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Article Abstract
Wound care always presents challenges as they are susceptible to bacterial infections and have mechanical compatibility issues with wound dressings, leading to a delayed recovery of the structure and functional integrity of skin tissue. Herein, an iron-based metal-organic framework loaded with gold (Fe-MIL-88NH-Au) nanozyme based composite hydrogel (HMAux) with excellent mechanical compatibility and dual-mode antibacterial properties was designed for wound care. To obtain HMAux, Fe-MIL-88NH-Au nanozyme with photothermal properties and peroxidase-like and oxidase-like activities was prepared. Then it was introduced into the hydrogel system with a sea-island structure which was prepared the copolymerization of acrylamide and acryloyl Pluronic F127 (PF127-DA) in the aqueous solution. Using dynamic micelles as the energy dissipation mechanism, double bonds and intermolecular interactions as two crosslinking methods in HMAux make it possess good stretchability (3244 %-4524 %), toughness (593.8 kJ/m to 421.5 kJ/m), and low hysteresis (0.13-0.15). Furthermore, the synergistic photothermal and chemodynamic effects provide good antibacterial performance under mild conditions, with killing rates of approximately 95.02 % and 97.28 % for and , respectively. experiments have proved that HMAux can effectively adapt to the contour of the wound and treat wound infections.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966732 | PMC |
| http://dx.doi.org/10.1016/j.mtbio.2025.101547 | DOI Listing |
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