A Wearable EMG-Driven Closed-Loop TENS Platform for Real-Time, Personalized Pain Modulation.

A wearable closed-loop transcutaneous electrical nerve stimulation (TENS) platform has been developed to address the limitations of conventional open-loop neuromodulation systems. Unlike existing systems such as CLoSES-which targets intracranial stimulation-and electromyography-triggered functional electrical stimulation (EMG-FES) platforms primarily used for motor rehabilitation, the proposed device uniquely integrates low-latency surface electromyography (sEMG)-driven control with six-channel current stimulation in a fully wearable, non-invasive format aimed at ambulatory pain modulation. The system combines real-time sEMG acquisition, adaptive signal processing, a programmable multi-channel stimulation engine, and a high-voltage, boost-regulated power supply within a compact, battery-powered architecture.

A 40-year bibliometric analysis of global research on neoadjuvant chemotherapy for oral cancer (1985-2024).

Background: Neoadjuvant chemotherapy (NAC) has become a critical component in the treatment of oral cancer, enhancing tumor resectability and improving patient survival. This study aimed to perform a bibliometric analysis to systematically explore global research trends, key contributors, and emerging hotspots in NAC for oral cancer.

Methods: Publications from 1985 to 2024 were retrieved from the Web of Science Core Collection.

Ciprofol exerts anti-tumour effects in hepatocellular carcinoma through the Raf-MEK-ERK signalling pathway.

Background: Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumours of the digestive system and the third leading cause of cancer-related deaths worldwide. As the most common type of primary liver cancer, HCC is associated with poor prognosis despite advancements in treatment options such as radical resection, liver transplantation, and adjuvant therapies. Surgical resection remains the cornerstone of HCC treatment; however, postoperative recurrence and metastasis pose significant challenges to patient survival.

Characterization of Novel WFS1 Variants in Three Diabetes Pedigrees.

Background: Mutations in the WFS1 gene are implicated in Wolfram syndrome (WS), Wolfram-like syndrome (WFLS), and maturity-onset diabetes of the young (MODY). Wolfram syndrome 1 (WFS1) is a diabetes-related gene encoding wolframin, a glycoprotein with nine transmembrane domains localized in the endoplasmic reticulum. However, the relationship between WFS1 mutations and their associated phenotypes remains incompletely understood, requiring additional patient data collection for further investigation.

Role of glycoproteins in hepatic lipid metabolism: emerging diagnostic markers and therapeutic targets.

The liver is an important metabolic organ in the human body, and abnormal hepatic lipid metabolism may lead to a variety of diseases such as metabolic dysfunction-associated fatty liver disease, cirrhosis, and hepatocellular carcinoma. These diseases are often closely associated with chronic diseases, including obesity, hypertension, high cholesterol and diabetes, and have become major factors increasing the global disease burden. Currently, the diagnosis of diseases related to hepatic lipid metabolism relies mainly on imaging findings and serologic markers.

Medical service utilization status and its influence factors in children with attention deficit hyperactivity disorder in China: a nationwide multicenter cross-sectional study.

Background: Children with attention deficit hyperactivity disorder (ADHD) need constant access to medical resources. This study aimed to evaluate the knowledge about attention deficit hyperactivity disorder (ADHD), preference for clinic visits, and treatment in China.

Methods: This multicenter cross-sectional study included children aged 6-12 along with their parents and head-teachers who filled in the Swanson, Nolan, and Pelham scale version IV-Parent/Teacher scales and self-compiled questionnaires.

Celastrol Alleviates Intestinal Epithelial Permeability by Inhibiting Ferroptosis through PI3K/Akt/FOXO1/HO-1 Signaling Pathway.

Ulcerative colitis (UC) is a recurrent inflammatory intestinal disorder characterized by systemic inflammatory response, abnormal intestinal epithelial cell death, and damage to the intestinal mucosal barrier. This study aimed to explore the role of celastrol in ferroptosis and intestinal epithelial barrier permeability. The results demonstrated that celastrol significantly inhibited ferroptosis in RSL3-induced intestinal epithelial cells by regulating the expression of ferroptosis-related proteins.

Challenges and future prospects of the 2D material-based composites for microwave absorption.

The widespread use of electronic devices inevitably brings about the problem of electromagnetic pollution. As a result, it is important and urgent to develop efficient absorbing materials to alleviate increasing pollution issues. Recently, two-dimensional (2D) material-based microwave absorbers have attracted wide attention in microwave absorption due to their unique lamellar structure, large specific surface area, low density, good thermal and chemical stability.

Nutritional status and systemic inflammation in COPD: prognostic value of the advanced lung cancer inflammation index.

Background: Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of global mortality, with systemic inflammation and malnutrition playing pivotal roles in its progression and outcomes. The Advanced Lung Cancer Inflammation Index (ALI), which integrates nutritional status and systemic inflammation, may offer potential prognostic value in COPD management.

Objectives: This study aimed to evaluate the relationship between ALI and mortality outcomes in COPD patients, with a specific focus on the interplay between nutrition, inflammation, and their non-linear associations with all-cause and cardiovascular mortality.

Cortical functional connectivity and topology based on complex network graph theory analysis during acute pain stimuli.

Purpose: We aimed to investigate alterations in the topological organization of functional brain networks in acute pain.

Methods: A total of 29 capsaicin group (CAP) and 19 sham controls (Sham) underwent a 10-min resting-state functional near-infrared spectroscopy scan. The CAP group applied capsaicin cream (0.

Enhancing and Shaping Closed-Loop Co-Adaptive Myoelectric Interfaces With Scenario-Guided Adaptive Incremental Learning.

Virtual environments have been employed in the myoelectric prosthetics field as effective training and assessment tools to enhance intrinsic motivation, thereby encouraging sustained engagement in neuromuscular rehabilitation. However, motivating amputees to maintain consistent participation and perseverance in long-term training remains a critical challenge. To address this, we propose a scenario-guided adaptive incremental learning strategy that leverages contextual information in unknown environments to improve pseudo-label prediction accuracy.

Exosomes derived from human amniotic mesenchymal stem cells promotes angiogenesis in hUVECs by delivering novel miRNA N-194.

Background: To investigate the effect and mechanism of exosomes derived from human amniotic mesenchymal stem cells (hAMSC-Exos) promoting angiogenesis.

Methods: HAMSC-Exos were isolated using ultracentrifugation and characterized by transmission electron microscopy, NTA, and Western blot. The uptake of hAMSC-Exos by hUVECs was analyzed using PKH-26 labeling, and the effect of hAMSC-Exos on angiogenesis was analyzed in human umbilical vein endothelial cells hUVECs by cell viability assay, Transwell migration assay, Matrigel tube formation assay, and Matrigel plug assays in nude mice.

Chinese Expert Consensus on Integrated Chinese and Western Medicine for the Treatment of Tic Disorders.

Objective: Tic disorders are neurodevelopmental conditions that manifest in childhood or adolescence and can significantly impact the quality of life of affected children and their families to varying degrees. Integrated traditional Chinese and Western medicine treatment strategies have demonstrated more pronounced efficacy and better safety profiles. However, there is currently no standardized clinical expert consensus on this approach.

Expression, Function, and Regulation of ABCG2 on the Intestinal Epithelial Barrier Permeability.

Human breast cancer resistance protein (BCRP, gene symbol ABCG2) is an ATP-binding cassette (ABC) efflux transporter that is highly expressed on the apical membranes of intestinal epithelium and contributes to the absorption, distribution, and elimination of xenobiotics and the efflux of endogenous molecules. Also, the intestinal epithelial monolayer is the largest interface and the most important functional barrier between the internal environment and the systemic circulation. Extensive studies have demonstrated that intestinal ABCG2 of humans and rodents plays a crucial role in limiting absorption of xenobiotics, which are ABCG2 transport substrates, in the small intestine by mediating distribution in the intestinal epithelial barrier.

Delayed Massive Hemothorax Induced by Tunneled Dialysis Catheter Placement via the Left Internal Jugular Vein: A Case Report.

The tunneled dialysis catheter is among the most commonly used vascular accesses for patients undergoing hemodialysis. Delayed hemothorax resulting from central venous perforation induced by catheterization is a rare but serious complication. However, there are few reports.

Enhancing and Optimizing User-Machine Closed-Loop Co-Adaptation in Dynamic Myoelectric Interface.

Co-adaptation interfaces, developed through user-machine collaboration, have the capacity to transform surface electromyography (sEMG) into control signals, thereby enabling external devices to facilitate or augment the sensory-motor capabilities of individuals with physical disabilities. However, the efficacy and reliability of myoelectric interfaces in untrained environments over extensive spatial range have not been thoroughly explored. We propose a user-machine closed-loop co-adaptation strategy, which consists of a multimodal progressive domain adversarial neural network (MPDANN), an augmented reality (AR) system and a scenario-based dynamic asymmetric training scheme.

Nanozyme based ultra-stretchable, low-hysteresis, and dual-mode antibacterial composite hydrogels for wound healing.

Wound care always presents challenges as they are susceptible to bacterial infections and have mechanical compatibility issues with wound dressings, leading to a delayed recovery of the structure and functional integrity of skin tissue. Herein, an iron-based metal-organic framework loaded with gold (Fe-MIL-88NH-Au) nanozyme based composite hydrogel (HMAux) with excellent mechanical compatibility and dual-mode antibacterial properties was designed for wound care. To obtain HMAux, Fe-MIL-88NH-Au nanozyme with photothermal properties and peroxidase-like and oxidase-like activities was prepared.

Correlation analysis of serum endothelial cell specific molecule-1, endothelial microparticles, hypoxia inducible factor-1α levels and acute myocardial infarction and their predictive value for major adverse cardiovascular events: a retrospective study.

Objective: This study aimed to analyse the correlation of endothelial cell specific molecule-1 (ESM-1), endothelial microparticles (EMPs) and hypoxia inducible factor-1α (HIF-1α) serum levels with the occurrence of acute myocardial infarction (AMI) and determine their short-term predictive value for major adverse cardiovascular events (MACE) following AMI treatment.

Methods: Retrospective data analysis was performed on the medical records of 106 patients with AMI admitted to our hospital between October 2020 and October 2022. The control group consisted of 106 healthy volunteers that received a physical examination at our hospital's physical examination centre within the same time frame.

Design and evaluation of powered lumbar exoskeleton based on human biomechanics.

Objectives: In view of the gradual rejuvenation and acceleration of lumbar spondylosis, a wearable powered lumbar exoskeleton based on a 6-SPU/SP parallel mechanism is designed based on the rehabilitation treatment method of lumbar forward flexion/extension, left/right lateral flexion and rotation.

Methods: First, the changes in human lumbar muscles are analyzed based on human biomechanics, and then the prototype design of the powered lumbar exoskeleton is implemented, including the mechanical mechanism design, and hardware module design. Finally, the simulation experiment of muscle force and output sensitivity test in the resistive mode are conducted.

Camera-based Gait Kinematic Features Analysis and Recognition of Autism Spectrum Disorder.

The atypical development in children with autism spectrum disorder (ASD) may cause varying degrees of gait deficits, characterized by uncoordinated and peculiar postures. However, these symptoms are often ignored due to their subtlety. This study aimed to quantify the atypical gait pattern in ASD and explore the feasibility of a gait-based method for ASD recognition.

Investigating the course and predictors of desire to void based on heart rate variability.

Urinary incontinence is closely related to the motor ability and toileting tasks. Some nursing home residents with limited mobility who cannot reach the bathroom in time highly depend on caregivers for toileting assistance. However, nursing home staffing is often insufficient to meet the needs of all residents.

Identification of early prediction biomarkers of severity in patients with severe fever with thrombocytopenia syndrome based on plasma proteomics.

Background: Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging infectious disease. Given its rapid disease progression and high mortality rate, early warning is crucial in improving the outcomes, However, to date, relevant comprehensive predictors or an effective prediction model are still poorly explored.

Methods: A plasma proteomic profile was performed at early stages in patients with SFTS.

Evaluation of the efficacy of a novel lumbar exoskeleton with multiple interventions for patients with lumbar disc herniation: a multicenter randomized controlled trial of non-inferiority.

Background: Lumbar disc herniation (LDH) occurs when the nucleus pulposus or annulus fibrosus protrudes into the intervertebral space, potentially compressing nerve roots and causing symptoms such as sciatica, restricted mobility, and lower extremity weakness. The development of portable lumbar exoskeleton devices offers a new approach, combining traction, range of motion (ROM) exercises, and resistance training in a single system, potentially reducing treatment complexity and enhancing LDH patient outcomes.

Objective: This study aims to evaluate the efficacy and safety of a novel lumbar exoskeleton device compared to traditional traction methods combined with rehabilitation therapy for patients with LDH.

Targeting intracellular cancer proteins with tumor-microenvironment-responsive bispecific nanobody-PROTACs for enhanced therapeutic efficacy.

Proteolysis targeting chimeras (PROTACs) are pivotal in cancer therapy for their ability to degrade specific proteins. However, their non-specificity can lead to systemic toxicity due to protein degradation in normal cells. To address this, we have integrated a nanobody into the PROTACs framework and leveraged the tumor microenvironment to enhance drug specificity.