Effects of a 6-week semi-supervised exercise training program on physical fitness and mental health in post-COVID-19 healthcare workers: a randomized clinical trial.

Background: Healthcare workers rank among the groups that are most vulnerable to the SARS-CoV-2 infection. Deterioration in physical fitness and mental health is a common manifestation in the post-COVID-19 person, which require specific and effective treatment. This study aimed to evaluate the effects of a 6-week, semi-supervised exercise intervention on physical fitness and mental health in post-COVID-19 healthcare workers (HCWs).

Anti-tumor Effects of Pollen Pini on Hepatocarcinoma SMMC-7721 Cells via Modulation of PI3K-Akt Signaling Pathway.

Objectives: To explore the effect of Pollen Pini (PP) on SMMC-7721 hepatoma cells.

Methods: The anti-proliferative effects of PP on SMMC-7721 cells were evaluated using cell counting kit-8 assay following 48 h treatment with concentrations ranging from 1.25 to 37.

Comparison of two portable metabolic systems for measuring energy expenditure at rest and during exercise in untrained women.

Purpose: Portable metabolic systems are used as the "gold standard" for measuring energy expenditure (EE) in the development and validation of wearable devices. This study aimed to compare EE measurements obtained using the COSMED K5 (K5) and CORTEX METAMAX 3B (M3B) during the resting state and submaximal-intensity exercise in women without self-reported regular exercise training.

Methods: Twenty women aged 21.

doc2a and doc2b contribute to locomotor and social behaviors by down-regulating npas4b in zebrafish.

Background: Copy number variations (CNVs) occurring on chromosome 16p11.2 are associated with various neurodevelopmental disorders, including autism spectrum disorder (ASD), schizophrenia, and intellectual disability. Among the genes situated within the critical CNV region, DOC2A is noteworthy.

Streaming-based Tweezers for Routing, Engineering, and Manipulation of multiparticles: STREAM.

Contactless manipulation of samples, particularly the ability to dynamically handle multiple fragile specimens while maintaining their integrity and viability, is crucial for various applications in biology, medicine, engineering, and physics. While hydrodynamic tweezers have emerged as a promising approach for gentle, label-free manipulation of a wide range of sample types and sizes, they typically have limited flexibility in terms of dynamic control, making it challenging to realize high-resolution and programmable manipulation of multiple samples. Here, we introduce the Streaming-based Tweezers for Routing, Engineering, And Manipulation of multiparticles (STREAM) with sub-wavelength resolution.

TBC1D15 protects alcohol-induced liver injury in female mice through PLIN5-mediated mitochondrial and lipid droplet contacting.

Objective: Alcohol-induced hepatic steatosis and mitochondrial dysfunction are progressive conditions contributing to the development of alcoholic liver disease (ALD), often leading to cirrhosis and hepatocellular carcinoma. TBC1D15, a Rab7 GTPase-activating protein (GAP), has been implicated in mitochondrial homeostasis, however, its role in ALD remains elusive. This study aimed to investigate the functional role of TBC1D15 in ALD and elucidate the underlying mechanisms.

The impact of physical exercise on internalizing and externalizing problem behaviors among middle school students: correlation and regression prediction analysis.

Background: This study explored the impact of physical exercise on internalizing and externalizing problem behaviors among Chinese middle school students.

Methods: A cross-sectional survey was conducted among 6368 middle school students from Sichuan, Guangdong, Shandong, Henan, and Jiangxi provinces, using the International Physical Activity Questionnaire (IPAQ), Achenbach Youth Self-Report (YSR), and Depression-Anxiety-Stress Scales (DASS). Latent class analysis, multiple linear regression, and Kendall's tau coefficient tests were employed to analyze the data.

Experimental and numerical investigation on shock wave attenuation in a chamber.

New types of explosives, such as fuel-air explosive (FAE), are capable of generating high pressure and have a long duration of action, which is extremely destructive to personnel and equipment in underground spaces. Chambers are one of the most commonly used shock waves attenuating protection structures in engineering. However, the effect of the duration of shock wave action on the wave attenuation capacity of chambers with asymmetric structures has not been studied.

Evaluation of C-reactive protein levels in patients with penile cancer: a systematic review and meta-analysis.

Background: C-reactive protein (CRP) is an essential biomarker for evaluating penile cancer prognosis. Previous studies have reported conflicting outcomes concerning the correlation between CRP levels and penile cancer prognosis. This study aimed to investigate this relationship by conducting a meta-analysis of published literature.

Thrombotic events in patients with multiple myeloma and their impact on overall survival.

Objective: Thrombotic events (TEs) are common and severe complications of newly diagnosed multiple myeloma (NDMM). However, the impact of thrombosis on the survival of myeloma patients remains controversial. The aim of our study was to identify independent high-risk factors for thrombosis as well as to explore the association between the incidence of TEs and survival in patients with NDMM.

Clinicopathologic predictors of renal response and survival in newly diagnosed multiple myeloma with renal injury: a retrospective study.

Renal impairment (RI) is a common complication of multiple myeloma (MM), which is associated with poor prognosis. Here, we revealed the association between regular examination data and RI incidence, RI response and survival in newly diagnosed multiple myeloma (NDMM) patients. A retrospective analysis was conducted on the initial clinical data of 647 NDMM patients, comprising 193 patients (29.

The histone demethylase KDM5C enhances the sensitivity of acute myeloid leukemia cells to lenalidomide by stabilizing cereblon.

Background: The protein cereblon (CRBN) mediates the antileukemia effect of lenalidomide (Len). Len binds to CRBN, recruits IKZF1/IKZF3, and promotes their ubiquitination and degradation, through which Len exhibits its antileukemia and antimyeloma activity. Therefore, the protein level of CRBN might affect the antiproliferative effect of Len.

Causal associations between sleep traits, sleep disorders, and glioblastoma: a two-sample bidirectional Mendelian randomization study.

Glioblastoma (GBM), a highly aggressive brain tumor predominantly affecting individuals over 40, often co-occurs with sleep disorders. However, the causal relationship remains unclear. This study employed a bidirectional Mendelian randomization (MR) approach to investigate the causal links between sleep traits/disorders and GBM.

Pine pollen reverses the function of hepatocellular carcinoma by inhibiting α-Enolase mediated PI3K/AKT signaling pathway.

Objective: This study aimed to investigate the influence of pine pollen (PP) on hepatocellular carcinoma (HCC) behavior in vitro and in vivo and explore its mechanism of action by focusing on the phosphatidylinositol 3-kinase/protein serine-threonine kinase (PI3K/AKT) signaling pathway and α-Enolase (ENO1) gene expression.

Methods: We performed a bioinformatics analysis of ENO1. HCC cells overexpressing ENO1 were developed by lentivirus transfection.

Mechanisms of endocrine resistance in hormone receptor-positive breast cancer.

Hormone receptor-positive breast cancer may recur or metastasize years or decades after its diagnosis. Furthermore, hormone receptor expression may persist in relapsed or metastatic cancer cells. Endocrine therapy is one of the most efficacious treatments for hormone receptor-positive breast cancers.

Acoustography by Beam Engineering and Acoustic Control Node: BEACON.

Acoustic manipulation has emerged as a valuable tool for precision controls and dynamic programming of cells and particles. However, conventional acoustic manipulation approaches lack the finesse necessary to form intricate, configurable, continuous, and 3D patterning of particles. Here, this study reports acoustography by Beam Engineering and Acoustic Control Node (BEACON), which delivers intricate, configurable patterns by guiding particles along custom paths with independent phase modulation.

Nanotechnology used for siRNA delivery for the treatment of neurodegenerative diseases: Focusing on Alzheimer's disease and Parkinson's disease.

Neurodegenerative diseases (ND) are often accompanied by dementia, motor dysfunction, or disability. Caring for these patients imposes a significant psychological and financial burden on families. Until now, there are no effective methods for the treatment of NDs.

Maternal immune activation upregulates the AU020206-IRFs-STAT1 axis in modulating cytokine production in the brain.

Maternal immune activation (MIA) is reported to increase the risk of psychiatric disorders in the offspring. However, the underlying mechanism remains unclear. : We constructed a MIA mouse model by intraperitoneal injection of LPS into pregnant mice and evaluated the behaviors and gene expression profiles in the brains of the female and male offspring, respectively.

Causal effects of genetically determined metabolites and metabolite ratios on esophageal diseases: a two-sample Mendelian randomization study.

Background: Esophageal diseases (ED) are a kind of common diseases of upper digestive tract. Previous studies have proved that metabolic disorders are closely related to the occurrence and development of ED. However, there is a lack of evidence for causal relationships between metabolites and ED, as well as between metabolite ratios representing enzyme activities and ED.

Heterogeneous catalysis of methane hydroxylation with nearly total selectivity under mild conditions.

The efficient utilization of methane, a vital component of natural gas, shale gas and methane hydrate, holds significant importance for global energy security and environmental sustainability. However, converting methane into value-added oxygenates presents a formidable challenge due to its inert nature. Direct selective oxidation of methane (DSOM) under mild conditions is essential for reducing energy consumption and carbon emissions compared with traditional indirect routes.

Microfluidic QCM enables ultrahigh Q-factor: a new paradigm for in-liquid gravimetric sensing.

Acoustic gravimetric biosensors attract attention due to their simplicity, robustness, and low cost. However, a prevailing challenge in these sensors is dissipation which manifests in a low quality factor (Q-factor), which limits their sensitivity and accuracy. To mitigate dissipation of acoustic sensors in liquid environments we introduce an innovative approach in which we combine microfluidic channels with gravimetric sensors.