferior parietal lobe (IPL) supports diverse cognitive functions through the finely differentiated yet coordinated interactions of its subregions, including the supramarginal gyrus (SMG), angular gyrus (AG) and lateral bank of the intraparietal sulcus (lbIPS). However, how these subregions dynamically represent and exchange information during cognitive processing remains unclear. Language processing, integrating visual form, phonology, and semantics, provides an ideal model for investigating the IPL's functional capabilities and dynamics.

Rhizosphere microbial diversity and functional roles in tea cultivars: insights from high-throughput sequencing and functional isolates.

Rhizosphere microorganisms play a significant role in influencing the growth and quality of tea plants (). However, the complex mechanisms underlying the interactions between rhizosphere microorganisms and tea plants require further investigation. In this study, we employed high-throughput sequencing and the isolation of functional rhizosphere microorganisms to examine variations in rhizosphere microbial diversity and functional characteristics among five distinct tea cultivars: cv.

Understanding Language Model Scaling on Protein Fitness Prediction.

Protein language models, and models that incorporate structure or homologous sequences, estimate sequence likelihoods that reflect the protein fitness landscape and are commonly used in mutation effect prediction and protein design. It is widely believed in deep learning field that larger model performs better across tasks. However, for fitness prediction, language model performance declines beyond a certain size, raising concerns about their scalability.

The Smallest Worthwhile Effect as a Promising Alternative to the MCID in Estimating PROMs for Adult Idiopathic Scoliosis.

Background: The smallest worthwhile effect (SWE) enables patients to evaluate the expected value of a treatment by weighing its benefits, risks, and costs. It has emerged as an alternative to the minimal clinically important difference (MCID) for interpreting patient-reported outcome measures (PROMs). The purposes of this study were to determine the SWE estimates and MCID thresholds in patients undergoing surgery for adult idiopathic scoliosis (AdIS) and to verify whether meeting or exceeding the SWE estimates correlates with satisfaction at a minimum of 2 years postoperatively.

Distinct nucleus accumbens neural pathways underlie separate behavioral features of chronic pain and comorbid depression.

The comorbidity of depressive symptoms in chronic pain has been recognized as a key health issue. However, whether discrete circuits underlie behavioral subsets of chronic pain and comorbid depression has not been addressed. Here, we report that dopamine 2 (D2) receptor-expressing medium spiny neurons in the nucleus accumbens medial shell (mNAcSh) mediate pain hypersensitivity and depression-like behaviors in mice after nerve injury.

Surface-engineered hydrophobic hydrogels via cholesterol micelle rearrangement for robust wet adhesion and oral mucositis therapy.

Oral mucositis (OM), a prevalent and debilitating complication in patients undergoing chemotherapy or radiotherapy, is characterized by persistent neuropathic pain and impaired food intake. Conventional treatments are often limited by poor mucosal adhesion in the dynamic, saliva-rich oral environment. To address this challenge, we developed a mussel-inspired robust wet adhesive hydrogel via cholesterol micelle rearrangement, in which negatively charged catechol-functionalized hyaluronic acid (HD) forms a polyelectrolyte network with positively charged polyethyleneimine (PEI), triggering cholesterol-micelle chain rearrangement and directional surface micelle aggregation to achieve hydrophobic hydrogel surface.

GbTRB1 binds telomeric DNA in Ginkgo biloba.

Unlabelled: Telomere-binding proteins play a crucial role in maintaining the stability of telomere structures. In this study, we found that GbTRB1, a double-stranded telomere-binding protein, can bind telomeric DNA., plays a pivotal role in telomere complex stability in .

ApoBDs: a paradigm shift from cellular debris to therapeutic vehicles.

Apoptosis, a genetically programmed cell death process, is essential for maintaining tissue homeostasis. Apoptotic vesicles (ApoVs), membrane-bound vesicles generated during apoptosis and once considered mere cellular debris, can be classified into apoptotic bodies (ApoBDs), microvesicles, and apoptotic extracellular vesicles (ApoEVs) based on their grain size. These vesicles, packed with bioactive molecules, not only drive tumor growth and metastasis, but also contribute to tissue and organ repair.

Chip-to-Chip Quantum Photonic Controlled-not Gate Teleportation.

Quantum networks provide a novel framework for quantum information processing, significantly improving system capacity through the interconnection of modular quantum nodes. Beyond the capability to distribute quantum states, the ability to remotely control quantum gates is a pivotal step for quantum networks. Here, we implement high-fidelity quantum controlled-not (cnot) gate teleportation with high-dimensional path encoded silicon photonic integrated circuits.

Unraveling the sensory metabolome of blueberries: An integrated metabolomics and machine learning approach across cultivars and geographical origins.

Consumer-driven blueberry quality improvement requires a deeper understanding of how metabolic composition influences sensory perception. This study integrates untargeted metabolomics and machine learning to identify biomarker metabolites shaping sensory attributes across blueberry cultivars and geographical origins. Metabolite profiling of four cultivars from four areas revealed significant cultivar- and geographical-dependent differences in metabolic patterns of volatile and non-volatile compounds.