Comparison of ciprofol and propofol for endoscopic retrograde cholangio-pancreatography anesthesia: a systematic review and meta-analysis.

Objective: The potential of ciprofol in endoscopic anesthesia is receiving increasing attention. Compared to propofol, ciprofol exhibits stronger sedative effects and requires a lower dosage. This study aimed to compare the safety of ciprofol and propofol in Chinese patients undergoing endoscopic retrograde cholangio-pancreatography (ERCP) anesthesia.

Deciphering diabetic neuropathy: immune cell causality revealed.

Objective: This study assessed the causal effects of immune cell phenotypes on diabetic neuropathy (DN) using Mendelian randomization (MR) analysis.

Methods: Datasets of immune cell phenotypes and DN were collected from the European Bioinformatics Institute and FinnGen. Single nucleotide polymorphisms that met the specified criteria were subjected to a stepwise selection based on the hypotheses of association, independence, and exclusivity.

Definition and validation of recompensation in patients with primary biliary cholangitis-related decompensated cirrhosis treated with ursodeoxycholic acid: Based on the BAVENO VII criteria.

Background And Objectives: Few studies have provided real-world data on the biochemical response, risk assessment, and prognosis of patients with primary biliary cholangitis (PBC)-related decompensated cirrhosis undergoing ursodeoxycholic acid therapy. The objective of this study is to define recompensation in this patient population based on the BAVENO VII criteria.

Methods: This retrospective analysis included 170 patients with cirrhosis who presented with ascites, hepatic encephalopathy, and/or variceal bleeding as their initial decompensating events at Xijing Hospital from 2006 to 2023.

Potential of ciprofol as an alternative to propofol in elderly patients undergoing gastrointestinal endoscopy: a meta-analysis and trial sequential analysis.

Objective: Ciprofol is increasingly being used for sedation and induction of anesthesia in China. However, it remains unclear whether ciprofol is a more appropriate sedative than propofol in gastrointestinal endoscopy, especially in the elderly population. This study aimed to compare the safety of ciprofol with propofol in elderly patients undergoing gastrointestinal endoscopy.

Rosmarinic acid improves intestinal barrier integrity through PI3K/AKT/Nrf2-mediated regulation of tight junction protein expression.

Rosmarinic acid (RA), a polyphenolic compound, exhibits diverse pharmacological activities, including anti-inflammatory, antioxidant, and antitumor effects. Despite its therapeutic potentials, the mechanisms underlying its efficacy in ulcerative colitis (UC), a chronic inflammatory bowel disease characterized by intestinal epithelial barrier dysfunction, remain incompletely elucidated. This study investigates RA's protective effects in UC using complementary in vivo and in vitro models.

Hydrogel-Based Sequential Photodynamic Therapy Promotes Wound Healing by Targeting Wound Infection and Inflammation.

Impaired wound healing remains a significant clinical challenge, often exacerbated by bacterial infections and persistent inflammation. Photodynamic therapy (PDT) has demonstrated efficacy in combating bacterial infections; however, its utility in wound healing is limited due to its inability to address inflammation. To overcome this limitation, we have developed a PDT-based sequential therapy.

Endothelial Tgfbr2 Deficiency Ameliorate Liver Fibrosis Through Regulating Angiocrine Signalling and Macrophage Accumulation.

Background & Aims: Transforming growth factor (TGF)-β signalling plays an indispensable role in promoting the activation of hepatic stellate cells and inducing epithelial-mesenchymal transition of hepatocytes during liver fibrosis. Liver sinusoidal endothelial cells (LSECs) undergo capillarisation and promote inflammatory responses following liver injury. Here, we investigated the role of TGF-β signalling in LSECs during liver fibrosis.

Unveiling the causal effects of phosphatidylethanolamine (18:1_0:0) via glutamine conjugate of CHO (2) and X-23648 in Parkinson's disease: insights from mediation Mendelian randomization.

Objective: The effects of lipidome and its metabolites on Parkinson's disease (PD) have not been fully elucidated. This study aimed to assess the causal effects of lipidome on PD and the mediated effects of metabolites using Mendelian randomization (MR).

Methods: Datasets of the lipidome, metabolites, and PD were acquired from genome-wide association studies, and single nucleotide polymorphisms were screened according to the basic assumptions of MR.

Switchable five-function terahertz metasurface based on graphene and vanadium dioxide with single-sized nanostructure.

Driven by the need for miniaturization and integration, incorporating multiple functions into a single metasurface based on hybridized tunable materials is particularly demanding in the terahertz (THz) range. However, existing hybrid material metasurfaces either need to change their sizes or cannot fully explore their design potential, particularly failing to integrate both near-field and far-field functions into a single metasurface, which restricts the development and application of terahertz metasurface devices. In this paper, combing with graphene and vanadium dioxide (VO), a multifunctional terahertz metasurface is designed with only a single-sized nanostructure, which can achieve five-functional switchable and integration.

AlTPS6 from Is a Crucial Regulatory Target for Root-Knot Nematode Infestation.

Root-knot nematodes (RKNs) are widespread parasites that damage crops by weakening the plant immune system, causing root galls and stunting growth. However, the molecular mechanisms behind how RKNs regulate host plant defenses remain largely unknown. The medicinal plant frequently suffers losses from RKNs.

Ciprofol vs Propofol for Gastrointestinal Endoscopy Sedation: a Systematic Review and Meta-analysis.

Background: Ciprofol, a propofol derivative, is increasingly used for sedation in China. However, the specific benefits of ciprofol in gastrointestinal endoscopic sedation have not been fully evaluated. This meta-analysis aimed to compare the efficacy and safety of ciprofol with propofol in gastrointestinal endoscopy.

Manual acupuncture for the treatment of chronic spontaneous urticaria: a systematic review and meta-analysis.

Background: The benefits and risks of manual acupuncture for treating chronic spontaneous urticaria (CSU) remain unclear. To address this gap, this systematic review and meta-analysis aimed to evaluate the efficacy and safety of manual acupuncture for treating CSU.

Methods: Seven major databases were searched for relevant literature published up to 1 January 2025.

Global Burden of Alzheimer's disease and other dementias in adults aged 65 years and older, 1991-2021: population-based study.

Objectives: This study aims to analyze the prevalence, impact, and disparities of Alzheimer's disease and other dementias (ADRD) among adults aged 65 years and older worldwide, across different regions and countries, spanning the years 1991-2021.

Methods: GBD 2021 obtained data on dementia from vital registration systems, published scientific literature and surveys, and data from health-service encounters on deaths, excess mortality, prevalence, and incidence from 1991 to 2021, through systematic review and additional data-seeking efforts. Individuals aged ≥65 years from 21 regions and 204 countries and territories (Global Burden of Disease and Risk Factors Study 2021) from 1991 to 2021 were analyzed.

Association of lipidome with senility and the mediated effect of metabolites: A Mendelian randomization study.

The aim of this study was to assess the causal effects of lipidome on senility and the mediated effects of metabolites by Mendelian randomization (MR). Lipidome, metabolites, and senility datasets were acquired in genome-wide association study, and single nucleotide polymorphisms were screened according to the underlying assumptions of MR. Subsequently, inverse variance-weighted was used as the primary method to analyze the causal effect of lipidome on senility and the mediated effect of metabolites.

Vesicle-associated membrane protein 5 is an intrinsic defense factor for embryonic stem cells against coronaviruses.

Embryonic stem cells (ESCs) display a distinctive resistance against various viruses, irrespective of any interferon response. Nevertheless, the underlying mechanism of this resistance remains unclear. In this study, we identify vesicle-associated membrane protein 5 (VAMP5) as a potent cell-autonomous defense factor against coronaviruses, including SARS-CoV-2, with high expression levels observed in ESCs and mesoderm.

Meta-image displays using unidirectional guided-wave-driven metasurfaces.

Metasurfaces can freely manipulate the wavefronts of incident beams, making them a highly effective platform for holographic imaging or nanoprinting. However, their on-chip integration is hindered by the need for external light excitation, and the resonant nature of the meta-atoms that compose them presents a challenge for achieving meta-image with super-resolution. In this work, by leveraging the unique dispersion properties of unidirectional guided waves instead of resonant meta-atoms, we introduce a novel approach to realize meta-imaging.

Celastrol Alleviates Intestinal Epithelial Permeability by Inhibiting Ferroptosis through PI3K/Akt/FOXO1/HO-1 Signaling Pathway.

Ulcerative colitis (UC) is a recurrent inflammatory intestinal disorder characterized by systemic inflammatory response, abnormal intestinal epithelial cell death, and damage to the intestinal mucosal barrier. This study aimed to explore the role of celastrol in ferroptosis and intestinal epithelial barrier permeability. The results demonstrated that celastrol significantly inhibited ferroptosis in RSL3-induced intestinal epithelial cells by regulating the expression of ferroptosis-related proteins.

Reprocessing status of flexible bronchoscopes in 202 intensive care units in Hubei province, China: a multicentre cross-sectional study.

Background: Unstandardised reprocessing procedures for flexible endoscopes can lead to infection outbreaks and threaten the lives of ICU patients. Despite recent updates to technical specification, there was a paucity of studies on the current status of flexible endoscopic reprocessing, particularly concerning flexible bronchoscopes (FB). This study aimed to assess the current practices of reprocessing FBs in ICUs in Hubei Province, China.

Navigating the paradox of senescence and chemoresistance in pancreatic cancer.

Cellular senescence, described as a mechanism of irreversible cell cycle arrest, has emerged as a complex and multifaceted process with significant implications in cancer biology, particularly in pancreatic ductal adenocarcinoma (PDAC). This literature review aims to explore the intricate role of senescence in PDAC, focusing on its dual nature during tumorigenesis, in addition to therapy resistance, and its potential as a therapeutic target. Senescence escape was found to play a crucial role in PDAC progression, prompting the development of various pro-senescence therapies.

Collaborate large and small language models for multi-modal emergency rumor detection.

Multi-modal emergency rumors are spreading in the current digital era, causing significant disruptions and negative impacts. Most existing methods focus on exploring rumor detection using individual small language models (SLMs) or large language models (LLMs), achieving a certain degree of success but with underlying issues. Approaches based on SLMs have reached a bottleneck due to their limited knowledge and capacity.

A novel-miR-164 from Atractylodes lancea targets AlNAC1 regulating leaf senescence.

A novel miR164-AlNAC1 module adjusting the expression of genes related to chlorophyll synthesis and ROS synthesis, and regulating leaf senescence in Atractylodes lancea. Leaf senescence is a critical developmental process regulated by complex genetic networks. In this study, a novel miRNA belonging to the MIR164 family was identified as a key regulator of leaf senescence in A.

Exploration of the optimal retention method in vivo for stem cell therapy: Low-intensity ultrasound preconditioning.

Bone marrow mesenchymal stem cells (BMSCs) are pluripotent and self-renewing, exerting a crucial role in the domain of regenerative medicine. Nevertheless, BMSCs encounter challenges such as low cell viability and inadequate homing during transplantation, thereby restricting their therapeutic efficacy. Hence, current research is concentrated on identifying optimal retention approaches following BMSCs transplantation to enhance its effectiveness.

The potential of low-intensity pulsed ultrasound to apply the long-term ovary protection from injury induced by 4-vinylcyclohexene diepoxide through inhibiting granulosa cell apoptosis.

The potential of low-intensity pulsed ultrasound (LIPUS) in regulating ovarian function has been demonstrated; however, there is a lack of scientific evidence regarding the long-term efficacy of LIPUS in treating ovarian injury and understanding its regulatory mechanisms. In this study, 4-vinylcyclohexene diepoxide (VCD) was used to induce ovarian injury in rats, and LIPUS was applied to target the damaged ovarian tissues. The research aimed to investigate the long-term protective effect of LIPUS against ovum toxicity induced by VCD and elucidate the associated molecular mechanisms.

Hydrogen peroxide in midbrain sleep neurons regulates sleep homeostasis.

Sleep could protect animals from oxidative damage, yet the dynamic interplay between the redox state and sleep homeostasis remains unclear. Here, we show that acute sleep deprivation (SD) in mice caused a general increase in brain oxidation, particularly in sleep-promoting regions. In vivo imaging of intracellular hydrogen peroxide (HO) real-time dynamics revealed that in nigra sleep neurons, the increase in cytosolic but not mitochondrial HO reflects sleep debt and tracks spontaneous wakefulness by positively correlating with wake duration.